一氧化氮吸入对脓毒血症幼猪血流动力学影响

目的探讨脓毒血症幼猪吸入一氧化氮(nitric oxide,NO)及突然停吸NO后血流动力学的动态变化。方法幼猪8只,采用静脉注射革兰氏阴性杆菌内毒素方法诱导脓毒血症模型,幼猪吸入浓度为10cm3/m3的NO,于吸入前10min、吸入10、20、30min和停止吸入后30min应用脉波指示剂连续心排血量监测仪监测心率、心脏指数、胸腔内血容积指数和全心舒张末容积指数,并行血气分析。结果幼猪吸入NO 10、20、30min时股动脉pa(O_2)[(38.10±5.22)、(50.76±3.89)、(53.86±3.03)kPa]和心脏指数[(2.58±0.12)、(3.03±0.25)、(3.24±0.26)L/(min·m^2)]均明显高于吸入前[(55.85±3.16)kPa、(3.43±0.18)L/(min·m^2)](P<0.01);突然停吸NO后30min,pa(O_2)[(38.01±4.50)kPa]和心脏指数[(2.83±0.43)L/(min·m^2)]较吸入NO 20、30min时均明显下降(P<0.05),但仍明显高于吸入前(P<0.05);吸入NO及停吸NO期间,心率、中心静脉压、全心舒张末容积指数、胸腔内血容积指数差异均无统计学意义(P>0.05)。结论吸入低浓度NO气体对脓毒血症幼猪的氧合功能和心脏指数有明显改善,但突然停吸NO后股动脉pa(O_2)和心脏指数均下降,存在反跳现象。     

一氧化氮吸入对羊感染性急性呼吸窘迫综合征血液动力学和肺氧合功能的影响

目的：探讨一氧化氮（NO）吸入对羊感染性急性呼吸窘迫综合征（ARDS）血流动力学和肺氧合功能的影响。方法：静脉注入小剂量内毒素诱导羊感染性ARDS模型。随机分为两组：（1）NO组（n=6）为ARDS建立后，在容量控制通气基础上持续吸入40ppmNO 3h；（2）对照组（n=6)为ARDS一单纯容量控制通气，观察3h以确定模型的稳定性并与NO组比较，通过肺动脉导管和动脉血气分析，测定各组每小时肺气体交换和血流动力学参数，3h结束实验时，检测血中高铁血红蛋白（MetHb）浓度。结果：静脉注入小剂量内毒素能够诱导稳定的羊感染性ARDS模型，该模型的平均肺动脉压（MPAP）较基础值明显升高（P＜0．01），体循环血液动力学则能维持稳定。NO组各时点MPAP均较治疗前和同时点的对照组低（P＜0．01），动脉氧分压（PaO2）则明显增加（P＜0．01），肺泡动脉血氧分压差（PA－aO2)和肺内分流（Qs/Qt)明显低于治疗前和同时点的对照组（P＜0．01）。两组平均动脉压（MAP）和心排量（CO）各时点及治疗前后比较均无明显变化（P＞0．05），MetHb未见明显升高，结论：吸入NO选择性降低肺动脉压，改善肺氧合，无明显毒副作用。     

俯卧位通气联合一氧化氮吸入对急性呼吸窘迫综合征患者氧合的影响

目的 评价俯卧位通气(PPV)联合NO吸入对急性呼吸窘迫综合征(ARDS)患者氧合的影响.方法 将我院重症医学科2008年9月至2011年1月收治的,应用最佳PEEP后仍需较高的吸入氧体积分数(FIO2≥60％)的21例ARDS患者,随机(随机数字法)分为三组进行对照研究.A组采取单纯NO吸入4h;B组采取俯卧位通气2h,2h后恢复仰卧位通气;C组采取俯卧位通气联合NO吸入2h,2h后恢复仰卧位通气并继续吸入NO.分别测三组患者治疗干预前、2h及4h氧合指数.统计学处理采用SPSS 13软件,数据以均数±标准差(-x±s)表示,组间比较用单因素方差分析,组内比较用t检验,P ＜0.05为差异有统计学意义.结果 与治疗干预前比较,三组患者2h后氧合指数均较前改善,但A组患者差异无统计学意义(P＞0.05),B组和C组患者差异有统计学意义(P ＜0.05);4h后A组和B组氧合指数跟治疗干预前比较无显著差异(P＞0.05),C组氧合指数仍保持改善(P＜0.05).结论 俯卧位通气可以有效地改善严重ARDS患者氧合,俯卧位通气联合NO吸入不但可以改善氧合,而且恢复仰卧位后能有效的维持氧合,因此卧位通气联合NO吸入的方法在改善氧合的同时能减少俯卧位通气时间.     

米力农对心肌损伤病人血流动力学和氧动力学的影响

目的 探讨米力农对心肌损伤病人血流动力学和氧动力学的影响。方法 对12例胸部外伤致心肌损伤病人放置Swan-Ganaz导管，按0．45μg(kg.min）持续静脉滴注米力农，分别在滴注前和滴注后6、12、24、48、72h测定血流动力学和氧动力学指标。结果 心脏指数（CI）自滴注6h后即明显升高（P＜0．01），平均动脉压（MAP）从12开始有显著提高（P＜0．05），全身血管阻力指数（SVRI）和肺血管阻力指数（PVRI）在6h后均呈显著下降（P＜0．01），心率（HR）在测定过程中无明显变化；全身氧供给（DO2）在滴注6h后均呈显著下降（P＜0．01），心率（HR）在测定过程中无明显变化；全身氧供给（DO2）在滴注6h后有明显升高（P＜0．01），同时伴氧摄取率（ExtrO2）显著降低，全身氧消化（VO2）则在测定过程中保持相对稳定。结论 米力农能明显提高心肌损伤病人的心肌收缩力，降低全身和肺血管阻力，增加全身组织的氧供给，有利于维持微循环的稳定。     

感染性休克患者血流动力学和氧合功能的变化

目的：研究感染性休克患者血流动力学和氧合功能的变化。方法：因输液致感染性休克患者８ 例,入ＩＣＵ后置入Ｓｗａｎ Ｇａｎｚ导管测定中心静脉压（ＣＶＰ）、肺动脉平均压（ＭＰＡＰ）、肺毛细血管嵌压（ＰＣＷＰ）;用热稀释法测定心排血量（ＣＯ）,同时监测平均动脉压（ＭＡＰ）和心率。于入ＩＣＵ 后１、２、３、４ 和５ 日内进行血气分析,计算出氧输送（ＤＯ２ ）、氧耗量（ＶＯ２ ）、氧摄取率（Ｏ２ｅｘｔｒ）、肺内分流率（Ｑｓ／Ｑｔ）、肺泡 动脉血氧分压差〔Ｐ（Ａ－ ａ）Ｏ２ 〕、外周血管阻力指数（ＳＶＲＩ）、肺血管阻力指数（ＰＶＲＩ）和心排指数（ＣＩ）。结果：感染性休克患者入ＩＣＵ 后１ 日内ＭＡＰ和ＣＶＰ分别降低３８．５％ 和４２．８％ （Ｐ均＜ ０．０１）;入ＩＣＵ 后３ 日内ＰａＯ２ 降低３０．６％ ～４３．２％ ,〔Ｐ（Ａ－ ａ） Ｏ２ 〕和Ｏ２ｅｘｔｒ分别升高３８．８％ ～５０．３％ 和８．０％ ～３２．０％ （Ｐ均＜ ０．０１）;入ＩＣＵ 后５ 日内ＣＩ、ＰＶＲＩ、ＭＰＡＰ、ＤＯ２ 、ＶＯ２ 和Ｑｓ／Ｑｔ分别升高１２．０％ ～２２．３％ 、３５．３％ ～５８．２％ 、１７．２％ ～２４．８％ 、１１．９％ ～２０．９％ 、１４．９％     

去甲肾上腺素对山羊急性呼吸窘迫综合征吸入一氧化氮疗效的影响

目的 观察去甲肾上腺素(NE)对山羊感染性急性呼吸窘迫综合征(ARDS)吸入一氧化氮(NO)疗效的影响。方法 静脉注入小剂量内毒素诱导山羊感染性ARDS模型6只,在吸入体积分数为40×10-6的NO 30 min后,联合静脉泵入NE 0.5μg·kg-1·min-1治疗。通过肺动脉导管、动脉和混合静脉血气分析,测定基础、ARDS时、NO吸入治疗30 min和联合NE静脉泵入治疗30 min后血流动力学指标和肺气体交换参数。结果 NO吸入治疗能显著降低ARDS山羊的平均肺动脉压(MPAP),增加动脉氧分压(PaO2),减少肺泡动脉氧分压差[P(A-a)O2]和肺内分流率(Qs/Qt);联合NE静脉泵入不影响吸入NO后降低的MPAP,增加吸入NO后升高的PaO2,降低NO吸入后减少的P (A-a)O2和Qs/Qt,升高吸入NO后无改变的平均动脉压(P<0.05或P<0.01);吸入NO及联合应用NE治疗均不改变ARDS山羊的心排血量。结论静脉注入NE能增强吸入NO后改善感染性ARDS肺气体交换的疗效。     

吸入一氧化氮联合反比通气治疗感染性急性呼吸窘迫综合征

目的 :观察吸入一氧化氮 (NO)联合反比通气 (IRV)对感染性急性呼吸窘迫综合征 (ARDS)羊血流动力学、肺气体交换和机械力学的影响。方法 :静脉注入小剂量内毒素诱导的羊感染性 ARDS模型 12只 ,随机均分为两组。 NO组吸入 4 0× 10 - 6 NO,复合组联合容量控制反比通气 (VC IRV)和吸入 4 0× 10 - 6 NO。通过肺动脉导管、动脉和混合静脉血气分析 ,测定基础、ARDS和治疗 30 m in后肺气体交换和血流动力学参数 ,记录相应时间点的气道峰压 (PIP)、平均气道压 (Pm)和内源性呼气末正压 (PEEPi)。结果 :NO组和复合组治疗期间平均肺动脉压较 ARDS时均显著降低 (P均 <0 .0 1) ,动脉血压和心排血量则无明显变化 ;治疗 30 m in后 ,两组均能明显提高 ARDS的 Pa O2 (P均 <0 .0 1) ,减少肺泡动脉氧分压差〔 P( A a) O2 〕和肺内分流 (Qs/ Qt,P均 <0 .0 1) ,复合组更为显著 (P均 <0 .0 5 ) ;NO组各监测时间点 PIP、Pm均无明显变化 ,复合组的 Pm较治疗前及NO组对应时间点高 (P均 <0 .0 5 ) ,PIP则低 (P均 <0 .0 5 )。复合组治疗时 ,PEEPi为 (2 .5± 0 .5 ) cm H2 O(1cm H2 O=0 .0 98k Pa)。结论 :吸入 NO复合 IRV可协同改善 ARDS肺氧合 ,不影响体循环。     

吸入氧气和一氧化氮对肺心病患者血清动力学的影响

目的：评价分别吸入３１％Ｏ２和６０ｐｐｍＮＯ对肺心病肺动脉高压的治疗作用。方法：１９例肺心病患者分成两组，分别在右心微导管检查时吸入Ｏ２或ＮＯ３０分钟，观察吸入气体前后血流动力学参数、氧饱和度的变化。结果：吸入ＮＯ后，肺动脉收缩压、舒张压及平均压分别下降１５．８５％、２６．４２％和１９．０３％；而吸入３１％Ｏ２后则下降１３．６３％、１７．２９％和１５．７１％。结论：吸入Ｏ２或ＮＯ均可使肺心病患者肺     

高频震荡通气与吸入一氧化氮在严重氧合障碍患者中的应用

我们对 6例常规机械通气无效的患者 ,分别予以吸入一氧化氮 (NO)和换用高频震荡通气治疗 ,报告如下。1　病例与方法1.1　病例 :1999— 2 0 0 1年治疗的 6例患者中 ,男 5例 ,女 1例 ,均有严重的氧合功能障碍 ,并合并多器官功能不全或衰竭。 6例患者的一般情况见表 1。根据急性生理学与慢性健康状况评价系统 (APACHE )评分 ,所有患者病死率预计均达 10 0 % ,常规机械通气时所有患者均使用高档电脑呼吸机 ,模式容量控制通气 (VCV)或压力控制通气 (PCV)加呼气末正压 (PEEP) ,经 48小时以上 ,氧合指数仍 <(5 1.0± 6 .4) k Pa(1k Pa=7.5…     

连续性血液净化对感染性休克患者血流动力学及氧合指数的影响

目的观察连续性血液净化(CBP)对感染性休克患者血流动力学及氧合指数的影响。方法我科确诊的25例感染性休克患者行CBP治疗及脉搏波形心排量监测(PICCO)72小时,治疗前和治疗后1、2、6、12、24、48、72小时分别测量持续心排量指数(CCI),外周血管阻力指数(SVRI)等血流动力学参数,同时检测动脉血气分析计算氧合指数,记录心率(HR)、有创平均动脉压(MAP)及去甲肾上腺素(NA)剂量的变化。结果治疗前、后血流动力学指标MAP、CCI、SVRI及氧合指数(OI,PaO2/FiO2)均有明显的改善(P0.05),在48及72小时改善尤为明显(P0.01),同时伴随去甲肾上腺素剂量的下降。结论 CBP可改善感染性休克患者血流动力学参数及氧合指数。     

生物喋呤对烫伤脓毒症大鼠一氧化氮合成的影响

目的：探讨生物喋呤BH4在金黄色葡萄球菌（简称金葡菌）脓毒症中的生物学效应，阐明BH4对一氧化氮（NO）诱生的调控作用。方法：76只Wistar大鼠随机分为正常对照组（n=10)、烫伤对照组（n=10)、烫伤后金葡菌感染组（n=40)和羟基嘧啶（DAHP）拮抗组（n=16)。无菌留取动物肝、肺组织采用RT－PCR方法检测三磷酸鸟苷环水解酶I（GTP－CHI）、诱生型一氧化氮合酶（iNOS)基因表达，同时测定组织中BH4和NO的水平。结果：烫伤后金葡菌感染组动物肝、肺组织中GTP－CHI基因表达明显上调，BH4产生显著增加，iNOS mRNA表达和NO的水平亦明显升高，DAHP组GTP－CHI基因表达上调和BH4合成NO的产生亦明显下降。结论：烫伤后金葡菌感染可诱导体内BH4的合成，BH4在基因和蛋白水平调控着iNOS所介导的NO大量生成，从而对金葡菌脓毒症的病理过程起促进作用。     

Improvement in oxygenation by prone position and nitric oxide in patients with acute respiratory distress syndrome

Objective: Inhaled nitric oxide (NO) and prone position improve arterial oxygenation in patients with the acute respiratory distress syndrome. This study was undertaken to assess the combined effects of NO and prone position in these patients. Design: Prospective clinical study. Setting: General intensive care service in a community teaching hospital. Patients: 14 mechanically ventilated adult patients with the acute respiratory distress syndrome (mean lung injury score 3.23 ± 0.27). Measurements and results: We measured hemodynamic and oxygenation parameters in the supine position and 2 h later in the prone position, before and during inhalation of 10 ppm NO. A positive response in oxygenation was defined as a ≥ 20 % increment in the arterial oxygen tension/fractional inspired oxygen ratio (PaO₂/FIO₂). In the prone position PaO₂/FIO₂ increased significantly (from 110 ± 55 to 161 ± 89 mmHg, p < 0.01) and venous admixture decreased (from 38 ± 12 to 30 ± 7 %, p < 0.01) compared to the supine position. Ten of the 14 patients were responders in the prone position. In the supine position, inhalation of NO improved oxygenation to a lesser extent, increasing PaO₂/FIO₂ to 134 ± 64 mmHg (p < 0.01) and decreasing venous admixture to 35 ± 12 %, (p < 0.01). Five of the 14 patients responded to NO inhalation supine and 8 of 14 responded prone (p = 0.22). The combination of NO therapy and prone positioning was additive in increasing PaO₂/FIO₂ (197 ± 92 mmHg) and decreasing venous admixture (27 ± 8 %) (p < 0.01). This combination also showed a positive oxygenation response on compared to the supine value without NO in 13 of the 14 patients (93 %). NO-induced changes in PaO₂/FIO₂ were correlated to changes in pulmonary vascular resistance only in the prone position. Conclusions: In patients with the acute respiratory distress syndrome, the combination of NO and prone position is a valuable adjunct to mechanical ventilation. Received: 15 June 1998 Final revision received: 13 October 1998 Accepted: 30 October 1998     

血液滤过对严重创伤后并发急性呼吸窘迫综合征患者氧合功能和血流动力学的影响

目的 研究血液滤过对严重创伤后并发ARDS患者氧合功能和血流动力学的影响。方法 选择严重创伤后ARDS患者12例，在呼吸机辅助或控制呼吸下行血液滤过治疗，于血液滤过后1－5d内用Swan-Ganz漂浮导管监测血流动力学和肺氧功能的变化。结果 与血液滤过前比较，滤过后第1天CVP、MPAP、SVRI、PVRI显著降低，整个血液滤过时间PaO2／FiO2升高非常显著，MAP、PCWP、HR、CI、DO2、VO2、ExtrO2、Qs/Qt无显著变化。结论 血液滤过对严重创伤后ARDS患者的血流动力学和氧合功能无明显影响，但可使氧合指数升高。     

一氧化氮对细菌性肺炎大鼠炎症介质的影响

目的探讨吸入一氧化氮(NO)对肺炎克雷白杆菌肺炎大鼠肺部炎症介质的影响。方法健康大鼠随机分为肺炎组(P)和正常对照(C)组,P组气道注入肺炎克雷白杆菌(约1.3×108cfu只),然后分组(n=8～10)干预24h:吸入空气(PA)、NO(20×10-6,PNO)、低氧(FiO20.4,PLO)、低氧加NO(PLONO)、高氧(FiO21.0,PHO),高氧加NO(PHONO);C组吸入空气(CA)或NO(CNO)。测定肺组织原生型和诱生型NO合酶(cNOS和iNOS)活性,肿瘤坏死因子α(TNFα)和细胞间黏附分子1(ICAM1)蛋白水平及mRNA表达。结果PA组iNOS活性显著高于CA组(P<0.01),cNOS活性显著低于CA组(P<0.01);PNO、PLO、PLONO、PHO及PHONO组均可使被抑制的cNOS活性增强,PHO及PHONO可抑制iNOS活性增加;TNFα水平PA和PHONO组均显著高于CA组(P<0.01),PNO、PLO和PLONO组均显著低于PA组(P<0.01);ICAM1水平PA组显著高于CA组(P<0.01),PNO、PLONO和PHONO组分别低于PA、PLO和PHO组(P<0.01)。各组肺组织TNFα、ICAM1、内皮细胞型NOS和iNOSmRNA表达差异均无显著性。结论吸入NO和或氧气对肺炎大鼠肺内cNOS及iNOS活性具有不同调节作用;吸入NO可抑制肺组织ICAM1表达;吸入NO和或低浓度氧可降低TNFα表达。吸入NO可能通过调节急性炎症反应介质预防炎症性肺损伤。     

Prolonged exposure to inhaled nitric oxide does not affect haemostasis in piglets

Objective To examine possible adverse effects on haemostasis from prolonged exposure to inhaled nitric oxide (iNO). Design and setting Blinded, randomised, experimental animal study in a university animal laboratory. Interventions Anaesthetised and intubated piglets received central venous, arterial, and transabdominal urinary catheters. Twelve piglets were studied with triggered pressure support ventilation breathing with an air–oxygen mixture for 30 h with nitric oxide (NO), 40 parts per million (ppm) (n = 6) or without NO gas (n = 6) added. The tests of platelet function were assessed in a separate 1-h experiment in which 12 additional animals were blindly randomised to receive intravenous acetylsalicylic acid (ASA) (n = 7) or placebo (n = 5). Measurements and results All 12 animals were clinically stable during the study period of 30 h. Haemostasis was assessed in terms of bleeding time and platelet function by Adeplat-S, reflecting platelet adhesion. Prothrombin fragment 1 + 2, fibrin D-dimer, tissue plasminogen activator and prothrombin complex were measured to investigate whether inhaled NO (iNO) had any effects on thrombin formation, fibrin formation, fibrinolysis or coagulation. All parameters including bleeding time and Adeplat-S were unaffected by iNO. ASA significantly increased bleeding time, but did not affect Adeplat-S. Nitrate in plasma and NOx (nitrate and nitrite) in urine increased significantly in pigs receiving iNO compared with controls. Conclusions Prolonged exposure to iNO at 40 ppm did not affect bleeding time or coagulation parameters in healthy piglets. The findings do not support the hypothesis that iNO increases the risk of bleeding in humans. The study was performed at the Department of Experimental Surgery and Biomaterials Research, Medical University of Wroclaw, Poland.     

Delivery and monitoring of inhaled nitric oxide

Inhaled nitric oxide is rapidly gaining popularity as a selective pulmonary vasodilator in patients with acute lung injury and pulmonary hypertension. The development of nitric oxide as a drug has bypassed the usual regulatory and commercial processes, and as a result clinicians have devised a wide range of delivery and monitoring systems. This review describes these systems, and discusses their advantages, disadvantages and safety. The monitoring of nitric oxide metabolites is also discussed.     

Modulation of hypoxic pulmonary vasoconstriction is time and nitric oxide dependent in a peritonitis model of sepsis

Objective This study assessed modulation of hypoxic pulmonary vasoconstriction (HPV) in isolated perfused rat lungs during sepsis induced by cecal ligation and perforation (CLP) at different times and its relationship to nitric oxide synthases (NOS).Design and setting Prospective controlled trial in a university research laboratory.Subjects 102 male Sprague-Dawley rats.Interventions Groups 1–3 received sham laparotomy 6 h before lung isolation: group 1, only laparotomy; group 2, concurrently l-N ⁶-(1-iminoethyl)-lysine (L-NIL, 3 mg/kg); group 3, concurrently N -nitro-l-arginine methylester (L-NAME, 5 mg/kg). Groups 4–6 received CLP 6 h before lung isolation: group 4, only CLP; group 5, concurrently L-NIL; group 6, concurrently L-NAME. The same experiments were carried out with sham and CLP treatment for 24 h (groups 7–12). Exhaled NO from rats lungs was measured after anesthesia and tracheostomy. After the pulmonary circuit was isolated and perfused, angiotensin II (0.1 µg) was injected into the inflow tract. The lungs were ventilated with the hypoxic mixture (HPV, 3% O₂) for 10 min and then again with the normoxic mixture (21% O₂) for an equal period. Changes in perfusion pressure were measured. Endothelial (eNOS) and inducible NOS (iNOS) expression of the lungs was determined.Measurements and results Treatment with L-NAME but not L-NIL increased HPV in sham lungs. HPV was unaltered after CLP 6 h and decreased after CLP 24 h compared to sham. In CLP animals eNOS protein expression was reduced whereas iNOS expression was increased compared to sham animals. Exhaled NO, reflecting NOS activity was twice as high in the CLP 24 h group than in the CLP 6 h group.Conclusions In the CLP sepsis model modulation of HPV was time-dependent. In addition, vasoconstriction to hypoxic stimuli was dependent on NOS activity.L.G. F. is supported by Innovative Medizinische Forschung Münster, Germany (Fi-1-2000-4)     

连续性血液净化对感染性多脏器功能障碍综合征患者血流动力学及氧代谢的影响

目的 探讨连续性血液净化(CBP)对感染所致多脏器功能障碍综合征(MODS)患者血流动力学及氧代谢的影响。方法 选择感染所致MODS患者17例,应用连续静脉-静脉血液滤过(CVVH)联合血浆置换(PE)进行治疗,治疗期间用Swant-Ganz漂浮导管监测血流动力学变化并检测氧代谢指标。结果 与CBP前比较,CBP治疗后,体血管阻力指数(SWRI)明显改善,平均动脉压(MAP)回升,心率(HR)下降,肺动脉压及肺动脉楔压(PAP、PCWP)也明显降低,动脉血氧分压明显上升(P<0.01),氧供及氧耗均有所增加(P<0.05),动脉血乳酸含量明显降低(P<0.01),混合静脉血氧分压、静脉血氧饱和度及氧摄取率无明显变化(P>0.05)。结论 CBP可改善MODS患者的全身血流动力学状况,提高患者的氧供,但对氧摄取率无明显影响。     

彩色多普勒超声心动图、Swan-Ganz导管和脉波指示剂连续心排血量监测仪血流动力学检测的同步比较研究

目的对比研究彩色多普勒超声心动图(CDE)、Swan-Ganz导管和脉波指示剂连续心排血量(PiCCO)监测仪在血流动力学检测中的相关性。方法选取2006年3月至2008年10月入苏州市立医院东区ICU的心功能不全的危重病患者共8例,男5例,女3例,平均(51.4±21.1)岁。记录患者一般情况,并置入PiCCO导管和Swan-Ganz导管,通过CDE、Swan-Ganz导管法和PiCCO导管法同步测量每搏输出量(SV)和每分输出量(CO),比较三种方法所测数据的相关性。结果运用CDE、Swan-Ganz导管法和PiCCO导管法测量所得的SV依次为(62.4±29.3)ml、(53.1±14.0)ml和(49.9±14.7)ml。组间差异无统计学意义(P均0.05),组间均具有相关性,相关系数值分别为0.78、0.91和0.76;测量所得的CO分别为(5.9±2.2)L/min、(5.1±1.4)L/min和(5.0±1.4)L/min。组间差异无统计学意义(P均0.05),组间均具有相关性,相关系数值值分别为0.75、0.96和0.72。结论 CDE、Swan-Ganz导管和PiCCO监测仪检测的SV、CO具有相关性。