Cronkhite-Canada综合征一例

患者男 ,6 9岁。 4个月前无明显诱因出现厌食 ,腹胀 ,嗳气 ,无反酸。在当地医院行抗炎、补液及中药治疗 ,病情无缓解 ,并出现下腹隐痛 ,腹泻 ,为黄色稀便 ,每日达 10余次。发病以来体重减轻 15ｋｇ。无胃肠道息肉病家族史。体检 :体温 36 .5°Ｃ ,脉搏 72次 /ｍｉｎ ,呼吸 2 0次 /ｍｉｎ ,血压 16 .0 / 10 .7ｋＰａ(1ｋＰａ =7.5ｍｍＨｇ)。皮肤巩膜无黄染 ,浅表淋巴结未触及 ,脱发 ,指甲萎缩 ,皮肤色素沉着 ,腹软 ,肝脾未及 ,上腹有压痛 ,无反跳痛 ,无移动性浊音。实验室检查 :血红蛋白118ｇ/Ｌ,大便常规正常、隐血阴性 ;血沉 :37ｍｍ/ｈ ;…     

Cronkhite-Canada综合征患者行胶囊内镜检查一例

自Cronkhite-Canada综合征（CCS）首次报道以来，对患者小肠病变的观察只能依靠间接的放射学检查或手术。新近研究显示胶囊内镜在小肠疾病诊断上具有明显的优越性，因此尝试应用胶囊内镜直接观察CCS小肠黏膜的改变，这对深入了解CCS和评价胶囊内镜在诊断中的应用价值具有十分重要的临床意义。     

Cronkhite-Canada综合征1例并文献复习

<正>Cronkhite-Canada综合征(CCS)国内又称胃肠道息肉病-皮肤色素沉着-秃发-指(趾)甲萎缩综合征,是一种罕见的非遗传性疾病,以广泛的消化道息肉伴外胚层病变为特点。1病历摘要患者男,68岁,因"腹泻、腹痛2月"于2016年1月14日入院。患者于2月前无明显诱因解黄色稀水样便,每日2~10余     

Cronkhite-Canada综合征国内文献复习

胃肠道息肉-色素沉着-秃发-指(趾)甲萎缩综合征(Cronkhite-Canada syndrome，CCS)是由Cronkhite和Canada于1955年首先报道的一组临床综合征。国内1985年首次报告本病，现就山西医科大学第二医院收治的1例患者及国内发表有关文献24篇加以总结分析。     

Cronkhite-Canada综合征一例并文献复习

目的记录并报道Cronkhite—Canada综合征1例,以加强对本病的认识。方法搜集患者的临床资料,包括症状、体征及辅助检查,查阅相关文献,尝试各种治疗方法。结果患者符合Crankhite—Canada综合征,普通的中西止泻药物无效,激素治疗有效。结论Cronkhite—Canada综合征患者为非家族性,镜下特点为多发胃肠道息肉,以腹泻为主要症状并伴有外胚层改变。普通止泻药物无效,可尝试激素治疗。     

多学科诊治Cronkhite-Canada综合征1例

加拿大综合征(CCS)临床罕见,以胃肠道多发息肉和外胚层三联征为主要特征,临床表现为腹泻、腹痛、食欲不振,味觉减退,脱发、皮肤色素沉着、指(趾)甲萎缩脱落等.现报道多学科诊治CCS一例并文献复习,以供临床医师参考.     

Cronkhite-Canada综合征1例并文献复习

Cronkh ite-Canada综合征是一种罕见疾病,病因尚不清楚,以胃肠道多发息肉伴皮肤色素沉着、脱发、指（趾）甲萎缩等为主要特征,目前缺乏特异性治疗方法,主要是对症治疗。     

Cronkhite-Canada综合征1例

<正>Cronkhite-Canada综合征(CCS)又称为胃肠道息肉病-皮肤色素沉着-秃发-指(趾)甲萎缩综合征,该病罕见。CCS自1955年由Cronkhite等〔1〕首次报告以来,目前全球均有散发个案报道,75%为日裔人种〔2〕,其易感性可能与种族、地域差异有关〔3〕,国内首次报道〔4〕本病是在1985年,以华北及广东地区为主。发病年龄多在50⁷0岁,男性多于女性,但也有学者提出其可能是一种迟发疾病,可能始于成年甚至儿童〔5〕。     

Cronkhite-Canada综合征1例

Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)非常罕见,病因不明,以胃肠道多发性息肉和外胚层三联征两大症候群为主.主要表现为慢性腹泻、腹部不适、毛发脱落、色素沉着、指(趾)甲萎缩等.本文报道CCS 1例,通过病史及内镜检查结果并结合相关文献对该病进行分析讨论,探讨CCS的临床特征,提高对该病的认识.     

Cronkhite-Canada syndrome: Report of six cases and review of literature

Cronkhite-Canada syndrome (CCS) is a rare nonfamilial polyposis syndrome characterized by epithelial disturbances in the gastrointestinal tract and skin. The aim of this study was to investigate the clinical features and potential therapies for CCS. Six patients with CCS admitted from December 1992 to July 2008 to Peking Union Medical College Hospital were evaluated. All patients had clinical manifestation of nonhereditary gastrointestinal polyposis with diarrhea, skin hyperpigmentation, alopecia, and nail dystrophy. Fecal occult blood was positive in all six cases. Serum hemoglobin, potassium, calcium and protein were below the normal range in two cases. Anti-Saccharomyces cerevisiae and antinuclear antibodies were present in three cases. Multiple polyps were found in all patients by gastroscopy and colonoscopy, with only one in the esophagus. Histologically, there were hyperplastic polyps in five cases, tubular adenoma in three, and juvenile polyp in one with chronic inflammation and mucosal edema. Comprehensive treatment led by corticosteroids can result in partial remission of clinical symptoms, and long-term follow-up is necessary.     

胃肠道息肉-皮肤色素沉着-指(趾)甲萎缩综合征1例

Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)是以胃肠道多发息肉和外胚层三联征两大症候群为主,临床表现为慢性腹泻、腹痛、脱发、皮肤色素沉着、指(趾)甲萎缩脱落等.发病罕见,病因不明,预后较差.本文报道CCS1例,通过病史及内镜检查并结合文献进行分析讨论,提高对CCS的认识.     

Cronkhite-Canada syndrome A case of sustained partial-remission

A case of Cronkhite-Canada syndrome is described. Few cases have been published and in most patients the prognosis is poor. A variety of medical measures have been attempted in those in whom remission has been reported. In the patient presented here, a sustained partial-remission has been achieved with steroids.     

Cronkhite-Canada syndrome associated with myelodysplastic syndrome

We report a case of Cronkhite-Canada syndrome (CCS) associated with myelodysplastic syndrome (MDS). A 54-year-old woman, diagnosed as MDS the prior year after evaluation of anemia, visited our hospital with the chief complaint of epigastric discomfort. She also had dysgeusia, alopecia, atrophic nail change, and pigmentation of the palm, all of which began several months ago. Blood tests revealed severe hypoalbuminemia. Colonoscopy (CS) showed numerous, dense, red polyps throughout the colon and rectum. Biopsy specimens showed stromal edema, infiltration of lymphocytes, and cystic dilatation of the crypt. Her clinical manifestations and histology were consistent with CCS. We prescribed corticosteroids, which dramatically improved her physical findings, laboratory data, and endoscopic findings. This is the first report of CCS in a patient with MDS.     

Cronkhite-Canada syndrome: report of two cases

Two cases of Cronkhite-Canada syndrome are reported. In the first case, a 56-year-old woman had an adenoma of the colon, arising within the Cronkhite-Canada polyps, which was removed by endoscopic polypectomy. This suggests possible neoplastic transformation of polyps in this syndrome. She achieved remission with corticosteroids, but the polyposis recurred (only in the stomach) 7 months after the remission. In the recurrent polyposis, corticosteroid therapy resulted again in complete remission, which has lasted for 5 years. In the second case, a 69-year-old man developed typical manifestations of the syndrome while under emotional stress. He had a past history of chronic pityriasis lichenoides, and serum antinuclear antibody was positive. These findings suggested a possible role of autoimmune response in the pathogenesis of the syndrome. Corticosteroids were also effective in this patient. Received: August 27, 1999 / Accepted: January 28, 2000