左旋咪唑等驱虫药致变态反应性脑炎21例分析

报道21例左旋咪唑等驱虫药致变态反应性脑炎，发病前均无感染和接种史。分别于服药后3－24天出现神经，精神症状，脑电图检查17例，14例异常，CT检查11例，9例为急性脱髓鞘性脑炎改变。结果：痊愈17例，好转3例，死亡1例。实践证明，早期诊断，应用激素为主的治疗预后较好。对本病的发病机理进行了探讨。     

吩噻嗪衍生物的式电位、驱虫活性与分子结构间关系

目的：研究吩噻嗪式电位与驱虫活性关系的分子结构基础。方法：AMI半经验量子化学方法计算分子结构参数，主因子和多元线性回归分析寻找相关性。结果：吩噻嗪的式电位与总电子能量，Et(e)，总分子能量，Et(M),总偶极矩，μt,和分子z轴方向的偶极矩，μz,线性相关，E^0=1.1369-0.00966Et(e)-0.00052Et(M)-0.07602μz-0.06396μt(R=0.9665,SD=0.0336).吩噻嗪的驱虫活性与环上电荷，e(r)，分子生成热，Hf,总偶极矩，μt，和在分子z方向的偶极矩，μz，线性相关，a=3.8343-0.8832μz 0.671μt 2.781e(r)-0.00154Hf(R=0.7404,SD=0.5338).偶极矩不仅影响吩噻嗪的式电位而且影响其驱虫活性，是两的共同因子。结论：偶极矩可能是吩噻嗪驱虫活性与其式电位相关的分子结构因素。     

Phytochemical,Anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb

Objective

The present study was carried out to investigate the phytochemical constituents, in vitro antioxidant potential and anthelmintic activities of Flacourtia sepiaria Roxb leaves.

Methods

The dried powdered leaves of Flacourtia sepiaria were extracted using petroleum ether, chloroform, ethyl acetate and methanol by a soxhlet extractor and preliminary phytochemical screening was performed using standard protocols. All the extract was evaluated for their potential antioxidant activities using test such as DPPH, superoxide anion radical, hydroxyl radical, nitric oxide radical scavenging abilities, ferrous chelating ability and total phenolic and flavanoid content. Anthelmintic activity of extract was screened in adult Indian earthworm model.

Results

Preliminary screening revealed the presence of bioactive compounds especially phenolics, tannins and terpenoids in all extracts. The phenolic and flavanoid content was highest in methanolic extract and lowest in petroleum ether extract. The paralytic (9.46±0.212) and death time (31.43±0.148) of methanolic extract was found to be significant (P<0.05) when compared with paralytic (7.33±0.206) and death time (18.60±0.229) of standard piperazine citrate at 100 mg/mL concentration.

Conclusions

The results of the present study indicate that the leaf extracts of Flacourtia sepiaria exhibited strong antioxidant activity and possess significant anthelmintic activity and thus it is a good source of antioxidant and anthelmintic constituents.     

阿苯达唑乳治疗包虫病及犬用长效缓释驱虫剂的研究

包虫病是流行于我国西部地区的一种严重的人畜共患寄生虫病。全国有22个省、市和自治区有本病发生,垒1990年底止仅西部6个省