颈椎前后路融合治疗多节段颈椎病术后不良事件的Meta分析

目的:治疗多节段脊髓型颈椎病的最佳手术方式仍存在争议.近年,后路椎板切除/椎板成形融合在治疗脊髓型颈椎病领域的应用逐渐增多.然而,很少有综合研究将前路减压与融合和后路椎板切除/椎板成形融合的术后不良事件发生率进行比较.因此,文章采用Meta分析法观察颈椎前后路融合治疗多节段颈椎病术后不良事件的差异.方法:计算机检索20...     

钛金属cage与聚醚醚酮cage在颈前路减压融合术后临床疗效的Meta分析

目的 采用Meta分析比较钛金属cage与聚醚醚酮(PEEK)cage在颈前路减压椎间融合术(ACDF)中的临床效果,为ACDF植入物的选择提供临床依据。方法 计算机检索PubMed数据库、Cochrane数据库、Embase数据库、中国知网数据库、万方数据库,并辅以手工检索,收集2007年1月—2017年3月有关钛金属cage和PEEK cage 用于ACDF临床效果对照研究的中英文文献,按照Jadad量表严格评价纳入文献质量,并提取相关数据,运用Revman 5.0软件对所有相关数据进行分析。结果 纳入5项研究共361例患者,其中高质量文献4篇,中质量文献1篇。Meta分析显示对于ACDF,PEEK cage下沉发生率低于钛金属cage(OR=3.49,95%CI 1.75~6.99,P=0.0004),而在融合率(OR=1.60,95%CI 0.05~53.73,P=0.79)、脱位发生率(OR=3.61,95%CI 0.91~14.34,P=0.07)、手术时间(WMD=0.87,95%CI -24.95~26.69,P=0.95)、Odom评分优良率(OR=0.89,95%CI 0.49~1.63,P=0.71)、NDI评分(WMD=3.24,95%CI -0.44~6.93,P=0.08)及手术节段术后Cobb角(WMD=-2.29,95%CI -4.63~0.05,P=0.05)等方面两种cage差异无统计学意义。结论 钛金属cage和PEEK cage 应用于ACDF均能获得理想的临床效果,术后PEEK cage下沉发生率更低。     

吸烟与脊柱术后手术部位感染相关性的Meta分析

目的:探讨吸烟对脊柱术后手术部位感染（SSI）的影响,为预防脊柱术后SSI的发生提供循证依据。方法:检索2000年1月至2020年6月,在PubMed、EMBASE、中国知网、万方等数据库中的相关文献,由2名研究人员独立进行检索及提取数据,采用Stata13.0软件对纳入文献进行统计分析,根据不同种族、研究类型及是否调...     

脊柱术后发生手术部位感染独立危险因素的Meta分析

文题释义：手术部位感染：术后30 d内(或者置入内固定装置1年内)发生的浅表、深部或者器官的感染。浅部感染指术后30 d内发生感染,感染只涉及切口皮肤或皮下组织。深部感染指若无植入物留在原位,感染发生在术后30 d内;若植入物在原位,感染发生在1年内,并且感染可能与手术有关,深部感染涉及深部软组织。当感染涉及解剖的任何部分(如器官或空间)而非手术操作的切口感染即为器官感染。背景：脊柱术后手术部位感染的危险因素多样且复杂,目前国内外对于脊柱术后手术部位感染相关危险因素的研究仍然存在较大的争议。目的：系统评价脊柱术后手术部位感染的独立危险因素,为手术部位感染的防治提供理论依据。方法：检索2004年1月至2019年6月中外数据库,按照拟定的文献纳入与排除标准获得有关脊柱术后手术部位感染独立危险因素的病例-对照研究和队列研究,提取有效数据,分别采用固定效应模型和随机效应模型计算各独立危险因素(高血压、糖尿病、肥胖、吸烟、手术史)的合并OR值和95%CI进行Meta分析,比较其结果的一致性,分析合并结果的可靠性。结果与结论：①共纳入19篇文献,共包括脊柱术后发生手术部位感染的病例1 008例,对照组7 527例;②各独立危险因素合并OR值(95%CI)由高到低依次为：糖尿病(OR=3.24,95%CI：2.09-5.02)、肥胖(OR=2.99,95%CI：1.77-5.05)、手术史(OR=2.12,95%CI：1.79-2.50)、高血压(OR=1.90,95%CI：1.34-2.69)、吸烟(OR=1.85,95%CI：1.39-2.48);③提示糖尿病、高血压、肥胖、吸烟、手术史均为脊柱术后发生手术部位感染的独立危险因素,各独立危险因素与脊柱术后发生手术部位感染的概率均呈正相关。ORCID: 0000-0002-4963-6988(覃作恒)中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程     

血清胆红素水平与肾病综合征关系的Meta分析

目的综合评价胆红素与肾病综合征(nephrotic syndrome,NS)的关系,为诊治NS提供依据。方法通过检索Pub Med,CNKI、维普数据、万方数据等数据库,收集国内外公开发表的有关胆红素与肾病综合征关系的病例对照研究,按纳入和剔除标准筛选文献,提取数据。采用Stata12.0软件进行Meta分析。结果共纳入7个研究,798例患者。Meta分析结果显示,肾病综合征组胆红素水平低于对照组,其差异有统计学意义[MD=-5.86,95%CI(-6.95,-4.77);Z=10.54,P<0.01]。结论低水平的胆红素水平与NS密切相关,胆红素水平有可能可作为NS的实验室诊断参考指标。     

脊柱减压固定融合术后症状性心血管事件发生率及危险因素分析

目的 分析脊柱减压固定融合术后症状性心血管事件(SMI)的发生率及危险因素,为手术方案制定和临床决策提供参考。方法 回顾性分析2015年1月—2016年12月河北医科大学第三医院脊柱外科接受脊柱减压、固定、融合手术治疗的462例患者临床资料,依据住院期间是否发生SMI分为观察组(61例)和对照组(401例)。比较两组患者一般资料、术前心脏功能评估指标、手术因素、术后因素。采用二分类logistic回归分析探讨术后SMI发生的危险因素。结果 462例患者中61例(13.2%)术后发生SMI。与对照组比较,观察组的年龄更大 (60.7岁∶52.3岁)、心肌缺血病史和心脏手术史占比更高(分别为24/61∶50/401和 23/61∶23/401)、颈椎手术占比也更高 (38/61∶168/401),而术中舒张压 (77.0 mmHg∶80.5 mmHg, 1 mmHg=0.133 kPa)、术后次日血清Ca²⁺浓度则较低 (2.2 mol/L∶2.3 mol/L),差异均有统计学意义(P值均＜0.05)。logistic回归分析显示:术后次日血清Ca²⁺浓度低于2.2 mmol/L、心脏手术史、年龄＞55岁与SMI发生具有显著相关性(P值均＜0.05)。结论 脊柱减压固定融合术后SMI的发生率为13.2%,危险因素包括患者年龄＞55岁、术后低血钙和心脏手术史。对于老年患者和既往行心脏手术的患者,术前需详细告知风险,术后监测电解质是必要的。     

丙戊酸对癫痫患儿骨代谢影响的Meta分析

目的采用Meta分析方法定量分析丙戊酸对癫痫患儿骨代谢的影响。方法电子检索中国维普科技期刊数据库、万方数据库、中国知网、中国生物医学文献数据库、EMCC、PubMed、OVID及Cochrance图书馆,纳入丙戊酸对癫痫患儿骨代谢影响的观察性研究,采用NOS量表评估纳入文献的质量。采用RevMan5．2软件进行Meta分析。结果14篇文献（英文10篇,中文4篇）进入Meta分析,均为病例对照研究,累计病例组507例,对照组480例。Meta分析结果显示,丙戊酸对血钙（MD=0．0l,95％CI：-0．05—0．06,P=0．13）、血磷（MD=-0．03,95％CI：-0．19—0．13,P=0．67）、碱性磷酸酶（MD=0．37,95％CI：-19．02～19．77,P=0．97）无明显影响,但丙戊酸组骨密度低于对照组,MD=-0．03,95％CI：-0．06～-0．00,P=0．03;丙戊酸组甲状旁腺激素水平显著高于对照组,MD=4．83,95％CI：1．15～8．50,P=0．01;丙戊酸组25-羟维生素D水平显著低于对照组,MD=-2．46,95％CI：-4．37～-0．55,P=0．01。结论现有证据表明,丙戊酸对癫痢患儿血钙、血磷和ALP无显著影响．但对骨密度、25-OH—VtiD和PTH有影响。     

斜外侧入路与后入路椎体融合术治疗腰椎退行性疾病临床疗效的Meta分析

目的 系统性对比评价斜外侧入路椎间融合术(OLIF)与后入路椎体融合术(PLIF)在治疗腰椎退行性疾病中的临床疗效。方法 在中国知网数据库、万方数据库、维普数据库以及PubMed数据库、Cochrane数据库,以“斜外侧椎间融合术”“后入路椎间融合术”和 “oblique lumbar interbody fusion” “oblique lateral interbody fusion” “anterior to psoas” “posterior lumbar interbody fusion”为关键词,计算机检索2010年1月-2019年9月国内外已发表关于OLIF与PLIF对比的病例对照研究或随机对照研究的中英文文献,严格评价文献质量,并提取相关数据,运用RevMan 5.3软件对手术时间、术中出血量、住院时间、疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、椎间隙高度(IDH)、腰椎前凸角(LL),以及手术并发症情况进行Meta分析。结果 纳入10篇研究共580例患者,其中经OLIF手术276例,经PLIF手术304例。1项随机对照研究,Cochrane偏倚风险评估为低风险;9项病例对照研究纽卡斯尔-渥太华评分(NOS),其中高质量6项、较高质量3项。Meta分析结果显示,OLIF较PLIF平均手术时间短(WMD=-84.02,95% CI -118.29～-49.74,P＜0.01),平均术中出血量少(WMD=-269.12, 95% CI -319.84～-218.41,P＜0.01),平均住院时间短(WMD=-3.29, 95% CI -4.70～-1.89, P＜0.01),术后IDH恢复更高(WMD=1.11, 95% CI 0.44～1.77, P＜0.01),差异均有统计学意义;而术后ODI(WMD=0.16, 95% CI -1.98～2.30, P＞0.05)、VAS(WMD=0.02, 95% CI -0.52～0.56, P＞0.05)、LL(WMD=0.77, 95% CI -0.40～1.94, P＞0.05)、并发症发生情况(OR=0.91, 95% CI 0.50～1.64, P＞0.05),OLIF和PLIF比较差异均无统计学意义。结论 OLIF与PLIF应用于椎体间融合术均能取得良好的临床疗效,但OLIF手术时间、术中出血量、住院时间更低,术后IDH恢复更高,有更大优势。     

精神分裂症患者伴发代谢综合征的相关因素

目的:探索住院精神分裂症患者伴发代谢综合征的相关因素。方法:抽取5个地区5家医院的住院精神分裂症患者,调查伴发代谢综合征的相关因素。内容包括:年龄、病程、精神病药物与剂量、空腹血糖、血脂等。结果:资料完整的797例住院精神分裂症患者,伴发代谢综合征者共153例(19．2％)。病程长、服用氯氮平、服用药物时间长、高剂量用药患者MS发生率高(P<0．05、P<0．01);L0gistic回归分析显示:代谢综合征的危险因素有高龄、服用氯氮平、CRP浓度偏高、吸烟、服用抗精神病药物时间长。结论:影响住院精神分裂症患者伴发代谢综合征的相关因素有氯氮平、病程、用药时间、吸烟等。     

代谢综合征增加心肌梗死后的发病率和死亡率

意大利研究人员在2005年7月19日的《美国心脏病学杂志》（J Am Coll Cardiol，2005；46：277—283）上报告，心肌梗死（MI）后存活的患者中半数有胰岛素抵抗，这与不良预后和较高死亡率相关。     

Association between metabolic syndrome and psoriasis: a meta-analysis of observational studies with non-psoriasis control groups

IntroductionPsoriasis is a highly prevalent condition that affects the quality of life of affected individuals. Several studies have indicated an association between psoriasis and metabolic syndrome (MS). However, the results were inconsistent. The objective of this study was to evaluate the relationship between psoriasis and MS.Material and methodsElectronic databases (PubMed, EBSCO, Elsevier, Springer, Wiley, and Cochrane) were searched systematically for published studies up to November 2, 2018. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the association between psoriasis and MS. The heterogeneity of the study was estimated with the I² statistic and analyzed by meta-regression and subgroup analyses.ResultsTwenty-two studies with a total of 137,053 participants were included in this meta-analysis. Psoriasis was associated with MS and the combined OR (95% CI) was 2.02 (1.67–2.43). The results showed high heterogeneity (I² = 83.60%, p < 0.001) and no publication bias among the included studies (p = 0.119). The source of controls may have influenced the heterogeneity according to the meta-regression. There was no heterogeneity in studies with matched non-psoriasis control groups according to the subgroup analysis.ConclusionsPsoriasis was associated with MS. The source of the control group was an influencing factor on heterogeneity in this study. Treating for MS in patients with psoriasis might improve psoriasis and reduce the risk of cardiovascular disease.     

Coffee consumption and risk of fractures: a meta-analysis

Introduction

Recent studies have indicated higher risk of fractures among coffee drinkers. To quantitatively assess the association between coffee consumption and the risk of fractures, we conducted this meta-analysis.

Material and methods

We searched MEDLINE and EMBASE for prospective studies reporting the risk of fractures with coffee consumption. Quality of included studies was assessed with the Newcastle Ottawa scale. We conducted a meta-analysis and a cumulative meta-analysis of relative risk (RR) for an increment of one cup of coffee per day, and explored the potential dose-response relationship. Sensitivity analysis was performed where statistical heterogeneity existed.

Results

We included 10 prospective studies covering 214,059 participants and 9,597 cases. There was overall 3.5% higher fracture risk for an increment of one cup of coffee per day (RR = 1.035, 95% CI: 1.019-1.052). Pooled RRs were 1.049 (95% CI: 1.022-1.077) for women and 0.910 (95% CI: 0.873-0.949) for men. Among women, RR was 1.055 (95% CI: 0.999-1.114) for younger participants, and 1.047 (95% CI: 1.016-1.080) for older ones. Cumulative meta-analysis indicated that risk estimates reached a stabilization level (RR = 1.035, 95% CI: 1.019-1.052), and it revealed a positive dose-response relationship between coffee consumption and risk of fractures either for men and women combined or women specifically.

Conclusions

This meta-analysis suggests an overall harm of coffee intake in increasing the risk of fractures, especially for women. But current data are insufficient to reach a convincing conclusion and further research needs to be conducted.     

新疆维吾尔族人STEAP4基因遗传变异的分布及其与代谢综合征的关联

目的 探讨前列腺六次跨膜上皮抗原4(six transmembrane epithelial antigen of prostate 4,STEAP4)基因多态与维吾尔族人代谢综合征(metabolic syndrome,MetS)的关联.方法 采取以流行病学调查为基础的病例对照研究,选择682例MetS和1228名对照为研究对象.测序筛查维吾尔族MetS患者STEAP4基因功能区的变异,选择代表性变异在维吾尔族自然人群中进行关联分析.结果 维吾尔族人STEAP4基因单核苷酸多态(single nucleotide polymorphism,SNP)的最小等位基因频率不同于中国北京汉族人和欧洲人.rs34741656多态与MetS相关[P=0.034,控制年龄、性别后OR=0.757(95%CI:0.584～0.982)],在对照组,该位点与空腹和餐后2 h血糖水平有关(分别P=0.049,P=0.027).常见单倍型H4(rs8122/rs1981529/rs34741656,G-A-A)可能与MetS有关(permutation P=0.089).结论 STEAP4基因遗传变异可能与维吾尔族人代谢综合征相关.

Abstract：

Objective To investigate the genetic variations of the six transmembrane epithelial antigen of prostate 4 gene (STEAP4)in Chinese Uygur patients with metabolic syndrome (MetS) and to analyze the association of the representative genetic variations of STEAP4 gene with MetS in the population.Methods The sequences of STEAP4 gene functional region (all exons, exon-intron boundaries and the putative promoter region, including the -1 kb 5' and 3'untranslated regions) were amplified and sequenced for patients with MetS. The representative variations were selected based on the function (missense mutation) and linkage disequilibrium (γ2 ＞0. 8) and genotyped with TaqMan-PCR method in 1910 general populations (682 MetS and 1228 non-MetS controls). The subjects were selected from the cross-sectional study of obesity, hypertension, diabetes, dyslipidemia from January to February 2007 among Uygur people,a relatively isolated population with a relatively homogeneous environment, in Hetian area in Xinjiang Uygur Autonomous Region. Results (1) Fourteen novel and six known single nucleotide polymorphisms (SNPs)or mutations, including 2 missense mutations, were identified at the functional region of STEAP4 gene in 96 Uygur patients with MetS. The minor allele frequencies of the SNPs of STEAP4 gene in Uygur population were different from that in European and Chinese Han in Beijing area. (2) The SNP 364G/A (rs34741656,Ala122Thr) was significantly associated with MetS [dominant model P = 0. 034, OR = 0. 757 (95% CI:0. 584-0. 982) adjusted for age and gender], and was associated with fasting blood glucose (FBG) (P =0. 049) and 2-hour postprandial glucose (2HPG) (P = 0. 027) levels in controls. In this SNP, the AA carriers had lower blood glucose levels compared with subjects carrying GG and GT genotypes. (3) The common haplotype H4 (rs8122/rs1981529/rs34741656, G-A-A), may be associated with MetS (permutation P= 0. 089). Conclusion STEAP4 genetic polymorphisms may be associated with MetS risk in Chinese Uygur population.     

微小切口与经椎间孔腰椎融合治疗腰椎退行性病的Meta分析

背景：大量研究已证实微小切口与开放经椎间孔腰椎椎间融合治疗单节段和多节段腰椎退行性疾病均有较好的疗效,但两种治疗方法的优劣目前尚无定论。目的：系统评价微小切口与开放经椎间孔腰椎椎间融合治疗腰椎退行性疾病的疗效及安全性。方法：计算机检索 The Cochrane Library(2014 年第2期)、PubMed、EMbase、MEDLINE、SCI、CNKI、CBM、WanFang Data,检索时限为到2014年2月;收集采用微小切口与开放经椎间孔腰椎椎间融合治疗腰椎退行性疾病的随机或非随机同期对照试验。由2名评价者按照纳入与排除标准选择试验、提取资料和评价质量后,采用RevMan 5.2软件进行Meta分析。结果与结论：纳入1个随机对照试验,18个非随机对照试验,共1 400例患者。Meta分析结果显示,与传统开放经椎间孔腰椎椎间融合相比,微小切口经椎间孔腰椎椎间融合具有椎旁肌损伤小,出血量少,住院时间短,早期疗效好,腰痛远期缓解率高等优点;但是微小切口经椎间孔腰椎椎间融合在改善远期运动功能,远期腿痛缓解率,减少并发症方面并不优于开放经椎间孔腰椎椎间融合治疗;且手术时间更长。因此,在严格掌握适应证的前提下,采用微小切口经椎间孔腰椎椎间融合能较好解决腰椎退行性疾病患者的病痛。由于纳入研究数量和质量存在局限性,上述结论仍需大样本、高质量的随机对照试验进一步验证。临床应根据患者的具体情况,综合评估病情,选择最佳治疗方案。中国组织工程研究杂志出版内容重点：人工关节;骨植入物;脊柱;骨折;内固定;数字化骨科;组织工程全文链接：     

Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis

Acinetobacter baumannii has emerged as a major cause of healthcare-associated infections. Controversy exists as to whether antimicrobial resistance increases the risk of mortality. We conducted a systematic review and meta-analysis to examine this association. We searched MEDLINE and EMBASE databases up to May 2013 to identify studies comparing mortality in patients with carbapenem-resistant A. baumannii (CRAB) vs. carbapenem-susceptible A. baumannii (CSAB). A random-effects model was used to pool Odds Ratios (OR). Heterogeneity was examined using I². We included 16 observational studies. There were 850 reported deaths (33%) among the 2546 patients. Patients with CRAB had a significantly higher risk of mortality than patients with CSAB in the pooled analysis of crude effect estimates (crude OR = 2.22; 95% CI = 1.66, 2.98), although substantial heterogeneity was evident (heterogeneity I² = 55%). The association remained significant in the pooled adjusted OR of 10 studies. Studies reported that patients with CRAB compared to patients with CSAB were more likely to have severe underlying illness and also to receive inappropriate empirical antimicrobial treatment, which increases the risk of mortality. Our study suggests that carbapenem resistance may increase the risk of mortality in patients with A. baumannii infection. However, cautious interpretation is required because of the residual confounding factors and inadequate sample size in most studies.     

Magnitude of Cryptococcosis among HIV patients in sub-Saharan Africa countries: a systematic review and meta-analysis

BackgroundCryptococcus is encapsulated opportunistic yeast that causes life threatening meningoencephalitis of patients with human immunodeficiency virus (HIV). The magnitude of Cryptococcosis among HIV patients varies from 1–10% in Western countries as opposed to almost a one third of HIV-infected individuals in sub-Saharan Africa where it is associated with high mortality.MethodologyBy using key terms “Cryptococcosis among HIV patients in sub-saharan Africa countries”, articles that published in different journals from 2010–2017 searched on Pub-Med and Google scholar database. Those freely accessible and included the prevalence of Cryptococcosis in the result section, their PDF file was downloaded and the result extracted manually and presented in table. Articles that did not report the prevalence of Cryptococcosis, with a study design otherthan cross sectional, or a sample size less than 100, and those duplicated in the same study area and period by the same authors were excluded. The article selection followed the PRISMA guidelines and meta- analysis was performed using OpenMeta(analyst).ResultsThe overall pooled magnitude of Cryptococcosis among HIV patients in sub saharan African countries was 8.3% (95%CI 6.1–10.5%). The highest prevalence was from Uganda (19%) and the least was from Ethiopia at 1.6%. There was 87.2 % of substantial heterogeneity among the studies with p-value<0.001. The symmetry ofthe forest plot showed that there was little publication bias. The most commonly used method for diagnosis of Cryptococcosis was lateral flow assay and latex agglutination test and culture was the least method employed.ConclusionThe overall pooled magnitude of Cryptococcosisis high among HIV patients in sub-Saharan African countries. The studies showed substantial heterogeneity, and little publication bias. Most of the studies relied on LFA & LA that showed the scarcity of facilities for fungal culture. Therefore, paying attention to screening HIV patients; those with signs and symptoms of meningitis may help to reduce the loss of HIV patients.     

PD-L1 expression in vulvar cancer: a systematic review and meta-analysis

Programmed cell death ligand-1 (PD-L1) expression in cancer may predict clinical response to immunotherapeutic treatment with PD-1/PD-L1 inhibitors. Within the vulvar cancer field, PD-L1 expression has only been assessed by a few studies. We conducted a meta-analysis to examine the prevalence of PD-L1 positivity in vulvar cancer. PubMed, Embase, and Cochrane were searched for articles reporting on PD-L1 expression in vulvar cancer. Study selection and data extraction were performed independently by two authors. We extracted data on PD-L1 prevalence in vulvar cancer according to combined positive score (CPS) and tumour proportion score (TPS). Cutoff values for positivity were ≥1 or ≥10 for CPS and ≥1% and ≥5% for TPS. Random-effects models were used to estimate pooled PD-L1 prevalence, with 95% confidence intervals (CIs). Tests of between-study heterogeneity were evaluated by the I² statistics. Sources of heterogeneity were explored by subgroup analyses and meta-regression. In total, 19 studies were included. Pooled PD-L1 prevalence in vulvar cancer was 83.4% (95% CI: 70.8–91.3; I² = 80.0) and 53.9% (95% CI: 37.4–69.6; I² = 93.0) according to CPS and TPS, respectively. Based on TPS, human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (SCC) showed a lower PD-L1 prevalence (39.9%; 95% CI: 13.3–74.2) compared with HPV-independent SCC (62.6%; 95% CI: 33.7–84.6), but meta-regression showed no significant variation in PD-L1 prevalence by HPV status. PD-L1 prevalence was similar in advanced (44.9%; 95% CI: 29.8–61.1) and localized vulvar cancer (56.7%; 95% CI: 18.9–76.7). In conclusion, PD-L1 expression in vulvar cancer is frequent but between-study heterogeneity was high. Based on a subgroup of heterogenous studies, we found no strong variation in PD-L1 prevalence according to HPV status and stage.     

Relationships between serum adiponectin with metabolic syndrome and components of metabolic syndrome in non-diabetic Koreans: ARIRANG study

Purpose

Growing evidence suggests that hypoadiponectinemia may play a significant role in the development of metabolic syndrome (MetS). Therefore, the relationships between serum adiponectin with MetS and components of MetS were investigated in non-diabetic samples of drawn from the Koreans general population.

Materials and Methods

We performed a cross-sectional study in samples of older Koreans (age > 40 years) including 2,471 men and 3,463 women. MetS was defined according to the Asian modified criteria of the National Cholesterol Education Program Adult Treatment Panel III report. Serum adiponectin concentrations were measured by radioimmunoassay.

Results

The median adiponectin level in MetS was significantly lower than that in non-MetS subjects in men (6.00 vs. 8.00 µg/mL, p < 0.001) and women (10.12 vs. 11.74 µg/mL, p < 0.001). Adiponectin concentration was negatively correlated with waist circumference and levels of triglyceride, C-reactive protein (CRP), fasting glucose, and insulin, and positively correlated with high-density lipoprotein and age in both genders (p < 0.001). In a multivariate regression model after adjustment for age, body mass index, smoking, CRP, and lipid profiles, the odds ratio of MetS comparing extreme quartiles of adiponectin distribution was 0.32 [95% confidence interval (CI), 0.20 to 0.50] in men and 0.57 (95% CI, 0.43 to 0.76) in women.

Conclusion

Adiponectin levels are independently associated with the phenotype of MetS, as well as components of MetS in the non-diabetic Korean general population.     

Nel样分子1型蛋白在脊柱融合术后促进骨性融合的作用与机制

背景:在脊柱融合术中进行充分植骨是非常必要的,然而,老龄患者自身成骨细胞数量有限和骨微环境改变以及骨形态发生蛋白2体内应用会引起例如异位骨等不利影响,导致目前的治疗方法会引起骨不连和其他并发症.在此情况下,Nel样分子1型(Nel-like type 1 molecular,Nell-1)进入研究人员的视野,Nell-...