Oral health care in diabetes mellitus.

Diabetes mellitus produces many complex changes in the lives of those affected. Elevated blood glucose levels, which may occur in the absence of symptoms, lead to late complications from tissue damage. There is an increased susceptibility to infection, poor wound healing and periodontal disease. Furthermore, chronic oral infection itself may contribute to raised blood glucose levels and hence to the later complications of diabetes. Acute infection in the oral cavity needs specific and aggressive management, just as in the acutely infected diabetic foot.' The dental team may not have made a significant contribution to the shared management of the person with diabetes in the past; however, recent findings suggest that the dental team may contribute greatly to the shared care of diabetes with the diabetic team itself, and regular liaison is strongly recommended.     

Management of an emergency tooth extraction in diabetic patients on the dental chair

Background and objectiveApproximately 75% of diabetic patients in Saudi Arabia had poor glycaemic control. A high proportion of these patients will attend dental surgery clinics for treatment. Therefore, dentists should be well-prepared to control any complications they might arise on the dental chair during the dental procedures. Management of the associated risk factors is important to limit disease complications and improve the health of patients with diabetes.The objectives of this review were to determine the maximum acceptable level of blood glucose for tooth removal in diabetics, show a systematic technique for the management of patients with diabetes on the dental chair. By using PRISMA guidelines, analysis of the published articles and reports across the world is considered one of the most appropriate available methods to obtain strong evidence about the acceptable levels of blood glucose where teeth extraction can be done safely.ResultsA total of 1080 studies were retrieved using the search strategy. After screening 185 titles, abstracts and 85 full-text articles, 36 studies were included. The outcome of this systematic review revealed that fasting blood glucose level of 240 mg/dl is a critical point for any dental treatment because the warning signs of diabetes start coming out. Maximum acceptable levels of blood glucose for removal of teeth in diabetics are 180 mg/dl (before meal) and 234 mg/dl (2 h after a meal). High blood glucose levels reduce the secretion of nitric oxide (powerful vasodilator) in the body which leads to poor circulation and slow-healing socket. Uncontrolled diabetics are at high risk of infection because of the high ketone levels in the blood.ConclusionFasting blood glucose level of 180 mg/dl is a cut-off point for any selective dental extraction. However, Random blood glucose level of 234 mg/dl (13 mmol/l) is a cut-off point for an emergency tooth extraction. Tightly controlled diabetic patients (blood glucose level below 70 mg/dl) are susceptible to hypoglycemia.     

Diabetes and its effects on dental pulp

Uncontrolled or poorly controlled diabetes mellitus may be a risk factor for the development of oral complications. The objective of this investigation was to determine the effect of diabetes mellitus progression on inflammatory and structural components of dental pulp. Male Wistar rats were given a single injection of Streptozotocin (STZ), and induction of diabetes was confirmed 24 h later. Dental pulp tissue samples were taken from central incisors and molars of diabetic rats 30 and 90 days after the STZ treatment. Plasma glucose levels in diabetic rats 30 and 90 days after STZ treatment were significantly increased when compared to control rats (P < 0.001). Nitrite and kallikrein levels in dental pulp tissue were higher in diabetic rats 30 days after STZ treatment than in controls, while only nitrite were decreased 90 after of STZ treatment. Myeloperoxidase activity showed changes 30 and 90 days after STZ injection when compared to controls. The activity of alkaline phosphatase showed significant changes 30 and 90 days after STZ treatment. On the other hand the concentration of collagen was decreased in diabetic rats 30 and 90 days after STZ injection. These results suggest that diabetes is a critical factor that has profound effects upon oral tissues, resulting in expression of inflammatory mediators and modifications of structural components of dental pulp.     

Diabetes mellitus: update and relevance for dentistry

In light of growing evidence of the association between oral and nonoral diseases, some investigators believe that oral disease is a clinically useful predictor of nonoral conditions in certain individuals. As the dental profession has become more involved in treating medically compromised patients, dentistry has gone from being an "oral health profession" to being part of the general health team. As a result, a partnership between dentists and physicians that involves an expanded notion of oral-medical communication during the course of treating such patients should be embraced in order to better serve these patients. Michael Glick, senior editor of the Journal of the American Dental Association, believes that oral health providers should take an active role in screening certain groups for common medical conditions, ie, to check the patient's blood pressure, plasma glucose, and cholesterol for indications of heart disease and DM. Furthermore, dentists can be part of the diabetic patient's support network by becoming actively involved in monitoring blood glucose levels and blood pressure, as well as reminding patients of the importance of having their regular medical exams. Dentists are not going to diagnose or treat a systemic disease, but early detection will certainly result in better medical and dental outcomes. It is the dentist's role to be a part of the healthcare team in order to help reduce the incidence and adverse impact of diabetes.     

糖尿病与口腔疾病的相关性研究

糖尿病是一组以慢性血葡萄糖水平增高为特征的代谢疾病群，由于患者自身代谢紊乱可引起多系统多器官病变。口腔常见的并发症有牙周病、口腔白假丝酵母菌病、龋病等；其中牙周病被列为糖尿病的第6大并发症．严重时往往影响患者的生活质量。本文综述了糖尿病患者口腔健康状况．着重分析糖尿病与牙周病的相互关系；强调糖尿病患者口腔保健的重要性并为糖尿病患者口腔保健提供依据。     

Diabetes mellitus: medical and dental considerations

Diabetes mellitus is challenging to the clinician, researcher, and patient because of its complex pathogenesis, questionable cause, and often frustrating course of treatment. The two relatively distinct forms, adult-onset and juvenile-onset diabetes, can be considered separately because their cause, clinical course, and treatment is often radically different. Adult-onset diabetes is most commonly seen in middle-aged, overweight individuals and is generally easily managed by diet control and weight reduction. The chronic complications are rare, and patients experience a normal lifespan. Juvenile-onset diabetes affects younger individuals and is associated with the classic triad of diabetes: polydipsia, polyuria, and polyphagia. Its course is more acute and associated with greater swings in blood glucose. Although insulin is the treatment of choice, maintenance of normoglycemia is often difficult. The chronic complications of diabetic neuropathologic, retinopathologic, and angiopathologic conditions, relatively constant features of juvenile-onset diabetes, are somewhat independent of insulin control. The fasting blood glucose and oral glucose tolerance tests are used to diagnose diabetes, and the level of urine sugar is used as a measure of control. Specific oral problems have been noted with higher frequency in the diabetic population. The caries pattern seen in diabetics is related to xerostomia and results in rapidly advancing decay, affecting smooth and interdental surfaces. Periodontal disease is more common in diabetics, especially poorly controlled insulin-dependent diabetics. These patients are more prone to the development of acute periodontal problems such as abscesses and the chronic, often rapidly progressive, destruction of the periodontal support apparatus. Dental treatment is directed toward the prevention of caries and periodontal disease through periodic dental care, daily use of topical fluoride, and meticulous oral hygiene.     

Type 1 diabetes mellitus, xerostomia, and salivary flow rates

OBJECTIVE: The Oral Health Science Institute at the University of Pittsburgh has completed a cross-sectional epidemiologic study of 406 subjects with type 1 diabetes and 268 control subjects without diabetes that assessed the associations between oral health and diabetes. This report describes the prevalence of dry-mouth symptoms (xerostomia), the prevalence of hyposalivation in this population, and the possible interrelationships between salivary dysfunction and diabetic complications. STUDY DESIGN: The subjects with diabetes were participants in the Pittsburgh Epidemiology of Diabetes Complications study who were enrolled in an oral health substudy. Control subjects were spouses or best friends of participants or persons recruited from the community through advertisements in local newspapers. Assessments of salivary function included self-reported xerostomia measures and quantification of resting and stimulated whole saliva flow rates. RESULTS: Subjects with diabetes reported symptoms of dry mouth more frequently than did control subjects. Salivary flow rates were also impaired in the subjects with diabetes. Regression models of potential predictor variables were created for the 3 self-reported xerostomia measures and 4 salivary flow rate variables. Of the medical diabetic complications studied (ie, retinopathy, peripheral and autonomic neuropathy, nephropathy, and peripheral vascular disease), only neuropathy was found to be associated with xerostomia and decreased salivary flow measures. A report of dry-mouth symptoms was associated with current use of cigarettes, dysgeusia (report of a bad taste), and more frequent snacking behavior. Xerogenic medications and elevated fasting blood glucose concentrations were significantly associated with decreased salivary flow. Resting salivary flow rates less than 0.01 mL/min were associated with a slightly higher prevalence of dental caries. Subjects who reported higher levels of alcohol consumption were less likely to have lower rates of stimulated salivary flow. CONCLUSIONS: Subjects with type 1 diabetes who had developed neuropathy more often reported symptoms of dry mouth as well as symptoms of decreased salivary flow rates. Because of the importance of saliva in the maintenance and the preservation of oral health, management of oral diseases in diabetic patients should include a comprehensive evaluation of salivary function.     

Periodontitis and diabetes interrelationships: role of inflammation

Diabetes mellitus is a systemic disease with several major complications affecting both the quality and length of life. One of these complications is periodontal disease (periodontitis). Periodontitis is much more than a localized oral infection. Recent data indicate that periodontitis may cause changes in systemic physiology. The interrelationships between periodontitis and diabetes provide an example of systemic disease predisposing to oral infection, and once that infection is established, the oral infection exacerbates systemic disease. In this case, it may also be possible for the oral infection to predispose to systemic disease. In order to understand the cellular/molecular mechanisms responsible for such a cyclical association, one must identify common physiological changes associated with diabetes and periodontitis that produce a synergy when the conditions coexist. A potential mechanistic link involves the broad axis of inflammation, specifically immune cell phenotype, serum lipid levels, and tissue homeostasis. Diabetes-induced changes in immune cell function produce an inflammatory immune cell phenotype (upregulation of proinflammatory cytokines from monocytes/polymorphonuclear leukocytes and downregulation of growth factors from macrophages). This predisposes to chronic inflammation, progressive tissue breakdown, and diminished tissue repair capacity. Periodontal tissues frequently manifest these changes because they are constantly wounded by substances emanating from bacterial biofilms. Diabetic patients are prone to elevated low density lipoprotein cholesterol and triglycerides (LDL/TRG) even when blood glucose levels are well controlled. This is significant, as recent studies demonstrate that hyperlipidemia may be one of the factors associated with diabetes-induced immune cell alterations. Recent human studies have established a relationship between high serum lipid levels and periodontitis. Some evidence now suggests that periodontitis itself may lead to elevated LDL/TRG. Periodontitis-induced bacteremia/endotoxemia has been shown to cause elevations of serum proinflammatory cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), which have been demonstrated to produce alterations in lipid metabolism leading to hyperlipidemia. Within this context, periodontitis may contribute to elevated proinflammatory cytokines/serum lipids and potentially to systemic disease arising from chronic hyperlipidemia and/or increased inflammatory mediators. These cytokines can produce an insulin resistance syndrome similar to that observed in diabetes and initiate destruction of pancreatic beta cells leading to development of diabetes. Thus, there is potential for periodontitis to exacerbate diabetes-induced hyperlipidemia, immune cell alterations, and diminished tissue repair capacity. It may also be possible for chronic periodontitis to induce diabetes.     

影响糖尿病患者口腔颌面部多间隙感染治疗结果的因素分析

目的:分析影响口腔颌面部多间隙感染患者治疗结果 (住院天数和并发症)的转归因素,并比较糖尿病患者与非糖尿病患者口腔颌面部多间隙感染的临床特征。方法:对2007—2010年间收治的117例口腔颌面部多间隙感染病例进行回顾分析。研究变量包括一般资料、病因学、临床指标(症状发作到入院治疗的时间、受累间隙的种类和数量)和实验室检查(细菌学、入院时血糖水平、入院时血白细胞总数和中性粒细胞百分比),结果变量为患者住院天数和并发症。采用SAS8.0软件包对数据进行t检验、卡方检验、方差分析、Logistic回归和线性回归分析。结果:糖尿病口腔颌面部多间隙感染患者与非糖尿病患者相比,前者受累的间隙更多,住院时间更长,全身各种并发症情况更多见,严重者可导致死亡。糖尿病存在与否与口腔颌面部多间隙感染的治疗转归(住院时日和并发症)直接相关。入院时血糖水平是影响口腔颌面部多间隙感染并发症严重程度的主要因素。结论:糖尿病患者与非糖尿病患者口腔颌面部多间隙感染的临床特征和转归不同,为临床上治疗糖尿病口腔颌面部多间隙感染提供了重要的参考依据。     

Diabetes and oral health promotion: a survey of disease prevention behaviors

BACKGROUND: Diabetes is a chronic metabolic disease known to affect oral disease progression. The authors surveyed health behaviors essential for preventing dental and periodontal diseases and maintaining oral health is a population of adult patients with type 1 (insulin-dependent) diabetes. The goals of this study were to assess these patients' oral health behaviors, access to dental care and need for improved health education. METHODS: As part of a dental and periodontal examination, 406 subjects with type 1 diabetes completed a questionnaire regarding their oral health attitudes, behaviors and knowledge. The authors also evaluated 203 age-matched nondiabetic control subjects. RESULTS: The authors found that diabetic subjects' tobacco use and oral hygiene behaviors were similar to those of the nondiabetic control subjects. Diabetic subjects, however, more frequently reported the cost of dental care as a reason for avoiding routine visits. Most of these subjects were unaware of the oral health complications of their disease and the need for proper preventive care. CONCLUSIONS: Patients with diabetes appear to lack important knowledge about the oral health complications of their disease. The results of this survey did not indicate improved prevention behaviors among the subjects with diabetes compared with nondiabetic control subjects. CLINICAL IMPLICATIONS: Dentists have an opportunity and the responsibility to promote good oral health behaviors such as regular dental examinations, proper oral hygiene and smoking cessation that may significantly affect the oral health of their diabetic patients.     

Risk factors for oral postoperative infection in patients with diabetes

The prevalence of diabetes mellitus in the general population has been increasing sharply. Currently, much is feared but little is known about postoperative complications of oral surgery among persons with diabetes. Existing dental education and practice guidelines cite excess infectious risk among patients with diabetes; however, empiric evidence to support such concerns is lacking. In fact, dentists commonly prescribe antibiotics when dental surgical procedures involve bone. This practice may contribute to the rising problem of microbial resistance and may increase overall healthcare costs. The growing number of dental patients with diabetes warrants strengthening the evidence base to guide their dental care and prevent possible morbid complications.     

Root caries and diabetes: risk assessing to improve oral and systemic health outcomes

This report reviews the current understanding of the relationship between diabetes and root caries, and investigates the evidence for dental chairside testing of gingival crevicular blood (GCB) glucose levels to assess risk for type 2 diabetes mellitus. Diabetes is linked with the progression of periodontal disease and a greater number of exposed root surfaces at risk for root caries. The rapidly increasing prevalence of type 2 diabetes coupled with a general trend towards retention of teeth means that the number of patients with increased risk for root caries is expanding significantly. Many patients with diabetes or abnormal blood glucose levels are unaware of their condition or that they are at increased risk for oral disease. Systemic blood glucose concentrations are comparable to those found in GCB and therefore may be a useful adjunctive clinical aid in determining appropriate care for patients and providing timely referrals to general medical practitioners. Use of GCB testing within the dental clinic is described. It is proposed that future studies be undertaken to provide clinicians with improved risk assessment strategies and to evaluate GCB glucose screening models.     

Current practice in dental oncology in the U.K

The clinical management of cancer patients, particularly where it affects the head and neck, may result in short- and long-term complications. Specialist management of the dental sequelae of cancer is often recognized nowadays by the term'Dental Oncology' Members of the dental team play a vital role in preventing and promptly managing such complications and all dental professionals should have a sound understanding and knowledge of the oral implications of cancer therapy and their management, and the contribution of this to the patient's quality of life. CLINICAL RELEVANCE: This article offers the dental team an overview of the impact of cancer therapy and strategies for preventing and managing the oral side-effects of cancer therapy prior to, during, and beyond cancer treatment.     

Diagnostic & therapeutic strategies for the management of the diabetic patient

The bridge between oral and systemic health exists and becomes more concrete as data continue to emerge in support of this relationship. The medical management of diabetes is affected by the presence of chronic infections, such as periodontitis. This article reviews the pathogenesis of periodontal disease as it relates to diabetes. The author discusses patient susceptibility in terms of risk and recommends risk assessment to determine optimal treatment strategies. Patients with poorly controlled diabetes are at greater risk for developing periodontitis. The opportunity for systemic exposure to periodontal pathogens and proinflammatory mediators associated with periodontitis is discussed relative to their specific effects on patients with diabetes. The importance of good metabolic control in terms of risk for developing long-term complications of diabetes is presented and the impact of periodontitis on achieving adequate metabolic control is described. Special considerations for the management of patients with diabetes in the dental office are reviewed, including the signs and symptoms of diabetes, risk assessment for diabetes, and the challenges of "tight control" with insulin and oral agents with regards to hypoglycemia. It is recommended by the author that a thorough medical history of the patient be obtained, that the patient's medications are known, that the dentist consults with the patient's physician to assess the patient's glycemic control, and that the patient's blood glucose levels and dietary intake be monitored before treatment. Finally, the author reviews the long-term complications of diabetes, particularly the oral complications that can affect overall health. The author concludes with the belief that the treatment of periodontal diseases should not be considered optional or elective but, instead, should be a necessary and integral part of a patient's overall healthcare program.     

Diabetes mellitus and the dental pulp

This study attempts to evaluate the oral manifestations of and the limited available dental pulp information on diabetes mellitus, a common metabolic disorder of carbohydrate and lipid metabolism affecting over 16 million Americans. Diabetics are particularly prone to bacterial or opportunistic infections. This vulnerability is caused by a generalized circulatory disorder whereby the blood vessels are damaged by the accumulation of atheromatous deposits in the tissues of the blood vessels lumen. In addition, blood vessels, particularly capillaries, develop a thickened basement membrane, which impairs a leukotactic response, and there is a decrease in the polymorphonuclear leucocyte microbicidal ability and failure to deliver the humoral and cellular components of the immune system. Because the dental pulp has limited or no collateral circulation, it is more prone to be at risk for infection. Clinical and radiographic studies by other investigators have shown that there is a greater prevalence of periapical lesions in diabetics than in nondiabetics. In a study of 252 diabetics with poor glycemic control, a high rate of asymptomatic tooth infection was found. Inflammatory reactions are greater in diabetic states, and the increased local inflammation causes an intensification of diabetes with a rise in blood glucose, placing the patient in an uncontrolled diabetic state. This often requires an increase in insulin dosage or therapeutic adjustment. Removal of the inflammatory state in the periodontium created a need for a lesser amount of insulin for glycemic control. Thus, it is essential to remove all infections including those of the dental pulp. When diabetes mellitus is under therapeutic control, periapical and other lesions heal as readily as in nondiabetics.     

Oral health of patients with insulin-dependent diabetes mellitus

Abstract — Oral health, the amount of salivary Streptococcus mutans and lactobacilli, and the flow rate, pH and buffer capacity of paraffin-stimulated whole saliva were analyzed in 35 adult diabetic patients and their age- and sex-matched non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (± SD) duration of 14.0 ± 9.1 yr. The prevalence of dental caries was as high in the diabetic group as in the controls but the past caries experience was remarkably lower in those individuals whose diabetes had started at a very early age (= 7 yr). In agreement with the clinical data, the salivary levels of cariogenic microorganisms were of the same order of magnitude in both study groups. However, the relative proportion of S. mutans from the total cultivable aerobic microflora was significantly higher ( P <0.01) in diabetics compared to the controls. The other studied salivary parameters did not differ between the groups. Remarkable individual differences were observed in the correlation between glucose levels of blood and whole saliva among diabetics. In spite of the noncariogenic dietary habits, the adult diabetic patients seem to be at least as susceptible to dental caries as non-diabetics, probably due to the leakage of glucose from blood into the oral cavity.     

Oral health of patients with insulin-dependent diabetes mellitus

Oral health, the amount of salivary Streptococcus mutans and lactobacilli, and the flow rate, pH and buffer capacity of paraffin-stimulated whole saliva were analyzed in 35 adult diabetic patients and their age- and sex-matched non-diabetic, clinically healthy controls. All patients had insulin-dependent diabetes (IDDM) with a mean (+/- SD) duration of 14.0 +/- 9.1 yr. The prevalence of dental caries was as high in the diabetic group as in the controls but the past caries experience was remarkably lower in those individuals whose diabetes had started at a very early age (less than or equal to 7 yr). In agreement with the clinical data, the salivary levels of cariogenic microorganisms were of the same order of magnitude in both study groups. However, the relative proportion of S. mutans from the total cultivable aerobic microflora was significantly higher (P less than 0.01) in diabetics compared to the controls. The other studied salivary parameters did not differ between the groups. Remarkable individual differences were observed in the correlation between glucose levels of blood and whole saliva among diabetics. In spite of the noncariogenic dietary habits, the adult diabetic patients seem to be at least as susceptible to dental caries as non-diabetics, probably due to the leakage of glucose from blood into the oral cavity.     

Dental management of patients with diabetes

Diabetes is a disease of metabolism resulting from impaired insulin secretion, varying degrees of insulin resistance, or both. Management of the diabetic dental patients must take into consideration the impact of dental disease and dental treatment on the management of diabetes as well as an appreciation for the comorbidities that accompany long-standing diabetes. Those comorbidities include obesity, hypertension, and dyslipidemia. Central to the management of diabetes is the intensive regulation of plasma glucose along with management of comorbidities comprising the "metabolic syndrome." Management of the diabetic dental patient should focus on periodontal health and the delivery of comprehensive dental care with minimal disruption of metabolic homeostasis and recognition of diabetic comorbidities.     

Diabetes mellitus and oral care

Diabetes is a common condition. Its incidence is increasing. It can lead to medical complications including visual impairment, neuropathies, renal and cardiovascular disease. Diabetes can have an adverse effect on oral health and healthcare. Conversely, poor oral health can have an adverse effect on blood glucose control. Repeated oral infections can indicate uncontrolled diabetes and lead to its diagnosis. Whereas hyperglycaemia may occur in untreated diabetes, hypoglycaemic episodes are not uncommon in well-controlled diabetes Type 2. The tight glycaemic control required to prevent its long-term complications can be destabilized by infection, anxiety or missed meals.     

Glycemic control in patients with diabetes mellitus upon admission to a dental clinic: considerations for dental management.

OBJECTIVE: The purpose of this study was to determine the level of glycemic control in dental patients with diabetes upon admission to a dental school clinic. METHODS AND MATERIALS: One hundred patients (mean age: 57.7 years) of the Oral Diagnosis-Admissions Clinic at the University of Minnesota School of Dentistry, Minneapolis, Minnesota, with diabetes mellitus were chosen as subjects. Fasting blood glucose was measured using a portable blood glucose monitoring device as a part of their initial dental examination. RESULTS: Twenty-eight of the 100 patients were found to be hyperglycemic (> or = 126 mg/dl; 174.8 +/- 40.8 mg/dl; mean +/- SEM); 2 patients were found to be hypoglycemic (< 70 mg/dl). Of the 8 patients with type 1 diabetes in the cohort, 3 (37.5%) were very hyperglycemic, with fasting blood glucose levels > 250 mg/dl. CONCLUSIONS: This is important information for dental practitioners because patients with diabetes may not be under good glycemic control, and dentists may have to take special precautions before, during, and after treatment. This paper reviews the pathogenesis of diabetes, the detection of patients with undiagnosed or poorly controlled diabetes, and the management of patients with diabetes during dental treatment.