大小剂量仁苏罗红霉素全身联合局部用药治疗宫颈衣原体、支原体感染

研究表明，目前生殖道衣原体和支原体感染人群中的发生率和危害性已远远超过淋球菌感染而居性传播疾病之首，其感染是不孕症、异位妊娠、宫颈炎、盆腔炎和宫颈癌等多种疾病的潜在因素。我院采用大小剂量仁苏罗红霉素全身联合局部对96例宫颈衣原体、支原体感染患者进行治疗，疗效显著、副反应小且经济，现将资料总结如下。     

女性生殖道支原体、衣原体感染分析

目的:了解患有阴道炎、尿道炎、盆腔炎、流产、不孕不育、早产、异位妊娠的女性生殖道支原体、衣原体感染状况及支原体对部分药物敏感性的变化。方法:支原体采用珠海黑马试剂盒、衣原体采用胶体金法对586例上述女性进行支原体、衣原体检测。     

100例急性呼吸道感染住院患儿肺炎支原体、肺炎衣原体及嗜肺军团菌分布特点分析

目的分析100例急性呼吸道感染住院患儿肺炎支原体、肺炎衣原体及嗜肺军团菌分布特点。方法选择2014年1月至2016年1月湖南省儿童医院呼吸科收治住院的急性呼吸道感染患儿100例为研究对象,总结不同性别、不同年龄段、不同季节中肺炎支原体、肺炎衣原体、嗜肺军团菌的检出情况。结果 100例急性呼吸道感染住院患儿中肺炎支原体检出35例,肺炎衣原体检出22例,嗜肺军团菌检出10例,其他病原体检出33例。不同性别肺炎支原体、嗜肺军团菌检出率比较差异无统计学意义(P0.05),男患儿肺炎衣原体检出率显著低于女患儿,差异有统计学意义(P0.05)。年龄分布上肺炎支原体年龄分布差异有统计学意义(P0.05),而肺炎衣原体、嗜肺军团菌差异无统计学意义(P0.05)。3种病原体检出率在不同季节的分布比较,差异无统计学意义(P0.05)。结论肺炎支原体、肺炎衣原体及嗜肺军团菌为急性呼吸道感染的重要病原体,应引起临床的重视。     

女性生殖道支原体和衣原体感染对妊娠的影响

支原体和衣原体在人类中的致病性一直备受关注。近年来,女性生殖道支原体与衣原体感染率在逐年上升,并可致女性输卵管性不孕,妊娠期可上行感染胎盘、胎儿,造成流产、胎死宫内、早产、胎儿生长受限等。因此,预防及治疗二种病原体的感染对减少不良妊娠结局十分重要。1支原体及衣原体的致病机制1·1支原体目前人体分离出的支原体有20多种,其中至少5种已被确定是致病菌或条件致病菌,分别为肺炎支原体(MP)、解脲支原体(UU)、人型支原体(MH)、生殖支原体(MG)和发酵支原体(MF)。其致病机制大致如下[1]:(1)支原体分泌的有毒代谢产物破坏机体微生…     

沙眼衣原体、解脲支原体感染与男性不育

目的:了解沙眼衣原体、解脲支原体感染患者精子密度、活率和抗精子抗体的变化及其对生育影响。方法:选取沙眼衣原体、解脲支原体感染男性不育患者50例,测定其抗生素治疗前后的精液常规参数和抗精予抗体,进行动态分析和统计学比较。结果:治疗后精子密度。精子活率显著提高,畸形率和抗精子抗体滴度明显降低。结论:沙眼衣原体、解脲支原体感染从多方面影响男性生育能力。     

重视女性生殖道支原体和衣原体感染的防治

近年来引起女性生殖道感染的病原微生物,除淋病奈瑟菌增多外,较常见的还有支原体和衣原体。引起女性生殖道感染的致病支原体,主要有解脲支原体(ureaplasmaurealyticum,UU)、人型支原体(mycoplasma hominis,MH)和生殖支原体(mycoplasma genitalium,MG)。女性生殖道沙眼衣原体(chlamydia trachomatis,CT)、UU、MH、MG感染均属于性传播疾病(sexually transmitted diseases,STD)范畴。STD是一组通过性接触而传播的疾病,因其传播速度快,影响范围广,并能引起并发症和后遗症,已经成为世界上备受关注的公共卫生问题之一。由于UU和CT引起的…     

女性生殖道支原体和衣原体感染对围生儿的影响

孕妇生殖道感染支原体或衣原体是否引起不良妊娠结局,一直存有争议,关于对围生儿的影响,多数作者认为可以导致早产、胎膜早破和新生儿感染,也有报道认为与死胎、胎儿生长受限和低出生体重儿的发生有关,但和胎儿畸形相关的报道不多。支原体是能在无细胞培养基内自行复制的最小的原核细胞微生物。人类至少是12种支原体的自然宿主,人生殖道支原体病是由人型支原体(mycoplasma hominis,MH)、解脲支原体(ureaplasma urealyticum,UU)和生殖道支原体(mycoplasma genitalium,MG)引起的。在阴道内寄居的多是MH和UU。衣原体是一类介于病毒和立克次…     

奥平栓治疗支原体、衣原体感染及慢性宫颈炎的临床观察

奥平栓治疗支原体、衣原体感染及慢性宫颈炎的临床观察姜淑芬为探索一个更新的治疗方法，自１９９７年２月至８月我们采用由武汉天奥制药有限公司生产的奥平栓治疗女性生殖道支原体（ＵＵ）和沙眼衣原体（ＣＴ）感染４５例及治疗宫颈糜烂７６例，取得较满意的效果，现报告...     

生殖道支原体和衣原体感染与不孕

近年来,国内外研究证实:解脲支原体(UU)和沙眼衣原体(CT)是影响人类生殖道健康的重要病原体之一,生殖道支原体和衣原体感染者是不孕不育的高发人群,它可造成女性输卵管的粘连和阻塞及子宫内膜炎等,导致不孕不育,且与不良孕产结局有较高相关性。1女性生殖道支原体和衣原体感染与不孕的关系女性生殖道支原体感染是导致不孕的重要因素之一。张月莲等[1]的研究指出:无论生殖道哪个部位(包括宫颈,子宫内膜,输卵管等)被UU感染,均可引起输卵管通液障碍,UU阳性组中输卵管通液障碍者占75%,显著高于UU阴性组。对上述患者行腹腔镜检查发现,UU感染…     

宫内感染与胎儿发育异常

宫内感染是指孕妇受病原体感染后所引起的胎儿感染。引起宫内感染的病原体有 :①病毒 ,如巨细胞病毒、风疹病毒、单纯疱疹病毒、人乳头瘤病毒、人类微小病毒Ｂ19、乙肝病毒、丙肝病毒、柯萨奇病毒、人类免疫缺陷病毒、带状疱疹病毒、腮腺炎病毒、流感病毒等 ;②原虫 ,如弓形虫 ;③衣原体 ,如沙眼衣原体 ;④支原体 ,如解脲支原体 ,肺炎支原体等 ;⑤螺旋体 ,如梅毒螺旋体 ;⑥细菌 ,如Ｂ族链球菌等。孕妇感染上述病原体后 ,多数无特殊症状或症状轻微 ,但有可能对胎儿造成严重后果 ,引起流产、早产、胎儿宫内发育迟缓、死胎、畸形等。在胎儿发育…     

Blood lead and cadmium and birth weight among sub-arctic and arctic populations of Norway and Russia

BACKGROUND: Delivering women and their newborns in the Kola Peninsula of Russia and the neighboring arctic area of Norway were studied to explore relationships between maternal cadmium and lead status and birth weight as a pregnancy outcome. METHODS: Life-style information, maternal blood and cord blood specimens were collected from 50 consecutive mother-infant pairs from hospital delivery departments in three Russian and three Norwegian communities. Pregnancy outcomes were verified by consulting medical records. Lead and cadmium were determined in the blood samples by electrothermal atomic absorption spectrometry. RESULTS: The median blood-cadmium concentration for the Russian mothers was 2.2 nmol/L (n = 148) versus 1.8 nmol/L in the Norwegian group (n = 114, p = 0.55). A weak association was observed between maternal cadmium and amount smoked (r = 0.30, p<0.001); no correlation was found between maternal blood cadmium and birth weight. The corresponding maternal lead values were 0.14 (Russia) and 0.06 micromol/L (Norway), p<0.001. The latter lead concentration constitutes one of the lowest adult population values reported to date. Maternal and cord blood lead levels were strongly correlated (r = 0.88, p<0.001). In a multivariate linear regression model, maternal blood lead was recognized as a negative explanatory variable (p<0.05) for birth weight and child's body mass index (BMIC), with or without adjustment for gestational age. A similar association was suggested by ANOVA-analysis of maternal blood lead by quartiles. CONCLUSION: Maternal blood-lead level as an environmental factor is an apparent predictor of low birth weight and BMIC. It reduced substantially the contribution of a country factor in explaining the observed differences in birth weight.     

Pharmacokinetics and endometrial and tubal tissue penetration of cefalotin and cefazolin

The pharmacokinetics and concentrations of the two antibiotics cefazolin and cefalotin were studied during gynecologic operations in endometrial and tubal tissue. The patients received 0.05 g/kg of the antibiotics by intravenous injection. Under the given conditions, pharmacokinetic calculation of the plasma elimination gave half-lives of 24.8 min for cefalotin and of 63 min for cefazolin. Fitting of the tissue levels to the Bateman function showed that the two antibiotics diffuse rapidly into both tubal and endometrial tissue and attain peak concentration levels between 10 and 25 min. In both tissues the concentrations of cefazolin were higher than those of cefalotin. Higher tissue concentrations of cefazolin could also be demonstrated in experiments of longer duration.     

Toll样受体与子宫内膜及子宫内膜异位症

子宫内膜异位症(EMs)发病机制尚未完全阐明.大量研究表明,免疫因素在EMs的发病机制中起重要作用.EMs免疫应答异常主要是巨噬细胞数量和活性增加及其分泌产物,如生长因子、细胞因子和血管生成因子的改变.Toll样受体(TLRs)识别特异性的病原体相关分子模式,启动和介导免疫应答,在固有免疫中发挥重要作用,并诱导产生适应性免疫反应.TLRs在正常子宫内膜中的生理作用以及在EMs中的相关研究已逐步开展,对其深人认识和研究将为EMs诊断、治疗和预后判断提供新思路和手段.