Correlation between cerebral blood flow and items of the Hamilton Rating Scale for Depression in antidepressant-naive patients

BACKGROUND: The purpose of this study was to correlate the basal cerebral blood flow (CBF) in patients with major depressive disorder (MDD) with the score for each of the 21 questions in the Hamilton Rating Scale for Depression (HRSD), in order to determine the cerebral regions associated with each item. METHODS: Fourteen antidepressant-naive patients with unipolar depression (DSM-IV criteria for MDD) participated in this study with a HRSD score of >/=20 points. CBF images obtained by SPECT were analyzed by SPM99 software. The significant correlation threshold for a priori regions (frontocortical and limbic regions) was a Z value of at least 2.25 and clusters formed by more than 10 voxels. RESULTS: Items 1, 6, 11 and 20 were positively correlated with right medial frontal gyrus; item 7 was negatively correlated with bilateral medial frontal gyrus. Items 2 and 10 were positively correlated with right anterior and medial cingulate, respectively. Item 5 was negatively correlated with the left amygdala. Item 9 was negatively correlated with bilateral insula, and item 16 with right insula. Items 12 and 14 were positively correlated with right and left precentral frontal gyrus, respectively. Limitations: The small sample size and only out-patients included in the study. CONCLUSIONS: The frontal cortex plays an important role in the expression of MDD symptoms. Not all the symptoms evaluated correlated with one single structure, which may explain the diverse results reported in the literature. These preliminary results support the necessity of further analyses by symptoms that could provide more specific information on the pathophysiology of MDD.     

静息态脑功能技术对平衡针治疗中枢机制的分析应用

背景：平衡针治疗疾病疗效显著,但缺乏相关现代科学理论机制。 目的：利用静息态脑功能成像技术探讨平衡针疗法的中枢作用机制。 方法：纳入10例腰椎间盘突出腰腿痛患者及10例正常受试者,于平衡针针刺前后进行功能磁共振扫描,通过AFNI软件对与双侧杏仁核表现为显著联系的脑区进行功能连接分析,并对平衡针刺后腰椎间盘突出患者及正常受试者的脑功能连接的差异进行探讨。 结果与结论：经平衡针治疗后10例腰椎间盘突出患者疼痛均有好转。脑功能连接分析显示腰椎间盘突出患者丘脑、脑干、腹前核、腹外侧核、额内侧回、额上回、额叶眶上回、额下回、颞上回、颞中回、海马回、扣带回、岛叶等脑区功能连接增强。正常受试者双侧颞中回、双侧眶上回、双侧尾状核头、双侧岛叶、左侧腹背侧核、双侧额上回、左侧额中回、前扣带回、右侧顶下小叶与杏仁核连接增强;双侧小脑齿状核、小脑蚓、左侧小脑坡、双侧舌回、左侧枕中回、右侧额上回、右侧中央前回、双侧顶下小叶、右侧顶上小叶、右侧中央后回与杏仁核连接下降。提示通过静息脑功能成像技术对杏仁核的研究有助于更深入理解平衡针灸治疗腰腿痛的中枢机制。     

Comparative study of regional homogeneity in schizophrenia and major depressive disorder

Compelling evidence suggests that there is a considerable overlap in structural and functional alternation in the brain between different neuropsychiatric disorders. However, whether these overlaps are specific for schizophrenia has yet to be investigated. A total of 36 patients with paranoid schizophrenia, 43 patients with major depressive disorder (MDD), and 44 healthy controls were recruited to undergo resting‐state functional magnetic resonance imaging (rs‐fMRI) for analysis of regional homogeneity (ReHo). Twelve regions of interest (ROIs) in the frontal and temporal lobes were generated and one‐way ANOVA was performed to test the ReHo differences within these ROIs between the above three groups. The ReHo values within ROIs were extracted to investigate whether a left‐right asymmetry existed in a mental disorder. One‐way ANOVA showed significant differences in ReHo in the right superior frontal gyrus and left superior temporal gyrus; post hoc analysis revealed that schizophrenic patients had lower ReHo in the left superior temporal gyrus than either control subjects or patients with MDD. Increased ReHo was observed in the right superior frontal gyrus in schizophrenic patients compared with control subjects, and a left‐less‐than‐right asymmetry was also found in this region in schizophrenic patients. The above alterations in ReHo were not affected by age and genders. Our study suggests that the altered ReHo in the superior frontal and temporal gyrus may be specific for schizophrenia rather than MDD. A left‐less‐than‐right asymmetry activation pattern may exist in the resting‐state superior frontal gyrus in schizophrenia. This finding would be helpful for better understanding the pathological mechanisms of schizophrenia. © 2012 Wiley Periodicals, Inc.     

High (15 Hz) and low (1 Hz) frequency transcranial magnetic stimulation have different acute effects on regional cerebral blood flow in depressed patients

BACKGROUND: High and low frequency repetititve transcranial magnetic stimulation (rTMS) are both effective in treating depression but have contrary effects on motor cortical activity. This study aimed to understand further the mechanisms of action of high and low frequency rTMS by examining their acute effects on regional cerebral blood flow (rCBF) in depressed patients. METHOD: Eighteen depressed subjects underwent brain single photon emission computerized tomography (SPECT) scanning using split-dose 99mTc-HMPAO, and were examined during sham and active rTMS to the left prefrontal cortex, at 15 Hz or 1 Hz (N=9 each). Relative rCBF changes were examined by statistical parametric mapping and by regions of interest analysis. RESULTS: High (15 Hz) frequency rTMS resulted in relative rCBF increases in the inferior frontal cortices, right dorsomedial frontal cortex, posterior cingulate and parahippocampus. Decreases occurred in the right orbital cortex and subcallosal gyrus, and left uncus. Low (1 Hz) frequency rTMS led to increased relative rCBF in the right anterior cingulate, bilateral parietal cortices and insula and left cerebellum. High frequency rTMS led to an overall increase, whereas low frequency rTMS produced a slight decrease, in the mean relative rCBF in the left dorsolateral prefrontal cortex. CONCLUSIONS: High (15 Hz) and low (1 Hz) frequency rTMS led to different frontal and remote relative rCBF changes, which suggests different neurophysiological and possibly neuropsychiatric consequences of a change in frequency of rTMS.     

基于脑网络组图谱的首发-未服药抑郁症白质结构网络研究

使用图论的分析方法对首发-未服药抑郁症（MDD）的扩散磁共振数据进行分析,探讨其白质结构网络变化。结果显示相较于健康对照组,MDD患者的网络节点拓扑属性受到了破坏,主要位于双侧海马旁回、双侧基底节、双侧顶下小叶、左侧中央后回、左侧中央旁小叶、右侧颞中回、右侧顶上小叶、右侧岛叶、右侧枕叶皮层腹中部、右侧扣带回以及右侧丘脑。进一步的相关分析结果表明,MDD患者的右侧顶上小叶、右侧岛叶的节点介数与病程呈正相关,右侧丘脑、左侧海马旁回的节点介数,左侧海马旁回、右侧顶下小叶的节点度与汉密尔顿的抑郁得分呈显著正相关。     

首发抽动秽语综合征经阿立哌唑治疗前后静息态脑功能成像变化的初步研究

目的探索首发抽动秽语综合征(Tourette综合征简称TS)儿童经阿立哌唑治疗前后患儿的脑功能变化。方法对20例首发未经治疗患儿使用阿立哌唑进行规范治疗,4周后对患者再次行fMRI检查。静息态fMRI数据处理过程中使用AAL90模板进行脑区划分,使用皮尔森相关构建脑功能连接矩阵,接下来使用Bonferroni矫正(P0.05)构建二值网络。基于图论的方法计算了网络拓扑属性。结果首发TS使用阿立哌唑治疗前后全局属性无统计学差异(P0.05)。局部属性方面:左侧嗅皮质、左侧颞上回颞极、左侧颞中回颞极处Degree和gE治疗后显著低于治疗前(P=0.0150,0.0275,0.0112),且数值趋向接近正常组,使用阿立哌唑治疗后TS组右侧额上回、前扣带回和旁扣带回左右侧、左侧梭状回、左侧角回、左右侧中央旁小叶处Degree和gE显著高于治疗前组;左侧颞上回处Betweenness治疗后显著低于治疗前(P=0.0046,0.0300,0.0170,0.0174,0.0040,0.0117,0.0455);与治疗前相比,左侧额中回、左侧枕下回、左侧中央旁小叶、左右侧尾状核处LocE显著高于治疗前组(P=0.0096,0.0291,0.0100,0.0314,0.0181)。结论 TS患者存在脑功能异常,并且这些异常可通过药物治疗在一定程度上可以纠正。     

糖尿病视网膜病变患者自发活动性异常的脑区与MoCA的相关性研究

目的 基于静息态功能磁共振局部一致性技术探讨糖尿病视网膜病变患者局部脑区一致性的改变及与认知关系.方法 选择27例糖尿病视网膜病变(DR)及与之年龄、性别、受教育年限相匹配的单纯糖尿病(N-DR)患者27例,均进行实验室检查、蒙特利尔量表(MoCA)检测及头颅磁共振扫描.利用多元回归分析及Pearson回归分析观察临床变量与活动性异常活动脑区ReHo值之间的关系.结果 相对于N-DR,DR患者在左小脑后叶、右额叶/额中回/内侧回、右枕叶/楔叶/距状回、左颞叶/上/中回、右边缘叶/后扣带回、左顶叶/中央后回ReHo值降低;在左额叶/眶部额上回、左顶叶/楔前叶ReHo值增强.而且MoCA量表评分与颞叶及楔前叶异常活动的脑区存在相关性.降低的枕叶距状回及颞叶中回与糖化血红蛋白呈负相关,增强的眶额叶与糖化血红蛋白呈正相关.结论 糖尿病视网膜病变患者存在多个脑区活动性异常的表现,且这些局部异常活动的脑区与认知功能及糖化血红蛋白存在相关.     

Relationship between regional cerebral blood flow and separate symptom clusters of major depression: a single photon emission computed tomography study using statistical parametric mapping

This study examined the relationship between resting regional cerebral blood flow (rCBF) patterns in patients with major depressive disorder (MDD) and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD) and the Mini Mental State Examination. We hypothesized that the functional activity in frontal, parietal, anterior cingulate, basal ganglia and limbic regions would be related to specific symptom domains. Fifteen patients fulfilling DSM-IV criteria for MDD who were off all psychotropic medications for >4 weeks and 15 normal volunteers were recruited. Single photon emission computed tomography (SPECT) images were obtained after (99m)Tc-ECD injection, and correlations between rCBF patterns and symptom severity ratings were calculated on a voxel-by-voxel basis, using statistical parametric mapping (SPM). Severity of depressive mood was inversely correlated with rCBF in the left amygdala, lentiform nucleus, and parahippocampal gyrus, and directly correlated with rCBF in the right postero-lateral parietal cortex (p < 0.001, uncorrected for multiple comparisons). Insomnia severity was inversely correlated with rCBF in the right rostral and subgenual anterior cingulate cortices, insula and claustrum. Anxiety severity was directly correlated with rCBF in the right antero-lateral orbitofrontal cortex, while cognitive performance was directly correlated with rCBF in the right postero-medial orbitofrontal cortex and in the left lentiform nucleus. Our findings confirmed the prediction that separate symptom domains of the MDD syndrome are related to specific rCBF patterns, and extend results from prior studies that suggested the involvement of anterior cingulate, frontal, limbic and basal ganglia regions in the pathophysiology of MDD.     

动态表情情绪识别相关脑区的fMRI研究

目的:利用事件相关的功能核磁共振成像技术研究健康汉族女性对动态表情的识别情况并探讨其神经基础。方法:利用1.5T功能核磁共振成像系统检测13名女性健康受试者识别悲伤、喜悦及中性动态表情视频时的脑部反应。图像数据经SPM2软件处理和统计分析,获得脑区激活图。结果:与识别十字架相比,识别中性表情激活左额中回、双侧中央前回、右侧杏仁核、左顶下小叶、右中央后回以及丘脑等。与识别中性表情相比,识别喜悦表情激活右额内侧回、右额上回、右额中回、右前扣带回、左胼胝体下回、右枕上回、右枕下回、左枕中回及右颞上回等脑区,而识别悲伤表情激活左额内侧回、右额中回、左颞下回以及左颞上回等脑区。结论:面孔加工及动态表情的识别由脑内一个分布式神经网络所调控,其中额内侧回参与多种情绪的加工,可能是情绪加工的共同通路,而颞上回主要负责面部动态特征的加工。     

Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using 99m Tc-HMPAO single photon emission computerized tomography (SPECT)

BACKGROUND AND PURPOSE: Depressive symptoms are frequently associated with heart failure (HF), but the brain mechanisms underlying such association are unclear. We hypothesized that the presence of major depressive disorder (MDD) emerging after the onset of HF would be associated with regional cerebral blood flow (rCBF) abnormalities in medial temporal regions previously implicated in primary MDD, namely the hippocampus and parahippocampal gyrus. METHOD: Using 99mTc-SPECT, we measured rCBF in 17 elderly MDD-HF patients, 17 non-depressed HF patients, and 18 healthy controls, matched for demographic variables. Group differences were investigated with Statistical Parametric Mapping. RESULTS: Significant rCBF reductions in MDD-HF patients relative to both non-depressed HF patients and healthy controls were detected in the left anterior parahippocampal gyrus and hippocampus (ANOVA, p=0.008 corrected for multiple comparisons) and the right posterior hippocampus and parahippocampal gyrus (p=0.005 corrected). In the overall HF group, there was a negative correlation between the severity of depressive symptoms and rCBF in the right posterior hippocampal/parahippocampal region (p=0.045 corrected). CONCLUSIONS: These findings are consistent with the notion that the medial temporal region is vulnerable to brain perfusion deficits associated with HF, and provide evidence that such functional deficits may be specifically implicated in the pathophysiology of MDD associated with HF.     

Brain single photon emission computed tomography findings in depressive pseudodementia patients

BACKGROUND: Recently, there have been studies suggesting that depressive pseudodementia would include early-stage dementing disorder. Through the comparison of the 99mTc-HMPAO single photon emission computed tomography (SPECT) image of depressive pseudodementia subjects, healthy comparison subjects, depressed subjects free of cognitive impairment, and dementia of Alzheimer's type (DAT) subjects, we aimed to see part of pathophysiology of the depressive pseudodementia of elderly patients. METHODS: Study subjects consisted of seven patients with depressive pseudodementia, seven healthy comparison subjects, seven patients with depression free of cognitive impairment, and eleven patients with DAT. Depression patients were diagnosed according to DSM-III-R. DAT patients were diagnosed by DSM III-R and NINCDS-ADRDA criteria of DAT. Other measures for assessment include Hamilton Rating Scale for Depression and Mini Mental State Exam. All underwent 99mTc-HMPAO SPECT scan. The images of each group were analyzed using statistical parametric mapping of Friston, which compares the images on voxel-by-voxel basis. RESULTS: The results were as follows (1) The DAT group showed significant decreases of cerebral blood flow (CBF) in the right frontal, right temporal region, and both parietal regions as compared with control group (P < 0.05). (2) The depression group showed a significant decrease of CBF in the left frontal region as compared with control group (P < 0.05). (3) The depressive pseudodementia group showed significant decreases of CBF in both parietal regions as compared with control group (P < 0.05). (4) The depressive pseudodementia group showed significant decreases of CBF in the right temporal region and both parietal regions as compared with depression group (P < 0.05). (5) The DAT group showed significant decreases of CBF in the right temporal region, both frontal regions, and both parietal regions as compared with depressive pseudodementia group (P < 0.05). LIMITATIONS: The small number of subjects may make it difficult to generalize from our results. Because decreased CBF in depressive pseudodementia is found while the subjects were depressed, we cannot tell whether it is a state marker or a trait marker. CONCLUSIONS: The depressive pseudodementia group showed decreased CBF in the temporo-parietal region, similar to that of the DAT group and different from that of the depression group.     

基于偶极子特征优化的情绪重评同步EEG-fMRI源定位研究

为研究情绪重评时的大脑皮层源活动,针对情绪重评实验范式下采集的15例健康人同步EEG-fMRI数据,首先提出一种新颖的基于偶极子特征优化的融合源定位方法:根据fMRI加权最小范数估计源定位结果,采用20 ms EEG滑动时间窗,提取每个时窗内的偶极子空间融合特征,将其作为动态融合先验进行加权最小范数估计溯源;随后将该结...     

遭受多重侵害高职高专女生静息态脑功能局部一致性的研究

目的:探讨遭受多重侵害的高职高专女生静息态脑功能磁共振特点。方法:15名遭受多重侵害无创伤后应激症状被试(PV无PTSS组)、15名多重侵害有创伤后应激症状被试(PV有PTSS组)和15名正常对照接受静息态脑功能扫描。采用SPM8和静息态功能磁共振数据处理工具包分别进行数据预处理和ReHo分析。结果:静息状态下,与对照组相比,PV无PTSS组左侧额下回、左右额内侧回、右侧中央后回、左侧梭状回、左右海马旁回、右侧扣带回、左右豆状核和右侧岛叶的ReHo值降低;左右额上回、左右额中回、左右额下回、左右顶下小叶、左右楔前叶、左右颞上回、左侧颞横回、左右颞中回、右侧舌回和右侧扣带后回的ReHo值升高。与PV有PTSS组相比,PV无PTSS组在右侧额中回和额下回、左侧楔前叶、左侧舌回、左右海马旁回、左侧扣带回和左侧豆状核ReHo值降低;在左右额上回、左右额中回、左侧额内侧回、右侧中央后回、左侧缘上回、左右顶下小叶、左侧梭状回和左侧尾状核ReHo值升高。结论:遭受多重侵害但无创伤后应激症状的高职高专女生在静息状态下脑默认网络以及岛叶、基底神经节、海马旁回存在局部一致性信号异常,这些脑区异常可能为遭受多重侵害导致精神障碍的发病机制提供重要线索。     

Activation of brain regions using task-state FMRI in patients with mild traumatic brain injury: a meta-analysis

Activation likelihood estimation meta-analysis was performed to examine the activation characteristics of cognition-related brain regions in patients with mild traumatic brain injury (mTBI). The databases PubMed, Ovid, Cochrane Library, Google Scholar, CNKI, WFSD, and VIP were systematically searched. The software Ginger-ALE 3.0.2 was used for coordinate unification and meta-analysis. Seven studies with a total of 314 subjects were included. Meta-analysis results indicated that compared with healthy subjects, mTBI patients had enhanced activation in the left anterior angular gyrus, left occipital joint visual, left midbrain, right temporal angular gyrus, right cerebellar tonsil, left frontal insula, and right inferior frontal gyrus. mTBI patients had attenuated activation in the right dorsolateral prefrontal lobe, left cerebellar anterior lobe, left dorsolateral prefrontal lobe, right middle frontal gyrus, right posterior cingulate gyrus, left joint visual, left supramarginal gyrus, left middle frontal gyrus, right precuneus, left dorsolateral prefrontal cortex, right frontal eye field, right lower parietal gyrus, corpus callosum, right frontal pole region, and left prefrontal lobe. Further joint analysis revealed that the dorsolateral prefrontal lobe of the right middle frontal gyrus was a region of attenuated co-activation. The dorsolateral prefrontal lobe of the right middle frontal gyrus showing attenuated activation was the main brain region distinguishing mTBI patients from healthy subjects. Cognitive deficits could be associated with attenuated activation in the dorsolateral prefrontal lobe of the right middle frontal gyrus, which could be due to a decline in the recruitment ability of the neural network involved in controlling attention.     

基于低频振幅的吸烟成瘾者戒烟2周后脑功能活动变化的研究

探讨吸烟成瘾者戒烟前后的脑功能活动差异,使用3.0T磁共振扫描仪采集14名吸烟成瘾者戒烟前和戒烟后的静息态MRI数据,采用低频振幅(amplitude of low-frequency fluctuation, ALFF)的方法来比较分析吸烟成瘾者在戒烟前和戒烟两周后的脑功能活动情况.与戒烟前相比,吸烟成瘾者戒烟两周后静息状态下的右侧楔前叶、右侧后扣带回、左侧缘上回、左侧背外侧额上回和左侧额中回的ALFF活动降低;双侧距状裂周围皮层、双侧楔叶、左侧中央后回和左侧中央旁小叶的ALFF活动增加.研究结果表明:吸烟成瘾者在戒烟两周后额叶、边缘叶、顶叶和枕叶脑区的脑功能活动发生了改变,提示ALFF可作为监测或评价戒烟效果的潜在生理指标.     

Measurements of cerebral blood flow and metabolism in patients with Alzheimer's disease

Positron emission tomography (PET) was used to measure cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2), and cerebral metabolic rate of glucose (CMRglc) in patients with Alzheimer's disease. In the patients, values for CBF, CMRO2, and CMRglc have been shown to drop by 30-50% in comparison to age-matched normal controls. In the early stage (stage I), reductions in CBF and CMRO2 are prominent in the temporal and the temporoparietal cortices. In stage II, reduction in the parietal cortex also become quite prominent, and in the late stage (stage III) reduction begins prominently in the frontal cortex as well. These PET findings in Alzheimer's disease differ from those in vascular dementia, Pick's disease, and Huntington's disease. In the interrelationship among CBF, CMRO2 and higher brain function, CBF and CMRO2 decrease especially in the left frontal, the left temporal and the left parietal cortices in patients with marked language disability. On the contrary, CBF and CMRO2 decrease in the right temporal and the right parietal cortices in patients with marked apraxia and visuospatial deficits. Cerebral blood flow and metabolism are closely related to the functioning of nerve cells. Therefore we can isolate the region responsible for higher brain dysfunction and similarly evaluate the effects of treatment using cerebral blood flow and metabolism measurements.     

Regional cerebral blood flow in depression: associations with psychopathology

Regional cerebral blood flow (rCBF) was measured during rest and cognitive activation in 21 patients with a major depressive episode and 21 healthy subjects. Depressive patients had significantly lower rCBF during rest in the right global, frontal, parietal, occipital and temporal regions and in the left global and frontal regions. During mental activation patients showed significantly lower values in all right and left parietal regions. rCBF was correlated with the scores of the Brief Psychiatric Rating Scale (BPRS), the parietal regions. rCBF was correlated with the scores of the Brief Psychiatric Rating Scale (BPRS), the Bech-Rafaelsen Melancholia Scale (BRMS), the Hamilton Depression Scale (HAM-D) and the Hamilton Anxiety Scale (HAM-A). The most significant negative correlations were obtained with the BPRS. Correlation analyses between each single item of the BPRS and CBF values revealed the strongest associations between emotional withdrawal and decreased CBF. Patients with 'reactive' features had higher CBF than patients without 'reactive' symptoms. Only patients without 'reactive' symptoms had a lower CBF than controls. 'Endogenous' features had no impact on CBF.     

男性攻击性精神分裂症患者杏仁核功能连接的磁共振研究

目的:探讨男性攻击性精神分裂症患者是否存在杏仁核与其他脑区功能连接的异常.方法:对有攻击行为和没有攻击行为的男性精神分裂症患者各13例进行静息状态下功能磁共振成像.结果:与非攻击组相比,攻击组双侧额中回、右侧额上回、右侧脑岛、右侧顶上小叶、右侧扣带回等脑区与左侧杏仁核功能连接增强;双侧额上回、额中回、双侧颞上回、右侧颢中回等脑区与右侧杏仁核功能增强.结论:杏仁核与多个脑区之间特别是与额上回、额中回的功能连接增强可能与男性精神分裂症患者的攻击行为有关.     

Hemispheric lateralization of somatosensory processing

Processing of both painful and nonpainful somatosensory information is generally thought to be subserved by brain regions predominantly contralateral to the stimulated body region. However, lesions to right, but not left, posterior parietal cortex have been reported to produce a unilateral tactile neglect syndrome, suggesting that components of somatosensory information are preferentially processed in the right half of the brain. To better characterize right hemispheric lateralization of somatosensory processing, H(2)(15)O positron emission tomography (PET) of cerebral blood flow was used to map brain activation produced by contact thermal stimulation of both the left and right arms of right-handed subjects. To allow direct assessment of the lateralization of activation, left- and right-sided stimuli were delivered during separate PET scans. Both innocuous (35 degrees C) and painful (49 degrees C) stimuli were employed to determine whether lateralized processing occurred in a manner related to perceived pain intensity. Subjects were also scanned during a nonstimulated rest condition to characterize activation that was not related to perceived pain intensity. Pain intensity-dependent and -independent changes in activation were identified in separate multiple regression analyses. Regardless of the side of stimulation, pain intensity--dependent activation was localized to contralateral regions of the primary somatosensory cortex, secondary somatosensory cortex, insular cortex, and bilateral regions of the cerebellum, putamen, thalamus, anterior cingulate cortex, and frontal operculum. No hemispheric lateralization of pain intensity-dependent processing was detected. In sharp contrast, portions of the thalamus, inferior parietal cortex (BA 40), dorsolateral prefrontal cortex (BA 9/46), and dorsal frontal cortex (BA 6) exhibited right lateralized activation during both innocuous and painful stimulation, regardless of the side of stimulation. Thus components of information arising from the body surface are processed, in part, by right lateralized systems analogous to those that process auditory and visual spatial information arising from extrapersonal space. Such right lateralized processing can account for the left somatosensory neglect arising from injury to brain regions within the right cerebral hemisphere.     

基于ReHo方法的大学生网络成瘾静息功能磁共振成像研究

目的:探讨网络成瘾大学生静息状态脑功能特点。方法:采用ReHo分析方法 ,19名网络成瘾大学生及19名对照进行磁共振脑功能成像,比较两组平均脑ReHo图的差异。结果:IAD组ReHo值升高区域主要集中在小脑、脑干、扣带回(右侧)、双侧海马旁回、右侧额叶(直回,额中回及额下回)、左侧额上回、左侧楔前叶、右侧中央后回、右侧枕中回、右侧颞下回、左侧颞上回及颞中回;ReHo降低的区域仅表现在左侧顶叶的楔前叶。结论:网络成瘾大学生局域一致性存在异常,大部分脑区同步性增强,小脑、脑干、边缘叶、额顶叶同步性增强可能与网络成瘾奖赏通路有关。