肿瘤患者的情绪障碍与心理社会因素的相关性研究

目的探讨肿瘤患者的情绪障碍及心理社会影响因素.方法用病例对照和多因素统计分析法,随机选取肿瘤患者37例,年龄43～82岁,男性61例,女性13例.采用心理问卷测试和心理量表评定,一次性完成EPQ、SCL-90、SAS、SDS、LES、SSRS、DSQ、HAMD、HAMA等量表的测试和评定.结果肿瘤组与对照组情绪障碍发病率分别为89.19%和13.51%(P＜0.01).情绪障碍的发生与性别、年龄、文化程度、EPQ量表P分和E分、SCL-90总分、负性生活事件、社会支持量表总分等因素相关.结论肿瘤患者具有更高的情绪障碍发生率,后者与负性生活事件、内向性格、文化程度及对疾病的自我认识密切相关.     

颞下颌关节紊乱综合征患者的心理健康状况及其影响因素分析

目的 探讨颞下颌关节紊乱综合征患者的心理健康状况及其影响因素。方法 采用SCL－90、EPQ、SAS和生活事件量表评定55例TMJDS患者及39例对照组受试者的心理健康状况。结果 （1）TMJDS患者的SCL－90阳性症状总分、焦虑和抑郁分数与对照组相比较有显著差异（P＜0．005）;（2）TMJDS患者的焦虑情绪受患者个性中的N,P值及负性生活事件的关性,抗焦虑和抗抑郁治疗对TMJDS的防治可能有重要意义。     

糖尿病、非糖尿病心理社会调查问卷对照分析

目的：探讨心理社会因素对糖尿病发生、发展有何影响．方法：同时对63例原发性糖尿病患者及63例非糖尿病者进行SCL—90、焦虑自评量表（SAS）、抑郁自评量表（SDS）及生活事件量表的评定．结果：糖尿病患者在躯体化、强迫、抑郁、焦虑等方面明显高于对照组，差异有统计学意义，糖尿病组有明显情绪障碍，受负性生活事件影响．结论：糖尿病的发生、发展与心理因素密切相关，要重视糖尿病的心理治疗．     

中小学教师焦虑症状及相关因素的研究

目的：探讨中小学教师焦虑症状的发生情况及相关因素．方法：采用SAS、SCL—90、LES、EPQ四种量表对520名中小学教师进行测试．结果：520名中小学教师SAS均分为32．36±8．20分，SAS≥50分者占5．19％，常见的焦虑症状为乏力、焦虑心境、睡眠障碍、静坐不能、多汗、惊恐、恶梦等．SAS与SCL—90的各因子分呈显著相关，与EPQ的N量表呈著正相关，与LES的生活事件总值，负性生活事件值里显著正相关．结论：中小学教师焦虑症状的发生率低于其它人群．焦虑症状的发生不是孤立、单一因素作用的结果，与其心理健康水平、遭遇的生活事件的个性特征密切相关．     

医学生个性心理和心理健康状况调查

目的：为掌握在校医学生个性心理和心理健康状况，有针对性地提供心理健康教育和心理健康咨询。方法：采用艾森克人格问卷（EPQ）和症状自评量表SCL－90，对94人进行了测试。结果：EPQ调查，情绪不稳定者42人占51％，SCL－90筛选在躯体化、强迫、人际敏感、抑郁、焦虑等因子中明显高于国内常模有显著性差异P＜0．01，其中强迫因子男生明显高于女生显著性差异P＜0．01。结论：在校生心理健康障碍发生率较高，与学习及就业压力有关。     

泌尿系肿瘤与C型行为和情绪障碍的相关性分析

目的探讨泌尿系肿瘤患者的C型行为和情绪障碍倾向,完善综合诊治方案。方法用病例对照和相关回归分析方法,选取肿瘤患者46例。采用心理问卷测试和心理量表评定,一次完成C型行为、SDS、SAS、LES、SCL-90等量表的测试和评定。结果肿瘤组C型行为符合抑郁和焦虑发生率较高分别为81．3％、74．6％。泌尿系肿瘤的发生发展与C型行为相关,其发展和转归受抑郁和焦虑的影响,而抑郁和焦虑的发生又与年龄、文化程度、经济状况及生活事件有关。结论泌尿系肿瘤患者与C型行为密切相关,具较高的抑郁和焦虑发生率,和年龄较轻、文化程度低、经济状况差、负性生活事件有关,可采用心理治疗和抗抑郁焦虑的治疗。     

鼻咽癌病人的心理症状及相关因素分析

目的　探讨鼻咽癌病人的心理症状及相关因素。方法　作者采用 SCL- 90、SAS、SDS、EPQ、生活事件量表和应付方式问卷六种心理测验量表 ,对 6 4例首发鼻咽癌病人进行评定。结果　 1SCL- 90评定除敌对分与正常人无差异外 ,各项分均有差异 ,抑郁分接近神经症病人。 2 92 .1%病人有焦虑 (SAS≥ 41) ,6 6 .6 %病人存在抑郁 (SDS≥ 0 .5 1)。 3经逐步回归分析发现 ,个性特性、应付方式与负性生活事件等因素对心理症状有影响。结论　鼻咽癌病人存在有复杂的心理症状 ,心理干预对鼻咽癌的防治可能有重要意义。目的　探讨鼻咽癌病人的心理症状及相关因素。方法　作者采用 SCL- 90、SAS、SDS、EPQ、生活事件量表和应付方式问卷六种心理测验量表 ,对 6 4例首发鼻咽癌病人进行评定。结果　 1SCL- 90评定除敌对分与正常人无差异外 ,各项分均有差异 ,抑郁分接近神经症病人。 2 92 .1%病人有焦虑 (SAS≥ 41) ,6 6 .6 %病人存在抑郁 (SDS≥ 0 .5 1)。 3经逐步回归分析发现 ,个性特性、应付方式与负性生活事件等因素对心理症状有影响。结论　鼻咽癌病人存在有复杂的心理症状 ,心理干预对鼻咽癌的防治可能有重要意义。     

高原汽车兵心理健康状况及相关因素分析

目的：了解汽车兵在高原条件下的心理健康状况及相关因素，为部队心理卫生保健提供依据。方法：采用艾森克个性问卷（EPQ）、症状自评量表（SCL－90）、社会支持评定量表（SSRS）、焦虑自评量表（SAS）、抑郁自评量表（SDS）和生活事件量表（LES）对高原汽车兵进行个性测定和心理卫生状况调查。结果：高原汽车兵EPQ－E分低于全军常模，EPQ－N、EPQ－P分高于全军常模（P＜0．01），EPQ－L无显著性差异（P＞0．05）。大多数SCL－90因子分高于全军常模及普通高原军人（P＜0．01－0．05）。高原汽车兵的心理健康水平与EPQ－N、EPQ－P分及生活事件成正相关，与EPQ－E、EPQ－L及社会支持成负相关。多元回归分析表明，EPQ的N、P因子、负性事件，主观支持、军龄和社会支持总分等因素是影响高原汽车兵心理健康的几个重要因素。结论：高原汽车兵存在较多的心理问题，可能与其居住环境、工作性质及个性特征、社会支持等多种因素有关。     

乳腺肿瘤患者术前抑郁焦虑情绪及影响因素

目的 探讨乳腺肿瘤患者术前抑郁和焦虑状况及其影响因素。方法 应用临床心理问卷(EPQ、HAMD、HAMA、LES、SSRS、DSQ)对术前的乳腺肿瘤患者进行评定,以HAMD、HAMA总分为因变量,其它心理社会因素为自变量,进行多元逐步回归分析。结果 乳腺肿瘤患者术前抑郁和焦虑状态的发生率分别是 36. 21%、60. 34%;HAMD总分与负性生活事件刺激量、DSQ不成熟防御因子分、EPQ的N分呈显著正相关,与社会支持总分和年龄呈显著负相关。HAMA总分与患者的经济状况、主观支持分呈显著负相关,与DSQ不成熟防御因子分、EPQ的N分呈显著正相关。结论 乳腺肿瘤患者术前存在较普遍焦虑和抑郁情绪。术前经历较多负性生活事件、采用不成熟防御方式、具有神经质人格、年龄较小、经济状况较差的乳腺肿瘤患者术前较易出现焦虑和抑郁情绪,而良好的社会支持能减轻术前情绪问题。     

乳腺肿瘤患者术前抑郁焦虑情绪及影响因素

目的探讨乳腺肿瘤患者术前抑郁和焦虑状况及其影响因素.方法应用临床心理问卷(EPQ、HAMD、HAMA、LES、SSRS、DSQ)对术前的乳腺肿瘤患者进行评定,以HAMD、HAMA总分为因变量,其它心理社会因素为自变量,进行多元逐步回归分析.结果乳腺肿瘤患者术前抑郁和焦虑状态的发生率分别是36.21%、60.34%;HAMD总分与负性生活事件刺激量、DSQ不成熟防御因子分、EPQ的N分呈显著正相关,与社会支持总分和年龄呈显著负相关.HAMA总分与患者的经济状况、主观支持分呈显著负相关,与DSQ不成熟防御因子分、EPQ的N分呈显著正相关.结论乳腺肿瘤患者术前存在较普遍焦虑和抑郁情绪.术前经历较多负性生活事件、采用不成熟防御方式、具有神经质人格、年龄较小、经济状况较差的乳腺肿瘤患者术前较易出现焦虑和抑郁情绪,而良好的社会支持能减轻术前情绪问题.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.