Rectal cancer risk in hereditary nonpolyposis colorectal cancer after abdominal colectomy. International Collaborative Group on HNPCC.

OBJECTIVE: The authors analyzed the incidence of rectal cancer in patients with hereditary nonpolyposis colorectal cancer (HNPCC) after an abdominal colectomy. SUMMARY BACKGROUND DATA: The treatment of choice for a newly diagnosed patient with HNPCC with colon cancer is an abdominal colectomy. The incidence of rectal cancer after abdominal colectomy in HNPCC is not known. MATERIALS AND METHODS: A questionnaire was mailed to all International Collaborative Group on HNPCC members to identify patients in whom rectal cancer developed after total, subtotal or completion colectomy. Statistics were performed using the log-rank test, Kaplan-Meier method, and Cox's proportional hazards model. RESULTS: Rectal cancer developed in 8 (11%) of 71 patients a median of 158 months (range, 38-282 months) from their primary procedure. Of these eight patients, adenomas in the rectal mucosa developed in five at risk either before (4) or synchronous (1) with the diagnosis of rectal cancer. At the time of diagnosis of rectal cancer, six of eight patients were being observed. Age at first procedure and whether the patient was under surveillance were the only significant variables (p < 0.05) in the multivariate analysis in terms of rectal cancer risk. The risk of developing rectal cancer was estimated to be 3% every 3 years after abdominal colectomy for the first 12 years. CONCLUSIONS: The risk of rectal cancer in patients with HNPCC after an abdominal colectomy is approximately 12% at 12 years. Age at first surgical procedure and surveillance correlated with rectal cancer risk. Aggressive endoscopic surveillance of the rectum should be performed after abdominal colectomy.     

Hand-assisted laparoscopic total colorectal resection for familial adenomatous polyposis with coexisting rectal cancer

When familial adenomatous polyposis (FAP) is diagnosed in a patient, prophylactic surgery must be performed whether colorectal cancer is present or not. Operations for FAP have been performed through a large median abdominal incision or an additional perineal incision, depending on the coexistence of rectal cancer. Recently, we reported a technique of laparoscopic rectal amputation without abdominal skin incision for patients with rectal cancer to minimize postoperative cardiac and respiratory complications [6]. In this article, we report a case of laparoscopically assisted proctocolectomy with ileostomy through a minimal abdominal and perineal skin incision performed by a hand-assisted procedure. The purpose of combining the perineal and laparoscopic approaches is to minimize the skin incision, while retaining a rate of cure and safety equivalent to those of conventional rectal amputation, by using the advantages of laparoscopic procedures, and to facilitate postoperative recovery and improve the quality of life for relatively young patients with FAP. apd: 3 April 2001     

Unspecific spondylodiscitis following anastomotic leakage after rectal resection

Anastomotic leakage is a serious complication in abdominal surgery. We report on two cases of spondylodiscitis L5/S1 following anastomotic leakage with fistula after low anterior rectal resection. Within five months after rectal resection two patients with massive back pain were admitted to our department. MRI established the diagnosis of spondylodiscitis. Ventral debridement, spondylodesis and protective stoma were performed. With this procedure we were able to achieve control of infection. There were no further complications in the follow-up. Stability of the spinal column was restored and massive back pain was entirely relieved. No signs of rectal cancer recurrence were seen in both cases during the observation period.     

Quality of Life Among Five-Year Survivors After Treatment for Very Low Rectal Cancer With or Without a Permanent Abdominal Stoma

Background Low rectal cancers situated less than 5 cm from the anal margin are still usually treated with abdomino-perineal excision (APE). Our aim is to compare the quality of life (QOL) of five-year survivors treated for low or very low rectal cancer with an advanced/complex coloanal procedure with the QOL of patients submitted to a standard APE with a definitive abdominal stoma. Methods Sixty-two patients, operated on radically for low or very low rectal cancer, who came for their fifth year follow-up visit and were free from cancer, were studied. Thirty patients (group 1) had an APE with permanent abdominal stoma. Thirty-two patients (group 2) had undergone a radical advanced and complex procedure to avoid the abdominal stoma. The patients received the European Organisation for the Research and Treatment of Cancer (EORTC) QOL-30 generic and the CR38 colorectal cancer QOL questionnaires with the recommendation to return the questionnaire to the hospital. The Mann–Whitney U-test and χ ² Fisher test were employed for statistical analysis. Results All questionnaires were returned. Patients without a terminal abdominal stoma had a better score in six categories of the QOL 30 and in two categories of the CR38. No differences were observed in the other variables examined. Conclusions After five years, cancer-free patients operated on for low or very low rectal cancer have a better QOL if a definitive terminal abdominal stoma was avoided. The paper has been partially presented at the 9^th International Meeting of Coloproctology, Stresa, Italy, March 27–29, 2006     

An unusual location of cloacogenic carcinoma

A 61 year-old female presented with abdominal pain, rectal bleeding, mucus discharge, tenesmus and constipation. Rectal examination and proctoscopy demonstrated rectal stenosis at 5 cm from the anal verge. Transrectal ultrasonography detected a capsulated lesion as a mesenchymal rectal tumor. Computed tomography and endorectal magnetic resonance detected a mesenchymal lesion in the lower-middle rectal thirds. Serum TPA, GICA, SCC and CYFRA were pathological. At surgery the tumour was fixed to the levator ani muscle with rectal folding. Frozen sections of the levator ani muscle biopsies revealed cloacogenic tumour. Abdominoperineal resection was performed. The rectal lesion was cloacogenic carcinoma at 9 cm from the dentate line (pT4 pN0; Ki67 35%; CD31 181 vessels/mm2). Adjuvant radio-chemotherapy was performed. The patient is alive and disease free at 19 months. Extra-anal cloacogenic tumours are an unusual finding. Perhaps cloacal cells were originally present in the rectal wall, but secondary rectal involvement by cloacal remnant from the levator ani muscle cannot be excluded.     

腹腔镜下腹壁无切口直肠癌切除术

目的 探讨无切口腹腔镜下直肠癌切除术的临床应用价值.方法 对37例直肠癌患者行无切口腹腔镜下直肠癌切除术行回顾分析总结.结果 37例手术均成功,平均手术时间120 min,平均术中出血70 ml,术后平均胃肠蠕动恢复时间为38 h,平均住院时间为7d,无明显并发症.结论 无切口腹腔镜下直肠癌切除术安全可行,无腹部切口手术损伤小、恢复快,值得推广应用.     

A case of localized peritonitis caused by obstructive colitis proximal to rectal carcinoma: A rare manifestation of obstructive colitis

A case of obstructive colitis associated with rectal carcinoma in a 56 year old Japanese man is reported herein. He presented to Shinkokura Hospital with severe abdominal pain following a one month history of anal bleeding and mild abdominal pain. On palpation, muscle guarding was observed in the left lower quadrant and the white blood cell count was 14,200/mm³. An exploratory laparotomy was performed under the provisional diagnosis of acute abdomen, which revealed localized peritonitis 8 cm oral to an area of rectal carcinoma. An anterior resection of the lesion was therefore performed together with a descendo-proctostomy. The histopathologic diagnosis revealed adenocarcinoma and obstructive colitis involving the entire thickness of the sigmoid colon and resultant fibrino-purulent peritonitis. His postoperative course was uneventful and he was continuing to do well on the 30th postoperative day, at the time of writing. The clinical significance of this combination of obstructive colitis with rectal carcinoma is briefly discussed following the presentation of this case.     

The use of abdomino-supra-anal resection of rectal cancer

The results of surgical treatment of 193 patients with upper- and middle ampullar cancer recti, to whom the abdominal supra-anal rectal resection was performed, were summarized. The operation procedure performance was depicted. There were no intraoperative complications. Postoperative complications had occurred in 19 (9.8%) of patients, 3 (1.6%) died. Necrosis of the descended intestine was not noted. The anal sphincter function had restored in 1 mo after performance of operative intervention.     

A new concept of the anatomy of the anal sphincter mechanism and the physiology of defecation: XII. Anorectal mobilization: A new surgical access to rectal lesions. Preliminary report

A new technique for the removal of inaccessible benign intrarectal lesions and malignant lower third rectal tumors with sphincter preservation is presented. The procedure was performed in eight patients, four with huge bilharzial papillomas and four with malignant lower third rectal tumors. The essential feature of the operation is preservation of the levator tunnel, which is responsible for maintaining normal, voluntary continence and defecation. The results were satisfactory. The technique provides easy access to the interior of the rectum, and it extends the indications for sphincter-saving operations to include malignant lower third rectal tumors. It is hoped that this procedure will eliminate the use of abdominoperineal excision in the treatment of rectal cancer.     

单孔腹腔镜直肠癌Dixon切除术的技巧

The efficacy of laparoscopic Dixon operation for the treatment of rectal cancer has been proven,while at the same time there are opportunities to make the procedure less invasive.From January 2010 to March 2011,9 cases of single access laparoscopic Dixon operation have been performed at the Shengjing Hospital.An incision with the length of 3 cm was created in umbilicus and 3 trocars were inserted through the fascia on the abdominal wall.The dissection and anastomosis were performed through the incision.The resected tumors were removed through the umbilical incision or anus.The operation was successfully performed on 9 patients,and one more incision with the length of 12 mm was created on the lower abdominal wall in 1 patient in order to install the stapling device.The average operation time was 202 minutes.No postoperative bleeding,intestinal obstruction or anastomosis leakage was found.     

Rectal cancer in women

A retrospective chart review was performed utilizing the First Department of Surgery of the University of Rome "La Sapienza" Medical School database. Ninety-two women who underwent abdominal surgery between 1980 and 1993 for rectal cancer were identified. Data collected included demographics, history, intraoperative findings and complications, cancer histology and stage and follow up. Special attention was focused on intraoperative incidental gynecological findings and follow up. Twenty-two patients being previously submitted to hysterectomy and three with oral intake of hormones were dismitted from the study. Of the remaining 67 patients gynecological procedure was associated to rectal surgery because of a previously undiagnosed gynecological condition. No prophylactic oophorectomies were performed. At follow up 7 patients experienced further surgery for gynecologic disease. The necessity to offer these patients the benefit of a preoperative informed decision about adjunctive gynecologic surgery and indications for bilateral oophorectomy is discussed.     

经肛门拖出标本的全腹腔镜直肠癌全系膜切除术

目的探讨腹腔镜直肠癌全系膜切除术中切除标本自肛门内拖出的可行性。方法 2007年1月~2010年5月,对30例肿块5 cm的直肠癌施行全腹腔镜直肠癌全系膜切除术,手术标本自肛门拖出,肠断端腔镜下荷包缝合及管型吻合器结直肠吻合。结果 30例在腹腔镜下顺利完成手术,无中转开腹。无腹腔、盆腔脏器的损伤。手术时间120~240min,平均150 min;术中出血20~80 ml,平均35 ml。发生吻合口漏4例,均经保守治疗治愈(18~30 d)。术后随访3~40个月,平均24.3月,2例1年后吻合口复发。结论直径5 cm的标本自肛门拖出的全腹腔镜直肠癌全系膜切除术是可行的,避免腹部辅助切口,创伤更小。     

Volvulus of an ileal pouch-rectal anastomosis after subtotal colectomy for ulcerative colitis: report of a case

Ileal J-pouch rectal anastomosis is a commonly performed procedure for patients who have undergone subtotal colectomy for ulcerative colitis or familial adenomatous polyposis without rectal involvement. We herein report the case of a patient with ileal pouch volvulus that developed 15 years after subtotal colectomy for ulcerative colitis. A 62-year-old female visited our emergency room with complaints of abdominal pain and nausea that had persisted for 12 h. Abdominal radiography and contrast-enhanced computed tomography detected segmental distention of the small intestine around the staples. We diagnosed volvulus of the ileal pouch-rectal anastomosis and performed emergency laparotomy. We released the volvulus and performed pouchpexy. The patient was discharged on postoperative day 10, and recurrence of the volvulus has not been observed for 5 months since the procedure was performed. Our study indicates that an early diagnosis and intervention are needed to avoid serious complications, such as pouch necrosis and perforation, in such cases.     

Pseudoaneurysm rupture causing hemoperitoneum following rectal impalement injury: A case report

IntroductionAlthough vascular anatomy of the rectum is complex, pseudoaneurysm followed by massive hemoperitoneum after rectal impalement injury is extremely rare.Case presentationA 43-year-old man presented with abdominal distension. One day earlier, he had undergone sigmoid loop colostomy for rectal implement injury at a local hospital. After the operation, he had become hemodynamically unstable. Digital rectal examination showed a penny-sized anterior rectal wall defect 6 cm from the anal verge. Computed tomography (CT) revealed a hematoma (12 × 10 × 15 cm) with bleeding in the pelvic cavity and an adjacent pseudoaneurysm in the rectum. A large amount of blood and massive hematoma were evacuated by surgery. The Hartmann procedure was performed, but the pseudoaneurysm was not resected. On the 11th postoperative day, hemoglobin decreased (11.6 g/dL–7.9 g/dL), and CT revealed a recurrent hematoma (6.0 × 4.2 cm) in the pelvic cavity, with a residual pseudoaneurysm. Angiography failed to localize the pseudoaneurysm. Consequently, prophylactic embolization at the anterior branch of both the internal iliac arteries was performed. The subsequent hospitalization course was uneventful.DiscussionRectal impalement injury may result in pseudoaneurysm of the rectal arteries. However, pseudoaneurysm rupture of the mid rectal artery, followed by massive hemoperitoneum, has not been reported in the English literature. From our experience, preoperative diagnosis of a pseudoaneurysm is crucial for definite surgical management. When surgical resection is indicated, it should include the underlying pseudoaneurysm.ConclusionAlthough pseudoaneurysm rupture causing hemoperitoneum after a rectal impalement injury is extremely rare, meticulous preoperative evaluation is necessary for correct management.     

Simultaneous laparoscopic abdominal and transanal excision for low rectal tumours

Aim: In performing laparoscopic sphincter‐preserving total mesorectal excision, one of the technical challenges is to obtain an adequate distal mural margin of 2 cm in the case of low rectal tumours. Herein we describe a technique, known as simultaneous laparoscopic abdominal and transanal excision, where an adequate distal margin can be safely achieved at the beginning of the operation. Methods and Results: As the specimen is delivered per anum, the patient can enjoy the full benefits of minimally invasive surgery. Additionally, the simultaneous approach helps to shorten the operating time. The technique was attempted in five patients with radiological T2 or T3 disease, with two patients having received neoadjuvant chemoirradiation. The outcomes of these five patients are presented. Conclusion: As treatment of rectal cancer is increasingly stage dependent, the simultaneous laparoscopic abdominal and transanal excision procedure offers a clear alternative for treating patients with low rectal tumours in this laparoscopic era.     

无切口腹腔镜下直肠癌切除术

目的 探讨无切口腹腔镜下直肠癌切除术的临床应用价值.方法 回顾分析2012年1月至2013年5月在我科接受无切口腹腔镜下直肠癌切除术治疗的37例患者的临床资料,观察手术时间、术中出血、术后恢复情况及随访情况.结果 37例手术均成功,平均手术时间120 min,平均术中出血70 mL,术后平均胃肠蠕动恢复时间为38 h,平均住院时间为7d,无明显并发症.结论 无切口腹腔镜下直肠癌切除术安全可行,无腹部切口手术损伤小、恢复快,值得推广应用.     

Carcinoma of pelvic pouch following restorative proctocolectomy: report of a case and review of the literature

One of the possible long-term complications following an ileoanal pouch procedure is the development of malignancy in the mucosa of the rectal stump. Only 10 such cases have been reported so far. We report the case of a 23-year-old male who had ulcerative colitis with high-grade dysplasia and underwent an ileoanal pouch procedure. He was found to have a malignancy in the rectal stump 5 years after surgery. The malignancy presented with symptoms of refractory pouchitis. Pouch excision was performed. The risk of developing malignancy in the rectal mucosa after an ileoanal pouch procedure mandates regular follow-up in these patients, with a high index of suspicion especially in patients with delayed onset pouchitis.     

柱状经腹会阴切除术治疗直肠癌15例

目的 介绍直肠癌柱状经腹会阴切除术(cylindrical abdominoperineal resection,CAPR)的应用体会.方法 2009-2010年采用柱状经腹会阴直肠癌切除术治疗低位直肠癌15例.采用Holm等描述的手术方法.按TME技术要求游离直肠系膜,向下游离至肛提肌的起点处,结肠造口,关闭腹部切口.将患者置于俯卧位,实施扩大的会阴部切除,沿外括约肌、耻骨直肠肌、肛提肌外表面游离至肛提肌的盆壁起始处,即腹部向下游离的终点下方,后方自尾骨骶骨连接处切开,进入骶前,由背侧至腹侧,将肛提肌自起始处离断.结果 柱状经腹会阴切除术切除更多远端直肠周围组织,15例均无直肠穿孔,会阴切口均Ⅰ期愈合,1例发生会阴血肿,1例发生盆底腹膜疝,1例发生下肢深静脉血栓形成;术后平均随访6个月,1例发生盆腔腹膜后淋巴结转移,1例发生肝肺转移.结论 柱状经腹会阴切除术可以切除更多的低位直肠癌周组织,有利于减少术中穿孔发生率和环周切缘阳性率,进一步降低术后局部复发率.     

Transanal total mesorectal excision as a surgical procedure for diffuse cavernous hemangioma of the rectum: A case report

BackgroundThe safety and feasibility of transanal total mesorectal excision (TaTME) were demonstrated in the management of rectal cancer. However, its role in the management of patients with diffuse cavernous hemangioma of the rectum (DCHR) has not been evaluated.MethodsA female patient with DCHR was admitted to our hospital. Colonoscopy, magnetic resonance imaging (MRI), abdominal computed tomography (CT) and arteriography were performed. Lesions were detected in mesorectum and rectal wall extending from the dentate line to 5 cm proximally. TaTME with a protecting loop ileostomy were performed. The research work has been reported in line with the SCARE criteria Agha et al., 2016 [1].ResultsTaTME and a protecting loop ileostomy were safely performed, with an intact mesorectal specimen being harvested. The entire procedure took 348 min. The estimated blood loss was 100 ml. The patient recovered uneventfully. Her symptom of painless rectal bleeding was resolved satisfactorily following the surgery. The histopathological evaluation confirmed the diagnosis of DCHR.ConclusionsTaTME appears to be a safe and feasible procedure for patients with DCHR in experienced hands.     

It’s the procedure not the patient: the operative approach is independently associated with an increased risk of complications after rectal prolapse repair

Aim This study compares 30‐day outcomes following rectal prolapse repair, examining potential surgical and patient factors associated with perioperative complications. Method Using the NSQIP database, patients with rectal prolapse were categorized by surgical approach to repair (perineal or abdominal) and abdominal cases were further subdivided by procedure (resection compared with rectopexy alone). Univariate and multivariate analyses compared major and minor complication rates between the groups. Results Of 1275 patients, the perineal group (n = 706, 55%) was older, with more comorbidity, than those undergoing an abdominal procedure. There were fewer minor (odd ratio (OR) = 0.35; 95% confidence interval (CI), 0.20–0.60; P = 0.0038) and major complications (OR = 0.46; 95% CI, 0.31–0.80; P = 0.0038) in the perineal compared with the abdominal cohort. There was a significant increase in major complications amongst patients undergoing a resection compared with rectopexy only (OR = 2.15; 95% CI, 1.10–4.41; P = 0.0299). There was no difference in major complications between abdominal rectopexy and a perineal approach, but the latter had a lower chance of minor complications (OR = 0.47; 95% CI, 0.24–0.94; P = 0.0287). Conclusion A perineal approach is safer than an abdominal approach to the treatment of rectal prolapse. Regarding an abdominal operation, rectopexy has fewer major complications than resection.