冷光源蓝光治疗早产儿黄疸疗效研究

目的探讨冷光源蓝光治疗早产儿黄疸的临床疗效。方法 59例黄疸早产儿分成冷光源蓝光组和普通单面蓝光组,分别用两种光源照射黄疸早产儿,测定治疗前后血清胆红素水平,同时观察患儿体温、大便性状改变及皮疹发生情况等。结果治疗前两组患儿血清胆红素水平比较,差异无统计学意义(P>0.05)。光照8 h后,冷光源蓝光组患儿血清胆红素水平较普通单面蓝光组明显降低,差异有统计学意义(P<0.05)。冷光源蓝光组均未出现发热、腹泻、皮疹等;普通单面蓝光组5例出现皮疹,2例出现发热,1例大便次数增多。结论冷光源蓝光治疗新生儿黄疸疗效确切,且不良反应少,尤其适用于早产儿。     

间隙和持续蓝光照射治疗新生儿黄疸的临床效果观察

目的：观察新生儿黄疸利用间隙和持续蓝光照射治疗的临床效果。方法：随机将72例新生儿黄疸患儿分为A组和B组,各36例,A组患儿采用间隙蓝光照射治疗,B组患儿采用持续蓝光照射治疗,观察临床治疗效果,对比治疗前后总胆红素及直接胆红素水平。结果：治疗前,两组患儿总胆红素水平、直接胆红素水平无显著差异（P＞0.05）;治疗后,两组患儿治疗效果差异无统计学意义（P＞0.05）,A组患儿直接胆红素与总胆红素水平低于B组（P＜0.05）。结论：间隙、持续蓝光照射治疗新生儿黄疸的效果均比较好,但间隙蓝光照射治疗时患儿黄疸水平降低效果更为明显。     

不同方式蓝光照射治疗早产儿高胆红素血症的疗效分析

目的观察持续及间断蓝光照射治疗早产儿高胆红素血症的疗效。方法早产儿高胆红素血症患儿360例，分别采用持续蓝光照射治疗（持续组）和间断蓝光照射治疗（间断组），观察两组治疗前后血清总胆红素浓度的变化及不良反应。结果蓝光照射治疗3d后，血清总胆红素持续组为（168．8±20．7）μmol／L，间断组为（169．6±18．3）μmol／L，均较治疗前显著降低（P〈0．05），但治疗后两组血清总胆红素差异无统计学意义（P〉0．05）。两组腹泻、皮疹、低血钙的发生率差异无统计学意义（P〉0．05）；持续组发热、哭闹不安的发生率明显高于间断组（P〈0．05）。结论间断照射与持续蓝光照射治疗早产儿高胆红素血症疗效相近，但前者的副作用少，在临床上可根据病情尽量选用间断照射治疗。     

冷光源蓝光灯治疗新生儿黄疸的疗效研究分析

目的：探析新生儿黄疸采用冷光源蓝光灯治疗的临床效果。方法：选择2013年11月至2014年11月期间该院收治的108例新生儿黄疸患儿为研究对象，随机分为两组，其中给予对照组常规蓝光治疗，而观察组则运用冷光源蓝光灯治疗，对比分析两组疗效。结果：治疗前，两组的血清胆红素浓度比较无差异（P >0.05）；治疗后，与对照组相比，观察组的血清胆红素浓度明显下降，组间对比差异显著（P <0.05）；同时，两组治疗有效率比较有差异（P <0.05）。结论：临床上给予新生儿黄疸患儿冷光源蓝灯治疗，不仅可以降低血清胆红素浓度，还能提高治疗效果。     

间歇蓝光照射与持续蓝光照射治疗新生儿黄疸的疗效观察

目的：探讨多次间歇蓝光照射与持续蓝光照射治疗新生儿黄疸的疗效及对患儿的不良反应。方法：选择2007年1月～2008年12月500例患儿，并将所选患儿随机分为两组。分别为间歇蓝光照射组、持续蓝光照射组。对两组间歇蓝光照射与持续蓝光照射治疗的情况进行回顾性分析。结果：间歇蓝光照射组，在治疗前血清间接胆红素由原来的225～352μmol／L，降至为治疗后的112～180μmoL／L，平均下降了68～120μmol／L：持续蓝光照射组在治疗前血清间接胆红素由原来的230～382μmol／L，降至为治疗后的118—185μmol／L，平均下降了70～115μmoL／L。两组比较差异无显著性（P〉0．05）。结论：间断蓝光照射能达到持续蓝光照射同样的效果，而且间歇蓝光照射不良反应或不良反应的发生率较持续蓝光照射明显降低。     

妈咪爱治疗新生儿高胆红素血症疗效观察

目的：探讨妈咪爱对新生儿高胆红素血症的治疗效果。方法：通过随机抽样，将100例新生儿高胆红素血症的病人分为两组，每组50例，治疗组使用妈咪爱配以蓝光照射治疗，对照组以酶诱导剂及蓝光照射治疗。结果：治疗组在减轻血清总胆红素方面优于对照组（P〈0．01）。结论：妈咪爱治疗新生儿高胆红素血症可迅速降低血胆红素水平，缩短治疗时间，疗效确切、安全，可作为治疗新生儿高胆红素血症的方法之一。     

茵栀黄注射液加蓝光照射治疗新生儿病理性黄疸疗效观察

目的：观察茵栀黄注射液加蓝光照射治疗新生儿病理性黄疸的临床疗效。方法：将583例新生儿黄疸的患儿随机分为两组,对照组241例采用蓝光照射治疗,治疗组342例在对照组治疗基础上静脉滴注茵栀黄注射液,治疗前、后测定患儿总胆红素（TBIL）、直接胆红素（DBIL）;观察患儿黄疸消退时间及患儿治疗过程中出现的症状。结果：治疗组治疗后TBIL、DBIL低于对照组,两组比较差异有统计学意义（p〈0.05）。结论：茵栀黄注射液配合蓝光照射治疗新生儿病理性黄疸优于对照组。     

联合应用间断蓝光照射法和金双歧+茵栀黄疗法治疗新生儿高胆红素血症的疗效分析

目的：探讨联合应用间断蓝光照射法和金双歧+茵栀黄疗法治疗新生儿高胆红素血症的疗效。方法：将2011年7月至2013年5月我院收治的146例患儿分为参照组和临床组，为参照组患儿进行对症治疗和持续的蓝光照射治疗，为临床组患儿在采用对症治疗基础上加用金双岐、茵桅黄进行治疗，并实施间断的蓝光照射治疗，对比分析两组患儿胆红素指标的改善情况及退黄时间。结果：两组患儿在接受治疗24h、48h及72h后，其胆红素水平逐渐显著下降。与参照组患儿相比，临床组患儿胆红素水平下降的幅度更明显，退黄时间更短，差异显著（P＜0.05），有统计学意义。结论：为新生儿高胆红素血症患儿联合应用间断蓝光照射法和金双歧+茵栀黄疗法进行治疗可取得理想的疗效，此法值得在临床上推广使用。     

茵陈蒿汤联合蓝光照射治疗新生儿黄疸临床疗效观察

目的 观察茵陈蒿汤、蓝光照射联合治疗新生儿黄疸（NJ）临床疗效。方法 将我院收治的130例NJ患儿随机分治疗组与对照组各65例，对照组采用蓝光照射治疗，治疗组采用茵陈蒿汤+蓝光照射联合治疗。比较两组临床总有效率，光疗、住院时间、总胆红素（TBIL）、直接胆红素（DBIL）、免疫球蛋白（IgA）、免疫球蛋白G(IgG)水平。结果 治疗后，治疗组总有效率高于对照组有效率（P<0.05）；治疗组光疗时间、住院时间短于对照组（P<0.05）；两组TBIL、DBIL水平均下降，IgA、IgG水平均升高，且治疗组TBIL、DBIL水平低于对照组，IgA、IgG水平高于对照组（P<0.05）。结论 与蓝光照射比较，茵陈蒿汤、蓝光照射联合治疗NJ，明显缩短疗程，增强免疫功能，疗效更满意，值得推广。     

短时多次蓝光照射治疗新生儿高胆红素血症效果分析

目的：探讨短时多次蓝光照射治疗新生儿高胆红素血症的临床效果。方法：收集邳州市人民医院2019年1月-2021年11月治疗的100例新生儿高胆红素血症患儿,随机分成试验组和对照组各50例,两组均给予加强营养、病因治疗、保温等措施,口服茵栀黄溶液3 mL/次,3次/d,连续服用7 d。对照组给予持续蓝光照射,蓝光照射时间持续18 h,暂停6 h,连续照射3 d。试验组则采取多次蓝光照射,2次/d,8 h/次,间隔4 h进行第2次照射,连续照射3 d。结果：两组患儿治疗前血清总胆红素比较无显著性差异,治疗2 d和3 d后试验组血清总胆红素明显下降,远低于对照组,差异有统计学意义(P<0.05);两组患儿治疗前血清C反应蛋白、血清转铁蛋白比较无显著性差异,治疗后试验组与对照组相比,血清C反应蛋白明显下降,血清转铁蛋白明显升高,差异有统计学意义(P<0.05);两组患儿治疗前血清S100β蛋白和血清神经元特异性烯醇化酶比较无显著性差异,治疗后试验组均明显下降,远低于对照组,差异有统计学意义(P<0.05)。结论：短时多次蓝光照射治疗新生儿高胆红素血症临床效果显著,值得推广。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.