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1.
A. Elktaibi I. Rharrassi A. Boudhas M. Sina M. R. Elochi H. Chahdi M. Oukabli A. Albouzidi 《Journal Africain d'Hépato-Gastroentérologie》2013,7(4):217-219
Liposarcoma is the most common soft tissue sarcoma and accounts for 15%–20% of all mesenchymal malignancies. The tumor occurs most frequently in the limbs, retroperitoneum and rarely has a visceral location. We report a case of a gastric liposarcoma in a male patient who was admitted to hospital for abdominal discomfort and feeling fullness lasting for a month. The CT examination revealed a giant epigastric mass (36 cm × 34 cm) involving the wall of the stomach. A subtotal gastrectomy together was performed. The histopathological diagnosis was a myxoïd liposarcoma. The patient did not undergo any adjuvant treatment. He was under close follow up and nine months after surgery he represented with tumor recurrence. We report this case due to the rarity of this tumor in the stomach (fifteen cases reported in the literature). 相似文献
2.
Liakakos TD Troupis TG Tzathas C Spirou K Nikolaou I Ladas S Karatzas GM 《World journal of gastroenterology : WJG》2006,12(7):1149-1152
Liposarcoma is the most common soft tissue sarcoma inadult life while esophageal liposarcoma is an extremelyrare tumor.In the world literature,only 14 cases ofesophageal liposarcomas have been described.We reporta 72-year old male patient who was urgently admittedto our hospital for acute epigastric pain with a burningretrosternal sensation,persistent nausea,vomiting anddysphagia.Barium swallow,upper gastrointestinal(GI)endoscopy,esophageal manometry and CT scan,failedto accurately diagnose the lesion.After surgical resectionof an esophageal polypoid tumor,the histologicalexamination revealed a well-differentiated grade Iliposarcoma.Diagnostic and therapeutic tools were dis-cussed and the results of literature were reviewed. 相似文献
3.
Liposarcoma is one of the most common soft tissue sarcomas in adults, but the incidence of esophageal liposarcoma is extremely low. To our knowledge there are only 18 cases of esophageal liposarcoma reported in the English-language literature. Here we report a new case of primary esophageal liposarcoma in a 50-year-old male patient who complained of aggravating dysphagia with intermittent vomiting for 6 months. The tumor was located in the upper esophagus. Polypectomy was performed and histologic examination showed a well-differentiated liposarcoma. Diagnostic and therapeutic tools are discussed and the results of a literature review are discussed. 相似文献
4.
The most common site for abdominal liposarcoma is the retroperitoneum. We report a 32-year-old man with lesser-sac myxoid liposarcoma with extensive cystic degeneration. Cystogastrostomy was attempted elsewhere with a misdiagnosis of pancreatic pseudocyst. However, the procedure was abandoned after biopsy, which showed features of liposarcoma. The patient was re-explored at our institute 2 weeks later. Complete excision of the tumor was done. Histology revealed features of myxoid liposarcoma. The patient received adjuvant radiotherapy and is doing well 12 months later. 相似文献
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Ouedraogo M Ouedraogo SM Lougue C Cisse R Birba E Badoum G Zigani A Auregan G Bical O 《Revue des maladies respiratoires》2001,18(3):315-317
We report a fortuitous discovery of primary pulmonary myxoid liposarcoma in an HIV-positive patient. Primary pulmonary localizations are uncommon. Generally, pulmonary localizations are metastatic. There is a male predominance and diagnosis is generally made around 40 years of age. The two main features of liposarcoma are the large tumor size and the complex histology that evolves over time. Pathology findings are rarely reproducible and vary from one pathologist to another. Macroscopically, liposarcomas can mimic benign tumors. The risk of recurrence is high after simple enucleation due to microscopic extracapsular extensions. Surgery remains the predominant treatment. Wide complete excision, if possible, provides long-term survival. 相似文献
7.
原发性胸膜脂肪肉瘤的临床特点 总被引:1,自引:0,他引:1
目的原发性胸膜脂肪肉瘤是一种非常罕见的肿瘤,本文报道国内首例病例,并探讨其临床特点、诊断及治疗。方法分析我院近期发现的1例原发性胸膜脂肪肉瘤的临床资料并复习相关文献。结果原发性胸膜脂肪肉瘤全世界仅报道17例(包括此例)。本病好发于男性,中老年人多见,病理类型以黏液型多见;临床症状以胸痛和气促最常见;诊断主要依靠影像学和开胸探查。目前治疗推荐手术切除加辅助放疗。结论原发性胸膜脂肪肉瘤的治疗和预后的评估有待进一步积累资料。 相似文献
8.
Tepetes K Christodoulidis G Spyridakis ME Nakou M Koukoulis G Hatzitheofilou K 《World journal of gastroenterology : WJG》2007,13(30):4154-4155
Liposarcoma is the most common soft tissue sarcoma and accounts for 15%-20% of all mesenchymal malignancies. The tumor occurs most frequently in the limbs, retroperitoneum and rarely has a visceral location. We report a case of a gastric liposarcoma in a male patient. A 68 years old male patient was admitted to hospital for abdominal discomfort and fullness lasting for a month. He reported rare episodes of vomiting. The CT examination revealed a large epigastric mass (8 cm × 4 cm) involving the lesser curvature of the stomach, in contact with the pancreas and gallbladder. Fatty areas within the mass were evident. A total gastrectomy together with cholecystectomy was performed. The histopathological diagnosis was a well differentiated liposarcoma. The patient did not undergo any adjuvant treatment, he is under close follow up and two years later he is disease free. We report this case due to the rarity of this tumor in the stomach (nine cases reported in the literature). 相似文献
9.
Myxoid liposarcoma usually develops in the retroperitoneum or deep soft tissues of extremities. Synchronous cardiac and abdominal metastases are extremely rare. We describe the case of a 63-year-old man, with a history of a thigh liposarcoma, treated by resection, chemotherapy and postoperative radiotherapy 13 years ago. Patient now presented with an intracardial, a pericardial and an abdominal mass, identified as metastatic myxoid liposarcomas. He eventually underwent successful emergency sternotomy and subsequent laparotomy for tumor resection. 相似文献
10.
Hirata K Kanemitsu S Nakayama Y Nagata N Itoh H Ohnishi H Ishikawa H Furukawa Y;HNPCC registry genetic testing project of the Japanese Society for Cancer of the Colon Rectum 《The American journal of gastroenterology》2006,101(1):193-196
BACKGROUND: One of the clinical features of hereditary nonpolyposis colorectal cancer (HNPCC) is a high incidence of multiple primary neoplasms arising in various organs including the gastrointestinal and genitourinary tracts. Among extracolonic tumors, a limited number of soft tissue sarcomas associated with HNPCC have been reported, and the mechanism underlying liposarcoma in HNPCC patients remains unclear. AIM: We herein report the case of a HNPCC patient with liposarcoma, with the goal of elucidating the involvement of a mismatch repair deficiency in the tumor. METHODS AND RESULTS: A 40-yr-old Japanese patient, who had a past history of adenocarcinoma of the rectum and transitional cell carcinoma of the urinary bladder, developed a liposarcoma in his left thigh. Although his family history did not fulfill the revised Amsterdam criteria, his blood sample was subjected to genetic testing. Direct sequencing of the genomic DNA from the blood identified an AT deletion at codon 677 in exon 13 of hMSH2, a pathogenic mutation that has not been reported before. The expression of MSH2 in the liposarcoma and rectal cancer of the patient was analyzed by immunohistochemistry, which revealed loss of MSH2 expression in the tumors. To investigate whether the loss of MSH2 was a common feature of liposarcoma, we examined the MSH2 expression in an additional two sporadic liposarcomas, both of which were stained with anti-MSH2 antibody. CONCLUSION: We identified a novel pathogenic germline mutation of MSH2 in an HNPCC patient. Since an immunohistochemical analysis showed no nuclear staining for MSH2 protein in the liposarcoma as well as the rectal cancer, the loss of wild-type MSH2 protein was thus considered to possibly play a role in the development of liposarcoma in HNPCC patients. 相似文献
11.
Maàmouri N Cheikh I Ouerghi H Oukaà A Belkahla N Mnif E Hechiche M Driss M Ben Ammar A 《La Revue de médecine interne / fondée ... par la Société nationale francaise de médecine interne》2005,26(2):145-148
INTRODUCTION: Retroperitoneal Liposarcoma is a rare and primary malignancy developed from mesenchymal tissue. It's generally unique and shows an only one histologic component. We report a case of multicentric and synchronous liposarcoma (intraperitoneal and retroperitoneal) and with different histologic types. EXEGESES: A 53-year old man presented with abdominal pain, increased abdominal girth and weight loss. Physical examination revealed two abdominal masses. Computed tomography scan showed a very large retroperitoneal mass displacing the left kidney, digestive loops and vessels. The patient underwent surgery. One enormous mass of the left renal lodge measuring 50 cm, a retroduodenal mass measuring 15 cm and a nodule of the coecum were removed. Histological examination of the mass of the left renal lodge revealed mixed type liposarcoma (dedifferentiated and myxoid). Histological examination of the retroduodenal mass and of the nodule of the coecum revealed well-differentiated liposarcoma. CONCLUSION: Pathological, therapeutic and prognostic aspects of abdominal liposarcoma will be reviewed in this article. 相似文献
12.
Buyukhatipoglu H Sevinc A Camci C Buyukberber S Sari I 《Clinical and laboratory haematology》2006,28(5):343-346
Acute myelogenous leukemia (AML) is a hematological disorder that is characterized by an abnormal proliferation of immature myeloid cells. Dedifferentiated and well-differentiated liposarcomas are the two pathological subtypes of liposarcoma, based on the WHO classification. Transition from well-differentiated to dedifferentiated liposarcoma is a well-recognized phenomenon. Well-differentiated tumors are known to have low malignancy grade. However, when dedifferentiation occurs, the tumor acquires the aggressive features of a fully malignant lesion. This process largely is believed to progress in a time-dependant manner; however, time is not the only factor of importance. The potential roles of other factors in this transition are still unclear. To date, the coexistence of AML and liposarcoma has not been reported in the literature. In this paper, we report on a case of coexistence of AML and liposarcoma, and on the unusual behavior of a well-differentiated tumor after dedifferentiation occurs. 相似文献
13.
Lee YC Huang SP Liu CC Wu WJ Chou YH Huang CH 《The Kaohsiung journal of medical sciences》2003,19(11):579-582
Extrarenal angiomyolipoma is an uncommon disease entity and is rare in the retroperitoneum. We report a case of giant extrarenal retroperitoneal angiomyolipoma mimicking liposarcoma. A 35-year-old woman presented with a history of increased abdominal circumference and urinary frequency. Abdominal computerized tomography demonstrated a 24 x 21 x 16 cm retroperitoneal fatty tumor displacing the right kidney to the left upper quadrant of the abdomen. At laparotomy, the tumor was widely excised and the right kidney was successfully preserved. Final histologic examination identified the tumor as an angiomyolipoma. At 4-month postoperative follow-up, no evidence of tumor recurrence was found and the right kidney was fully functional. 相似文献
14.
Wen-Zhe Kang Li-Yan Xue Gui-Qi Wang Fu-Hai Ma Xiao-Long Feng Lei Guo Yang Li Wei-Kun Li Yan-Tao Tian 《World journal of gastroenterology : WJG》2018,24(25):2776-2784
Liposarcoma of the stomach is extremely rare, and only 37 cases have been reported worldwide. We herein report two cases of liposarcoma of the stomach. The first patient was referred to our hospital with upper abdominal discomfort. The endoscopic examination revealed a tumor mass about 3 cm in diameter. The patient underwent a partial gastrectomy and had an uneventful recovery. The histopathological examination revealed a welldifferentiated liposarcoma. The second patient had symptoms of upper abdominal discomfort combined with nausea and anorexia. Several palpable masses were found with endoscopy. Endoscopic submucosal dissection was the treatment used, and the postoperative course was uneventful. The histopathological diagnosis was a well-differentiated liposarcoma. The two patients did not undergo any adjuvant therapy. They are both currently in good condition without recurrence. Therefore, we believe that the outcome of liposarcoma of the stomach is positive, and surgical resection may be the first choice for treatment at present. 相似文献
15.
Hirakoba M Kume K Yamasaki M Kanda K Yoshikawa I Otsuki M 《Internal medicine (Tokyo, Japan)》2007,46(7):373-375
Liposarcoma is one of the most common primary neoplasms in the retroperitoneum, whereas primary mesenteric liposarcomas are rare. We encountered a case of liposarcoma which arose from the mesentery of the jejunum that was diagnosed by imaging studies before surgical operation. 相似文献
16.
Lococo F Cesario A Meacci E Vita LM Porziella V Margaritora S Granone P 《The Thoracic and cardiovascular surgeon》2011,59(3):172-173
Liposarcomas are the second most common soft tissue sarcoma in adults. They occur predominantly in the lower limbs and retroperitoneum, whereas primary mediastinal liposarcomas are extremely rare. Liposarcomas are often asymptomatic and may reach a considerable size before causing any symptoms related to direct invasion or compression of other thoracic organs. We report a case of a 69-year-old woman with a giant primary pericardial liposarcoma causing cardiac tamponade and discuss its clinical and imaging features and surgical treatment and review the literature. 相似文献
17.
H Tsutsumi S Ohwada I Takeyoshi M Izumi T Ogawa T Fukusato Y Morishita 《Hepato-gastroenterology》1999,46(27):2110-2112
An 83 year-old man was admitted because of abdominal pain and distention. A mass measuring 20x10 cm and associated with tenderness and guarding was palpable in the right lower abdomen. Ultrasonography and computed tomography showed a tumor with solid and multiple cystic areas. Celiac angiography showed slight tumor vascularity fed by the right gastroepiploic artery. A malignant tumor of the omentum was suspected. At laparotomy, torsion of the omental pedicle of the tumor was found. Histological examination of the resected tumor revealed characteristics of round-cell liposarcoma, which usually has a poor prognosis. The patient has been alive and well for 2 years. Primary liposarcoma of the omentum has been reported in only seven previous cases. None of these patients presented with torsion, and no report has thus far included a documented survival. 相似文献
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19.
Hanan Alshenawy 《Journal of cancer research and clinical oncology》2013,139(6):1073-1081
Purpose
Liposarcoma represents the most common soft tissue tumors in adults. The tumors are characterized by a high morphological diversity and a great variation in biological behavior. Atypical lipomatous tumors represent a distinctive subset of mesenchymal neoplasms featuring mature adipocytic differentiation. Histologically, atypical lipomatous tumor might be easily confused with lipoma. Conversely, dedifferentiated liposarcoma may be confused with other spindle cell/pleomorphic undifferentiated tumors.Methods
A group of liposarcomas was analyzed by investigating the MDM2, CDK4, and HMGI-C proteins. The study was extended to a group of lipomas and non-lipomatous sarcomas, to determine whether the immunohistochemical investigation of these proteins might play any diagnostic role.Results
Our data suggest that ordinary lipomas may form a molecular genetic and morphological continuum with atypical lipomatous tumor. At one end of the spectrum are lipomas characterized by HMGI-C activation and at the other end are atypical lipomatous tumors with overrepresentation of the HMGI-C, CDK4, or MDM2 proteins. These findings not only provide insights into the molecular pathogenesis of lipomatous tumors, but also indicate that the immunohistochemical analysis of HMGI-C, CDK4, or MDM2 may help to increase diagnostic accuracy.Conclusions
HMGI-C is a useful adjunct in the diagnosis of atypical lipomatous tumor and dedifferentiated liposarcoma and differentiates them from their mimics. Therefore, in our experience, HMGI-C expression alone is of rather limited value in the differential diagnosis of liposarcoma subtypes. 相似文献20.
69-jähriger Patient mit weißem Hemithorax rechts 总被引:1,自引:0,他引:1
Liposarcomas are the most common sarcomas in adults. Mediastinal occurrence is very rare. We report on a 69 year-old man with a huge tumor in the right pleural cavity leading to a complete atelectasis of the right lung. The tumor could be completely resected. Histology showed a well-differentiated liposarcoma of the mediastinum. One year after resection there was no evidence for local recurrence or metastatic spread. 相似文献