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Young‐Hak Kim Seong‐Wook Park Cheol Whan Lee Myeong‐Ki Hong Hyeon‐Cheol Gwon Yangsoo Jang Myoung Mook Lee Bon Kwon Koo Dong Joo Oh Ki Bae Seung Seung‐Jae Tahk Junghan Yoon Seung‐Jung Park 《Catheterization and cardiovascular interventions》2006,67(2):181-187
Objective: This study compared the efficacy of the sirolimus‐eluting stent (SES), the paclitaxel‐eluting stent (PES), and the bare metal stent (BMS) for long coronary lesions. Background: The outcome of drug‐eluting stent (DES) implantation in long coronary lesions remains unclear. Methods: The study involved 527 patients with de novo long coronary lesions (≥24 mm), which were treated with long (≥28 mm) SESs (223 lesions), PESs (194 lesions), or BMSs (201 lesions). Results: Lesions in the SES (36.0 ± 14.9 mm, P < 0.001) and PES (36.3 ± 14.5 mm, P < 0.001) groups were longer than those in the BMS group (32.0 ± 12.3 mm), meaning the two DES groups had longer stented segments than did the BMS group. Six‐month angiographic follow‐up showed the SES (9.3%, P < 0.001) and PES (21.3%, P < 0.001) groups had lower in‐segment restenosis rates than that of the BMS group (42.5%). The rate of major adverse cardiac events (MACE) including death, myocardial infarction, and target lesion revascularization at 9 months was higher in the BMS group (26.6%) than that in the SES (13.0%, P < 0.001) and PES (15.7%, P < 0.001) groups. Posthoc analysis of the two DES groups showed that the in‐segment restenosis rate was lower for the SES than that for the PES group (P = 0.002), while the MACE rate was similar. Conclusions: The use of DESs for long coronary lesions appears to be safe and more effective than the use of BMSs in terms of restenosis and adverse clinical events. SES use was associated with lower late luminal loss and a lower angiographic restenosis rate compared with PES use. © 2006 Wiley‐Liss, Inc. 相似文献
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Intravascular ultrasound assessment of optimal stent area to prevent in‐stent restenosis after zotarolimus‐, everolimus‐, and sirolimus‐eluting stent implantation 下载免费PDF全文
Hae‐Geun Song MD Soo‐Jin Kang MD PhD Jung‐Min Ahn MD Won‐Jang Kim MD Jong‐Young Lee MD Duk‐Woo Park MD PhD Seung‐Whan Lee MD PhD Young‐Hak Kim MD PhD Cheol Whan Lee MD PhD Seong‐Wook Park MD PhD Seung‐Jung Park MD PhD 《Catheterization and cardiovascular interventions》2014,83(6):873-878
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Kleanthis Theodoropoulos MD Marco G. Mennuni MD George D. Dangas MD PhD Omar A. Meelu MS Sameer Bansilal MD MS Usman Baber MD MS Samantha Sartori PhD Jason C. Kovacic MD PhD Pedro R. Moreno MD Samin K. Sharma MD Roxana Mehran MD Annapoorna S. Kini MD 《Catheterization and cardiovascular interventions》2016,88(5):777-785
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Lisbeth Antonsen MD Michael Maeng MD PhD Per Thayssen MD DMSci Evald Høj Christiansen MD PhD Knud Nørregaard Hansen MD Anne Kaltoft MD PhD Henrik Steen Hansen MD DMSci Leif Thuesen MD DMSci Jens Flensted Lassen MD PhD Lisette Okkels Jensen MD DMSci PhD 《Catheterization and cardiovascular interventions》2014,83(6):864-872
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Gyung‐Min Park MD Duk‐Woo Park MD PhD Yong‐Giun Kim MD Sung Won Cho MD Byung‐Joo Sun MD Ki Won Hwang MD Yoo Ri Kim MD Jung‐Min Ahn MD Hae‐Geun Song MD Won‐Jang Kim MD PhD Jong‐Young Lee MD Soo‐Jin Kang MD PhD Seung‐Whan Lee MD PhD Young‐Hak Kim MD PhD Cheol Whan Lee MD PhD Seong‐Wook Park MD PhD Seung‐Jung Park MD PhD FACC 《Catheterization and cardiovascular interventions》2013,81(2):274-282
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Sang Min Park MD Jung‐Sun Kim MD PhD Young‐Guk Ko MD Donghoon Choi MD PhD Myeong‐Ki Hong MD PhD Yangsoo Jang MD PhD Woong Chol Kang MD PhD Taehoon Ahn MD PhD Byoung‐Keuk Kim MD PhD Seong Jin Oh MD Dong Woon Jeon MD Joo‐Young Yang MD PhD 《Catheterization and cardiovascular interventions》2011,77(1):15-21
Objectives : The aims of this study were to identify the efficacy of optimal stent expansion (OSE) according to the Multicenter Ultrasound Stenting in Coronaries Study (MUSIC Study) criteria in drug‐eluting stent (DES) and compare paclitaxel‐eluting stent (PES) to sirolimus‐eluting stent (SES). Background : Although poststent high‐pressure balloon dilatation is proposed after bare metal stent implantation according to OSE, defined by the criteria of the MUSIC Study, very little data are available in DES. Methods : Two hundred fifty patients (M:F = 149:101; age, 61.5 ± 9.2 years) who underwent 9‐month follow‐up angiography in the Poststent Optimal Stent Expansion Trial (POET) were included in this study. We assessed angiographic in‐stent restenosis (ISR) and neointima volume (NV) using IVUS at 9 months. Results : At 9‐month follow up, there were no significant differences in ISR and NV index (NV/stent length, mm2) between patients with and without OSE. However, the rate of ISR and NV index were higher in PES [ISR: 18 (13.7%) and 4 (3.4%), P = 0.004; NV index: 1.02 ± 0.99 mm2 and 0.21 ± 0.37, P < 0.001 in PES and SES]. Conclusions : OSE according to the MUSIC Study criteria was not related to ISR and NV in the DES era but PES had a significantly higher ISR rate and NV than SES after poststent high‐pressure balloon dilatation. © 2010 Wiley‐Liss, Inc. 相似文献
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One‐year clinical outcomes after sirolimus‐eluting coronary stent implantation in diabetics enrolled in the worldwide e‐SELECT registry 下载免费PDF全文
Antonio L. Bartorelli MD Gabriele Egidy Assenza MD Alexandre Abizaid MD Adrian Banning MD Vladimír Džavík MD Stephen Ellis MD Runlin Gao MD David Holmes MD Myung Ho Jeong MD Victor Legrand MD Franz‐Josef Neumann MD Christian Spaulding MD Stephen G. Worthley MD Philip Urban MD for the e‐SELECT Investigators 《Catheterization and cardiovascular interventions》2016,87(1):52-62
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Dobrin Vassilev MD PhD Maxim Hazan MD Larry Dean MD 《Catheterization and cardiovascular interventions》2012,80(7):1223-1226
A 55‐year‐old male underwent paclitaxel‐eluting stent implantation in a bifurcation lesion of his left anterior descending artery (LAD) during an episode of unstable angina in 2008. A late in‐stent restenosis developed 15 months after implantation of the drug‐eluting stent (DES) and was treated with paclitaxel eluting balloon. Two months later, during angiography for functional assessment of the significance of lesions in the circumflex artery, an aneurysm at the place of drug‐eluting balloon (DEB) inflation was observed. The patient was left on double antiplatelet therapy and scheduled for clinical observation after 3 months and control coronary angiography after 6 months for aneurysm progression follow‐up. © 2012 Wiley Periodicals, Inc. 相似文献
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Influence of lesion length on restenosis after coronary stent placement 总被引:18,自引:0,他引:18
Adnan Kastrati MD Shpend Elezi MD Josef Dirschinger MD Martin Hadamitzky MD Franz-Josef Neumann MD Albert Schmig MD 《The American journal of cardiology》1999,83(12):8-1622
The length of a coronary lesion is a significant predictor of restenosis after balloon angioplasty. The influence of lesion length has not comprehensively been assessed after coronary stent placement. This study includes 2,736 consecutive patients with coronary stent placement. Only patients with recent or chronic occlusions before the intervention were excluded. Patients were divided in 2 groups: 573 patients with long lesions (≥15 mm) and 2,163 patients with short lesions (<15 mm). There were no significant differences between the groups with respect to the procedural success rate and incidence of subacute thrombosis. One-year event-free survival was lower in patients with long lesions (73.3% vs 80.0%, p = 0.001). Six-month angiography was performed in 82.5% of the eligible patients. The incidence of binary restenosis (≥50% diameter stenosis) was higher in patients with long lesions (36.9% vs 27.9%, p <0.001). Similarly, patients with long lesions presented more late lumen loss than those with short lesions (1.29 ± 0.89 vs 1.07 ± 0.77 mm, p <0.001). Multivariate models for both binary restenosis and late lumen loss demonstrated that lesion length was an independent risk factor for restenosis. The risk was further increased by multiple stent placement and overlapping stents that were also independent risk factors of restenosis. Stented segment length did not show any independent effect. Therefore, long lesions represent an independent risk factor for restenosis after coronary stent placement. The results of this study suggest that a possible way to reduce the risk is to cover the lesion with a minimal number of nonoverlapping stents. 相似文献
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Late (more than six months) total occlusion after coronary stenting is a progressive phenomenon occurring in approximately 4% of patients, leading to acute myocardial infarction in less than 0.5%. The process must be related to severe and progressive intimal hyperplasia. In patients receiving coronary stenting with simultaneous brachytherapy, late total occlusion has been reported at a higher rate and to be related to stent thrombosis rather than intimal hyperplasia. Late total occlusion presenting with an acute clinical event seven months after the implantation of a paclitaxel drug eluting stent is reported. The occlusion developed soon after the interruption of ticlopidine treatment, suggesting that the event had a thrombotic genesis and that the risk is not confined to the first six month period.
Keywords: paclitaxel eluting stent; late thrombosis 相似文献
Keywords: paclitaxel eluting stent; late thrombosis 相似文献
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Gennaro Sardella MD FACC FESC Giulia Conti MD Teodoro Bisceglia MD Emanuele Canali MD Massimo Mancone MD Carlotta De Carlo MD Leonardo Spedicato MD Giorgio Morocutti MD FESC Francesco Fedele MD Guglielmo Bernardi MD FESC 《Catheterization and cardiovascular interventions》2011,78(7):1068-1075
Objectives : The aim of our study is to evaluate the safety and efficacy of DES implantation in an unselected, “real world,” high‐risk population. Background : Several clinical trials showed that drug‐eluting stents (DESs) implantation is safe and effective in selected population. In spite of these encouraging results, there are some concerns about “real world” utilization of these stents. Methods : One thousand four hundred and fifty‐five off‐label patients have been included in our registry. Primary end‐points were: long‐term clinical incidence of major adverse cardiac and cerebrovascular events (MACCE) and thrombosis (ST). We detected the difference between uniDES vs. multiDES implantation in terms of MACCE, death, nonfatal‐MI, the composite of death/nonfatal‐MI and target lesion revascularization (TLR) and the difference between DES type in term of MACCE. Results : At 36 months follow‐up we found: cardiac death occurred in 20 patients (1.6%); 33 patients (2.6%) had a nonfatal MI and 81 patients (6.3%) had a TLR. We observed one (0.1%) acute, 9 subacute (0.6%), 6 late (0.6%), and 1 (0.5%) very late definite ST. No difference were found in terms of overall MACCE, MI, death and composite of death/nonfatal‐MI between uni‐ and multiDES implantation but multiDES group had a higher incidence of TLR. No difference between DES type in term of MACCE was detected. Conclusions : DES utilization shows their safety and efficacy in off‐label patients with complex clinical and angiographic profile in terms of long‐term incidence of MACCE. MultiDES implantation is associated with a higher risk of long‐term TLR. No difference between DES type was found. © 2011 Wiley Periodicals, Inc. 相似文献
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Jesper Khedri Jensen MD PhD Lisette Okkels Jensen MD DmSci PhD Christian Juhl Terkelsen MD DmSci PhD Jens Flensted Lassen MD PhD Hans Henrik Tilsted MD Knud Noerregaard Hansen MD Michael Maeng MD PhD Leif Thuesen MD DmSci Per Thayssen MD DmSci 《Catheterization and cardiovascular interventions》2013,81(2):260-265
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目的:研究冠脉内支架置入术后IL-6和IL-10在外周血中的变化及临床意义。方法:行冠脉内支架置入术后患者30例。取支架置入前和术后24 h股动脉血,检测血清IL-6、IL-10,并观察术中、术后并发症。结果:支架置入术后24 h外周血IL-6显著高于术前(215±118 pg/m lvs176±82 pg/m l,P<0.05),而IL-10较术前稍有下降但无统计意义(P>0.05),术后IL-6/IL-10比值较术前显著升高(3.3±1.9vs2.3±1.0,P<0.05)。伴并发症及再狭窄者较无并发症及再狭窄者术后IL-6、IL-6/IL-10比值均显著升高(分别为302±157 pg/m lvs193±99 pg/m l,P<0.05;5.4±2.0vs2.7±1.5,P<0.01)。结论:冠脉内支架置入后引起IL-6和IL-6/IL-10比值显著增加,IL-6及IL-6/IL-10比值增加可能与支架术后心血管并发症和再狭窄的发生有一定关系。 相似文献
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Rudolf Blasini Franz-Josef Neumann Claus Schmitt Hanna Walter Albert Schmig 《Catheterization and cardiovascular interventions》1998,44(4):380-386
This study was designed to test the hypothesis that patients fulfilling intravascular ultrasound (IVUS) criteria for optimal coronary stent implantation show a reduction in the restenosis rate at 6 months. IVUS guidance for stent dilation may be associated with faciliated stent implantation and an increased acute luminal gain, but it has not yet been determined, whether and to what extent this procedure is associated with a reduction in the restenosis rate. IVUS-guided optimization of Palmaz-Schatz stent placement was performed in 125 consecutive patients, 64 of whom fulfilled IVUS-criteria for optimal stent placement. Another 125 patients served as the non-IVUS control group. In 107 patients (86%) of the non-IVUS control group and 105 patients (84 %) of the IVUS group, angiographic follow-up was performed. The IVUS group of patients revealed a significantly lower restenosis rate of 20.9% as compared with 29.9% in the control group (P = 0.033). Patients that met IVUS criteria for optimal stent placement had a larger minimal lumen diameter immediately after stent implantation (3.13 ± 0.44 vs. 2.95 ± 0.47 mm; P = 0.045) and at 6-month follow-up (2.23 ± 0.78 vs. 1.87 ± 0.76 mm; P = 0.019) as well as a significantly lower restenosis rate (13.5% vs. 28.3%; P = 0.038) as compared with patients that did not fulfil these criteria. Our data suggest that patients fulfilling IVUS criteria for optimal stent placement demonstrate a reduced risk for the development of restenosis. Thus, IVUS investigation identifies factors predictive of restenosis after coronary stent placement. Cathet. Cardiovasc. Diagn. 44:380–386, 1998. © 1998 Wiley-Liss, Inc. 相似文献