Expression of integrin-α<Subscript>3</Subscript> mRNA in meningiomas and its correlation with proliferation and invasion

To investigate the expression of integrin-α3 mRNA in meningiomas and its correlation with proliferation and invasion, the expression of integrin-α3 subunit was detected by using in situ hybridization in patients with meningiomas （36 cases） and normal dura （2 cases） and arachnoid tis- sues （2 cases）. SABC immunohistochemical assay was used to study the expression of Ki-67 nuclear antigen. The results showed that the expression of integrin-% mRNA in benign, atypical and malig- nant meningiomas was 2.52±0.362, 1.75±0.316 and 1.42±0.633, respectively. The expression levels of integrin-α3 mRNA was significantly lower in atypical or malignant meningiomas than those in benign meningiomas （P〈0.05, P〈0,01, respectively）. The expression of integrin-α3 mRNA in those with invasive biological behavior was lower than that in those without invasion （1.63±0.462 vs. 2.61±0.526, P〈0.01）. Moreover, the expression of integrin-α3 mRNA was inversely associated with Ki-67 labeling index in all cases. It suggested that integfin-α3 subunit participated in the modulatory process of growth of meningiomas. The proliferation activity and malignant grade of meningiomas were increased with the decreased expression of integrin-α3 subunit, and the down-regulation of integrin-α3 mRNA was associated with the invasive biological behaviors in meningiomas.     

Clinical melanoma characteristics and survival—a single-center retrospective study between 2000 and 2010

Wiener Medizinische Wochenschrift - The aim of this study was to characterize clinical, histological, and outcome features of primary melanoma in 1329 patients managed at a&nbsp;single-center...     

先春;罗晶;辛志勇;孔秀英;景蕊莲;吴振录;李杏普;中

0081,北京100083,北京100081,北京100081,北京100081,新疆乌鲁木齐830000,石家庄050031小麦;;产量;;慢病性;;分子标记;;常规育种国际小麦育种呈现四大特点:一是进一步提高小麦产量,通过保护性耕作降低生产成本;二是分子标记辅助选择已成为常规育种的重要组成部分;三是慢病性利用是抗病研究的主流方向;四是品质研究更注重营养特性。Trend Analysis of International Wheat BreedingHE Zhong-hu~(1,2),XIA Xian-chun~1,LUO Jing~3,XIN Zhi-yong~1,KONG Xiu-ying~1,JING Rui-lian~1,WU Zhen-lu~4,LI Xing-pu~5 (1.Crop Science Institute,Chinese Academy of Agricultural Science,Beijing 100081;2.CIMM     

Impairment, disability and handicap—old fashioned concepts?

The drawbacks of using the concepts of models in discussing the problems of disabled people are discussed. It is suggested that the terms "impairment", "disability", and "handicap" can unify the different models and enhance the position of people with disabilities in society.     

亚麻籽对血脂的调节作用

以国产亚麻籽(低、中、高3种剂量)喂饲Wistar大鼠32d,观察其对大鼠血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、高密度脂蛋白胆固醇与总胆固醇的比值（HDL-C/TC）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白-B（Apo-B）及动脉硬化指标（AI）的影响,并与高脂饲料组和基础饲料组进行比较。结果,亚麻籽粉低、中、高剂量组的TC和LDL-C均显著低于高脂饲料组（P＜0.05）;中、高剂量组的TG、Apo-B及AI显著低于高脂饲料组（P＜0.05）,HDL-C/TC、AI显著高于高脂饲料组（P＜0.05）,而HDL-C则与高脂饲料组无显著差异（P＞0.05）。提示富含α-亚麻酸的国产亚麻籽具有良好的降低血脂的作用,值得进一步研究和开发。     

Effects of down-regulation of integrin-β<Subscript>1</Subscript> expression on migration and hepatic metastasis of human colon carcinoma

Organ-specific tumor cell adhesion to extracellular matrix (ECM) components and cell migration into host organs often involve integrin-mediated cellular processes. Direct integrin-mediated cell adhesion to ECM components in the space of Disse appears to be required for the successful liver metastatic formation of colon cancer. In the present study, human colon cancer HT-29 cells were transfected by liposome with integrin-β1 antisense oligodeoxynucleotide (ASODN). The integrin-β1 gene expression in HT-29 cel...     

"升"加词头后符号用"L"不用"l"

单位升是我国法定单位,其符号为“L ,(l)”。我国推荐采用“L”,“l”为备用符号。目前出版的科技书刊中升的符号几乎均选用“L”,因此加词头后其符号也应用“L”,即毫升应写作“mL”,不用“ml”;微升应写作“μL”,不用“μl”。“升”加词头后符号用“L”不用“l”@吴淑芬     

49;12;A;J;J149_1

s82-99X171B027;17;A;B;B027_17;80-97国土开发整治与区域规划0中国地理与资源文摘Chinese Geographical and Resources Abstracts100-101F301J149;12;A;J;J149_12;98-99地图与遥感0中国地缆“窃流现象”。大量的临床医学实践表明,对于某些非适应症患者或大剂量使用双嘧达莫会造成严重的不良后果,甚至诱发心血管疾病,出现了治疗矛盾,丁国华[1]综合国内文献,对此已有报道,近年来,实验证实双嘧达莫可抑制病毒核糖核酸与去氧核糖核酸的合成,从而抑制病毒的增殖过程,发挥了抗病毒作用,除此之外,双嘧达莫对提高机体免疫力及治疗糖尿病肾病、心血管疾病等多方面具有显著作用,现综合介绍如下。     

"痰"与"饮"同源异流

关于痰与饮的同源异流问题历来众说纷纭.从痰与饮的物质来源、形成过程来追溯其源流;又从二者的致病特点、所致疾病的治疗方法来阐述二者的异流,最后得出痰与饮同源异流的结论.     

"黑诊所"三大"黑招"

“黑招”一：拿“祖传秘方”蒙人。兰州医学院第二附属医院曾收治过一位病人。他从小广告上看到“祖传秘方专治疝气”，谁知这“祖传秘方”竟是用一根针头捅到他肚子里放气。医院给这位病人检查时发现，他的肠子已经被捅破了。称自己有“祖传秘方”专治疑难杂症，是“黑诊所”常用的骗人手段。他们主要是针对一些目前医学上还没有规范化治疗方案的病症，利用病人“病急乱投医”的心理骗其上当。