输卵管妊娠保守性手术96例手术

目的：探讨输卵管妊娠保守性手术及不同手术方式的近期效果及妊娠结局。方法：对96例未破裂型输卵管妊娠中77例行输卵管线型切开术,19例行输卵管伞端胚囊挤出术。绒毛肿植部位注射甲氨蝶呤20－30mg。结果：2．4％的患者发生持续性异位妊娠,均为行伞端挤出术患者。宫内妊娠率为41．5％,重复异位妊娠率为25．6％。对侧输卵管正常者,宫内妊娠率及重复异位妊娠率分别为70．5％和22．8％;当时侧输卵管异常或已被切除者,宫内妊娠率又重复异位妊娠率为7．9％和28．8％。结论：绒毛种植部位注射甲氨蝶呤可降低持续性异位妊娠率,而伞端绒毛挤出术后发生持续性异位妊娠的可能性较大,应尽量避免。     

输卵管妊娠保守性手术48例临床分析

目的:探讨在急诊情况下行输卵管保守性手术的安全可行性及疗效.方法:回顾分析开腹保守性手术治疗输卵管妊娠48例的手术方法,随访术后宫内妊娠率及重复异位妊娠率.结果:术后2年宫内妊娠率为72.96％,重复异位妊娠率为6.25％.无一例持续性异位妊娠发生.结论:输卵管妊娠保守性手术是一种可行的手术方法.提高手术技能,能提高手术成功率,降低保守性手术的并发症,为患者创造自然受孕的机会.     

输卵管妊娠腹腔镜保守性手术32例临床分析

输卵管妊娠是异位妊娠中最常见的一种类型,发病率呈逐年上升趋势,且年龄趋于年轻化,对有生育要求的患者,提高术后宫内妊娠率是医患共同追求的目标。腹腔镜保守手术具有创伤小、恢复快,再次宫内妊娠率高等优点,近年来被广泛应用于妇产科临床。我们使用腹腔镜技术对32例有生育要求的输卵管妊娠患者实施了保守性手术,取得了良好的效果,现报道如下。     

输卵管妊娠腹腔镜保守性手术120例临床分析

近年来，腹腔镜输卵管妊娠的治疗已经成为异位妊娠的常规术式。持续性异位妊娠（PEP）是输卵管妊娠保守性手术后最常见的并发症，是导致再次治疗的主要原因。本文对我院收治的相关病例进行总结分析。     

输卵管妊娠保守性手术46例分析

输卵管妊娠是妇科较常见也是较为凶险的急腹症之一，近年来随着超声技术尤其是阴式超声及β—HCG检测敏感性的提高，异位妊娠（输卵管妊娠未破裂前）的早期诊断率也大大提高，从而使输卵管妊娠保守性手术的成功率也随之提高。现对我院2004～2005年间46例输卵管妊娠保守性手术患者进行分析。     

输卵管妊娠保守性手术的探讨

治疗异位妊娠（ＥＰ）有剖腹手术、腹腔镜手术及药物治疗。后两种适于未破裂、未流产或无内出血者。对破裂、流产、腹腔内出血多者宜行剖腹探查术。传统的手术是输卵管切除术,切除患侧输卵管可及时止血、抢救生命。现对无腹腔镜手术条件或破裂型、流产型腹腔内出血多而且需保留输卵管的治疗方法探讨如下。１　资料与方法１．１　临床资料　１９８９年１月至１９９６年１２月,我院收治ＥＰ６２０例,行保守性手术２６例,２０～３５ｙ,停经３８～５２ｄ,未破裂型６例,破裂型１２例,流产型８例;妊娠部位：壶腹部２０例、峡部３例、伞部…     

异位妊娠30例保守性手术治疗临床观察

目的 探讨保守性手术疗法对异位妊娠的临床治疗效果。方法 对30例有生育要求的异位妊娠妇女，针对妊娠部位和妊娠结局，包括流产型、破裂型、未破裂型等采取相应的保守性手术。结果 手术后血hCG降至正常，平均时间16．5天，输卵管畅通率达98％，其中有1例再次发生宫外孕。结论 对有生育要求的异位妊娠妇女，可首选保守性手术。     

输卵管妊娠显微外科保守性手术治疗32例分析

输卵管妊娠显微外科保守性手术治疗３２例分析许如秀，王育华，刘春雨，李方连（山东省立医院）输卵管妊娠是常见的妇产科急腹症之一，对年轻未生育的患者应采用保持生育能力的治疗方法，保守性手术即属此类，术时清除宫外妊娠物，保存输卵管的解剖和功能。现将我院治疗的...     

腹腔镜输卵管妊娠保守性手术50例临床分析

目的:探讨腹腔镜输卵管妊娠保守性手术的临床效果。方法:借助腹腔镜技术在微创下清除妊娠物。结果:保留输卵管,恢复快。结论:对于未婚及希望保留生育功能的患者,腹腔镜手术更优于开腹手术。     

输卵管妊娠术后发生持续性异位妊娠相关因素及预防探讨

目的：探讨腹腔镜保守性手术后持续性异位妊娠（persistent ectopic pregnancy,PEP）发生原因以及预防。方法：近三年因输卵管妊娠行腹腔镜保守性手术680例,术后发生PEP43例（6.3%）,对年龄,停经时间,包块大小,术前β-HCG,术式,术中使用甲氨蝶呤,标本取出方式等行单因素统计分析。结果：以下情况与PEP发生有关,停经时间〈40天（27/228）VS停经时间≥40天（16/409）,χ2=4.512,P=0.048;包块直径〈1.5cm（25/181）vs包块直径≥1.5cm（18/456）,χ2=0.426,P=0.031;术前β-HCG≥3000U/L（28/326）VS术前β-HCG〈3000U/L（15/311）,χ22=0.356,P=0.045;输卵管切开取胚术（35/576）VS输卵管胚胎挤出术（8/61）,χ2=10.265,P=0.023;术中使用甲氨蝶呤（15/411）VS术中未使用甲氨蝶呤（28/226）χ2=21.891,P=0.000;标本未用标本袋取出（29/211）VS标本使用标本袋（14/426）,χ2=4.538,P=0.046。结论：PEP的发生与停经时间、包块直径、术前β-HCG、术式、术中甲氨蝶呤的使用、标本取出方法密切相关,与患者年龄无相关性。     

16例重复多次异位妊娠诊治分析

目的 :分析重复多次异位妊娠的诊断、治疗及结局。方法 :回顾性分析 1 995年 5月至 2 0 0 0年 1 2月我院 1 6例重复 2次以上异位妊娠的诊断 ,前次妊娠盆腔粘连情况、治疗方式与本次妊娠之间的关系。结果 :重复 2次以上异位妊娠 1 6例 ,发生率为 0 697% ,重复异位妊娠发生于原患侧与对侧比例基本相同。经腹保守性手术后再次异位妊娠 85 7%发生于原患侧 ,腹腔镜保守手术无同侧复发 ,两者有显著差异 (P <0 .0 5)。药物保守后原患侧再次异位妊娠与保守性手术相比无差异 (P >0 .0 5)。结论 :异位妊娠药物保守治疗与保守手术效果相近。如何防止异位妊娠重复发生 ,提高宫内妊娠率有待进一步研究     

Reproductive outcome after methotrexate treatment of tubal pregnancies

OBJECTIVE: To evaluate reproductive outcome after ectopic pregnancy (EP) treated with methotrexate (MTX) and to assess the relative contribution of various risk factors to future fertility. DESIGN: Telephone follow-up interviews in a cohort of patients treated for EP. SETTING: University hospital. PATIENT(S): A cohort of 158 patients treated with MTX for tubal pregnancies between April 1991 and March 1999. INTERVENTION(S): Assessment of fertility outcomes. MAIN OUTCOME MEASURE(S): Cumulative pregnancy rates for intrauterine and ectopic pregnancies. RESULT(S): Thirty-two patients (20.2%) were lost to follow-up. Of 126 patients, 93 (73.8%) sought to become pregnant, and of these 93 women, 76 (81.7%) did. Sixty-four pregnancies were spontaneous, and 12 resulted from in vitro fertilization (IVF). No pregnancies occurred in the group not trying to become pregnant. Of the 64 spontaneous pregnancies, 52 (81.2%) were intrauterine, with 12 (18.7%) resulting in miscarriages, and 12 (18.7%) were recurrent ectopic pregnancies. The cumulative intrauterine pregnancy rate was 57.5% after 1 year and 66.9% after 2 years. The cumulative ectopic pregnancy rate was 15.4% after 1 year and 23.7% after 2 years. After adjusting for factors associated with fertility with a Cox regression, only one factor was associated with poor reproductive performance: previous history of infertility. CONCLUSION(S): Within 1 year of seeking to become pregnant, more than half the women previously treated medically for EP conceived and had ongoing pregnancies. Our analysis indicates that fertility depends more on the patients' previous medical history than on her treatment for EP.     

Bilateral tubal pregnancies after a single‐embryo transfer

Case

To present an extremely rare case of bilateral tubal pregnancies following a single‐embryo transfer in a woman with a 4 year history of infertility prior to seeking assisted reproductive technology.

Outcome

A pregnancy resulted from the transfer of an embryo that had been thawed from a frozen blastocyst during a hormone replacement cycle. An ultrasound that was performed at 5 weeks and 5 days of gestation revealed a gestational sac, embryo, and heartbeat in the right fallopian tube and similar signs of a gestational sac in the left fallopian tube. A laparoscopy revealed clear signs of an ectopic pregnancy in the ampulla of the right fallopian tube. Signs of swelling also were seen in the ampulla of the left fallopian tube. As the possibility of bilateral tubal pregnancies could not be ruled out, both fallopian tubes were removed. Pathological tests revealed chorionic villi and trophoblasts in both the left and right fallopian tubes.

Conclusion

All previously reported cases of bilateral tubal pregnancies have been a result of multiple ovulations or multiple‐embryo transfer and no case of bilateral tubal pregnancies after a single‐embryo transfer has ever been reported. No genetic testing was performed; thus, it cannot be definitively stated that the divided chorionic villi and trophoblasts came from only one embryo.     

持续性异位妊娠的影响因素分析

目的：回顾性分析异位妊娠保守性手术后持续性异位妊娠发生的原因。方法：随机选取我科2008年至2010年因异位妊娠行腹腔镜下输卵管开窗取胚术患者98例,并分成AB两组,A组患者74例术中给予稀释后甲氨喋呤管残腔内注射．B组患者24例未给于药物管腔注射,两组患者于术后第3天及第5天复查血清13一HCG,同时进行相应处理,根据妊娠部位及术中是否用药与发生持续性异位妊娠的概率进行比较。结果：A组74例患者无1例发生持续性异位妊娠,B组24例患者发生持续性异位妊娠3例,其中2例妊娠部位为输卵管伞端妊娠,结论：输卵管伞端妊娠组织开窗清除术与输卵管其他部位开窗取胚术比较发生持续性异位妊娠率高（P〈O．05）。术中输卵管中未给药（甲氨喋呤）比术中给药发生持续性异位妊娠率高（P〈0．05）。     

Laparoscopic conservative approach to ovarian pregnancies: two cases

Primary ovarian ectopic pregnancy occurs quite rarely. Primary ovarian ectopic pregnancies usually occur in young, highly fertile, multiparous women using IUD. Two cases, we presented were middle aged, infertility and did not use IUD. The treatment of choice for ovarian pregnancy is usually ovarian wedge resection or oophorectomy, also there is a place for medical treatment of carefully selected patients. In this report, we aimed to present the laparoscopic conservative treatment of spontaneous ovarian ectopic pregnancy in two patients who had primary infertility.     

异位妊娠保守治疗分析

目的 分析异位妊娠保守治疗的方法与效果。方法将340例异位妊娠按治疗方案分为5组,其中I组为期待治疗,Ⅱ组为中药治疗,Ⅲ组为甲氨蝶呤(MTX)50mg肌肉注射单次治疗,Ⅳ组为MTX 50mg多次肌肉注射治疗,V组为MTX 20 mg肌内注射,1次/日,连用5 d。结果MTX50mg单次治疗与MTX 20 mg连用5 d治疗效果相似。治疗前血β-HCG<500mIU/ml时,期待治疗与药物治疗成功率差异无显著性,而β—HCG>500 mIU时,治疗效果明显降低,β—HCG>1 000 mIU时,中药治疗效果明显不如MTXC,β-HCG>3 000 mIU/ml,MTX 50mg单次治疗成功率明显下降。β—HCG>5 000mIU/ml,MTX50mg im多次治疗成功率也明显下降,但仍高于单次治疗。结论 血β—HCG是指导和监测EP治疗的重要指标。治疗前β—HCG<3 000 mIU/ml时,MTX50 mg im单次治疗是有效而安全的;>3 000 mIU/ml,推荐MIX多次用药。     

甲氨蝶呤预防腹腔镜手术后持续性异位妊娠的研究

目的:探讨异位妊娠腹腔镜保守性手术后预防持续性异位妊娠(PEP)的方法。方法:对86例输卵管妊娠患者行腹腔镜保守性手术后随机分成两组:A组采用甲氨蝶呤(MTX)注入患侧输卵管近端残腔;B组除用MTX外,并于术后口服米非司酮。所有患者均于术前及术后24小时、72小时、7天、12天检测血-βHCG值并观察其毒副反应的发生。结果:A组PEP发生1例(2.27%),B组2例(4.76%),差异无显著性(P>0.05);术后24小时血-βHCG值较术前明显下降(P<0.01),但两组间差异无显著性(P>0.05);术后72小时、7天血-βHCG值两组间差异无显著性(P>0.05),但12天两组间差异有非常显著性,B组明显高于A组(P<0.01);且B组出现的毒副反应明显多于A组。结论:单用MTX对异位妊娠腹腔镜保守性手术后预防PEP发生,可能要优于MTX加米非司酮。     

Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in In Vitro fertilization-embryo transfer patients

Purpose  To investigate the incidence of Tubal Ectopic Pregnancies (TEP) in IVF-ET patients with respect to the status of the fallopian tubes after a previous TEP. Material and methods  This retrospective study compares patients undergoing 481 IVF-ET cycles after conservatively or surgically treated TEP(s) with a Control Group (idiopathic or male factor for IVF-ET indication). Medical reports of surgery and/or hysterosalpingograms prior to the IVF cycles classified the status of the fallopian tubes. Results  12 TEPs (8.95%/Pregnancies (PR)) occurred in the Study Group. In the Control Group one TEP (0.75%/PR; p < 0.001) was found. Smoking increased the probability of TEPs (p = 0.0028) and of pathological pregnancies (abortion, biochemical and ectopic PR; (p = 0.0411)). For statistic evolution logistic regression (PROC GENMOD) and a repeated measure model were applied. Conclusion  Women with a previous TEP should be informed about the significantly increased risk for a further TEP in IVF-ET treatment, especially if they are smoking. Capsule Tubes after a Tubal ectopic pregnancy (TEP) and smoking lead to a significant higher number of repeated TEPs in following IVF-ET programs.