STIGMA AND THE SYNDEMIC OF HIV‐RELATED HEALTH RISK BEHAVIORS IN A DIVERSE SAMPLE OF TRANSGENDER WOMEN

This study examined HIV‐related health risk behaviors–unprotected anal intercourse, alcohol intoxication, and drug use–and their association with stigma in a sample of transgender women. We conducted a cross‐sectional survey of 191 transgender women recruited through purposive sampling in San Francisco, CA. Unprotected anal intercourse, alcohol intoxication, and illicit drug use were significantly intercorrelated, suggesting the presence of a “syndemic” among these HIV‐related behavioral health risks. In multivariable analyses controlling for sociodemographic and individual health characteristics, stigma was independently associated with greater levels of unprotected anal intercourse, illicit drug use, and a composite index of the 3 risk behaviors. Findings highlight a need for interventions to address stigma and the social context of unprotected sex, alcohol intoxication, and drug use, which may contribute to HIV risk among transgender women.     

A NEW TYPE OF MUCOLIPIDOSIS ASSOCIATED WITH HEREDITARY THROMBOCYTOPATHY AND COLOR BLINDNESS

Autopsy findings of a 22-year-old Japanese male who showed the symptoms of both mucopolysaccharidosis and sphingolipidosis are reported. The patient had a gargoyle-like face, bone change with cherry-red spot and absence of mucopolysacchariduria, and moreover accompanied by hereditary thrombocytopathy and color blindness. Autopsy Andings were almost the same as those of mucopolysaccharidosis, histochemically and electron microscopically. Unique findings were, however, present; In the hepatocytes, another inclusion containing dense Ane granuloreticular structures was found electron microscopically. Some foamy cells in the lymph nodes, liver including sinusoidal cells, bone marrow and spleen contained intracytoplasmic sudanophillc substance in the form of moderate electron dense globules by electron microscopy. The outstanding finding of the enzymatic activity was the decrease of β-galactosidase in the liver and brain.     

Wg3h细胞系转染PSV_2-neo质粒前后生长特性及表面超微结构改变的研究

本文对转染PSV_2-neo质粒后的Wg3h细胞系(Wg3h-neo)在长期传代中的生长特性和表面超微结构与母系Wg3h细胞进行了比较研究。结果发现:转染后Wg3h细胞的DNA合成及生长速度明显高于母系Wg3h细胞,生长饱和密度增大。在软琼脂培养中不形成集落,接种在裸鼠不长肿瘤。在扫描电镜下,细胞表面的微绒毛较母系Wg3h细胞丰富。Southern印迹杂交实验证明PSV_2-neo质粒已整合到宿主细胞的基因组中。转染后Wg3h细胞的生长特性和表面超微结构均发生了某些转化特征。     

GENERALIZED CYTOMEGALIC INCLUSION-BODY DISEASE ASSOCIATED WITH PNEUMOCYSTIS PNEUMONIA IN ADULTS: A REPORT OF THREE CASES, WITH WEGENER'S GRANULOMATOSIS, THROMBOTIC PURPURA, AND HODGKIN'S DISEASE AS PREDISPOSING CONDITIONS

Three cases of generalized cytomegalic inclusion-body disease (salivary virus disease) in adults are reported, bringing the number of published cases up to 34. The infection is very rare in adults although well known in infants. As is often found in infants with this disease, pneumonia due to Pneumocystis carinii was also present in each case.