Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix

A relation between apparent diffusion coefficient (ADC) values and tumor cellular density has been reported. The purpose of this study was to measure the ADC values of cervical cancers in the uterus and compare them with those of normal cervical tissues, and to test whether ADC could differentiate between normal and malignant cervical tissues in the uterus. Twelve consecutive female patients with cervical cancer of the uterus and ten female patients with other pelvic abnormalities were included in this study. ADC was measured at 1.5 T with b-factors of 0, 300 and 600 s/mm² using single-shot echo-planar diffusion-weighted imaging and a parallel imaging technique. The mean ADC value of cervical cancer lesions was 1.09±0.20×10^–3 mm²/s, and that of normal cervix tissue was 1.79±0.24×10^–3 mm²/s (P<0.0001). In nine patients treated by chemotherapy and/or radiation therapy, the mean ADC value of the cervical cancer lesion increased significantly after therapy (P<0.001). The present study showed, with a small number of patients, that ADC measurement has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix. Further study is necessary to determine the accuracy of ADC measurement in monitoring the treatment response.     

The utility of diffusion-weighted MR imaging in cervical cancer

Purpose

To investigate the value of diffusion-weighted MR imaging (DWI) in detection of cervical cancer, and to determine the diagnostic accuracy of apparent diffusion coefficient (ADC) values for evaluating cervical cancer before and after chemoradiotherapy.

Materials and methods

Thirty-three patients with cervical squamous carcinoma and 20 patients with other pelvic abnormalities underwent diffusion-weighted imaging (DWI) in addition to routine MR imaging. The ADC values of normal cervical tissue, cervical area before and after chemoradiotherapy were measured and compared. Receiver operating characteristic (ROC) analysis was employed to investigate whether ADC values could help in discrimination among normal cervical tissue, cervical cancer before and after therapy, and to obtain the optimal ADC threshold value.

Results

Cervical cancer lesion demonstrated obviously hyperintensity on DWI images. The mean ADC value of cervical carcinoma (1.110 ± 0.175 × 10⁻³ mm²/s) was significantly lower than that of normal cervical tissue (1.593 ± 0.151 × 10⁻³ mm²/s) (P < 0.001). The mean ADC value of the cervical area in 22 patients treated by chemoradiotherapy (1.436 ± 0.129 × 10⁻³ mm²/s) was significantly higher than that before therapy (1.013 ± 0.094 × 10⁻³ mm²/s) (P < 0.001). The difference of ADC values between normal cervical tissue and cervical area after therapy was statistically significant (P < 0.01). The optimal ADC threshold values for distinguishing between normal cervical tissue and cervical carcinoma was 1.359 × 10⁻³ mm²/s, between cervical area before and after therapy was 1.255 × 10⁻³ mm²/s, between normal cervical tissue and cervical area after therapy was 1.525 × 10⁻³ mm²/s. The sensitivity and specificity were 100% and 84.8%, 95.5% and 100%, 70% and 81.8%, respectively.

Conclusion

DWI can be applied for the detection of cervical cancer because of its superior disease contrast with normal tissue. The measurement of the ADC values can be a useful tool to monitor the response to therapy for cervical carcinoma.     

正常子宫内膜和子宫内膜癌的扩散加权成像特点

目的探讨子宫内膜癌、子宫内膜不同周期及病理状态下的扩散加权成像的特点,研究表观扩散系数(ADC)及相对表观扩散系数(rADC)在子宫内膜癌的鉴别诊断应用价值。方法对29例子宫内膜癌,9例子宫内膜良性病变者和26例正常对照者行1.5T MRI检查并进行ADC值的测定(b值为800s/mm2)。闭孔内肌作参比部位,测量正常子宫内膜及内膜癌的rADC值,将不同组别ADC、rADC值相比较,进行统计学分析。结果子宫内膜癌ADC、rADC值分别为〔(0.96±0.22)×10-3 mm2/s、0.72±0.22〕,显著低于正常子宫内膜的ADC、rADC值〔(1.39±0.27)×10-3 mm2/s、1.02±0.22〕和子宫内膜良性病变ADC、rADC值〔(1.33±0.18)×10-3 mm2/s、1.02±0.28〕。萎缩期子宫内膜ADC、rADC值〔(1.62±0.37)×10-3 mm2/s、1.16±0.27〕显著高于增生期〔(1.29±0.14)×10-3 mm2/s、0.98±0.19〕和分泌期内膜〔(1.27±0.12)×10-3 mm2/s、0.94±0.12〕。结论 ADC有潜力鉴别子宫良性病变与子宫内膜癌,以闭孔内肌作为参比部位,所获得的rADC值可以很好的反映子宫内膜癌及正常子宫的扩散特征。     

子宫内膜癌的DWI成像特征及其与PCNA、Ki-67表达相关性研究

目的:本研究拟利用PCNA及Ki-67的特殊标记物功能,通过测定不同恶性程度子宫内膜癌组织中的PCNA和Ki-67不同表达程度,及其与DWI图像ADC值及rADC值的相关性研究,探讨应用DWI对于子宫内膜癌恶性程度分子水平定量研究的鉴别诊断价值。方法:对23例子宫内膜癌患者在术前行常规MRI检查并进行ADC值的测定(b值为800s/mm2)。闭孔内肌作参比部位,测量内膜癌的rADC值。所有病例均经病理证实,包括高分化8例,中分化10例,低分化5例。用免疫组织化学染色方法(SP法)检测23例子宫内膜癌标本中PCNA及Ki-67的表达情况。结果:子宫内膜癌随着肿瘤恶性分化程度降低,各组的ADC及rADC值存在下降趋势。低分化组ADC、rADC值〔(0.79±0.14)×10-3mm2/s、0.55±0.11〕显著低于高分化组〔(1.05±0.18)×10-3 mm2/s、0.80±0.22〕,中分化组〔(0.89±0.15)×10-3 mm2/s、0.66±0.16〕ADC、rADC值与低分化组及高分化组相比均无统计学差异。子宫内膜癌PCNA、Ki-67表达程度与肿瘤ADC、rADC值呈显著性负相关。结论:子宫内膜癌DWI成像ADC、rADC值的测量有助于评价并鉴别肿瘤不同病理级别并有潜力作为评价肿瘤增殖程度的无创性方法。子宫内膜癌PCNA、Ki-67表达程度与ADC、rADC值显著性负相关,提示核磁共振扩散加权成像有潜力从分子水平反映细胞增殖程度。     

3.0 T磁共振扩散加权成像及表观扩散系数在淋巴瘤诊断及随访中的应用价值

目的 观察恶性淋巴瘤的扩散加权成像(DWI)特征及表观扩散系数(ADC)值在治疗前后的变化,探讨 DWI及ADC值在淋巴瘤诊断和随访中的应用价值.资料与方法 恶性淋巴瘤初发患者15例,男8例,女7例,平均年龄48.7岁.其中10例化疗后进行复查;健康志愿者10名,男5名,女5名,平均年龄48.4岁.在3.0 T MRI上行常规MRI及DWI检查.在ADC图上分别测量恶性淋巴瘤患者及健康志愿者颈部淋巴结的ADC值.10例复查患者在初次检查相一致部位再次测量淋巴结的ADC值,并进行前后对比,同时与健康志愿者进行比较.采用PSS 11.0统计软件,对淋巴瘤患者及正常对照组淋巴结的ADC值进行独立样本的t检验.结果 DWI与常规T2WI脂肪抑制序列比较,DWI能更敏感、直观地显示淋巴结.15例恶性淋巴瘤患者平均ADC值(753.33±31.28)×10-3 mm2/s,化疗后复查,平均ADC值(1088.32±51.28)×10-3 mm2/s.化疗前后ADC值差异有统计学意义(t=5.79,P＜0.05).健康志愿者颈部淋巴结平均ADC值(1264.20±71.60)×10-3 mm2/s.15例淋巴瘤患者治疗前ADC值与健康志愿者差异有统计学意义(t=6.53,P＜0.05),治疗后ADC值与正常人差异无统计学意义(t=1.97,P＞0.05).结论 3.0 T磁共振DWI及ADC值测量为淋巴瘤的诊断及疗效的观察提供了有价值的信息.     

Diffusion-weighted imaging of adnexal torsion

We report the diffusion-weighted imaging findings (DWI) of a case with ovarian torsion. Magnetic resonance imaging revealed a large cyst within a non-enhancing ovary. DWI depicted restricted diffusion which in turn was found to be related with the infarction of the ovary in the laparoscopic salpingo-oophorectomy performed.     

MR扩散加权成像在慢性肾病诊断中的价值分析

目的 探讨MR扩散加权成像(DWI)在慢性肾病(CKD)诊断中的价值. 资料与方法 对25例CKD患者25例正常人行肾脏DWI,比较分析肾脏表观扩散系数(ADC)值间的差异,分析肾脏ADC值与血清肌酐水平的关系. 结果 正常组双肾ADC值差异无统计学意义;正常组男女志愿者肾脏的ADC值差异无统计学意义.病例组双肾ADC值差异无统计学意义;病例组男女患者肾脏ADC值差异无统计学意义.正常组肾脏ADC值为(2.53±0.24)×10-3 mm2/s,病例组肾脏ADC值为(2.40±0.31)×10-3 mm2/s,两组间肾脏ADC值差异有统计学意义.早期肾功能损害组与正常组肾脏ADC值差异无统计学意义;中晚期肾功能损害组与正常组肾脏ADC值间差异有统计学意义.CKD患者肾脏ADC值与血清肌酐水平呈轻度负相关. 结论 肾脏DWI可用于慢性肾病的诊断,在中期肾功能损害诊断方面具有一定价值.     

扩散加权成像鉴别肺恶性肿瘤与实性良性病变的初步研究

目的探讨扩散加权成像(diffusion-weighted imaging,DWI)对肺恶性肿瘤与实性良性病变的鉴别诊断价值。资料与方法62例肺内恶性肿瘤和实性良性病变(共66个病灶)行常规MRI和DWI检查,b值为500s/mm2,观察病变区DWI信号特点并测量其表观扩散系数(apparent diffusion coefficient,ADC)值。结果不同病变组DWI信号虽有一定特点,但不具特征性。恶性病变组和良性病变组ADC值分别为(1.256±0.320)×10-3mm2/s、(1.648±0.416)×10-3mm2/s,两者差异有统计学意义(t=-3.637,P=0.001),ADC值鉴别肺内良恶性病变的最佳诊断阈值为1.400×10-3mm2/s,敏感性和特异性分别为83.3%和74.1%;小细胞肺癌ADC值为(1.064±0.196)×10-3mm2/s,非小细胞肺癌ADC值为(1.321±0.335)×10-3mm2/s,两者差异亦有统计学意义(t=2.967,P=0.007);原发性肺癌ADC值为(1.255±0.328)×10-3mm2/s,肺转移瘤ADC值为(1.263±0.280)×...     

MR扩散成像对宫颈癌放化疗早期疗效的评价

目的：探讨MR扩散成像评价晚期宫颈癌放化疗早期疗效的价值。方法：对18例经病理证实为晚期宫颈癌并接受放化疗的患者,在治疗前和开始治疗后2周、及治疗结束后行常规MRI及DWI检查。测量治疗前和治疗后不同时间点肿瘤最大径和ADC值,按治疗后肿瘤直径的变化进行分组,分析各组治疗前和治疗后不同时间点ADC值差异。结果：治疗后2周ADC值升高,完全缓解（CR）组ADC值变化高于部分缓解（PR）组,差异具有统计学意义（P〈0.05）。结论：MR扩散成像可以作为晚期宫颈癌放化疗早期评价的指标,并可根据ADC值升高情况预测治疗效果。     

Pre-Treatment Diffusion-Weighted MR Imaging for Predicting Tumor Recurrence in Uterine Cervical Cancer Treated with Concurrent Chemoradiation: Value of Histogram Analysis of Apparent Diffusion Coefficients

Objective

To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis for predicting tumor recurrence in patients with uterine cervical cancer treated with chemoradiation therapy (CRT).

Materials and Methods

Our institutional review board approved this retrospective study and waived informed consent from each patient. Forty-two patients (mean age, 56 ± 14 years) with biopsy-proven uterine cervical squamous cell carcinoma who underwent both pre-treatment pelvic magnetic resonance imaging with a 3.0 T magnetic resonance scanner and concurrent CRT were included. All patients were followed-up for more than 6 months (mean, 36.4 ± 11.9 months; range 9.0-52.8 months) after completion of CRT. Baseline ADC parameters (mean ADC, 25th percentile, 50th percentile, and 75th percentile ADC values) of tumors were calculated and compared between the recurrence and no recurrence groups.

Results

In the recurrence group, the mean ADC and 75th percentile ADC values of tumors were significantly higher than those of the no recurrence group (p = 0.043 and p = 0.008, respectively). In multivariate analysis, the 75th percentile ADC value of tumors was a significant predictor for tumor recurrence (p = 0.009; hazard ratio, 1.319). When the cut-off value of the 75th percentile ADC (0.936 × 10^-3 mm²/sec) was used, the overall recurrence free survival rate above the cut-off value was significantly lower than that below the cut-off value (51.9% vs. 91.7%, p = 0.003, log-rank test).

Conclusion

Pre-CRT ADC histogram analysis may serve as a biomarker for predicting tumor recurrence in patients with uterine cervical cancer treated with CRT.     

The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas

The usefulness of diffusion-weighted (DW) magnetic resonance (MR) imaging for the diagnosis of uterine sarcomas was investigated, as well as whether DW images and quantitative measurement of apparent diffusion coefficient (ADC) values can facilitate differentiating uterine sarcomas from benign leiomyomas. MR images including DW images were obtained in 43 surgically treated patients with 58 myometrial tumors, including seven uterine sarcomas (five leiomyosarcomas and two endometrial stromal sarcomas) and 51 benign leiomyomas (43 ordinary leiomyomas, two cellular leiomyomas and six degenerated leiomyomas). Qualitative analysis of non-enhanced and postcontrast MR images and DW images and quantitative measurement of ADC values were performed for each myometrial tumor. Both uterine sarcomas and cellular leiomyomas exhibited high signal intensity on DW images, whereas ordinary leiomyomas and most degenerated leiomyomas showed low signal intensity. The mean ADC value (10⁻³ mm²/s) of sarcomas was 1.17 ± 0.15, which was lower than those of the normal myometrium (1.62 ± 0.11) and degenerated leiomyomas (1.70 ± 0.11) without any overlap; however, they were overlapped with those of ordinary leiomyomas and cellular leiomyomas. In addition to morphological features on nonenhanced and postcontrast MR sequences, DW imaging and ADC measurement may have a potential ability to differentiate uterine sarcomas from benign leiomyomas.     

MR体素内不相干运动成像评价宫颈癌组织学特征的初步研究

目的 探讨MR体素内不相干运动(IVIM)成像评价宫颈癌组织学特征的可行性.方法 搜集24例宫颈癌患者(宫颈癌组)和24例因盆腔其他病变检查而宫颈正常者(宫颈正常组)的MRI资料.所有患者均行MR常规序列及IVIM序列扫描,测量宫颈癌组和宫颈正常组的标准表观扩散系数(ADC)、慢表观扩散系数(D)、快表观扩散系数(D*)和f值.比较宫颈癌与正常宫颈、宫颈癌不同病理类型以及不同病理分级上述各参数值的差异,采用受试者工作特征(ROC)曲线下面积评价各参数值的诊断效能.结果 宫颈癌组的标准ADC值、D值、f值均低于宫颈正常组,差异有统计学意义(P=0.000、0.000、0.001),ROC曲线下面积分别为0.872、0.848和0.762.宫颈鳞癌组的标准ADC值、D值、f值均低于官颈腺癌组,D*值高于宫颈腺癌组,差异有统计学意义(P=0.000、0.037、0.004、0.000),ROC曲线下面积分别为0.938、0.975、0.900和0.938.宫颈鳞癌高分化、中分化和低分化三组间标准ADC值、D值、D*值及f值差异无统计学意义(P=0.500、0.753、0.341、0.266).结论 IVIM成像能定量反映宫颈癌的组织学特征,具有临床应用价值.     

Diffusion-weighted MRI for evaluating perianal fistula activity: Feasibility study

Purpose

To assess the feasibility of using diffusion-weighted magnetic resonance (MR) imaging (DWI) for evaluating perianal fistula activity.

Materials and methods

This study retrospectively assessed 24 patients with clinically suspected perianal fistula who underwent a total of 28 MR examinations after conservative treatment with antibiotics. DWI was performed at 1.5 T, using b-values of 0 and 1000s/mm². Apparent diffusion coefficient (ADC) maps were created and ADCs of the lesions were measured. Lesions were classified into two groups based on the need for surgery and surgical findings: positive inflammation activity (PIA) and negative inflammation activity (NIA). ADCs of both groups were compared using an unpaired t-test, and Receiver Operating Characteristic (ROC) analysis was performed.

Results

The ADC (in 10⁻³ mm²/s) of the PIA group (0.908 ± 0.171) was significantly lower (P = 0.0019) than that of the NIA group (1.124 ± 0.244). The area under the ROC curve was 0.749. An optimal cut-off ADC of 1.109 yielded a sensitivity of 95.7%, a specificity of 50%, a positive predictive value of 71%, and a negative predictive value of 90%.

Conclusion

DWI is a feasible method for evaluating perianal fistula activity. The diagnostic performance of this technique should be established in future, larger prospective studies.     

乳腺癌MR弥散加权成像研究进展

MR在乳腺癌诊断方面的应用价值已经得到广泛认同,为增加检出乳腺癌的敏感性,需应用多种MR扫描技术。然而,常规MR在检测及描述乳腺病变特征时具有一定的局限性,弥散加权成像作为一种重要的功能成像技术,能够反映组织的生物物理学特征,有较大的发展前景。弥散加权成像是唯一能够检测活体组织内水分子弥散运动的非侵入性方法,可以检测出组织结构在分子水平上的改变。其成像时间短,敏感性高,无需使用对比剂,并且能比常规MR检查更早的发现病变,因此,它已经广泛应用于脑部疾病中,也越来越多地应用于乳腺疾病方面。本文就弥散加权成像在乳腺癌的应用方面予以综述。     

扩散张量成像在颈椎管狭窄中的应用初探

目的应用扩散张量成像(DTI)评价颈椎管狭窄对颈髓白质纤维表观扩散系数(ADC)及各向异性分数(FA)值等定量参数变化的影响。方法连续收集126例因颈肩部疼痛、感觉异常及运动功能减退等症状而行颈椎MRI检查的病人,同时纳入34名年龄条件匹配,无颈肩部不适的正常志愿者。根据颈椎管狭窄程度将病人分为3组,其中1度组82例、2度组36例、3度组8例,正常志愿者为0度组,进一步将所有受试者分为无脊髓受压组(0度组+1度组)及脊髓受压组(2度组+3度组)。所有受试者均行常规矢状面及横断面T2WI扫描,同时行DTI序列扫描。分别比较受试者各兴趣区(ROI)的FA及ADC值。结果4组间各ROI的FA值无明显差异,而ADC值除右后区ROI(F=1.56,P=0.20)外,其余5个ROI区的差异均有统计学意义(均P0.05)。2度组右前和左前区ROI的ADC值均高于0度组和1度组(均P0.05);2度组与3度组各ROI的ADC值间差异均无统计学意义(均P0.05)。3度组各个ROI的ADC值均高于0度组和1度组(P0.05)。除右后区ROI外,其余各区脊髓受压组的ADC值明显大于无脊髓受压组。结论 DTI可对颈椎管狭窄病人的颈髓进行定量研究,颈髓受压早期,白质区的ADC值升高而FA值无明显变化。     

3.0T MR扩散加权成像在甲状腺良恶性结节鉴别诊断中的价值

目的:探讨3.0T磁共振扩散加权成像(DWI)的表观扩散系数(ADC)在甲状腺良恶性结节鉴别诊断中的价值。方法:采用3.0T磁共振成像仪完成DWI成像,扩散敏感系数(b值)选用0、1000s/mm^2。测量经病理证实的13个甲状腺恶性结节、27个甲状腺良性结节以及20例正常甲状腺的ADC值,比较甲状腺良、恶性结节,正常腺体之间ADC值差异的统计学意义。结果:甲状腺良、恶性结节和正常腺体之间存在统计学意义上的差异(one-wayANOVA,F=26.664,P=0.000)。甲状腺良性结节平均ADC值为(2.43±0.54)×10^-3mm^2/s,恶性结节平均ADC值为(1.49±0.35)×10^-3mm^2/s,正常甲状腺平均ADC值为(1.84±0.20)×10^-3mm^2/s。甲状腺良、恶性结节ADC值之间的差异具有统计学意义(t=5.817,P=0.000)。将ADC值2.04×10^-3mm^2/s确定为甲状腺良恶性结节鉴别的阈值,其95%置信区间为0.84~1.01,诊断敏感性为85.2%,特异性为100%。结论:3.0T磁共振DWI成像的ADC值可以鉴别诊断甲状腺良恶性结节。     

Regional ADC values of the normal brain: differences due to age,gender, and laterality

The purpose of this study was to evaluate the stability of measurement for apparent diffusion coefficient (ADC) values in normal brain, to clarify the effect of aging on ADC values, to compare ADC values between men and women, and to compare ADC values between right and left sides of the brain. To evaluate the stability of measurements, five normal volunteers (four men and one woman) were examined five times on different days. Then, 294 subjects with normal MR imaging (147 men and 147 women; age range 20–89 years) were measured. The ADC measurement in normal volunteers was stable. The ADC values stayed within the 5% deviation of average values in all volunteers (mean±standard deviation 2.3±1.2%). The ADC values gradually increased by aging in all regions. In thalamus, no significant difference was seen between right and left in the subjects under 60 years; however, right side showed higher values in the subjects over 60 years (p<0.01). In the subjects under 60 years, women showed higher values in right frontal, bilateral thalamus, and temporal (p<0.01); however, in the subjects over 60 years, no region showed difference between men and women. The knowledge obtained in this study may be helpful to understand the developmental and aging mechanisms of normal brain and may be useful for the future quantitative study as a reference. Electronic Publication     

Alveolar echinococcosis of the liver: Diffusion-weighted MRI findings and potential role in lesion characterisation

Purpose

To report the diffusion-weighted MRI findings in alveolar echinococcosis (AE) of the liver and evaluate the potential role of apparent diffusion coefficients (ADCs) in the characterisation of lesions.

Materials and methods

We retrospectively included 22 patients with 63 AE liver lesions (≥1 cm), examined with 3-T liver MRI, including a free-breathing diffusion-weighted single-shot echo-planar imaging sequence (b-values = 50, 300 and 600 s/mm²). Two radiologists jointly assessed the following lesion features: size, location, presence of cystic and/or solid components (according to Kodama's classification system), relative contrast enhancement, and calcifications (on CT). The ADC_total, ADC_min and ADC_max were measured in each lesion and the surrounding liver parenchyma.

Results

Three type 1, 19 type 2, 17 type 3, three type 4 and 21 type 5 lesions were identified. The mean (±SD) ADC_total, ADC_min and ADC_max for all lesions were 1.73 ± 0.50, 0.76 ± 0.38 and 2.63 ± 0.76 × 10⁻³ mm²/s, respectively. The mean ADC_total for type 1, type 2, type 3, type 4 and type 5 lesions were 1.97 ± 1.01, 1.76 ± 0.53, 1.73 ± 0.41, 1.15 ± 0.42 and 1.76 ± 0.44 × 10⁻³ mm²/s, respectively. No significant differences were found between the five lesion types, except for type 4 (p = 0.0363). There was a significant correlation between the presence of a solid component and low ADC_min (r = 0.39, p = 0.0016), whereas an inverse correlation was found between the relative contrast enhancement and ADC_total (r = −0.34, p = 0.0072).

Conclusion

The ADCs of AE lesions are relatively low compared to other cystic liver lesions, which may help in the differential diagnosis. Although ADCs are of little use to distinguish between the five lesion types, their low value reflects the underlying solid component.     

3.0T MR-DWI评估溃疡性结肠炎可行性的初步研究

目的 探讨3.0 T MR-扩散加权成像(DWI)评估溃疡性结肠炎(ulcerative colitis,UC)病变肠管的可行性并比较UC病变肠管与非病变肠管和正常对照组肠壁间表观扩散系数(ADC)值的差异.资料与方法 对经病理证实的UC 13例和20例无炎症性肠病者(正常对照组)进行回顾性分析,观察各段肠管(直肠、降结肠、横结肠、升结肠、盲肠)的DWI图像及ADC图表现并测量ADC值,将病变组评估结果与内镜及病理所见相对照,计算其检出病变肠段的敏感性及特异性.结果 对13例共75段肠管进行分析;内镜及病理证实55段呈炎性改变,20段未见异常;DWI结果真阳性51段,真阴性17段,检出敏感性和特异性分别为92.7％和85.0％.病变段和非病变段肠壁ADC值分别为(1.63±0.4)×10-3mm2/s和(2.48±0.61)×10-3mm2/s,二者差异具有统计学意义(P＜0.001),但非病变段肠壁ADC值与正常对照组肠壁[(2.27 ±0.6)×10-3mm2/s]间差异无显著统计学意义(P＞0.05).结论 MR-DWI评估UC及判断病变范围较为可靠,并具有可行性.