共查询到20条相似文献,搜索用时 0 毫秒
1.
Correlation of ictal EEG and SPECT studies in patients of intractable epilepsy with normal MRI 总被引:3,自引:0,他引:3
Identification of the epileptic focus is the most important requirement for a successful surgical outcome in intractable epilepsy. Patients with normal MRI on high-resolution imaging pose a significant challenge in this regard. We tried to identify the epileptic focus using interictal / ictal SPECT and ictal EEG patterns in 14 patients with normal MRI. Rhythmic ictal onset activity helped to identify a single focus in 10 patients (71.43%). Inter ictal SPECT detected a focus corresponding to ictal EEG in 6 out of 10 patients (60%) in whom the test was performed. Ictal SPECT done in 5 patients correctly identified the focus in all patients (100%). Our data indicate that it is possible to obtain localization in patients with normal MRI using a combination of ictal EEG patterns and an ictal SPECT study. 相似文献
2.
C Adams P A Hwang D L Gilday D C Armstrong L E Becker H J Hoffman 《Pediatric neurology》1992,8(2):97-103
Twenty children with partial epilepsy who had surgery between the ages of 4 1/2 months and 18 years were studied preoperatively with electroencephalography (EEG), computed tomography (CT), and technetium-99m hexamethylpropyleneamineoxime 99mTc-HmPAO single photon emission computed tomography (SPECT; 20 interictal, 4 postictal). Fourteen had magnetic resonance imaging (MRI). All had an epileptiform focus (12 unilateral, 8 predominantly unilateral) on EEG. The combination of interictal and postictal regional cerebral blood flow (rCBF) abnormalities alone correlated with EEG foci in 16 of 20 patients. Interictal rCBF abnormalities correlated with EEG foci in 14 of 20. CT findings correlated with EEG foci in 14 of 20. MRI findings correlated with EEG foci in 13 of 14. Pathology demonstrated tumor in 6, cortical dysplasia in 4, mesial temporal sclerosis in 3, Sturge-Weber in 2, cavernous hemangioma in 1, Rasmussen encephalitis in 1, porencephalic cyst and gliosis in 1, and cysts found at surgery (but normal histology) in 2. Interictal and postictal SPECT, EEG foci, and CT findings each correlated with the pathology site in 17, 19, and 15 patients, respectively. MRI correlated with pathology site in 13 of 14 patients. Postictal and interictal abnormalities of rCBF correlated with EEG and pathology as frequently as CT. In 5 patients with normal CT scans and in 1 with a normal MRI, postictal and interictal rCBF correlated with EEG and pathology results; however, these 6 patients all had abnormalities on CT or MRI. SPECT, therefore, may be considered a valuable additional diagnostic procedure in the evaluation of epilepsy surgery candidates in that it adds to the evidence of abnormality at the involved site.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
3.
X Wu 《中华神经精神科杂志》1991,24(1):6-9, 60
The regional cerebral blood flows (rCBF) in 45 cases of epilepsy during the interictal period were determined with brain SPECT. The results were compared those obtained with CT scans and EEG. 48.89% of the SPECT were found to be abnormal while 8.98% were suspected to be abnormal; the 35.71% of the CT scans were found to be abnormal; 16 cases (39.02%) were found to show focal abnormalities in the EEG while 9 cases (21.95%) had epileptic form discharge. SPECT seemed to show more significance in discovering the abnormalities in the epileptics during the interictal period than CT or EEG. However, the combined use of these three methods of examinations would be of greater help for identifying the focal abnormalities in epilepsy. Two of the 22 cases with abnormal SPECT had increased rCBF, whereas the other 20 cases had decreased rCBF. Among the 22 cases of abnormal SPECT and 4 cases of suspected abnormalities, the locations of the lesions as indicated with SPECT in 3 cases were not consistent with those as with CT. There were 5 cases in which the SPECT findings were not consistent with those in EEG. 相似文献
4.
5.
目的探讨伴精神发育迟缓癫痫患者的CT及脑电图表现特征,为伴精神发育迟缓癫痫患者的诊断提供参考。方法选取佛山市第三人民医院2016年1月-2018年1月收治的符合《国际疾病分类(第10版)》(ICD-10)诊断标准的伴精神发育迟缓癫痫患者44例,对其行颅脑CT扫描和脑电图检查,收集并分析CT扫描和脑电图资料。结果 CT扫描表现异常24例,异常率为54. 55%;脑电图检查表现异常39例,异常率为88. 64%。不同性别、年龄及智力水平患者的CT扫描结果差异均有统计学意义(P均0. 05),但脑电图结果差异均无统计学意义(P均 0. 05)。结论 CT扫描对伴精神发育迟缓癫痫的诊断敏感性不高,脑电图检查对伴精神发育迟缓癫痫的诊断具有较高敏感性,不同性别、年龄和智力水平患者的CT扫描结果存在差异,脑电图检查结果无差异。 相似文献
6.
R Duncan J Patterson D M Hadley P Macpherson M J Brodie I Bone A P McGeorge D J Wyper 《Journal of neurology, neurosurgery, and psychiatry》1990,53(1):11-15
Cranial computed tomography (CT) with modified temporal lobe technique, 0.15T magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) were carried out on 30 patients with intractable temporal lobe epilepsy. Lateralising abnormalities were detected in 21/30 patients overall. Specific lesions were detected by CT in one patient and by MRI in seven patients (in one case bilateral). In addition CT detected asymmetry of the sylvian fissures or temporal horns in 10 patients, and MRI in eight patients. SPECT detected lateralising abnormalities in 19 patients (in five cases bilateral). It is concluded that low field MRI is superior to modified CT in demonstrating subtle structural lesions of the temporal lobe. Functional scanning with SPECT supports the evidence of origin of an epileptic focus in a substantial proportion of cases and may improve the selection of patients for surgery. 相似文献
7.
Allopurinol in severe epilepsy. A preliminary report 总被引:1,自引:0,他引:1
We have studied 64 epileptic subjects aged 2-54 years. The subjects were not hyperuricemic and presented daily or weekly severe seizures not controlled by optimal therapy with antiepileptic drugs maintained at 'therapeutic' plasma concentrations. Allopurinol at doses ranging from 150 to 300 mg daily was added to a preexisting antiepileptic drug treatment which was never modified throughout a study period of 1 year. After about 1 month of therapy, a progressive decrease of the seizure frequency was observed in two thirds of the patients. At the end of follow-up, seizures; were completely controlled in 18.75% of the patients; in 34.37% seizure frequency was reduced by more than 75%; in 15.62% of the subjects, a reduction of the seizure frequency superior to 50% was observed, while 25% of the population studied was unaffected by the treatment and 7.81% worsened. 相似文献
8.
Bryan J. Lynch Lorcan A. O''Tuama S. Ted Treves Mohamad Mikati Gregory L. Holmes 《Brain & development》1995,17(6):409-417
Sixteen children who had focal cortical resections for medically intractable epilepsy were preoperatively evaluated with99mtechnetium-labelled hexamethylpropyleneamineoxime single photon emission computed tomography (99mTc-HMPAO SPECT). Video-EEG monitoring was performed in all patients. Outcome was assessed according to the criteria of Engel et al. [1], at a mean follow up length of 13.4 ± 8.7 months, in all patients. Interictal SPECT showed appropriate localization in 11/15 cases, of whom nine had a class 1 outcome and two had class 2 and 4 outcomes. Interictal SPECT did not correlate with ictal EEG in 4/15 patients, of whom two had a class 1 outcome, and two had class 3 and 4 outcomes. Two postictal studies obtained in group I showed good correlation with the area of ictal EEG onset, and both patients had a class 1 outcome.
Interictal HMPAO SPECT imaging, when positively correlated with the ictal EEG focus or with the site of surgery determined by other means, may have prognostic value for outcome of cortical resections for epilepsy in children. The use of ictal and post-ictal studies shows promise for further improving prognostic information in this population. 相似文献
9.
Reflex epilepsy constitutes a rare form of epileptic seizures. We observed a 20-year-old man who presented with seizures induced by immersion in hot water. The trigger stimulus was specific. Contrast CT scan and MRI were all normal, not revealing any structural lesion. Ictal EEG recorded during a hot bath showed focal epileptic discharges in the left temporo-occipital area. Interictal SPECT showed a hypometabolism in the same cerebral region. Neuroimaging studies were rarely performed in this uncommon type of epilepsy. Nevertheless, in our case the result of the SPECT suggests a localized functional disturbance in the emergence of the disorder. 相似文献
10.
Nocuń A Szajner M Gil K Cholewiński W Trojanowski T Zaorska-Rajca J 《Neurologia i neurochirurgia polska》2004,38(5):373-379
BACKGROUND AND PURPOSE: The purpose of this study was to demonstrate scintigraphic evaluation of cerebral perfusion in patients with intracranial hemangiomas. MATERIAL AND METHOD: The examination was carried out in 12 patients aged from 12 to 67 years. In all the patients cerebral angiomas were previously diagnosed and all of them were qualified for intravascular embolization. Brain scintigraphy was performed after IV injection of 99mTcECD and included the dynamic phase with images obtained every 2 seconds for 1.5 minutes and SPECT imaging. The semiquantitative analysis of regional cerebral blood flow was based on the comparison between activity in two symmetrical regions of interest. Cerebral angiography combined with intravascular embolization followed the scintigraphic examination. RESULTS: Based on angiograms, the size of the nidus was estimated at 1.0 to 9.0 cm. In 8 patients the dynamic study showed an increased tracer accumulation in the region of angioma. On SPECT images the nidus was visualized as focally decreased perfusion in all cases. A decreased tracer accumulation in the area adjacent to the nidus was detected in 8 patients. The ratio of activity in the region of angioma to activity in normally perfused tissue calculated using the semiquantitative analysis was 52% to 89%. CONCLUSIONS: SPECT images and dynamic phase of cerebral perfusion scintigraphy allow perfusion changes caused by the presence of intracranial angiomas to be identified. 相似文献
11.
D. Ryglewicz M. Baranska-Gieruszczak K. Niedzielska T. Kryst-Widzgowska 《Acta neurologica Scandinavica》1990,81(6):488-490
The present study was undertaken to assess the diagnostic value of CT in patients with poststroke epilepsy, related to EEG in revealing the factors contributing to the development of epileptic fits. The EEG and CT results were evaluated in 50 patients with poststroke epilepsy and compared with those of 50 patients without epilepsy after stroke. Cortical and extensive lesions involving the cortex were more frequent among patients with poststroke epilepsy. Sparing of certain parts of cerebral cortex was observed within vasogenic lesion. This type of change was only found in the poststroke epilepsy group and may be responsible for development of epileptic fits. It seems that CT has a higher diagnostic value than EEG in evaluating the risk of development of poststroke epilepsy. 相似文献
12.
《Brain & development》1996,18(4):269-279
Single-photon emission computed tomography (SPECT) is being increasingly used in the investigation of children with epilepsy and may provide insights into congenital malformations. We analyzed the interictal99Tc-HMPAOSPECT in a series of seven children with developmental disorders of the neocortex, each of them representing a prototype of cerebral dysgenesis, such as lissencephaly, pachygyria, opercular dysplasia, polymicrogyria, nodular heterotopia and band heterotopia. The patients studied were selected among 22 epileptic children with neuronal migrational disorders (NMDs). Interictal SPECT hypoperfusion was observed in the area homologous to MRI findings in all the examined children. In three patients low perfusion was also present in the opposite hemisphere, probably due to functional involvement or related to an underlying microdysgenesis, not revealed by structural imaging. EEG features were in agreement with low perfusion areas, both anatomically and functionally, in all children. In one patient hypoperfusion area differed from that revealed by MRI and EEG. Ictal SPECT has been considered a useful tool for accurately locating the epileptic focus. Nevertheless, interictal brain perfusion studies, together with proton magnetic resonance spectroscopy, may play an important role in detecting anatomic substrate in developmental disorders of the neocortex. 相似文献
13.
Summary Blindness is a rare ictal phenomenon in epileptic seizures. It can occur as an aura, as the seizure itself, or postictally. We investigated two such patients, in one of whom blindness manifested as an aura prior to tonic clonic seizures; the interictal EEG exhibited a spike-wave focus bioccipitally. In the second patient blindness occurred postictally. An ictal SPECT, carried out at the onset of the seizure demonstrated marked hyperperfusion in both occipital regions. 相似文献
14.
15.
Correlation between provoked ictal SPECT and depth recordings in adult drug-resistant epilepsy patients 总被引:1,自引:0,他引:1
PURPOSE: To correlate ictal hyperperfusion single-photon emission computed tomography (SPECT) area during provoked seizures to the epileptogenic zone (EZ), as defined by depth recordings in adult drug-resistant patients. METHODS: We included in the study eight drug-resistant epilepsy patients, subjected to both noninvasive and invasive (stereo-electroencephalography, SEEG) presurgical evaluation in the Epilepsy Surgery Center of the Catholic University in Rome, from 2001 to 2003. All patients were subjected to interictal and provoked ictal SPECT scans during scalp video-EEG monitoring. The ictal hyperperfusion area assessed by visual image analysis and, when possible, by statistical parametric mapping (SPM), was compared with the EZ, as assessed by SEEG, to define whether they colocalized. RESULTS: For each provoked seizure, we obtained a SPECT hyperperfusion area. In five patients, the SPECT hyperperfusion area was included in the EZ as assessed by SEEG. The effectiveness of provoked SPECT was confirmed by comparison with SEEG data, SPM analysis (four patients), and spontaneous ictal SPECT (two patients). Our data were obtained in adult drug-resistant epilepsy patients whose EZ was either located in or extended to extratemporal regions in all but two patients. CONCLUSIONS: Provoked ictal SPECT confirmed its efficacy and accuracy in the presurgical evaluation because of the colocalization to the EZ. Although the low number of patients precluded any statistical correlation with the surgical outcome, it is worth pointing out that the five patients in whom the hyperperfusion area was included in the EZ showed very satisfactory results. 相似文献
16.
H. Stefan G. Pawlik H. G. Böcher-Schwarz H. J. Biersack W. Burr H. Penin W. -D. Heiss 《Journal of neurology》1987,234(6):377-384
Summary Ten patients suffering from drug-resistant complex partial seizures, with EEG abnormalities in the temporal region, were studied by means of non-invasive electrophysiological techniques (video-monitored, 16-channel, prolonged surface and sphenoidal EEG) as well as by imaging techniques (CT, MRI, SPECT and PET). Analysis of interictal and ictal EEG indicated the localization of epileptic activity in one side in eight cases. CT demonstrated focal abnormalities in three, SPECT in five unequivocally (in another four questionably, with the same lateralization as indicated by PET), MRI in eight, and PET in all cases. While only EEG provided specific diagnostic information, the focus definition was consistently good on PET images, poor on CT scans, and generally good but less consistent on MRI. 相似文献
17.
18.
19.
目的探讨无神经系统定位体征的癲癇大发作患者的脑电图(EEG)和脑CT变化.方法 68例无神经系统定位体征的癲癇大发作患者作EEG 及脑CT检查.结果 EEG异常率为82.35%,CT异常率为32.35%.CT正常组和异常组中,EEG异常率无明显差异.CT异常率与病程关系不大,但有发病诱因的继发性癲癇CT异常率较无明显原因者显著增高.结论 EEG为癲癇诊断的重要电生理检查方法,且有粗略定位意义,而CT能显示脑结构方面的病理改变,有利于查找病因及病变部位. 相似文献
20.