芦丁—β—环糊精包合物的研究

为了提高芦丁在水中的溶解度和稳定性,本文采用饱和水溶液法制备芦丁-β-环糊精包合物,用红外光谱测试、差示扫描量热分析等方法对包合物进行了鉴定,用紫外分光光度法测定包合物的含药量。实验结果表明,芦丁-β-环糊精包合物已经形成,主、客分子的摩尔比为1:1,包合反应平衡常数K_1为283.79 L/mol。芦丁在水中的溶解度由原来的51.23 mg/L增至包合后的643.19 mg/L(20℃)。     

当归油—β—环糊精包合物的研究

本文报道了当归油-β-环糊精包合物的制备方法;应用TLC对包合物进行定性分析;用挥发油测定器测定包合物中当归油的含量;并对包合物进行稳定性考察。     

盐酸雷尼替丁-β-环糊精包合物的研制

 目的：研究盐酸雷尼替丁-β-环糊精包合物的制备方法。方法：采用饱和溶液法制备盐酸雷尼替丁-β-环糊精包合物，并用红外光谱、X-射线衍射进行鉴定。结果：盐酸雷尼替丁-β-环糊精包合物主、客分子比为2∶1，平均包药量为12.41%±0.15%，平均收率75.8%±3.8%。结论：盐酸雷尼替丁-β-环糊精包合物可掩盖其不良嗅味。     

吡罗昔康与β-环糊精包合物的制备与鉴定

 本文采用搅拌法制备吡罗昔康与β-环糊精（β-CD）包合物。制备包合物的最佳搅拌时间为5.5h；3批包合物含量均为22~23%；包合物的主、客分子比为1:1。样品用X -射线衍射法及NMR法測定证明炎痛喜康与β-CD确己形成包合物，炎痛喜康的笨环部分被包入β-CD空腔内。     

酮康唑β-环糊精包合物的制备

 目的 探讨应用β-环糊精包合技术提高酮康唑溶解度和稳定性的方法。方法 采用混合搅拌法制备酮康唑β-环糊精包合物,经薄层色谱、X-衍射及差热分析图谱等鉴定,确证为包合物。结果 制备包合物的最佳主客分子摩尔比为1∶1,最佳搅拌时间为5 h,6批包合物包合率在71.59%～73.63%之间。结论 酮康唑β-环糊精包合物可提高酮康唑的溶解度和稳定性。     

莫诺苯腙与β-环糊精及羟丙基-β-环糊精包合作用的研究

 目的考察莫诺苯腙(MB)与β-环糊精(β-CD)及羟丙基-β-环糊精(HP-β-CD)的包合作用。方法采用紫外分光光度法测定莫诺苯腙含量,相溶解度法研究了β-CD及HP-β-CD对莫诺苯腙的包合作用、增溶作用及包合过程中热力学参数变化。结果莫诺苯腙与两种环糊精在包合过程中的吉布斯自由能变化(△G)、焓变(△H)和熵变(△S)均为负值。形成包合物后,莫诺苯腙的溶解度和溶出速率显著增加,HP-β-CD对莫诺苯腙的增溶作用强于β-CD,而莫诺苯腙β-CD的稳定常数高于HP-β-CD包合物。结论莫诺苯腙与两种环糊精在水溶液中均可自发形成1∶1(物质的量的比例)可溶性包合物,从而增加了其溶解度,所有包合过程为放热反应。HP-β-CD对莫诺苯腙的增溶作用强于β-CD,而莫诺苯腙β-CD的稳定常数高于HP-β-CD包合物。     

姜黄素-β-环糊精包合物的制备与验证

姜黄素是从中药黄中提取的一种酚类化合物,并被认为是姜黄的主要成分,具有抗炎、抗痒化、抗肿瘤、利胆的药理作用[1].     

救心油β-环糊精包合物的研究

利用β-环糊精对救心油进行包合,考察温度、投料比、时间等因素对包合的影响,用气相色谱法对包合物进行含量测定,选出最佳制备工艺,经差示扫描量热分析法和粉末X-射线衍射法鉴定,证明包合物确已形成。     

苯佐卡因-β-环糊精包合物的研究

 本文利用β-环糊精（cyclodextrin，简称β－C D）的特性，制备了苯佐卡因－β－CD包合物（简称包合物），经粉末X线衍射图谱鉴定，确证为包合物。经实验证明：包合物明显提高了客分子苯佐卡因的稳定性，增加了溶解度．并推断此包合物是以1：1（β-CD：苯佐卡因）主客分子相包合。     

羟丙基-B-环糊精对降香挥发油包合作用的研究

目的研究降香挥发油的羟丙基-β-环糊精包合物的制备方法及包合物的验证.方法采用水溶液搅拌法制备降香挥发油的羟丙基-β-环糊精包合物,采用HPLC法测定降香挥发油和包合物的水溶液中反式-橙花叔醇,并经薄层色谱、差示热分析、相溶解度法、核磁共振、扫描电镜法对包合物进行验证.结果降香挥发油已和羟丙基-β-环糊精形成包合物.结论羟丙基-β-环糊精可以包合降香挥发油,使降香挥发油溶解度提高41倍.     

Preliminary studies on the inclusion compound of cholate with beta-cyclodextrin

beta-Cyclodextrin inclusion compound has been proved able to eliminate the bitter taste of cholate and bile. A right amount of beta-cyclodextrin put in aqueous solution of cholate and bile will remove the bitter taste completely, beta-Cyclodextrin doesn't affect the identification or content determination of cholic acid.     

Stability examination of beta-cyclodextrin inclusion compound of Zingiber officinale volatile oil]

Based on different storage time and different methods, examination has been conducted of the appearance, properties contents and main constituents in the beta-cyclodextrin inclusion compound of Zingiber officinale volatile oil. The result shows that the oil with inclusion proves considerably more stable than that without inclusion.     

冬凌草甲素—β—环糊精包合物的研究

采用沉淀法制备冬凌草素-β-环糊精包合物,通过差示扫描量热法、薄层层析及比旋光度的测定得以证实。用连续递变法测定了包合物组成的摩尔比。     

毛叶香茶菜醇—β—环糊精包合物的制备

在水溶液中制备了毛叶香茶菜醇-β-环糊精包合物,通过差示扫描量热法、薄层层析及比旋光度的测定得以证实。测定了紫外吸收光谱,用连续递变法测定了包合物组成的摩尔比。     

Study on the inclusion compound of qucertin with hydroxypropyl-beta-cyclodextrin]

The inclusion compound of qucertin-HP-beta-CD was manufactured by aqueous solution-stirring method. The inclusion compound of qucertin-HP-beta-CD was confirmed by IR spectroscopy and differential theramal analysis (DTA). The results indicated that the inclusion compound of qucertion-HP-beta-CD was formed. The content analysis of the inclusion compound showed that the molecular ratio of qucertin to HP-beta-CD was 1:1. The solubility of qucertin increased when the drug was included by HP-beta-CD, which in water has added from 0.0392 mg/ml to 34.227 mg/ml.     

Application of beta-cyclodextrin inclusion technique in new dosage form of angelica sinensis essential oil]

OBJECTIVE: To make a solid form of Angelica Sinensis essential oil by preparing its inclusion compound with beta-cyclodextrin and evaluate the inclusion rate, dissolution rate and liberating rate of this complex. METHOD: GC-MS, X-ray diffraction and thin-layer chromatography were applied to characterize the essential oil and the inclusion compound. RESULT: The inclusion compound was shown to form a new phase by X-ray diffraction analysis. GC-MS and TLC check-up corroborated the composition of the free oil and the inclusion oil remaining the same. CONCLUSION: The results showed Angelica Sinensis essential oil was more stable with beta-cyclodextrin inclusion. The preparation of this inclusion compound has advantages in limited amount, long time effect, easily preserved and convenient administration as a new dosage form.     

Stability examination of the inclusion compounds of 8 Chinese medicinal volatile oils with beta-cyclodextrin

The content, hence the stability of volatile oils and their main components in the inclusion compounds of 8 Chinese medicinal volatile oils with beta-cyclodextrin have been examined with different storage times. The 8 Chinese medicines are Vitex negundo var. heterophylla, Notopterygium incisum, Alpinia officinarum, Atractylodes lancea, Pogostenon cablin, Asarum heterotropoides var. mandshuricum, Schizonepeta tenuifolia and Amomum villosum.     

β-环糊精与盐酸黄连碱包合物的制备及其结构研究

目的:优化盐酸黄连碱/β-环糊精(β-CD)包合物的制备工艺,表征包合物结构。方法:以包合温度、包合时间、冷却时间为考察因素,以盐酸黄连碱的包合率为考察指标进行工艺的优选;对包合物结构进行UV-Vis、DSC1、H-NMR表征以及增溶性实验。结果:包合最佳工艺为:β-CD(mol)∶盐酸黄连碱(mol)=2∶1,40℃,包合时间为2 h,冷却时间为3 d,盐酸黄连碱的包合率达到90.64%;UV-Vis表征得到二者的包结常数为3.11×106M-1;DSC表征说明包合物的形成大大提高了盐酸黄连碱的热稳定性;1H-NMR表征说明盐酸黄连碱的苯环进入了β-CD的空腔;而增溶性实验表明包合物的形成促进了盐酸黄连碱在水中的溶解度。结论:β-CD可以与盐酸黄连碱形成2∶1的稳定包合物,并提高了盐酸黄连碱的生物利用度。     

薄荷醇及其二组分系统对双氯芬酸钠的促透作用

 目的：以双氯芬酸钠作为模型药物，通过研究薄荷醇及其二组分系统对双氯芬酸钠的促透作用，比较薄荷醇与其二组分系统对某些药物促进作用的强弱。方法：采用两室扩散池体外实验装置，以兔皮为屏障，使用薄荷醇及其二组分系统，作为促透剂，测定双氯芬酸钠的渗透系数。结果：单独使用丙二醇、薄荷醇和月桂氮艹（上）卓（下）酮的药物渗透作用没有它们与薄荷醇联合使用时明显。结论：薄荷醇-月桂氮艹（上）卓（下）酮、薄荷醇-丙二醇系统能增加药物的皮肤通透性。