含NovaMin生物活性材料的牙膏抗牙本质过敏的临床试验

目的评价含NovaMin生物活性材料的牙膏对牙本质过敏的临床效果.方法遵照随机、双盲、对照的原则.按纳入和排除标准将75名受试者随机分成3组实验组含NovaMin生物活性材料的牙膏;阴性对照组不含NovaMin生物活性材料的牙膏和阳性对照组临床已证明抗过敏有效的牙膏.采用VAS记分评价空气刺激以及冷水刺激4颗过敏牙的的敏感程度.结果使用牙膏6周后,试验组和阳性组可显著减少牙本质过敏症状.试验组经空气刺激和冷水刺激的VAS 记分降低率分别为22%和39%,阳性试验组经空气刺激和冷饮水刺激的VAS 记分分别降低了19%和22%.阴性组使用六周后,VAS记分无显著性差异(P>0.05).结论含NovaMin生物活性材料的牙膏和阳性组牙膏有抗牙本质过敏的临床效果.     

Anti-gingivitis effect of a dentifrice containing bioactive glass (NovaMin) particulate

BACKGROUND: The objective of this pilot clinical trial was to evaluate the anti-gingivitis and anti-plaque effects of a dentifrice containing bioactive glass (NovaMin) compared with a placebo control dentifrice in a 6 weeks clinical study. METHODS: The study design was a randomized, double-blinded, controlled clinical trial. One hundred volunteers took part in the study and were matched for plaque index (PLI), gingival bleeding index (GBI), age and gender. The protocol was reviewed and approved by the Ethical Committee of the University. The subjects received a supragingival prophylaxis to remove all plaque, calculus and extrinsic stain. Following the baseline examination, subjects were instructed to brush with their assigned dentifrice and toothbrush. The PLI and GBI were determined for the baseline and 6 weeks. The data were analysed using a repeated-measures anova conducted on the two dependent measures to compare the effect between the test and control group. RESULTS: Ninety-five subjects finished the study. The results showed that the PLI (baseline=1.54, 6 weeks=1.29) and GBI (baseline=1.14, 6 weeks=0.47) were significantly reduced, respectively, over the 6 weeks period in the test group (p<0.001 for each measure). There was a 58.8% reduction in gingival bleeding and a 16.4% reduction in plaque growth. There was no difference of the PLI (baseline=1.60, 6 weeks=1.57) and GBI (baseline=1.18, 6-week=1.02) over the 6 week period in the control group. CONCLUSION: This study demonstrated that a dentifrice containing NovaMin significantly improves oral health as measured by a reduction in gingival bleeding and reduction in supragingival plaque compared with a negative dentifrice over the 6 weeks study period.     

Dentine hypersensitivity and the placebo response

Abstract A considerable number of varied agents are apparently effective in the treatment of dentine hypersensitivity. In particular, the literature supports the efficacy of strontium, potassium and fluoride containing toothpastes. This study was a double-blind, randomised, parallel group comparison of three products, namely strontium- and potassium-based desensitising toothpastes both containing fluoride, and a conventional fluoride toothpaste. A total of 131 subjects entered a 4-week wash-in phase using the conventional fluoride toothpaste, of whom 120 entered a 6-week treatment phase. Sensitive teeth were evaluated at wash-in baseline, treatment baseline and after 2 and 6 weeks use of the treatment pastes. Dentine hypersensitivity was assessed with tactile and cold air stimuli together with an overall subjective assessment. Analysis of the findings was performed using non-parametric statistical methods. Of the original 120 subjects, 112 completed the trial. All 3 toothpaste groups showed reductions in sensitivity over the 6 weeks; however, no significant differences were found between the three products at any given time. Interestingly, there was no significant change in sensitivity between wash-in baseline and treatment baseline for the cold air stimulus with the fluoride-only-based paste. However, for the group using the same fluoride toothpaste, there was significant improvement between wash-in baseline and week 6, and treatment baseline and week 6 for this stimulus, suggesting a substantial placebo effect occurred. There is a need for further investigation of a wash-in period and examination of the placebo effect when evaluating dentine hypersensitivity trials.     

Clinical evaluation of a potassium nitrate dentifrice for the treatment of dentinal hypersensitivity

Abstract The effectiveness of a 5% potassium nitrate dentifrice as a daily home treatment for dentinal hypersensitivity was evaluated in a double-blind study in 36 Japanese subjects who complained of cold and/or tactile hypersensitivity. The subjects were divided into 2 groups, with 18 being given a 5% potassium nitrate dentifrice (treated group) and the other 18 a vehicle paste (control group). Both groups were instructed to brush their teeth 2 × a day. The hypersensitivity levels of the affected teeth were assessed by 2 stimuli, one tactile and the other cold air, and by the perception of pain. The results of all 3 assessment methods indicated that the potassium nitrate dentifrice significantly decreased the level of hypersensitivity at weeks 4, 8, and 12. In the treated group, a rapid decrease of positive scores for both the cold air stimulus and the subjective symptoms appeared from week 2. Although a significant decrease of the assessment score was also observed in the control group, the reduction rate of the score was much greater in the treated group by ail 3 assessment methods at weeks 4, 8, and 12. Complete relief of subjective symptoms throughout the 12 weeks’examination was noted in 67% of the subjects in the treated group, but in only 6% in the control group. These results suggest the usefulness of a 5% potassium nitrate dentifrice in Japanese patients with dentinal hypersensitivity.     

The Effectiveness of a Calcium Sodium Phosphosilicate Desensitizer in Reducing Cervical Dentin Hypersensitivity

BackgroundNovaMin (NovaMin Technology, Alachua, Fla.) was introduced into the dental market as a desensitizer in December 2004. However, to the authors' knowledge, no researchers yet have evaluated the effectiveness of 100 percent NovaMin powder with NovaMin-containing toothpaste in reducing dentin hypersensitivity compared with the effectiveness of NovaMin-containing toothpaste only and a desensitizing toothpaste containing potassium nitrate as a control.MethodsThe authors divided 60 participants randomly into three groups: NovaMin powder with NovaMin-containing toothpaste (group 1), a placebo powder with NovaMin-containing toothpaste (group 2) and a placebo powder with the control toothpaste (group 3). The authors used tactile and cold stimuli and a visual analog scale to evaluate participants' pain at baseline, immediately after powder application and at one week, two weeks and four weeks after powder application. They analyzed data by using Friedman and Wilcoxon signed-rank tests for within-group comparison. They used Kruskal-Wallis and Mann-Whitney U tests for between-group comparison. They considered P < .05 to be statistically significant.ResultsGroups 1 and 2 showed significant hypersensitivity reduction over baseline at all time points. Group 3 showed significant hypersensitivity reduction at one week onward. Group 1 showed significant improvement compared with groups 2 and 3, except for response to tactile stimulus at four weeks with group 2. Between groups 2 and 3, there were significant differences at two and four weeks.Conclusions and Clinical ImplicationsThe use of NovaMin powder and NovaMin-containing toothpaste for hypersensitivity reduction is more effective than the use of a desensitizing toothpaste containing potassium nitrate and fluoride.     

Efficacy of a 3% potassium nitrate desensitizing mouthwash in the treatment of dentinal hypersensitivity.

BACKGROUND: Potassium nitrate has been used previously in a dentifrice or gel to alleviate dentinal hypersensitivity. The aim of this study was to compare a 3% potassium nitrate/0.2% sodium fluoride mouthwash with a 0.2% sodium fluoride control mouthwash in a 6-week double-blind study. METHODS: Fifty subjects were evaluated using 2 tactile methods and cold air sensitivity (dental air syringe), along with subjective perception of pain (0 to 10 scale) at baseline and at 2 and 6 weeks. RESULTS: There was a general decrease in dentinal hypersensitivity levels in both groups over the 6-week study period as demonstrated by all 4 methods of assessment. There was also a statistically significant difference in decrease in sensitivity between the groups. CONCLUSIONS: This study showed that a 3% potassium nitrate/0.2% sodium fluoride mouthwash appears to have therapeutic potential to alleviate dentinal hypersensitivity.     

Efficacy of strontium chloride in dental hypersensitivity

Controlled stimuli were used to evaluate a commercially available dentifrice containing 10% strontium chloride hexahydrate for efficacy in alleviating the symptoms of uncomplicated dentinal hypersensitivity. Sixty-one subjects with hypersensitivity were included in the 12-week, double-blind, parallel, comparative (placebo) study. Levels of hypersensitivity in affected teeth were assessed by three methods: thermally controlled cold air stimulus, tactile stimulus with an electronic pressure sensitive probe, and subjective response. The results from all three methods of assessment indicated that the strontium chloride dentifrice, in comparison with a placebo, reduced dentinal hypersensitivity to a significantly greater degree. This therapeutic response to the active agent was apparent within 2 weeks and increased continuously thereafter for the length of the study. One can conclude that the regular at-home use of a dentifrice containing 10% strontium chloride hexahydrate is an effective means for reducing the discomfort and pain engendered by thermal and tactile stimuli in patients with dentinal hypersensitivity.     

NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床研究

目的：评价NovaMin生物活性玻璃离子牙膏抗牙菌斑和牙龈炎的临床功效。方法：遵照随机、双盲、对照的试验原则,按纳入和排除标准将100名年龄在20～48岁的受试者随机分成试验组（使用NovaMin生物活性玻璃离子牙膏）和空白对照组（使用同一公司生产的普通牙膏）,采用菌斑指数和牙龈出血指数评价受试者的牙龈健康状况。结果：试验组菌斑指数和牙龈出血指数与试验前相比在统计学上有显著性差异,试验6周后牙龈出血指数和菌斑指数分别降低了58．8％和16．4％;而对照组菌斑指数和牙龈出血指数在统计学上无显著性差异（P〉0．05）。结论：本研究提示NovaMin生物活性玻璃离子牙膏能通过减少龈上菌斑和减轻牙龈出血而显著改善牙龈健康状况。     

Comparison of efficacy of three commercially available dentifrices on dentinal hypersensitivity: a randomized clinical trial

Background: Dentinal hypersensitivity has been defined as a short, sharp pain arising from exposed dentine as a result of various stimuli such as heat, cold, chemical, or osmotic, that cannot be ascribed to any other pathology. This study was conducted to assess the efficacy of three commercially available toothpastes in the reduction of dentinal hypersensitivity. Methods: A total of 149 subjects (72 males and 77 females; aged 20 to 60 years) were entered into the study and randomly divided into four groups: Group 1 – toothpaste containing 5% potassium nitrate; Group 2 – toothpaste containing 5% calcium sodium phosphosilicate with fused silica; Group 3 – toothpaste containing 3.85% amine fluoride; and Group 4 – a placebo toothpaste. After sensitivity scores for controlled air stimulus and cold water at baseline were recorded, subjects were given toothpastes and sensitivity scores were measured again at 2 weeks and 6 weeks. Results: All groups showed a reduction in sensitivity scores at 2 weeks and 6 weeks. The calcium sodium phosphosilicate group was found to be significantly better compared to the other groups at the end of 6 weeks. Conclusions: The calcium sodium phosphosilicate group showed a better reduction in the symptoms of dentinal hypersensitivity.     

Clinical effectiveness of a dentifrice containing fluoride and a citrate buffer system for treatment of dentinal sensitivity

Four test dentifrices were evaluated in a double-blind investigation to determine their effect on dentinal sensitivity in 87 adult human participants. Baseline data were obtained by patient questionnaire, dental examination and by soliciting subjective responses to controlled osmotic, thermal and tactile stimuli. The four dentifrices were: (1) a placebo dentifrice, (2) a fluoride dentifrice containing 0.1% fluoride, (3) a 2% citrate buffered dentifrice in a pluronic gel and (4) a dentifrice containing 0.1% fluoride and 2% citrate buffer in a pluronic gel. Precipitated silica provided the abrasive for all dentifrices. Dentifrices were supplied to participants on a random basis, and participants were instructed to brush twice daily for 8 weeks. Responses to the three stimuli as accomplished at baseline were obtained at 2, 4 and 8 weeks on 81 participants. A statistically significant stimulus reduction was found between treatment groups to thermal stimulus at the 2-month interval (P = 0.048) and to the tactile stimulus at 2 weeks (P = 0.019). Both the citrate dentifrice and the citrate/fluoride dentifrices demonstrated significant efficiency in reducing sensitivity.     

美白牙膏去除牙齿外源性色斑的临床效果观察

目的：与仅含有0．321％氟化钠的牙膏相比,评价含有0．321％氟化钠及20％高清洁二氧化硅（HCS）的牙膏减少外源性牙色斑的效果,方法：采用双盲,分层,二单位平行观察的临床研究方法,根据Lobene色斑指数均数（色斑指数包括染色部位及染色程度）,性别,将158名年龄为18－65岁的研究对象平衡地分为两组,随机地分配使用试验或对照牙膏,于基线,第4周及第8周固定由一名检查者完成研究对象的色斑指数测定,结果：4周时,使用美白牙膏的研究对象较对照组的牙齿色斑面积减少17．4％,染色程度减少19．2％（P＜0．01）,8周时,使用美白牙膏的研究较对照组的牙齿色斑面积减少38．6％,染色程度减少39．6％（P＜0．01）,结论：与对照组牙膏相比,使用含有0．321％氟化钠及20％HCS的牙膏可以有效地减少外源性牙色斑。     

The efficacy of a new dentifrice in treating dentin sensitivity: Effects of sodium citrate and sodium fluoride as active ingredients

The purpose of this clinical trial was to study the effectiveness of three new test and one control dentifrice. A total of 120 subjects participated in the study. Measurement of dentin sensitivity consisted of three clinical tests (saturated sucrose solution, cold air blast, and tactile) and a subjective patient assessment. The patients were first stratified by previous treatment attempts and presence of a history of periodontal surgery. Patients were randomly assigned into four groups: 1) dentifrice containing precipitated silica abrasive; 2) dentifrice containing 0.2% sodium citrate buffer in a pluronic gel with precipitated silica abrasive; 3) dentifrice containing 0.2% NaF with precipitated silica abrasive; 4) a formula containing both the 0.2% NaF and the 2% citrate buffer. Neither patients nor examiners were aware of the group assignments. The patients were examined at baseline and after 2 and 4 wk, and 2 months. The efficacy of the new dentifrice system was not established in this investigation nor were the separate efficacies of the major components of the dentifrice. Although subjective and clinical assessments demonstrated a placebo effect, it was present to the same extent for all products, including the placebo.     

含5.53%柠檬酸钾牙膏抗牙本质敏感的临床研究

目的：评价含5.53%柠檬酸钾牙膏减轻牙本质敏感症状的效果。方法：试验遵照随机、双盲、对照试验原则,将65名受试者随机分成试验组（含5.53%柠檬酸钾牙膏）和对照组（普通含氟牙膏）,两组受试者每天刷牙2次共4周。采用视觉模拟评分法（VAS）记,牙敏感症状。数据采用非参数检验进行统计分析。结果：与基线相比,使用牙膏4周后,试验组牙本质敏感VAS记分显著降低（P〈0.05）。与对照组相比,试验组4周后的牙本质敏感VAS记分明显低于对照组（P〈0.01）。83.9%的受试者认为使用该牙膏能缓解牙本质敏感症状;77.4%的受试者愿意继续使用该牙膏脱敏。结论：含5.53%柠檬酸钾牙膏具有显著的抗牙本质敏感效果。     

The effect of adhesive and flowable composite on postoperative sensitivity: 2-week results.

OBJECTIVE: To measure 2-week postoperative sensitivity in Class II composite restorations placed with a self-etching adhesive (Clearfil SE Bond) or a total-etch adhesive (Prime&Bond NT) with or without a flowable composite as cervical increment. METHOD AND MATERIALS: Upon approval by the University of Guarulhos Committee on Human Subjects, 100 restorations were inserted in 46 patients who required Class II restorations in their molars and premolars. Enamel and dentin walls were conditioned with a self-etching primer (for Clearfil SE Bond) or etched with 34% phosphoric acid (for Prime&Bond NT). A 1- to 2-mm-thick increment of a flowable composite (Filtek Flow) was used in the proximal box in 50% of the restorations of each adhesive. Preparations were restored with a packable composite (Surefil). The restorations were evaluated preoperatively and 2 weeks postoperatively for sensitivity to cold, air, and masticatory forces using a visual analog scale. Marginal integrity of the accessible margins was also evaluated. Statistical analysis used a mixed linear model with subject as a random effect. RESULTS: Ninety-eight teeth from 44 subjects were observed at 2 weeks. The type of adhesive and use of flowable composite had no significant effects or interaction for any of the four outcomes of interest, ie, change from baseline to 2 weeks in sensitivity and response time for the cold or air stimulus. For the air stimulus, the overall average change from baseline was not significant for either sensitivity or response time. For the cold stimulus, the overall average change from baseline was significant for both sensitivity and response time. No case of sensitivity to masticatory forces was observed. CONCLUSION: No differences in postoperative sensitivity were observed between a self-etch adhesive and a total-etch adhesive at 2 weeks. The use of flowable composite did not decrease postoperative sensitivity.     

Comparative investigation of the desensitizing efficacy of a new dentifrice containing 5.5% potassium citrate: an eight-week clinical study

OBJECTIVE: This double-blind clinical study was designed to investigate the relative effectiveness of a new desensitizing test dentifrice containing 5.5% potassium citrate, 1.14% sodium monofluorophosphate (MFP) and 10% high-cleaning silica (HCS) in a silica base for reducing dentinal hypersensitivity over an eight-week period, to that of a commercially available desensitizing positive control dentifrice containing 3.75% potassium chloride, 0.32% sodium fluoride and 0.3% triclosan in a silica base. METHODOLOGY: A total of 80 subjects were entered into the study, and stratified into two balanced groups according to their baseline mean thermal (air blast) and baseline mean tactile (Yeaple Probe) sensitivity scores. The two groups were randomly assigned to use either the test dentifrice containing potassium citrate/MFP/HCS, or the positive control dentifrice containing potassium chloride/sodium fluoride/triclosan. The two groups were well balanced with regard to their mean baseline thermal and tactile sensitivity scores, sex and age. Subjects were instructed to brush their teeth twice daily (morning and evening) for one minute with their assigned dentifrice and a commercially available soft-bristled toothbrush. Dentinal hypersensitivity examinations, which included tactile sensitivity and thermal sensitivity, were conducted at baseline, four weeks, and eight weeks. Examinations were conducted by the same dental examiner on the subjects at each examination. RESULTS: After four weeks' use of their assigned products, those subjects in the test dentifrice group demonstrated no statistically significant difference for controlling dentinal hypersensitivity as compared to the positive control dentifrice group in tactile and air blast. After eight weeks' use of their assigned products, those subjects in the test dentifrice group again demonstrated no statistically significant difference in tactile and air blast sensitivity as compared to the positive control dentifrice group. CONCLUSION: The results of this double-blind clinical study indicate that the use of a commercially available test dentifrice containing 5.5% potassium citrate, 1.14% sodium monofluorophosphate and 10% high-cleaning silica in a silica base demonstrates no statistically significant difference in tactile and air blast sensitivity compared to the commercially available desensitizing positive control dentifrice containing 3.75% potassium chloride, 0.32% sodium fluoride and 0.3% triclosan in a silica base.     

Dentifrice abrasivity and cervical dentinal hypersensitivity. Results 12 weeks following cessation of 8 weeks' supervised use.

Following an 8-week controlled investigation of 2 strontium chloride hexahydrate dentifrices (SCH) of differing abrasivity, 2 groups of 20 subjects each, with cervical dentinal hypersensitivity, were re-examined at 20 weeks; that is, 12 weeks after the active period. The examination procedures were conducted in the same manner as in the main clinical trial. Sensitivity levels were assessed by 2 instrument methods: tactile (Yeaple probe), and cold air (dental air syringe), and by subjective perception of pain by means of a Visual Analogue Scale. The results from these methods of assessment demonstrated that 12 weeks following the cessation of 8 weeks' controlled use of standard and low abrasive SCH dentifrices, sensitivity levels reversed on slightly in both groups and, overall, sensitivity remained significantly lower than at baseline. The abrasivity of the dentifrice did not affect the desensitivity activity.     

A 3‐Day Randomized Clinical Trial to Investigate the Desensitizing Properties of Three Dentifrices

Background: The aim of the present study is to evaluate the relative abilities of three desensitizing dentifrices to provide rapid relief of dentin hypersensitivity (DH). Methods: Using a double‐mask, randomized design, three dentifrices: 1) containing 8% arginine and 1,450 ppm sodium monofluorophosphate; 2) containing 8% strontium acetate and 1,040 ppm sodium fluoride; and 3) containing 30% microaggregation of zinc‐carbonate hydroxyapatite nanocrystals were compared after 3‐day treatment. Participant's DH was evaluated at baseline and after 3 days using air‐blast, tactile, cold water, and subjective tests. Results: The final sample consisted of 85 individuals: 29 received the arginine‐based dentifrice (group 1), 27 the strontium acetate–based dentifrice (group 2), and 29 the dentifrice based on zinc‐carbonate hydroxyapatite (group 3). All dentifrices were mostly effective to reduce DH: the percentage of score reduction from baseline to 3 days was >30% for all tests (except for subjective test of group 2). The comparison among the three dentifrices showed that, after 3 days, there was an improvement in air‐blast (mean percentage of reduction, 39.2% in group 1, 42.0% in group 2, and 39.2% in group 3), cold water (41.5%, 51.8%, and 50%), tactile (50.3%, 40.1%, and 33.8%), and subjective (33.1%, 17.4%, and 31.4%) test scores, with differences being significant for cold water and subjective tests. For air‐blast and tactile tests, there were no significant differences across groups at 3 days. Moreover, no significant differences at any test were observed in a subset of patients that were followed up to 8 weeks: all dentifrices were all highly efficacious. Conclusions: This study documents that the three tested dentifrices significantly reduced DH after 3‐day treatment, supporting their use in clinical practice. To the best of the authors’ knowledge, this is the first report documenting the rapid relief from DH of a zinc‐carbonate hydroxyapatite dentifrice.     

Effect of a desensitizing dentifrice on dentinal hypersensitivity

Abstract The objective of this study was to assess the effectiveness of a dentifrice with 2% dibasic sodium citrate in poloxamer 407 in decreasing dentinal hypersensitivity. The test toothpaste was compared with a control toothpaste containing 0.76% sodium monofluorophosphate in a 6-week double-blind clinical trial. A total of 75 hypersensitive teeth were examined in the test group, while 100 hypersensitive teeth were in the control group. Changes in hypersensitivity levels were monitored after 6 weeks, using thermal, chemical and mechanical stimuli. At the end of 6 weeks, the test dentifrice was not significantly more effective than the control in decreasing dentinal hypersensitivity. Of the stimuli used, cold was the most effective in eliciting a hypersensitive response, followed by chemical stimulation and air. Heat and toothbrushing caused the least discomfort.     

Effect of oxybenzone on PGE2-production in vitro and on plaque and gingivitis in vivo

OBJECTIVES: To study the effect of oxybenzone on prostaglandin E2 (PGE2) production in cell culture and to evaluate the effect of an oxybenzone-containing dentifrice on plaque and gingivitis in a 6-week clinical trial. MATERIAL AND METHODS: Human embryo palatal mesenchyme (HEPM) cells were used for testing the inhibition of IL-1beta-stimulated PGE2-production in vitro by different concentrations of oxybenzone. For the in vivo study, a total of 66 individuals with a Quigley & Hein plaque index of at least 1.5 and an Ainamo & Bay gingival index of at least 0.2 were included in a double-blind clinical trial with two cells and a parallel design. Two compositions of fluoride dentifrice were used, one with the addition of 0.5% oxybenzone, and one without. Plaque and gingival index were obtained at three time points: (1) at baseline, (2) after 3 weeks, and (3) after 6 weeks. RESULTS: A dose-dependent inhibition of PGE2-production was found in the HEPM cell culture following oxybenzone exposure. In the clinical trial, a 25% reduction of gingival index was observed in the oxybenzone group (p<0.001) after 6 weeks as compared with 2% for the placebo group. CONCLUSIONS: These findings indicate that PGE2-production is reduced by oxybenzone in vitro and that the use of oxybenzone in a dentifrice reduces gingivitis in vivo.     

Efficacy of a potassium nitrate mouthwash in alleviating cervical dentine sensitivity (CDS)

Abstract Potassium nitrate (KNO₃) has been used previously in a dentifrice or gel to alleviate cervical dentine sensitivity (CDS). The aim of this study was lo compare a 3% KNO₃ Silica/NaF mouthwash with a NaF/silica mouthwash in a 6-week multi-centre double-blind study. 47 subjects (12M; 35F. mean age 36.2 ISD 11.46) years) participated in the study. Subjects were evaluated for tactile (Yeaple probe) and air sensitivity (dental air syringe) together with subjective perception of pain (0–10 scale) at 0. 2 and 6 weeks. Results for Yeaple probe (gm wt) (Wilcoxon paired rank test) between 6 weeks and baseline, were highly significant for both groups. Differences between groups at 6 weeks were statistically significant. Subjective Yeaple probe scores (paired t-tests) between 6 weeks and baseline were significant for both groups. There were no significant differences (unpaired t-tests) between groups over 6 weeks for subjective Yeaple probe scores. Subjective air scores (paired t-tests) between 6 weeks and baseline were significant for both groups. There were significant differences (unpaired t-tests) between groups in favour of the 3% KNO₃./Silica/NaF group at 6 weeks. The 2 weeks and baseline results for both groups were the same as reported for 6 weeks and baseline. The results demonstrated that a 3% KNO₃/Silica/NaF mouthwash compared to a Silica/NaF control significantly reduced CDS when evaluated by tactile and thermal stimuli. A 3% KNO₃/silica/NaF mouthwash would, therefore appear to have therapeutic potential to alleviate CDS.