药物配合超短波治疗盆腔炎的疗效观察

目的 超短波电疗仪对治疗盆腔炎的疗效观察.方法 对我院2004年1月～2005年12月170例盆腔炎患者进行分组研究.结果 从观察指征中经统计学处理均有显著意义(P＜0.001).结论 超短波电疗仪在治疗盆腔炎中明显优于对照组,值得临床(特别是基层医院)大力推广应用.     

曲安奈德囊内注射+超短波电疗仪治疗耳郭假性囊肿的疗效分析

目的用曲安奈德囊内注射和超短波电疗仪治疗耳郭假性囊肿观察其疗效。方法选取耳郭假性囊肿患者165例分成治疗组和对照组,治疗组进曲安奈德囊内注射+超短波电疗仪治疗,对照组行超短波电疗仪治疗,观察其疗效。结果 2组中曲安奈德囊内注射+超短波电疗仪治疗治愈率明显高于对照组。结论曲安奈德囊内注射+超短波电疗仪治疗耳郭假性囊肿有非常好的治疗效果。     

针刺、电脑中频、电针综合治疗腰椎间盘突出症

目的观察腰部夹脊穴电针、电脑中频电疗仪治疗、针刺腰部夹脊穴及电针结合电脑中频电疗仪治疗腰椎间盘突出症的疗效。方法将108例腰椎间盘突出症患者,分别采用腰部夹脊穴电针、电脑中频电疗仪治疗、针刺腰部夹脊穴及电针结合电脑中频电疗仪治疗3种治疗方法,并进行疗效比较分析。结果 3种方法治疗腰椎间盘突出症都取得了较满意的疗效,腰部夹脊穴电针总有效率(66.67%)、电脑中频电疗仪治疗总有效率(61.1%)、针刺腰部夹脊穴及电针结合电脑中频电疗仪治疗治疗总有效率(100%),但综合治疗效果更好(P<0.0125)。结论将电针、电脑中频电疗仪治疗及针刺腰部夹脊穴综合在一起,可以提高疗效,缩短疗程,是腰椎间盘突出症保守疗法中具有较高实用价值的治疗方法。     

超短波治疗小儿急性支气管炎42例疗效观察

我们在药物抗炎的基础上,加用超短波治疗４２例,取得较优疗效,现报道如下。１ 一般资料１．１ 病例资料：８２例均为我院儿科２０００年２月～２００１年２月确诊的患者,随机分为超短波观察组和单纯药物对照组。超短波观察组男２２例,女２０例;年龄１月～１岁１５岁,～３岁１６例,～６岁４例,～１２岁７例。单纯药物对照组男２２例,女１８例;年龄１月～１岁１０例,～３岁１６例,－６岁５例,－１２岁９例。１．２ 治疗方法：超短波观察组采用广东汕头市医用设备厂生产的ＤＬ—Ｃ—Ｂ型超短波电疗仪,选择输出调节１、电源电压…     

浅谈盐酸氨溴索注射液在儿科呼吸系统疾病治疗中的效果观察

目的对盐酸氨溴索注射液在儿科呼吸系统疾病治疗中的效果进行观察分析。方法 90例呼吸系统疾病患儿,随机分为观察组及对照组,各45例。对照组采用布地奈德治疗,观察组采取盐酸氨溴索注射液治疗,对比两组患儿的治疗效果。结果观察组治疗总有效率(95.56%)明显优于对照组(82.22%),差异具有统计学意义(P<0.05)。结论采用盐酸氨溴索注射液治疗儿科呼吸系统疾病具有良好的效果,值得临床推广。     

在社区中运用盐酸氨溴索注射液治疗儿童呼吸系统疾病的临床效果

目的:对社区运用盐酸氨溴索注射液治疗儿童呼吸系统疾病的临床效果进行观察和分析.方法:以2015～2016年社区收治的100例呼吸系统疾病儿童患者为研究对象,并采用随机分组的方法分为观察组(n=50)和对照组(n=50),其中,观察组予以盐酸氨溴索静脉注射与雾化治疗,对照组予以常规治疗(非盐酸氨溴索注射液治疗),并观察和比较两组临床治疗效果.结果:观察组治疗有效率(96％)明显高于对照组(80％),观察组不良反应发生率(8％)明显低于对照组(26％),观察组病情复发率(2％)明显低于对照组(16％),差异均具有统计学意义(P<0.05).结论:与常规治疗相比,运用盐酸氨溴索静脉注射及雾化方法治疗儿童呼吸系统疾病具有更好的临床效果,可在临床推广.     

综合治疗腰椎间盘突出症的疗效观察

目的：观察综合治疗腰椎间盘突出症的疗效。方法：将130例腰椎间盘突出症患者随机分成治疗组,采用牵引、电脑中频电疗仪、超短波治疗、卧硬板床、佩戴腰围。对照组采用牵引、TDP（电磁波治疗仪）照射法。结果：治疗组治疗后疗效明显,与对照组相比差异有显著性（P〈0．05）。结论：综合治疗腰椎间盘突出症有较好疗效。     

中西医结合治疗老年呼吸系统疾病的临床分析

目的对中西医结合治疗老年呼吸系统疾病的临床疗效进行分析。方法以本院2011年6月～2012年6月治疗的144例呼吸系统疾病的老年患者为研究对象。对照组使用静脉滴注氨茶碱和菌必治,口服甘氨合剂进行治疗,同时予以对症治疗和支持治疗;在对照组治疗的基础上予以中医辨证治疗的患者纳入观察组。分组治疗后,对两组患者的临床症状消失时间及有效率进行比较,并进行统计学分析。结果观察组患者总有效率为95.8%,高于对照组(81.9%)的总有效率,观察组患者症状消失时间均较对照组有优势,均具有统计学差异(P0.05)。结论中西医结合疗法治疗老年呼吸系统疾病较西医疗法具有疗效显著,住院时间短等优势,值得临床推广使用。     

家庭雾化吸入糖皮质激素治疗小儿呼吸系统疾病的临床观察

目的:探讨家庭雾化吸入糖皮质激素治疗小儿呼吸系统疾病的临床效果。方法:以2017年2月~2018年2月这一时期来我院接受治疗的84例呼吸系统疾病患儿为本次研究观察对象,随机将其中42例设为观察组(开展家庭雾化吸入糖皮质激素治疗),另外42例为对照组(开展常规治疗),对比两组治疗结果。结果:治疗后观察组有效率为95.2%(40/42),对照组有效率为83.3%(35/42),即治疗效果方面相比于对照组,观察组明显较优(P0.05);观察组患儿呼吸不畅、喘息、咳嗽以及胸闷症状消失时间均明显短于对照组(P0.05)。结论:对呼吸系统疾病患儿开展家庭雾化吸入糖皮质激素治疗,治疗效果显著,能快速改善患儿症状,临床应用价值显著。     

痛点注射联合中频电疗仪促进脑卒中患者功能康复的应用效果

目的 探讨痛点注射联合中频电疗仪促进脑卒中患者功能康复的应用效果.方法 选取2019年2月至2020年12月广东省英德市人民医院收治的83例脑卒中患者作为研究对象,按照随机数字表法分为对照组(41例)和观察组(42例).对照组予以患者中频电疗仪治疗,观察组在对照组基础上实施痛点注射治疗技术,均干预4周.比较两组的疼痛评...     

我院合理用药监控工作开展情况与成效

目的:促进临床合理用药。方法:根据我院实际情况,按用药前、用药中、用药后监控的三步法,制定一整套合理用药监控体系,监控工作核心是规避"三超"(超适应证、超剂量、超疗程)现象和合理使用围手术期抗菌药物,工作对象主要是临床医师,以减少不合理用药现象的发生。结果与结论:通过实施监控,近3年来医院药品收入占业务总收入比例逐年下降,达到等级医院目标要求(小于45%),切实促进了临床合理用药,并在一定程度上减轻了患者的经济负担。     

鼻内窥镜联合低温射频等离子消融术微创治疗鼻中隔偏曲并鼻甲肥大疗效分析

目的探讨鼻内窥镜联合低温射频等离子消融术微创治疗鼻中隔偏曲并鼻甲肥大的手术治疗方法及其疗效。方法对36例鼻中隔偏曲并一侧或双侧下鼻甲和中鼻甲肥大的患者，应用鼻内镜下鼻中隔偏曲矫正手术，低温射频等离子对肥大鼻甲消融微创治疗。结果36例患者均能在局麻下完成治疗，随访3个月以上，该方法能彻底矫正鼻中隔偏曲，有效的缩小肥大鼻甲，术后患者鼻塞、头痛改善或消失，无并发症发生。结论鼻内窥镜联合低温射频等离子消融术微创治疗鼻中隔偏曲并鼻甲肥大效果明显，创伤小，安全，有较好的临床应用价值。     

Metastatic signet ring adenocarcinoma: an unusual cause of cardiac constriction

Pericardial constriction secondary to metastatic adenocarcinoma is exceedingly rare. We present the first recorded case of pericardial constriction secondary to metastatic signet-ring mucinous adenocarcinoma diagnosed by echocardiography. The cornerstones of echocardiographic diagnosis of constriction are the following: interventricular septal bounce phasic with respiration, M-mode recordings of the inferior vena cava, and the characteristic Doppler velocity patterns recorded from the mitral valve, hepatic veins, and mitral annulus.     

2010-2020年有关假劣药认定检验研究进展

目的：梳理分析假劣药认定检验研究现状和存在的薄弱环节,为下一步完善假劣药认定检验工作及开展相关研究提供参考。方法：采取系统综述的方法,对2010~2020年发表的假药、劣药检验相关文献资料进行综合分析。结果与结论：关于假劣药认定检验的研究报道不多,关于技术方法方面的内容相对较多,制度机制研究相对较少。做好假劣药认定检验工作,除了需要药品检验机构积极开发应用新技术新方法提升假劣药认定检验能力之外,还需要加强制度机制方面的研究,完善假劣药认定检验相关法规制度,明确检验报告在认定假劣药中的法律作用,健全药品检验机构之间的协作及与药监部门、司法机关的衔接机制,共同提升假劣药认定检验的效率和效果。     

Effects of Different Monoamine Oxidase Inhibitors on Respiratory Activity in Rats with Chronically Impaired Central Serotonergic Function

Abstract: Resting and CO₂ stimulated respiration were measured by means of a whole-body plethysmograph in rats lightly anaesthetized with halothane. Rats pretreated neonatally with intracisternal 5,7-dihydroxytryptamine (5,7-DHT) to destruct permanently central serotonergic neurones had significantly lower resting and CO₂ stimulated respiratory frequency (RF) and minute volume (V_M) than naive rats. In the 5,7-DHT pretreated rats, but not in naive rats, the monoamine oxidase inhibitors clorgyline and pargyline further reduced both resting and CO₂ stimulated RF and Vm, whereas 1-deprenyl stimulated respiration. The results provide additional evidence that monoaminergic mechanisms are involved in central modulation of respiration in which activation of a serotonergic neuronal system depresses, and dopaminergic activation stimulates respiration.     

从落实《药品管理法》角度探讨假劣药认定检验的管理

目的:为药品检验机构等相关单位落实《药品管理法》,规范高效开展假劣药认定检验提供参考.方法:通过对比研究、文献研究和政策分析,从假劣药定义、认定依据等方面的变化,分析新修订《药品管理法》对假劣药认定检验的影响,以及假劣药认定检验实际工作中面临的问题和挑战,提出落实《药品管理法》做好假劣药认定检验的建议.结果:新修订《药...     

An in vitro pulmonary permeation system with simulation of respiratory dynamics

To study the effect of respiration on transpulmonary permeation kinetics of drugs, an in vitro pulmonary permeation system, which consists of a setup for the simulation of respiratory dynamics, was developed. The system is composed offour major components: a pair of horizontal-type half-cells, a model air-blood barrier, an instrument for the application and regulation of respiratory pressure, and a pressure monitoring system. Calibration studies were performed and results showed that the primary respiration parameters (the peak inspiration pressure, respiratory frequency, and the percent inspiration time) can be controlled at a reproducible manner. This system appears to simulate very well the respiratory dynamics observed normally under physiologic conditions. After calibration, the system was utilized to characterize and quantitate the effect of respiration on the transpulmonary permeation of drugs using progesterone as the model drug. The results showed that progesterone permeability is increased as much as 1.8-5.6 folds by application of a respiratory pressure, depending on the combination of respiration parameters. Further studies demonstrated that the enhancement in pulmonary permeation triggered by respiratory pressure is resulted from the stretching of the lung tissue, not by the pressure gradient itself. The observations lead to the conclusion that the system developed in this investigation is a useful in vitro tool for studying the kinetics of pulmonary drug permeation under a physiologically simulating respiratory dynamics. The studies have provided scientific evidence for demonstrating that respiration is an important factor in determining the kinetics of transpulmonary drug permeation through possible alteration in the properties of the air-blood barrier.     

荫风轮总苷的一般药理学试验研究

目的观察荫风轮总苷(TSY)药效学以外的药理作用, 为临床用药提供参考.方法观察用药前后大鼠、小鼠自主活动行为能力,家猫呼吸频率、呼吸深度,狗血压、心率、心电图和大鼠、家兔子宫活动.结果用药后大鼠、小鼠自主活动行为能力,家猫呼吸频率、呼吸深度及狗血压、心率均无明显变化, 用药前后比较, 差异无显著性(P > 0.05);但对离体与在体子宫有兴奋作用.结论在药效剂量下荫风轮总苷对大鼠、小鼠的神经系统,家猫呼吸系统及狗的心血管系统系统均无明显影响;其兴奋子宫作用有助于止血药效的发挥.     

The Complexity of the Blood-Brain Barrier and the Concept of Age-Related Brain Targeting: Challenges and Potential of Novel Solid Lipid-Based Formulations

Diseases that affect the Central Nervous System (CNS) are one of the most exciting challenges of recent years, as they are ubiquitous and affect all ages. Although these disorders show different etiologies, all treatments share the same difficulty represented by the Blood-Brain Barrier (BBB). This barrier acts as a protective system of the delicate cerebral microenvironment, isolating it and making extremely arduous delivering drugs to the brain. To overtake the obstacles provided by the BBB it is essential to explore the changes that affect it, to understand how to exploit these findings in the study and design of innovative brain targeted formulations. Interestingly, the concept of age-related targeting could prove to be a winning choice, as it allows to consider the type of treatment according to the different needs and peculiarities depending on the disease and the age of onset. In this review was considered the prospective contribution of lipid-based formulations, namely Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), which have been highlighted as able to overcome some limitations of other innovative approaches, thus representing a promising strategy for the non-invasive specific treatment of CNS-related diseases.     

NIR药品快速检测系统查出一例劣药的情况分析

通过NIR药品快速检测系统查出盐酸洛哌丁胺胶囊掺入诺氟沙星的情况分析，提示药品检测车车载技术人员在NIR药品快速检测系统使用过程中，要注重对检测结果的综合分析，对筛选未通过品种应进行全面检验，从中发现劣药，从而促进NIR药品快速检测系统以查假为主到查假治劣并重的转变，更大限度的发挥该技术高科技打假治劣的优势，提高药品检测车运转效能。