A primitive lymphoma of the uterine cervix. Case report

A case of primitive lymphoma of the uterine cervix is discussed. After two years of vaginal post-coital bleeding, the echography showed the presence of a supraisthmic mass. The patient underwent a total hysterectomy with bilateral salpingo-oophorectomy. The histology was consistent with a B-cell non-Hodgkin's lymphoma (NHL), follicular centre derived. The patient was staged as IIE and treated with six cycles of chemotherapy (CHOP), achieving a complete remission. The paper stresses the value of histology in the diagnosis of lymphoma of the uterine cervix and the effectiveness of the treatment, and reviews the relevant literature.     

Primary malignant lymphoma of uterine cervix

Primary malignant lymphoma of the uterine cervix is a rare disease. Malignant lymphoma can be clinically and histopathologically misdiagnosed for the infrequent presentation in this are. A case of 56-year-old woman with uterine cervical tumor with infiltration to both parametria is presented. A biopsy was performed and histopathological studies reported a large cell B lymphoma. After the diagnosis CT abdominal, pelvic and thoracic scan was performed and shows infiltration to posterior bladder without evidence of disease in lymph nodes or another organ. The patient was treated with chemotherapy and radiotherapy. Six month after finish the treatment is well and free of disease.     

Successful pregnancy following treatment of primary malignant lymphoma of the uterine cervix

A case of primary histiocytic lymphoma in the uterine cervix of a 22-year-old nulligravid woman is reported. To avoid surgical or radiological castration she received six courses of combination chemotherapy (cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, vincristine 2 mg all iv on Day 1 and then together with oral prednisone 50 mg twice daily on Days 1-5). Approximately 20 months after therapy she delivered a healthy child. Six years have passed since primary treatment was initiated. No evidence of recurrent lymphoma has been observed.     

Primary malignant lymphoma of the cervix. A case report

BACKGROUND: Primary malignant lymphoma of the female genital tract is rare. A review of the literature suggests that 1 in 175 extranodal lymphomas in women is likely to originate in the vagina, uterus or cervix. Often the diagnosis of primary lymphoma is not established until after an operation has been performed. Postsurgical treatment is usually chemotherapy alone or followed by radiotherapy. CASE: A 40-year-old woman presented in January 2001 with uterine bleeding. After the patient underwent total abdominal hysterectomy, primary cervical malignant lymphoma was diagnosed. Six courses of chemotherapy were administered in an adjuvant setting. Twenty-seven months (April 2003) after the diagnosis the patient was alive and without signs of recurrent disease. CONCLUSION: Awareness of this rare clinical entity is important because these tumors can present at any age and may mimic squamous cell carcinoma of the cervix clinically and histologically. Abnormal uterine bleeding is the most common presenting symptom of primary malignant lymphoma of the cervix. Extent of disease, size of primary lesion and type of lymphoma are significant prognostic features. Radical surgery is unnecessary. Standard postsurgical treatment has not yet been established.     

Primary aneuploid lymphoma of the uterine cervix: a case report

A primary, diffuse, centroblastic lymphoma of the uterine cervix is described. The patient is a 77-year-old V-parous woman, who presented with postmenopausal bleeding, but no systemic symptoms. Gynecologic examination revealed a 4 x 8-cm tumor extending from the uterine cervix to the anterior vaginal wall and elevating the bladder neck, but with no sign of mucosal infiltration. According to the FIGO classification, the tumor was classified as stage IIIA. Flowcytometric analysis showed a grossly aneuploid tumor, with a DNA content of 3.5c. The S-phase rate was 30.6%. The patient was treated with external pelvic irradiation to 46 Gy. Six weeks later the therapy was completed with seven courses of a cyclophosphamide-vincristine-prednisolone (COP) regimen. Complete tumor response was achieved and 3 years later there is no sign of relapse. Despite unfavorable prognostic parameters: large tumor volume, diffuse growth pattern, aneuploidy, and a high S-phase rate, a combination of radiotherapy and chemotherapy was found to be a successful treatment of this rare form of advanced primary lymphoma of the uterine cervix.     

Primary lymphoma of the uterine cervix

Primary lymphoma of the cervix is very rare. A case report is presented and 24 cases published in the English literature are reviewed. Evaluation, staging, treatment, and prognosis of this rare tumor are discussed.     

Primary malignant melanoma of the uterine cervix: a case report.

We report on a case of a malignant melanoma of the uterine cervix. Histological and immunohistological examinations of a postsurgical specimen revealed malignant melanoma. The junctional activities did not occur due to extensive superficial ulceration. Radical surgery was performed. The patient is doing well and free of symptoms at this time, 2 1/2 year later.     

Primary malignant melanoma of the uterine cervix

A melanoma of the uterine cervix, 4 mm in diameter, considered primary, in a 44-year-old pluripara is described. She was subjected to hysterectomy coupled with adnexectomy and also to BCG immunotherapy. A year following the beginning of the therapy she is without any symptom of the disease. The rarity of the tumour in this localization is pointed out, and a short review is given of the cases reported in the literature, including those of benign melanosis and "blue nevus". The histogenesis and cytologic diagnosis are discussed, as well as therapeutic possibilities. Emphasis is laid on the varying biological behaviour of the tumour which prevents the assessment of the therapy with regard to the possibility of a very late development of metastases.     

Primary malignant lymphoma of the cervix in pregnancy. A case report.

BACKGROUND: Malignant lymphoma arising from the uterine cervix is a very rare entity. Only two such patients have been reported as pregnant at the time of diagnosis. CASE: A 35-year-old woman (negative Pap smear at antenatal clinics) was referred because of the accidental finding of a huge cervical mass during labor. The patient underwent cesarean section because of arrest of cervical dilatation and persistent floating of the fetal head. The final diagnosis of this cervical mass was malignant lymphoma, low grade B cell, after radical abdominal hysterectomy. CONCLUSION: Although labor obstructed by a tumor of the pelvic organs is a relatively rare event and the majority of cases are benign leiomyomas of the uterus or cervix, the risk of pelvic malignancies should be considered. Bimanual examination and pelvic ultrasound and/or color Doppler ultrasound should be applied without hesitancy in any uncertain situation during pregnancy or labor.     

Primary malignant melanoma of the uterine cervix: case report and review of the literature

A case of primary malignant melanoma of the uterine cervix is presented. So far only 26 cases have been reported. Vaginal bleeding was the most common complaint. Total abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy is the elective treatment. Prognosis for this entity is poor. The tumor seems to arise from melanocytes that are usually present in the cervix.     

Primary malignant melanoma of the uterine cervix: case report and review of the literature

Objective: To present a case of malignant melanoma of the uterine cervix and review the medical literature, evaluate the clinical presentations and prognosis, and establish a plan of management for this rare pathology.Methods: A case of cervical malignant melanoma treated at our institution was prospectively followed until her death. An extensive MEDLINE search was then performed to obtain all previous case reports on this entity. Information regarding age, clinical presentation, staging, pathology, lymphnode status, treatment, and survival was reviewed.Results: Our patient is a 70-year old white female who presented with a 4-month history of irregular vaginal bleeding. She was diagnosed with malignant melanoma of the cervix, stage IIa, for which she underwent a modified radical hysterectomy, partial vaginectomy, and pelvic and para-aortic lymph node dissection. She received adjuvant radiation therapy to the pelvis, total dose of 4500 cGy. The patient’s survival was 29 months. There have been only 24 published cases of primary cervical melanoma in the medical literature. The patients’ ages ranged from 39 to 78 years old. The main presenting symptom was vaginal bleeding (67%). The majority of the patients, 58%, presented in early stages (Ia to IIa). Treatment was varied, ranging from a simple excision of a mass to radical hysterectomy with lymph node dissection and adjuvant radiation or chemotherapy. Survival was widespread, even within the same stage.Conclusion: Cervical melanoma is a rare disease of which no prospective or retrospective studies exist, only case reports. Treatment controversies exist. We recommend radical surgical excision to obtain negative margins and lymphadenectomy only for grossly positive nodes. The prognosis is poor and unpredictable.     

Primary non-Hodgkin's lymphoma of the uterine cervix successfully treated by neoadjuvant chemotherapy: case report

INTRODUCTION: Primary non-Hodgkin's lymphoma of the uterine cervix is a rare malignancy. The mainstay of therapy consists of irradiation alone or irradiation with either surgery or chemotherapy. CASE REPORT: We present the case of a 56-year-old woman diagnosed with a bulky, Ann Arbor stage IE, primary, diffuse, large B-cell non Hodgkin's lymphoma of the uterine cervix. We administered neoadjuvant chemotherapy according to CHOP protocol (cyclophosphamide, adriamycin, vincristine, and prednisone) followed by radical hysterectomy, bilateral salpingo-oophorectomy, and regional lymph node dissection. Clinical and pathological responses to the chemotherapy were complete. The patient is alive 5 years after the initial diagnosis. CONCLUSION: Our case emphasizes the importance of neoadjuvant chemotherapy that can provide a control of the distant microscopic metastases.     

Primary malignant schwannoma of the uterine cervix: a case report and literature review.

Primary malignant schwannomas are a very rare neural sheath tumor. A case of primary epithelioid-type malignant schwannoma of the uterine cervix in a 65-year-old woman is presented. This tumor is the first epithelioid malignant schwannoma documented within gynecologic tissues. Only two other cases of primary malignant schwannoma of the uterine cervix have been reported, and these cases are reviewed.