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1.
目的系统评价改良仰卧位下行经皮肾镜碎石取石术(PCNL)的安全性和有效性。方法检索Pub Med,Web of Science,中国生物医学文献服务系统,中国期刊全文数据库及万方电子期刊全文数据库,按照纳入和排除标准筛选关于改良仰卧位与俯卧位PCNL的临床对照研究,提取纳入研究中关于手术时间、住院时间、结石清除率及围手术期并发症发生率的数据并进行Meta分析。结果最终纳入18项研究,共2696个病例,Meta分析显示改良仰卧位组的手术时间较俯卧位组缩短(WMD=-19.24,95%CI:-29.09~-9.39,P0.01),两组在住院时间(WMD=-0.81,95%CI:-0.85~0.41,P=0.59)、结石清除率(OR=0.95,95%CI:0.76~1.19,P=0.65)和围手术期并发症发生率(OR=0.77,95%CI:0.59~1.01,P=0.06)方面差异无统计学意义。结论改良仰卧位行PCNL安全有效,可缩短手术时间,值得推广应用。  相似文献   

2.
目的探讨应用脉搏指数连续心排血量(PiCCO)容量监测仪技术研究双水平正压通气模式对急性肺损伤(ALI)患者血气及血流动力学的影响,探讨这种新型呼吸模式应用于ALI患者的临床疗效,对循环系统的影响程度,以提高ALI的治愈率。方法42例ALI患者,男27例,女15例;年龄15~75岁。按患者的入院先后顺序将40例患者(2例未完成研究)分为两组,每组20例。双水平正压通气组:入院的第1~20例患者,给予双水平正压通气呼吸支持,采用支持/时间(S/T)模式,吸气末压初始设为8~10cmH2O,逐渐增加至14~20cmH2O,以患者舒适为宜;呼气末压初设为3~5cmH2O,逐渐增加至8~12cmH2O,吸入氧浓度(FiO2)保持不变。对照组:入院的第21~40例患者,采用辅助/控制(A/C)通气模式,并依次按5cmH2O,10cmH2O,15cmH2O,20cmH2O增加呼气末正压(PEEP),每种压力持续30min,通气支持过程中FiO2保持不变。观察两组患者的心排血量(CO)、体循环血管阻力(SVR)等血流动力学和血气指标改变。结果两组死亡13例,其中双水平正压通气组死亡5例,对照组死亡8例。死于多器官功能衰竭7例,感染性休克3例,循环衰竭3例。双水平正压通气组气管内插管时间(2.9±0.8dvs.4.2±0.9d,t=7.737,P=0.006)和住院时间(17.2±4.5dvs.18.5±3.6d,t=2.558,P=0.039)明显短于对照组。对照组:当PEEP在5~15cmH2O范围内,患者动脉血氧分压(PaO2)、氧合指数(PaO2/FiO2)随着PEEP的增高而逐渐增加(P〈0.05);当PEEP增加至20cmH2O时CO降低,SVR、肺循环阻力(PVR)和气道峰值压(PIP)较5~15cmH2O范围时增加(P〈0.05)。双水平正压通气组:PaO2、PaO2/FiO2随着EPAP的增高而逐渐增加,当EPAP增加至10cmH2O时PaO2、PaO2/FiO2达最大值(P〈0.05);与对照组比较PIP明显降低(t=7.831,P=0.000)。结论对ALI/急性呼吸窘迫综合征(ARDS)患者给予双水平正压通气治疗可减少对呼吸和血  相似文献   

3.
爆震伤并发ARDS患者采用翻身床交替卧位通气的护理   总被引:2,自引:0,他引:2  
对5例爆震伤并发ARDS的患者在治疗过程中应用翻身床(床尾抬高5°)仰卧位与俯卧位通气交替使用.结果5例患者血氧饱和度由仰卧位时的0.90~0.91上升至俯卧位的0.95~0.96;气道阻力由仰卧位的30 cmH2O降至俯卧位后的20 cmH2O.5例患者住院51~93 d全部治愈出院.说明利用翻身床俯卧位通气更有利于体位引流,改善通气及气体交换.使患者的血氧饱和度明显增加,气道阻力明显下降,提高救治成功率.  相似文献   

4.
目的探讨侧卧位对比仰卧膀胱截石位分娩对母婴结局的影响。方法采用计算机和手工检索中国知网、维普期刊资源整合服务平台、万方数据知识服务平台、PubMed、EMBASE、The Cochrane Library、Web of Science中2017年12月以前关于应用侧卧位分娩的临床随机对照试验。根据纳入标准,2名评价者独立检索、筛选文献、提取相关数据,并按照Cochrane系统评价方法对纳入文献进行质量评价,使用RevMan 5.3软件进行荟萃分析。结果共有10篇文献纳入荟萃分析,包括3 607例研究对象。侧卧位组阴道助产及剖宫产率低于仰卧膀胱截石位组(OR=0.36,95%CI:0.21~0.59,P0.01;OR=0.28,95%CI:0.15~0.54,P0.01);侧卧位组较仰卧位组有更高的会阴完整率和Ⅰ度裂伤率(OR=2.44,95%CI:1.34~4.44,P0.01;OR=7.74,95%CI:5.39~11.13,P0.01),更少的会阴侧切率(OR=0.11,95%CI:0.09~0.15,P0.01),两组分娩体位的会阴二度裂伤率无显著差异(OR=0.96,95%CI:0.25~3.67,P0.05。侧卧位分娩组新生儿窒息率低于仰卧位组(OR=0.34,95%CI:0.17~0.68,P0.01);两组分娩体位产后出血量比较,差异无统计学意义(MD=1.88,95%CI:-24.94~28.70,P0.05)。结论现有研究表明第二产程采用侧卧位分娩有更高的会阴完整率和Ⅰ度裂伤率,可提高自然分娩率、降低阴道助产和剖宫产率,减少新生儿窒息的风险,且不增加产后出血量。  相似文献   

5.
目的探讨一次性包皮切割缝合器与传统包皮环切术疗效及安全性。方法通过计算机检索中文数据库中国期刊全文数据库、维普、万方和中国生物医学文献数据库和英文数据库MEDLINE(2012~2015)、EMBASE(2012~2015)和协作网系统评价资料库CDSR,由2人分别对文献进行检索及筛选、对纳入文献行数据提取,利用Revman 5.3.0软件进行统计分析。结果本研究共纳入9篇相关文献,其中中文7篇,英文2篇。结果显示一次性包皮环切缝合器在手术时间(MD=19.96,95%CI:16.23~23.70,P0.000 1)、术中出血量(MD=10.23,95%CI:8.49~11.97,P0.000 1)、术后疼痛评分(MD=2.01,95%CI:0.75~3.27,P=0.002)、愈合时间(MD=3.74,95%CI:2.06~5.42,P0.000 1)以及外观满意率(RR=0.70,95%CI:0.50~0.98,P=0.04)均优于传统包皮环切术,总并发症发生率(RR=1.84,95%CI:0.95~3.56,P=0.07)和伤口术后发生血肿率(RR=1.67,95%CI:0.87~3.22,P=0.12)的差异没有统计学意义,但一次性包皮环切缝合器能明显降低术后切口发生感染的风险(RR=3.44,95%CI:1.24~9.57,P=0.02)。结论与传统的包皮环切术相比,一次性包皮环切缝合器在减少手术时间、术中出血量、术后疼痛、提高术后外观满意率及降低术后切口发生感染的风险,值得推广。  相似文献   

6.
目的 系统评价俯卧位对早产儿喂养的有效性和安全性.方法 计算机检索中国知网、万方数据库、维普网、中国生物医学文献数据库、PubMed、Cochrane图书馆、Embase数据库中有关不同体位对早产儿胃潴留影响的随机对照试验.检索时限从建库至2020年3月18日.由2名经过培训的研究员独立筛选文献、提取资料并评价文献质量,采用RevMan5.3软件、StataMP16软件进行Meta分析.结果 共纳入28项随机对照试验和3项随机交叉试验,包括3178例研究对象.与仰卧位相比,俯卧位能够降低早产儿胃潴留量、发生率[RR =0.34,95%CI(0.17,0.70),P=0.003];呕吐次数和发生率[RR=0.30,95%CI(0.19,0.46),P=0.000];腹胀次数、发生率[RR =0.28,95%CI(0.17,0.44),P=0.000];呼吸暂停次数和发生率[RR=0.36,95%CI(0.25,0.52),P=0.000].与侧卧位相比,俯卧位能够降低早产儿胃潴留量.结论 俯卧位可有效减少早产儿胃潴留、呕吐、腹胀及呼吸暂停的发生,但受纳入研究数量和质量的影响,上述结论尚需开展更多高质量研究予以进一步证实.  相似文献   

7.
俯卧位通气下急性呼吸窘迫综合征患者氧合的变化   总被引:1,自引:0,他引:1  
目的探讨俯卧位通气下急性呼吸窘迫综合征(ARDS)患者氧合的变化及其机制。方法23例早期ARDS患者(病程<72 h),在镇静、肌松下持续俯卧位通气2 h。呼吸机参数设定为潮气量6-8 ml/kg,吸气时间1.0-1.2 s,吸气流速40 L/min,呼吸频率12-20次/min。吸入氧浓度0.4- 1.0,呼气末正压6-18 cm H2O。观察俯卧位前即刻、俯卧位0.5、2 h及恢复仰卧位2 h的氧合指数(PaO2/FiO2)、呼吸系统静态顺应性(Cst)、心率(HR)、平均动脉压(MAP)、中心静脉压(CVP)、平均肺动脉压(MPAP)。肺动脉楔压(PAWP)、心脏指数(CI)、气道峰压(PIP)及气道阻力(Paw)。俯卧位后PaO2/FiO2比俯卧位前上升超过20%作为氧合改善的判断标准。结果与俯卧位前比较,87%患者俯卧位0.5、2 h、恢复仰卧位2 h时PaO2/FiO2和PaO2升高(P<0.01);Cst HR、MAP、CVP、MPAP、PAWP、CI、Raw、PaCO2、PIP差异无统计学意义;87%氧合改善的患者在俯卧位0.5、2 h时Cst差异无统计学意义, 恢复仰卧位2 h时Cst升高(P<0.05)。结论俯卧位通气可改善早期ARDS患者的氧合,且恢复仰卧位后氧合改善持续存在。  相似文献   

8.
龚梦  明蕾  张露  李春燕  项燕 《生殖医学杂志》2014,23(10):797-804
目的系统评价口服避孕药(OC)在卵巢储备功能正常不育患者IVF-ET治疗周期妊娠结局中的作用。方法计算机检索Cochrane Library、PubMed、Embase、Biomed Central、CNKI、维普(VIP)和万方数据库的原始论著,收集在IVFET治疗周期前,使用OC和不使用OC对患者妊娠结局影响的临床随机对照研究,同时筛选纳入文献的参考文献。根据Cochrane系统评价方法,由3名独立研究者对文献的质量进行严格的评价和信息提取,并通过RevMan5.2软件对符合质量标准的随机对照试验(RCT)进行Meta分析。结果本研究共纳入6个RCT文献,共计1 620例患者,其中1例退出;Meta分析结果显示:对卵巢功能正常不育患者在IVF-ET前使用OC预处理会使临床妊娠率降低[RR=0.70,95%CI(0.55,0.88),P=0.002],继续妊娠率亦降低[RR=0.70,95%CI(0.54,0.92),P=0.01],但是两组间获卵数[WMD=0.53,95%CI(-1.20,2.26),P=0.55]、可移植胚胎数[WMD=-0.14,95%CI(-0.40,0.11),P=0.27]、优胚数[WMD=0.37,95%CI(-0.36,1.11),P=0.32]、种植率[RR=0.98,95%CI(0.79,1.21),P=0.83]比较均无统计学意义。结论本研究结果表明,对于卵巢功能正常的不育患者,使用OC预处理并不显著改善其IVF-ET的妊娠结局,甚至可能会降低临床妊娠率和继续妊娠率。  相似文献   

9.
目的采用Meta分析评价磷霉素氨丁三醇治疗泌尿系统感染的有效性和安全性。方法计算机检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库、中国知网、维普和万方数据库,检索时限均为建库至2016年9月10日。由2位作者独立进行文献筛选和资料提取,采用Revman5.3软件进行Meta分析。结果纳入29项研究共计4 451例患者。Meta分析结果显示,磷霉素氨丁三醇的临床治愈率(RR=1.02,95%CI=0.98~1.06,P=0.29)、临床总有效率(RR=1.02,95%CI=0.97~1.04,P=0.16)、细菌清除率(RR=1.02,95%CI=0.99~1.08,P=0.24)及不良反应发生率(RR=0.87,95%CI=0.69~1.08,P=0.20)与其他抗生素相当。亚组分析显示,磷霉素氨丁三醇组不良反应发生率显著低于β-内酰胺类药物组(RR=0.56,95%CI=0.34~0.94,P=0.03);此外,在妊娠期女性患者中,磷霉素氨丁三醇组的不良反应发生率显著低于其他抗生素组(RR=0.52,95%CI=0.32~0.85,P=0.01)。结论当前证据表明,磷霉素氨丁三醇治疗泌尿系统感染的疗效与其他抗生素相当,但磷霉素氨丁三醇组不良反应发生率显著低于β-内酰胺类药物组,且在妊娠期女性中其不良反应发生率较其他抗生素更低,其显著优势在于单剂量单次口服,值得临床推广使用。  相似文献   

10.
目的比较人工鼻与热加湿器对机械通气患者影响的差异。方法计算机检索PubMed、CENTRAL、EMbase、CNKI、VIP和万方数据库,查找人工鼻与热加湿器对机械通气的随机对照试验,检索时间为建库至2015年10月。采用RevMan5.2软件进行Meta分析。结果共纳入21篇文献,共3 147例受试者。Meta分析结果显示:人工鼻与热加湿器对机械通气患者影响比较,两者气道阻塞率RR=1.59,95%CI(1.00,2.51),P=0.05;在病死率及呼吸机相关肺炎发生率方面差异无统计学意义(均P0.05)。结论人工鼻与热加湿器治疗机械通气患者均取得较好的效果。人工鼻可减少每日吸痰次数,但是否会增加气道阻塞发生概率需进一步探讨,且本研究纳入文献质量偏低,需要更多高质量大样本的研究来进一步论证。  相似文献   

11.
俯卧位通气是一种改善严重急性呼吸窘迫综合征患者氧合的体位治疗方式。对于发生严重急性呼吸窘迫综合征的孕妇,俯卧位通气在一定程度上可以缓解肺部区域塌陷,降低妊娠子宫的压力,改善患者氧合。本文对已有的严重急性呼吸窘迫综合征孕妇俯卧位通气成功案例进行综述,以期从临床差异、作用机制、临床应用、病情观察和应用效果对严重急性呼吸窘迫综合征孕妇俯卧位通气的护理进行总结,为临床干预提供参考。  相似文献   

12.
13.
Prone positioning has been suggested since 1974 as a ventilatory strategy to improve oxygenation and pulmonary mechanics in patients with acute lung injury and acute respiratory distress syndrome. Although this mode of ventilation can improve gas exchange, the optimal role of the prone position is uncertain. The aim of this article is to examine the evidence in support of this mode of ventilation in adult patients with acute lung injury and acute respiratory distress syndrome. Limitations of the currently available evidence upon which the recommendations are made must be recognized. With these limitations in mind, however, the available evidence has been considered and conclusions presented. Considerable clinical experience confirms that prone ventilation can improve oxygenation in the majority of patients. It is difficult to predict which patients will respond. There are few contraindications and with experienced staff it can be achieved safely. Most patients should therefore be considered for a trial of prone positioning. Prolonged and repeated prone ventilation may be more effective. Whether the improvement in physiological parameters translates into improved clinical outcomes is less certain and well-designed randomized controlled trials will be required to address this issue.  相似文献   

14.
唐燕  冯萍  宋艳  俞瑾  任秀琴 《护理学杂志》2023,28(20):56-58
目的 提高清醒患者俯卧位耐受性和通气治疗效果。方法 将75例普通型新型冠状病毒肺炎患者随机分为对照组39例、观察组36例;在常规治疗的基础上对照组给予常规俯卧位,观察组给予攀岩式俯卧位。连续1周后评价效果。结果 观察组第2个及第7个24 h俯卧位时间及总时间显著长于对照组,俯卧位48 h氧合指数显著高于对照组,俯卧位24 h颈腰部酸痛发生率显著低于对照组(均P<0.05),未发生压力性损伤。结论 与常规俯卧位通气方式比较,清醒患者对攀岩式俯卧位耐受性更好,早期治疗效果明显、安全。  相似文献   

15.
BACKGROUND: Prone positioning has been shown to improve oxygenation in 60-70% of patients with acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Another way to improve matching of ventilation to perfusion is the use of partial ventilatory support. Preserving spontaneous breathing during mechanical ventilation has been shown to improve oxygenation in comparison with controlled mechanical ventilation. However, no randomized studies are available exploring the effects of preserved spontaneous breathing on gas exchange in combination with prone positioning. Our aim was to determine whether the response of oxygenation to the prone position differs between pressure-controlled synchronized intermittent mandatory ventilation with pressure support (SIMV-PC/PS) and airway pressure release ventilation with unsupported spontaneous breathing (APRV). METHODS: We undertook a prospective randomized intervention study in a medical-surgical adult intensive care unit of a university hospital. Of 45, 33 ALI patients (acute lung injury) within 72 h after initiation of mechanical ventilation, and in whom the prone position was applied according to a predefined strategy, were included in the study. After initial stabilization the patients were randomized to receive either SIMV-PC/PS or APRV with predefined general ventilatory goals (PEEP, tidal volume, inspiratory pressure and PaCO2-level). The protocol for prone positioning was the same for both treatment arms. Prone positioning was triggered by finding a PaO2/FiO2-ratio below 200 mmHg evaluated twice per day. The duration of each prone episode was 6 h. RESULTS: The first two episodes of prone positioning were analyzed. Gas exchange was measured before and at the end of prone positioning. Of the 45 patients enrolled, 33 were turned prone once and 28 twice. No significant differences were detected in baseline characteristics. Changes in oxygenation were analyzed in response to the first and second prone episodes 5 h and 24 h after randomization and initiation of SIMV-PC/PS or APRV respectively. Before the first prone episode the PaO2/FiO2-ratio was significantly better (P = 0.02) in the APRV-group (median; interquartile range) (162; 108-192 mmHg) than in the SIMV-PC/PS-group (123; 78-154 mmHg). The response in oxygenation to the first prone episode was similar in both groups: PaO2/FiO2-ratio increased 39.5; 17.75-77.5 mmHg in the SIMV-PC/PS-group and 75.0; 9.0-125.0 mmHg in the APRV-group (P = 0.49). Before the second prone episode, the PaO2/FiO2-ratio was comparable (SIMV-PC/PS 130.5; 61.0-161.0 mmHg vs. APRV 134; 98.3-175.0 mmHg). Improvement in oxygenation was significantly (P = 0.02) greater in the APRV group (82; 37.0-141.0 mmHg) than in the SIMV-PC/PS group (50; 24.0-68.8 mmHg) during the second prone episode. General ventilatory and hemodynamic variables and use of sedatives were similar in both groups during the study. CONCLUSIONS: APRV during prone positioning is feasible in the treatment of ALI patients. APRV after 24 h appears to enhance improvement in oxygenation in response to prone positioning.  相似文献   

16.

Study Objective

To compare the effects of volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) on respiratory mechanics and hemodynamics in steep Trendelenburg position.

Design

Prospective, randomized clinical trial.

Setting

University hospital.

Patients

34 ASA physical status 1 and 2 patients undergoing RLRP.

Interventions

Patients were randomly allocated to either the VCV (n = 17) or the PCV group (n = 17). After induction of anesthesia, each patient's lungs were ventilated in constant-flow VCV mode with 50% O2 and tidal volume of 8 mL/kg; a pulmonary artery catheter was then inserted. After establishment of 30° Trendelenburg position and pneumoperitoneum, VCV mode was switched to PCV mode in the PCV group.

Measurements

Respiratory and hemodynamic variables were measured at baseline supine position (T1), post-Trendelenburg and pneumoperitoneum 60 minutes (T2) and 120 minutes (T3), and return to baseline after skin closure (T4).

Main Results

The PCV group had lower peak airway pressure (APpeak) and greater dynamic compliance (Cdyn) than the VCV group at T2 and T3 (P < 0.05). However, no other variables differed between the groups. Pulmonary arterial pressure and central venous pressure increased at T2 and T3 (P < 0.05). Cardiac output and right ventricular ejection fraction were unchanged in both groups.

Conclusions

PCV offered greater Cdyn and lower APpeak than VCV, but no advantages over VCV in respiratory mechanics or hemodynamics.  相似文献   

17.
目的比较采取侧卧位和俯卧位两种不同体位进行胸腔镜食管切除术的安全性和有效性。方法回顾性分析2008年1月至2009年12月间复旦大学附属中山医院胸外科收治的88例胸腔镜食管切除术患者的临床资料,其中侧卧位下胸腔镜食管切除术52例(侧卧位组),俯卧位下食管切除术36例(俯卧位组)。结果两组均无中转开胸病例。与侧卧位组相比...  相似文献   

18.
BACKGROUND: Prone position has been used for several years to treat acute lung insufficiency, but in previous studies patients with unstable intracranial pressure (ICP) are mostly excluded. The aim of this study was to investigate if prone position is a safe and useful treatment in patients with reduced intracranial compliance. METHODS: A consecutive, prospective pilot study of 11 patients admitted to the neuro intensive care unit (NICU) due to traumatic brain injury or intracerebral haemorrhage. ICP, cerebral perfusion pressure (CPP), heart rate (HR), mean arterial blood pressure (MABP), arterial partial pressure of oxygen (PaO(2)), arterial partial pressure of carbon dioxide (PaCO(2)), arterial oxygen saturation (SaO(2)) and respiratory system compliance were measured before, three times during and two times after the patients were placed in the prone position. RESULTS: No significant changes were demonstrated in ICP, CPP or MABP. PaO(2) and SaO(2) were significantly increased in the prone position. HR was significantly increased in the prone position and after 10 min in the supine post-prone position and the respiratory system compliance was increased after 1 h in the supine post-prone position. CONCLUSION: Turning NICU patients from the supine to the prone position did not influence ICP, CPP or MABP, but significantly improved patient PaO(2), SaO(2) and respiratory system compliance.  相似文献   

19.
Purpose  Hypoxemia is one of the major problems during one-lung ventilation (OLV). During two-lung ventilation (TLV) using a double-lumen bronchial tube, bronchial endtidal carbon dioxide partial pressure () can be determined on both sides, independently. The is mainly dependent on the pulmonary perfusion to each lung. If the degree of oxygenation disorder during OLV were to be predictable before starting OLV, this could provide time to prepare for any subsequent hypoxemia. The aim of this study was to investigate whether the difference of (D-) between the dependent and the nondependent lungs during TLV in the lateral decubitus position (LP) could be a predictive factor for the severity of oxygenation disorder under subsequent OLV. Methods  Eighteen patients undergoing lung surgery were enrolled in this study. Anesthesia was induced with intravenous thiopental and fentanyl, supplemented by the inhalation of sevoflurane. A left-sided double-lumen bronchial tube was placed. The was independently determined on each side during TLV in the supine position (SP) and at 10 min after changing the position from SP to LP. / inspiratory fraction of oxygen () was taken at 15 min after switching from TLV to OLV in LP. Results  The decrease of / at 15 min during OLV in LP correlated with the reduction of the D- predetermined during TLV in LP (r = 0.698; P < 0.01). Conclusion  The D- predetermined during TLV in LP could be a predictive factor for the severity of oxygenation disorder after starting OLV in LP.  相似文献   

20.
Tetralogy of Fallot with absent pulmonary valve syndrome is commonly associated with respiratory failure both before and after surgery. This report describes our experience using prone positioning with bilateral pillows to avoid compression of the anterior chest wall after surgery. In the case here, the patient’s respiratory distress was improved by this positioning. Prone position and avoiding anterior chest compression has an effect on severe respiratory distress of tetralogy of Fallot with absent pulmonary valve syndrome.  相似文献   

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