Bronchoconstriction during cross-country skiing: is there really a refractory period?

PURPOSE: The asthmatic airway responds to exercise by bronchodilation (BD) during and bronchoconstriction (BC) after exercise. A refractory period induced by an initial exercise challenge that provides protection against BC during a subsequent exercise bout has also been observed. However, no studies examining during-exercise response or refractoriness during long-duration field exercise by elite athletes have been performed. This study examined airway response and refractoriness during approximately 42-min cross-country ski time trial preceded by a 6- to 9-min 2.5-km high-intensity warm-up ski. METHODS: Eighteen elite athletes cross-country skied seven successive 2.5-km loops. Spirometry was performed pre- and at 5, 10, and 15 min post loop 1; loops 2-7 were treated as a race (XCR) with maneuvers performed within 20 s after loops 2-6 and serially for 15 min after lap 7. RESULTS: Nine of 18 subjects demonstrated a >or=10% fall from baseline in FEV(1) (EIB+): five after lap 1 and four during or after laps 2-7. FEV(1) for EIB+ athletes during XCR was not different from post lap 1 FEV. Only one EIB+ subject demonstrated significant refractoriness. Four EIB+ athletes had a less than 10% fall in FEV after the initial 2.5-km exercise challenge but developed EIB (>or=10% fall) during the subsequent 6 x 2.5 km XCR exercise challenge. FEF(25-75) falls mirrored FEV(1), but demonstrated greater BD during XCR. CONCLUSION: Bronchoconstriction occurs in athletes during prolonged exercise and may thus influence performance. Variability in bronchial hyperresponsiveness onset and the lack of significant refractoriness in our study cohort of athletes is consistent with an exercise bronchoconstrictive dysfunction that is different than frank asthma and is yet to be clearly defined.     

Energy cost of free technique and classical cross-country skiing at racing speeds

PURPOSE: First, to measure the O(2) uptake ([OV0312]O(2)) and the blood lactate concentration during cross-country skiing at competition speed. Second, to compare these entities for the free technique and the classical technique. Further, to establish the subjects' [OV0312]O(2max) and the [OV0312]O(2) corresponding to the onset of blood lactate accumulation (OBLA, 4 mmol.L-1) during skiing, and finally to relate these entities to those of treadmill running. METHODS: Five high-level female junior cross-country skiers with a mean [OV0312]O(2max) of 63 mL.kg-1.min-1 served as subjects in five tests: examination of the [OV0312]O(2max) and the [OV0312]O(2) corresponding to the OBLA during up-hill cross-country skiing (both styles), inclined treadmill running, and a 6-km simulated cross-country ski race (both styles). RESULTS: The [OV0312]O(2max) obtained during up-hill cross-country skiing did not differ from that during treadmill running, nor did it differ between the two skiing styles. The peak heart rate was significantly lower during uphill cross-country skiing than during treadmill running. During the simulated competitions, the [OV0312]O(2) averaged 84% of the [OV0312]O(2max) or 95% of the [OV0312]O(2) at the OBLA found for uphill skiing. CONCLUSION: High-level female junior cross-country skiers are unable to ski at intensities close to their [OV0312]O(2max) or maintain an average intensity above that corresponding to their OBLA even during races lasting less than 25 min. Thus, training at intensities around the OBLA may be particularly relevant for cross-country skiers.     

Aerobic exercise adaptations in trained adolescent runners following a season of cross-country training

Adaptations in aerobic exercise responses as well as the relationship between aerobic exercise responses and running performance were examined in a group of previously trained adolescent runners (n = 9; 15.9 +/- 1.0 years) over the course of a competitive cross-country season. Running economy (RE), submaximal blood lactate concentration [BLa] and VO2max were assessed before and immediately after the season. Five-km race time improved (P < 0.05) from 18.68 +/- 1.10 min at the beginning of the season to 18.16 +/- 1.11 min at the end of the season. Significant increases were observed in peak VO2 (61.6 +/- 3.5 to 65.3 +/- 2.9 mL x kg(-1) x min(-1)) and graded exercise test time (11.32 +/- 1.56 to 12.22 +/- 0.79 min). There was a tendency for RE (P = 0.051) to worsen slightly and for [BLa] (P = 0. 057) to decline as a result of training. At the beginning of the season submaximal [BLa] at 14 km x hr(-1) (r = 0.86) and graded exercise test time (r = -0.87) were significantly related to 5-km time. At the end of the season, RE (r = 0.78) and [BLa] (r = 0.77) at 14 km x hr(-1) and graded exercise test time (r = -0.69) were significantly related to race time. In this well-trained group of runners, further training during the cross-country season increased peak VO2 and improved race time. Submaximal [BLa] and graded exercise test time appear to be the most robust predictors of performance, while RE became a significant predictor of race time at the end of the season.     

Serum FSH, LH, and testosterone in humans after physical exercise

The serum levels of FSH, LH, and testosterone were determined by radioimmunoassay in 63 men before, during, and after maximal and submaximal physical short- and long-term exercise (800-n running, climbing, 36-k cross-country skiing). In the 800-meter run, significant elevations of FSH, LH, and testosterone were observed, while in all other field and laboratory test (climbing, 36-km cross-country skiing, maximal stepwise bicycle and treadmill ergometry, 90-min submaximal bicycle ergometry) the hormone levels remained unchanged or were decreased. In contrast to FSH and LH, which did not show any clear modification with duration or intensity of exercise or with the state of training, changes of testosterone in the endurance field test (36-km cross-country skiing) seemed to be training dependent. In highly endurance-trained subjects, there was an increase and in less well-trained subjects a decrease of testosterone for equal distances and intensities of exercise.     

Serum erythropoietin in cross-country skiers

Serum erythropoietin (Epo) activity, hemoglobin (Hb), and hematocrit (Ht) were determined in 21 cross-country skiers during the training season. The Epo levels were not significantly reduced in the skiers relative to the normal population (P less than 0.01 and P less than 0.001, respectively). In 11 athletes Epo, Ht, urinary gamma-glutamyltransferase, N-acetyl-beta-glucosaminidase, and microalbuminuria were determined before and after a 50-km ski race at 1600 m above sea level. A significant increase of these variables (except for Ht) was found after the competition (P less than 0.001). It is concluded that while the reductions in Hb and Ht, which are typical of several endurance exercises, are not accompanied by a renal hypoxia sufficient to stimulate Epo overproduction, the renal hypoxia reached during the strenuous exercise of the race at altitude may be effective in determining blood increases in Epo.     

Maximal strength training improves work economy in trained female cross-country skiers.

PURPOSE: The present study examines the hypothesis that maximal strength training improves work economy and anaerobic threshold in trained female cross-country skiers while working on a ski ergometer. METHODS: Fifteen female cross-country skiers (17.9 +/- 0.3 yr, 166.7 +/- 1.3 cm, 60.1 +/- 1.9 kg, and 55.3 +/- 1.3 mL x kg(-1) x min(-1)) participated in the study. Eight skiers made up the high-intensity strength-trained group, and seven served as the control group. Endurance performance was tested on a specially instrumented ski ergometer. Strength training and testing simulated double poling in cross-country skiing. RESULTS: A significant (P < 0.001) improvement in double-poling economy on the ski ergometer was observed among the strength-trained group. Anaerobic threshold did not change during the experimental period for either group. After a 9-wk training period, time to exhaustion increased from 5.2 (+/-0.9) to 12.3 (+/-1.6) min (P < 0.001) and from 4.0 (+/-0.9) to 6.3 (+/-0.9) min (P < 0.01) for the strength and control group, respectively. Time to exhaustion was significantly higher (P < 0.001) for the strength group compared with the control group after training. One repetition maximum increased 14.5% (1.8) (P < 0.001) in the strength group but was unchanged in the control group. Expressed in relation to peak force at one repetition maximum, strength training resulted in a significant reduction in the relative available force employed working on the ski ergometer (P < 0.01). Time to peak force at maximal aerobic velocity on the ski ergometer was significantly reduced in the strength-training group (P < 0.01). CONCLUSIONS: It is concluded that maximal strength training in the upper-body improved the double-poling performance by improved work economy. Work economy was improved by a reduction in relative workload and time to peak force while double poling.     

Effect of skiing speed on ski and pole forces in cross-country skiing

PURPOSE: The present study characterized pole and ski forces in classical technique cross-country skiing. Eight elite junior cross-country skiers performed diagonal skiing at 65%, 75%, 90%, and 100% of maximum speed on a stable 100-m-low uphill (2.5 degrees ). METHOD:: The ski and the pole forces (vertical (Fz) and horizontal (Fy) directions) on the right and left sides were recorded separately when the skier skied over a special custom-made force platform system placed at the end of the uphill course. The entire system consisted of four separate 20-m-long rows of 1-m-long force plates connected in series, row by row. RESULTS: When the forces were averaged for the various functional phases of skiing cycle, the ski Fz during the gliding phase decreased and the braking ski Fy and Fz remained the same with higher skiing speed. During the subsequent kick phase, both ski Fy and Fz increased significantly as a function of the skiing speed. Consequently, the Fy ratio between the ski and the pole plant increased with faster skiing speed. Simultaneously measured EMGs from five different muscles showed that the abdominals had a pattern of increasing activation with increase in speed of skiing. All the other muscles, vastus lateralis (VL), rectus femoris (RF), erector spinae (ES), and medial gastrocnemius (MG), were obviously active in the preloading and the kick phases. CONCLUSIONS: The speed dependence of the ski and the pole force distributions in the present study are important for further understanding of the complexity of cross-country skiing. Especially relevant is to use these results as basis for studies aimed at better understanding of the propulsive force production, when more comprehensive EMG analysis is complemented with simultaneous kinematic recordings at varied slope, speed, and waxing conditions.     

Effect of exercise on plasma renin substrate

Effects of physical exercise on plasma renin substrate (RS) and plasma renin activity (PRA) levels were studied during short-term and prolonged exercise. Six healthy male volunteers performed a dynamic exercise test with exercise levels of 50, 100, 150, and 200 W for 4 min at each level. Measured with direct radioimmunoassay (RIA), which measures both intact RS and des-angiotensin I-RS (des-A I-RS), a significant increase in RS was seen during short-term exercise. RS measured with indirect (enzymatic) assay, which measures intact RS only, did not change, whereas PRA increased significantly. During prolonged exercise, a 75-km cross-country ski race, PRA increased more than two fold in ten healthy males participating in the study. Measured with direct RIA, RS increased by 22%, the corresponding increase in RS measured enzymatically was 10%. The increases in RS were not significant, however. It is concluded that the increased consumption of RS by rising PRA during exercise is counterbalanced by increased synthesis or release of RS by the liver or extrahepatic tissue. During prolonged exercise, liver production rate of RS apparently reaches a plateau which can be sustained for at least 7-8 h.     

Hyponatremia in ultradistance triathletes.

PURPOSE: Hyponatremia ([plasma sodium] <135 mmol x L(-1)) is a potentially serious complication of ultraendurance sports. However, the etiology of this condition is still uncertain. This observational cohort study aimed to determine prospectively the incidence and etiology of hyponatremia in an ultradistance triathlon. METHODS: The subjects consisted of 605 of the 660 athletes entered in the New Zealand Ironman triathlon (3.8-km swim, 180-km cycle, and 42.2-km run). Subjects were weighed before and after the race. A blood sample was drawn for measurement of plasma sodium concentration after the race. RESULTS: Complete data on pre- and postrace weights and plasma sodium concentrations were available in 330 race finishers. Postrace plasma sodium concentrations were inversely related to changes in body weight (P = 0.0001). Women (N = 38) had significantly lower plasma sodium concentrations (133.7 vs 137.4 mmol x L(-1); P = 0.0001) than men (N = 292) and lost significantly less relative weight (-2.7 vs -4.3%; P = 0.0002). Fifty-eight of 330 race finishers (18%) were hyponatremic; of these only 18 (31%) sought medical care for the symptoms of hyponatremia (symptomatic). Eleven of the 58 hyponatremic athletes had severe hyponatremia ([plasma sodium] < 130 mmol x L(-1)); seven of these 11 severely hyponatremic athletes were symptomatic. The relative body weight change of the 11 severely hyponatremic athletes ranged from 2.4% to +5%; eight (73%) of these athletes either maintained or gained weight during the race. In contrast, relative body weight changes in the 47 athletes with mild hyponatremia ([plasma sodium] 130-134 mmol x L(1)) were more variable, ranging from -9.25% to +2.2%. CONCLUSIONS: Hyponatremia is a common biochemical finding in ultradistance triathletes but is usually asymptomatic. Although mild hyponatremia was associated with variable body weight changes, fluid overload was the cause of most (73%) cases of severe, symptomatic hyponatremia.     

Upper body power comparison between groups of cross-country skiers and runners.

The purpose of this study was to evaluate relationships between upper body power (UBP) and cross-country ski skating race velocity (R) in a cross sectional representation of cross-country skiers. Additionally, cross-country skiers' UBP was compared to UBP of distance runners. Participants (n = 195) were tested on a Street Arm Ergometer for UBP using a ramped maximal UBP test simulating a double poling motion. A strong relationship (r = 0.89) between UBP and RV in skiers was determined. High school skiers were separated into slow and fast groups based on reported RV; significant differences (p < 0.05) in both UBP was found to be an effective partial predictor of RV, independent of gender. Mean UBP for the cross-country runners was 46% of mean UBP for the cross-country skiers. With UBP contributing so much to performance in cross-country ski racing, it is recommended that cross-country skiers focus a large portion of their training on the specific development of that fitness component.     

Immune and oxidative changes during and following the Western States Endurance Run

Changes in immune and oxidative stress parameters were measured in ultramarathon runners competing in the 160-km Western States Endurance Run. Forty-five runners agreed to provide blood and saliva samples the morning before the race event, at the 90-km aid station, and 5 - 10 min post-race. Upper respiratory tract infection (URTI) during the two-week period post-race was assessed retrospectively by telephone interviews. Forty subjects completed 90-km (race time, 13.1 +/- 0.3 h), and 31 completed the 160-km race event (27.0 +/- 0.4 h). The blood neutrophil and monocyte counts rose 249 % and 214 %, respectively, in the 31 finishers. Salivary IgA (sIgA) secretion rate decreased significantly from 508 +/- 40 micro g/min pre-race, to 287 +/- 39 micro g/min at 90-km, and 254 +/- 30 micro g/min post-race (50 % decrease). Significant increases were measured in cytokines at 90-km and post-race, with post-race IL-10 increasing 9.5-fold, IL-1ra 6.1-fold, IL-6 50.2-fold, and IL-8 2.5-fold over pre-race levels. Post-race indicators of oxidative stress, F (2)-isoprostane and lipid hydroperoxides, increased 33 % and 88 %, respectively. Pearson product-moment correlations revealed positive correlations at 90-km between F (2)-isoprostane and IL-6 (r = 0.31, p = 0.048), IL-10 (r = 0.31, p = 0.050), and IL-8 (r = 0.43, p = 0.005), but no other significant relationships between immune and oxidative stress indicators at 90-km and post-race. In the group of runners completing at least 90 km of the race, 26 % reported an URTI episode during the two-week period post-race. A low sIgA secretion rate at 90-km was the best predictor of post-race URTI (173 +/- 34 micro g/min in those who later acquired URTI compared to 325 +/- 40 micro g/min in those without URTI, p = 0.007). In conclusion, a modest correlation was found between cytokines and F (2)-isoprostane at 90-km when the greatest oxidative stress occurred, but no other significant correlations in immune and oxidative stress indicators during and following a 160-km ultramarathon race event were noted. About one in four ultramarathoners reported URTI during the two-week period post-race, and a low sIgA secretion rate mid-race best predicted URTI occurrence.     

Physiological adaptations and analysis of training content in high school cross-country runners

The purposes of this study were to examine effects of a season of training on aerobic performance in cross-country distance runners and to analyze the training using subjective and objective techniques. Subjects averaged 184 minutes of running per week, with 45%, 24%, and 31% occurring in zones below, near, and above the heart rate (HR) corresponding to ventilatory threshold (VT(HR)), respectively (Zone 1: HR > 15 bpm below VT(HR); Zone 2: HR between Zone 1 and VT(HR); Zone 3: HR > VT(HR)). Maximal oxygen uptake (VO(2 max)) increased by 5.1%, 5-km race time by 46 seconds (3.7%), and 2-km time trial performance by 54 seconds (10.7%) from pre- to postseason. Results are similar to previous research demonstrating that short-term (< 3 months) endurance training elicits improvements in various physiological parameters. Findings were not consistent with previous research that suggests a discrepancy may exist between the runners' perceptions and the physiological effects of their training.     

Physiological determinants of cross-country ski racing performance

PURPOSE: Previous laboratory testing has identified the importance of upper-body aerobic and anaerobic power to cross-country skiing performance. The purpose of this investigation was to extend laboratory research into a field setting to identify predictors of performance through ski-specific testing. METHODS: Thirteen male collegiate skiers performed three field-testing sessions on roller skis to establish lactate threshold (LT) and ski economy (ECON) and maximal oxygen uptake (SK VO(2max)) and a 1-km double-pole time trial (UBTT) to determine peak upper-body oxygen uptake (UB VO(2)). As a measure of skiing performance, the subjects performed a 10-km skating time trial (TT) and were ranked according to competitive season performance (RANK). RESULTS: Significant correlations (P < 0.05) were found between SK VO(2max), LT VO(2), UB VO(2), and RANK (r = -0.66 to -0.84) and TT time (r = -0.74 to -0.79), as well as ECON to RANK (r = 0.57) and TT time (r = 0.68). Time to complete the UBTT (UB time) exhibited the strongest correlation to both RANK (r = 0.95) and TT time (r = 0.92). Multiple regression analyses revealed that UB time was the best predictor of RANK and TT time, as demonstrated by the significant beta values (0.77, P < 0.001, and 0.79, P < 0.001, respectively). The importance of the UB component was further seen in that UB time was still the best predictor of performance when the subjects were divided into two distinct groups of greater and lesser competitive ability. CONCLUSIONS: These findings identify the importance of the upper body component to cross-country skiing performance, suggesting a need to focus on upper-body conditioning within a well-rounded endurance training program. Additionally, the UBTT exhibits potential as a simple field test to predict cross-country skiing performance over more sophisticated and costly laboratory and field testing.     

Assessment of the reliability of a custom built Nordic Ski Ergometer for cross-country skiing power test

AIM: Despite the recent development of cross-country ski technique having led to an increase in the importance of upper body power, there is a substantial lack of specific equipment for upper body force and power evaluation. In order to achieve good reproducibility of the skiing motion, a new upper body ergometer has been developed in our lab and tested by elite cross-country skiers. In this study, the reliability of this device was assessed comparing upper body power measurements with double poling ski performance in the field. METHODS: The new apparatus consists of an electric motor acting as load and actively controlled by a personal computer on the basis of force and velocity data. Nine cross-country skiers (age: 21.7+/-3.12 years; body weight: 72.2+/-3.8 kg), competing at international level, performed a ski test on a 1.2 km long sprint track and a 50 s exercise on the Nordic Ski Ergometer. The velocity of the last section (180 m, slope 1.37%) of the track, performed using the double poling technique at maximal voluntary intensity, was related to the upper body power measured at the ergometer. RESULTS: Mean upper body power was 9.22+/-2.29 W kg(-1), while average velocity on the section considered was 6.66+/-0.67 m s(-1). A high correlation (R(2)=0.871) was found between upper body power and ski velocity. CONCLUSION: In addition to overcoming the main limitations that affect traditionally used equipment, the strong relationship between the parameters obtained with the new ergometer and ski velocity indicates their ability to assess athletes performance. The new apparatus could therefore be considered a ski specific testing equipment for cross-country skiers which is useful for reproducing upper body involvement in cross-country ski-ing in a laboratory setting.     

Does a pre-exercise carbohydrate feeding improve a 20-km cross-country ski performance?

AIM: Carbohydrates are known to improve exercise performance, but their effects on actual competitions are not studied in detail. Aim of the present work was to evaluate the effects of maltodextrins ingestion on a simulated cross-country ski competition. METHODS: Ten athletes (15-24 years) repeated twice, in random order, a 20-km time-trial; 45 min prior to the start, they consumed 508+/-64 mL of a beverage containing either 0.7 g x kg(-1) body mass of maltodextrins or carbohydrate free placebo. RESULTS: Blood glucose, lactate and rate of perceived exertion (RPE) were measured periodically; heart rate was acquired continuously. Maltodextrins ingestion did not affect the increase in lactate and RPE at the end of the trial (5.2+/-3.7 mmol x L(-1) and 17.5+/-2.2), nor heart rate, which was constant throughout the exercises (177.1+/-4.3 bpm). The environmental conditions changed statistically in the second experimental session (-10.2+/-1.8 degrees C vs -0.8+/-0.5 degrees C for snow temperature, P<0.05), giving rise to shorter performance times of all the athletes (67.9+/-5.9 min vs 63.5+/-5.8 min, P<0.005). Within each session, the average performance time of the athletes receiving maltodextrins was shorter, even if not significantly. However, the difference in performance time of the group fed with the maltodextrins the 2nd day, was statistically higher (6.1+/-1.7 min vs 3.4+/-1.5 min, P<0.03). The effects of maltodextrins ingestion were disentangled mathematically, leading to an estimated gain in performance time of 2%. CONCLUSIONS: In spite of the different environmental conditions during the 2 experimental sessions, the illustrated results suggest an improvement of total performance time following the maltodextrins feeding.     

Running economy of African and Caucasian distance runners

PURPOSE: Anecdotal evidence suggests an advantageous physiological endowment of the African endurance athlete. Higher fractional utilization of VO2max has been suggested but not measured directly, and investigations of running economy have been inconclusive. The aim of the current study was to measure a) running economy and b) fractional utilization of VO2max, in African and Caucasian 10-km runners of similar body mass. METHODS: Eight African and eight Caucasian runners had no significant difference in mean race time (32.8 +/- 2.8, 32.0 +/- 2.5 min, respectively), body mass (61.4 +/- 7.0, 64.9 +/- 3.0 kg), age, body fat, or lean thigh volume. Caucasian runners were 6 cm taller (P < 0.05). Subjects completed a progressive treadmill VO2peak test. On a separate day, subjects completed two 6-min workloads (16.1 km x h(-1) and 10-km race pace) separated by 5 min. RESULTS: Mean VO2peak was 13% lower in the Africans (61.9 +/- 6.9, 69.9 +/- 5.4 mL x kg(-1) x min(-1), P = 0.01). At 16.1 km x h(-1), the Africans were 5% more economical (47.3 +/- 3.2, 49.9 +/- 2.4 mL x kg(-1) x min(-1), P < 0.05). This difference increased to 8% (P < 0.01) when standardized per kg(0.66). At race pace, the Africans utilized a higher %VO2peak (92.2 +/- 3.7, 86.0 +/- 4.8%, P < 0.01) and had higher HR (185 +/- 9, 174 +/- 11 b x min(-1), P < 0.05) and plasma [ammonia] (113.2 +/- 51, 60.3 +/- 16.9 micromol x L(-1), P < 0.05). Despite the higher relative workload, the plasma [lactate] was not different (5.2 +/- 2.0, 4.2 +/- 1.7 mmol x L(-1), NS). CONCLUSIONS: This study indicates greater running economy and higher fractional utilization of VO2peak in African distance runners. Although not elucidating the origin of these differences, the findings may partially explain the success of African runners at the elite level.     

Prediction of triathlon race time from laboratory testing in national triathletes

PURPOSE: Four days after competing in an Olympic-distance National Triathlon Championship (1500-m swim, 40-km cycle, 10-km run), five male and five female triathletes underwent comprehensive physiological testing in an attempt to determine which physiological variables accurately predict triathlon race time. METHODS: All triathletes underwent maximal swimming tests over 25 and 400 m, the determination of peak sustained power output (PPO) and peak oxygen uptake (VO2peak) during an incremental cycle test to exhaustion, and a maximal treadmill running test to assess peak running velocity and VO2peak. In addition, submaximal steady-state measures of oxygen uptake (VO2), blood [lactate], and heart rate (HR) were determined during the cycling and running tests. RESULTS: The five most significant (P < 0.01) predictors of triathlon performance were blood lactate measured during steady-state cycling at a workload of 4 W x kg(-1) body mass (BM) (r = 0.92), blood lactate while running at 15 km x h(-1) (r = 0.89), PPO (r = 0.86), peak treadmill running velocity (r = 0.85), and VO2peak during cycling (r = 0.85). Stepwise multiple regression analysis revealed a highly significant (r = 0.90, P < 0.001) relationship between predicted race time (from laboratory measures) and actual race time, from the following calculation: race time (s) = - 129 (peak treadmill velocity [km x h(-1)]) + 122 ([lactate] at 4 W x kg(-1) BM) + 9456. CONCLUSION: The results of this study show that race time for top triathletes competing over the Olympic distance can be accurately predicted from the results of maximal and submaximal laboratory measures.     

Vitamin E and immunity after the Kona Triathlon World Championship

PURPOSE: To measure the influence of vitamin E ingestion on oxidative stress and immune changes in response to the Triathlon World Championship in Kona, Hawaii. METHODS: Thirty-eight triathletes received vitamin E (VitE) (800 IU x d(-1) alpha-tocopherol) or placebo (Pla) capsules in randomized, double-blind fashion for 2 months before the race event. Blood, urine, and saliva samples were collected the day before the race, 5-10 min postrace, and 1.5 h postrace. RESULTS: Race times did not differ between VitE (N = 19, 721 +/- 24 min) and Pla groups (N = 17, 719 +/- 27 min, P = 0.959), and both groups maintained an intensity of approximately 80% maximum heart rate during the bike and run portions. Plasma alpha-tocopherol was approximately 75% higher in the VitE versus Pla group prerace (24.1 +/- 1.1 and 13.8 +/- 1.1 micromol x L(-1), P < 0.001, respectively) and postrace. Plasma F2-isoprostanes increased 181% versus 97% postrace in the VitE versus Pla groups (P = 0.044). IL-6 was 89% higher (166 +/- 28 and 88 +/- 13 pg x mL(-1), respectively, P = 0.016), IL-1ra was 107% higher (4848 +/- 1203 and 2341 +/- 790 pg x mL(-1), respectively, P = 0.057), and IL-8 was 41% higher postrace in the VitE versus Pla groups (26.0 +/- 3.6 and 18.4 +/- 2.4 pg x mL(-1), respectively, P = 0.094). CONCLUSION: These data indicate that vitamin E (800 IU x d(-1) for 2 months) compared with placebo ingestion before a competitive triathlon race event promotes lipid peroxidation and inflammation during exercise.     

Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2

PURPOSE: Oxidative stress was examined with use (N = 29) or nonuse (N = 25) of ibuprofen in ultramarathoners after the Western States Endurance Run. METHODS: Oxidative stress was assessed by measuring plasma and urinary F2-isoprostanes, plasma nitrite, and plasma urate. A urinary prostaglandin E2 metabolite (PGE-M) was used as an end point to assess ibuprofen use. Ibuprofen users consumed 600 and 1200 mg of ibuprofen the day before and on race day, respectively, and nonusers avoided all antiinflammatory medications. Blood and urine were collected in the morning before the race and immediately after the race. RESULTS: Use compared with nonuse of ibuprofen significantly increased plasma (P 相似文献