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英文摘要

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2009年上海地区细菌耐药性监测

Soriano A,Marco F,Martinez JA,et al.Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia[J].Clin Infect Dis,2008,46(2):193-200.

Sun W,Chen H,Liu Y,et al,Prevalence and characterization of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates from 14 cities in China?[J].Antimicrob Agents Chemother,2009,53(9):3642-3649.

Clinical and Laboratory Standads Institute.Performance Standards for Antimicrobial Susceptibility Testing[S].Eighth Informational Supplement,1998,M100-S8.

Clinical and Laboratory Standads Institute.Performance Standards for Antimicrobial Susceptibility Testing[S].Sixteenth Informational Supplement,2006,M100-S16.

Lahey Clinic.Amino acid sequences for TEM,SHV and OXA extended-spectrum and inhibitor-resistant β-lactamases[EB/OL].URL:http://www.lahey.org/studies/webt.asp.

Clinical and Laboratory Standads Institute.Performance Standards for Antimicrobial Susceptibility Testing[S].Twentieth Informational Supplement,2010,M100-S20.

沈继录,朱德妹,吴卫红,等.革兰阴性杆菌碳青霉烯酶产生与细菌耐药性关系的研究[J].中华检验医学杂志,2008,31(4):408-414.

Clinical and Laboratory Standads Institute.Performance Standards for Antimicrobial Susceptibility Testing[S].Twentieth Informational Supplement(June 2010 Update),2010,M100-S20-U.

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抗肿瘤血管生成在淋巴瘤治疗领域的研究进展

Wang ES,Temya-Feldslein J,Wu Y,et al.Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo.Blood,2004,104:2893-2902.

Elezkurtaj S,Kopitz C,Baker AH,et al.Adenovirus-mediated overexpression of tissue inhibitor of metallopmteinases-1 in the liver:efficient protection against T-cell lymphoma and colon carcinoma metastasis.J Gene Med,2004,6:1228-1237.

Kruger A,Arit MJ,Gerg M,et al.Antimetastalic activity of a novel mechanism-based gelatinase inhibitor.Cancer Res,2005,65:3523-3526.

O'Reilly MS,Boehm T,Shing Y,et al.Endostatin:an endogenous inhibitor of angiogenesis and tumor growth.Cell,1997,88:277-285.

Abdollahi A,Hahnfehh P,Macrcker C,et al.Endostatin's antiangiogenic signaling network.Mol Cell,2004,13:649-663.

Carmeliet P.Angiogenesis in life,disease and medicine.Nature,2005,438:932-936.

Ribatti D.Judah Folkman,a pioneer in the study of angiogenesis.Angiogenesis,2008,11:3-10.

Li ww,Hutnik M,Gehr G.Anfiangiogenesis in haematological malignancies.Br J Haematol,2008,143:622-631.

Wolpin BM,Mayer RJ.Systemic treatment of coloreetal cancer.Gastroenterology,2008,134:1296-1310.

Dong X,Han ZC.Yang R,et al.Angiogenesis and antiangiogenic therapy in hematologic malignancies.Crit Rev Oncol Hematol,2007.62:105-118.

Giatromanolaki A,Koukourakis MI,Pezzella F,et al.Pbosphorylated VEGFR2/KDR receptors are widely expressed in B-cell nonHodgkin's lymphomas and correlate with hypoxia inducible factor activation.Hematol Oncol,2008,26:219-224.

Folkman J.Antiangiogenesis in cancer therapy-endostatin and its mechanisms of action.Exp Cell Res,2006,312:594-607.

Bertolini F,Fusetti L,Mancuso P,et al.Endostatin,an antiangiogenie drug,induces tumor stabilization after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human highgrade non-Hodgkin lymphoma.Blood,2000,96:282-287.

Ling Y,Yang Y,Lu N,et al.Endostar,a novel recombinant human endostatin.exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells.Biochem Biophys Res Commun,2007,361:79-84.

王金万,孙燕,刘永煜,等.重组人血管内皮抑索联合NP方案治疗晚期NSCLC随机、双盲、对照、多中心Ⅲ期临床研究.中国肺癌杂志,2005,8:283-290.

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人血小板抗原检测及其在胎儿新生儿同种免疫血小板减少症中的应用

2006(zl)

2.0.TX;2-3.aspx'>Establishment of an HPA-1-to-16-typed platelet donor registry in China [其它论文] 2006(05)

Human platelet antigen genotyping by using sequence-specific primers and the particle gel agglutination assay 2005(04)

2.0.TX;2-N.aspx'>Real-time quantitative PCR assay for analysis of platelet glycoprotein Ⅲ a gene expression [其它论文] 2005(03)

Ficko T.Galvani V.Rupreht R Real-time PCR genotyping of human platelet alloantigens HPA-1,HPA-2,HPA-3 and HPA-5 is superior to the standard PCR-SSP method [其它论文] 2004(06)

Liu TC.Shih MC.Lin CL Gene frequencies of the HPA-1 to HPA-8w platelet antigen alleles in Taiwanese,Indonesian,and Thai [其它论文] 2002(05)

Higgins M.Hughes A.Buzzacott N High-throughput genotyping of human platelet antigens using the 5'-nuclease assay and minor groove binder probe technology [其它论文] 2004(02)

Bres JC.Merieux Y.Dugas V New method for DNA microarrays development:applied to human platelet antigens polymorphisms [其它论文] 2005(02)

卞茂红.刘淼.杨鹏 多重聚合酶链反应-微流芯片检测人血小板抗原系统基因型方法的建立与应用 [其它论文] -中华检验医学杂志2006(07)

Metcalfe P.Allen D.Kekomaki R 29th International Congress of the International Society of Blood Transfusion:HPA genotyping-where are mistakes made 2006(z2)

Mohanty D.Kulkarni B.Ghosh K Human platelet specific antigens and their importance 2004(08)

Andrei-Selmer C.Socher I.Bein G 29th International Congress of the International Society of Blood Transfusion:real-time analysis of HPA-la antigen-antibody interaction by surface plasmon resonance technology 2006(z2)

Castro V.Kroll H.Origa AF A prospective study on the prevalence and risk factors for neonatal thrombocytopenia and platelet alloimmunization among 9332 unselected Brazilian newborns [其它论文] 2007(01)

Ohto H.Miura S.Ariga H The natural history of maternal immunization against foetal platelet alloantigens [其它论文] 2004(06)

Kroll H.Yates J.Santoso S Immunization against a low-frequency human platelet alloantigen in fetal alloimmune thrombocytopenia is not a single event:characterization by the combined use of reference DNA and novel allele-specific cell lines expressing recombinant antigens [其它论文] 2005(03)

Mandelbaum M.Koren D.Eichelberger B Frequencies of maternal platelet alloantibodies and autoantibodies in suspected fetal/neonatal alloimmune thrombocytopenia,with emphasis on human platelet antigen-15 alloimmunization [其它论文] 2005(01)

Killie MK.Husebekk A.Kaplan C Maternal human platelet antigen-la antibody level correlates with the platelet count in the newborns:a retrospective s tudy [其它论文] 2007(01)

Bertrand G.Martageix C.Jallu V Predictive value of sequential maternal anti-HPA-la antibody concentrations for the severity of fetal alloimmune thrombocytopenia [其它论文] 2006(03)

Ghevaert C.Campbell K.Stafford P HPA-la antibody potency and bioactivity do not predict severity of fetomaternal alloimmune thrombocytopenia [其它论文] 2007(07)

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太极拳锻炼周期对原发性高血压的血压及心血管危险因素的影响:系统性评价和Meta分析

目的 采用Meta分析系统性评价太极拳锻炼持续周期是否影响原发性高血压患者的治疗效果,为原发性高血压患者提供合理的运动干预方案。方法 检索从中国知网、万方数据库、PubMed、Cochrane Library、Science Direct、Web Of Science等电子数库中关于太极拳对原发性高血压治疗效果的随机对照试验,采用RevMan 5.3软件进行Meta分析。结果 最终筛选21篇文献,总计有2 129名参与者。Meta分析结果提示:与对照组相比太极拳锻炼持续周期12周以上更有利于收缩压[M D=-10.20,95% C I(-14.57,-5.83)]和舒张压[M D=-5.12,95% C I(-7.63,-2.60)]水平的降低;能提高原发性高血压患者NO含量[M D=6.87,95% C I(4.83,8.90)];改善高血压患者除HDL-C之外的血脂代谢水平:TC[M D=-0.51,95% C I(-0.69,-0.33)]、TG[M D=-0.72,95% C I(-1.09,-0.36)]、LDL-C[M D=-0.59,95% C I(-0.87,-0.32)]。亚组分析结果提示运动频率≥5次/周、运动时间<60 min/d有较好的降压效果。结论 Meta分析表明,与其他持续周期相比,太极拳锻炼持续周期12周以上,每次运动时长控制在60 min以内,每周运动5次以上对降低血压水平、提高NO含量,改善血脂代谢效果最为明显,应值得在临床上推广。     

糖皮质激素对晚期肿瘤患者免疫疗效影响的Meta分析

目的 探讨糖皮质激素(glucocorticoid, GC)的使用对接受免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)治疗的肿瘤患者的总生存期(overall survival, OS)和无进展生存期(progression-free survival, PFS)的影响。方法 使用PubMed、Wiley、Web of Science和Cochrane Library数据库检索2020年10月以前发表的有关肿瘤患者在接受ICIs治疗期间,GC使用对患者预后影响的文献,采用Review Manager 5.3软件和Stata14.0软件进行统计分析。结果 总共有23篇文献被纳入荟萃分析,Meta分析结果显示在晚期肿瘤患者接受ICIs治疗期间,GC的使用是死亡(H R=1.54, 95% C I=1.29~1.83)和疾病进展(H R=1.82, 95% C I=1.36~2.43)的危险因素。此外,亚组分析结果显示,GC用于缓解脑水肿、癌痛等肿瘤相关并发症时会增加患者死亡(H R=2.14, 95% C I=1.62~2.81)和疾病进展(H R=2.26,95% C I=1.72~2.96)的风险。然而,GC被用于处理免疫相关不良反应(immune-related adverse events,irAEs)等非肿瘤相关性并发症,GC的使用与未使用或者小剂量(<10 mg/d)使用相比差异无统计学意义(P>0.05)。结论 当GC用于处理肿瘤相关性并发症时,GC的使用对接受免疫治疗的肿瘤患者的预后会造成负面影响。     

韶关市农村留守儿童孤独感状况调查

目的了解广东省韶关市农村地区留守儿童孤独感现状及其影响因素。方法对韶关市某地区两所农村小学3～6年级学生中的489名留守儿童采用儿童孤独量表和自编调查表进行问卷调查。结果17．6％留守儿童存在孤独感，不同性别孤独感发生率无差异性，不同年龄及不同年级间孤独感发生率差异均有极显著性（P〈0.01）；随年级增加，孤独感发生率呈下降趋势（X^2趋势=5．970，P〈0.05）。留守儿童孤独感与健康状况、学习成绩、学习困难程度、父母教育方式、父母间关系和老师教育方式等因素显著相关（P〈0.01～0．05）。结论农村地区留守儿童中存在一定程度的孤独感问题，老师和家长应以正确的态度和方法对待留守儿童，以减少其孤独感的发生。     

产科新生儿不同部位经皮测黄报警预值的可靠性观察

目的对比观察产科新生儿不同部位经皮胆红素（TCB）报警预值的可靠性。方法132例产科新生儿采取随机数字分组法分为正常产组和剖宫产组各66例,新生儿均于产后第4天同一时间点应用KJ8000经皮测黄仪分别测量额、胸、腹、额胸、额胸腹TCB值,TCB〉12．9mg／dl者,取得亲属同意抽取静脉血检测血清胆红素（SB）,对比分析不同部位TCB及其与sB值的差异。结果两组分别有17例或21例达到TCB报警预值。两组TCB或sB相同方法及相同部位比较,差异无统计学意义（P〉0．05）;两组TCB不同部位对比,额部值最低、胸部值最高,且与其他部位同组对比差异均有统计学意义（P〈0．01）;两组sB值对比差异无统计学意义（t=1．53,P〉0．05）,与不同部位TCB对比均以胸部数值差异无统计学意义（P〉0．05）,而与其他部位TCB两组差异均有统计学意义（P〈0．01）。结论正常产与剖宫产新生儿术后sB对比差异无意义;TCB动态监测以胸部结果更接近SB。     

Determination of loss of quality of life

Physiatrists are a valuable resource in legal settings, where assessment of functional capacity to perform work and of future medical needs must be determined. Physiatrists help determine what future medical care is needed to restore and maintain an individual at the maximum level of life function. This article focuses on the use of a quality of life (QOL) rehabilitation model, rather than a medical model, for enhancing functional performance, modifying environments, and facilitating patient coping. We discuss use of the QOL model to describe and influence a patient's physical, psychological, cognitive, vocational/economic, and social/leisure domains.     

护士选择性应用静脉留置针现状分析

[目的]了解护士选择性应用留置针的现状以及主要影响因素,为指导临床留置针合理应用提供理论依据。[方法]采用自设问卷对138名护士留置针选择性使用情况及其影响因素进行调查。[结果]约1／4的护士并不知道应选择性使用留置针,近60％的护士在实际工作中选择留置针的意识较差;护士选择性应用留置针的决策受多因素影响;不同科室、职称及是否具有带教资格选择性应用留置针的影响因素不尽相同;绝大部分护士希望参加选择性应用留置针相关内容的培训。[结论]临床护士操作前考虑留置针选择的意识有待加强。建议实施有针对性的培训以提高护士选择性应用留置针的能力。     

血液透析患者家庭护理提供者的生活质量调查

目的:了解江汉油田血液透析(血液透析)患者家庭护理提供者(护理者)的生活质量。方法:对60例血液透析患者的家庭护理提供者进行一般情况和生活质量综合评定问卷(QOLI-74)调查,并进行相关性和多因素回归分析。结果:家庭护理提供者各维度的主观生活满意度与其客观指标相关,但也与其需求、年龄、文化程度、与患者的关系有关。结论:客观状态是影响主观生活满意度的重要因素,同时应考虑护理者的需求、年龄、文化程度、与患者的关系对护理者主观生活满意度的影响。