冠心病患者血清铜锌比值测定的临床意义探讨

目的:探讨冠心病(CHD)患者与微量元素铜(Cu)、锌(Zn)及其铜/锌(Cu/Zn)比值的关系,评价Cu/Zn比值是否可以作为CHD预防监测指标。方法:用OLYMPUS2700生化分析仪对95例冠心病患者及90例健康对照组测定血清铜、锌及计算其比值。结果:冠心病组血清Cu值12.5±3.2μmol/L;Zn值17.26±1.567μmol/L;Cu/Zn0.601±0.213,健康对照组Cu值15.2±2.3μmol/L,Zn值15.45±0.443μmol/L;Cu/Zn0.969±0.219,两组间Cu值差异有统计学意义(P<0.05),Zn值有统计学意义(P<0.05),Cu/Zn比值有统计学意义(P<0.01),CHD组明显低于健康组。结论:Cu/Zn比值可以作为CHD预防监测指标。     

实验性动脉粥样硬化对血清铜、锌、铬、锰、硒的影响

本研究观察高胆固醇血症和实验性动脉粥样硬化形成对必需微量元素Cu、Zn、Cr、Mn、Se代谢的影响。将22只家兔随机分为动脉粥样硬化造型组和对照组。造型组每只家兔每天喂胆固醇0.5g,该组在形成高胆固醇血症和动脉粥样硬化的4个月过程中,血清Cu均值逐渐升高,Zn逐渐降低,Ca/Zn比值逐渐增大,前后对比差异显著。对照组血清Cu、Zn无显著变化。两组的血清Cu、Zn同次测定值对比有显著或高度显著差异。血清Cr、Mn、Se均无显著变化。相关性检验证实,造型组血清胆固醇均值与血清Ca均值无显著相关(P>0.5),而与血清Zn均值呈高度负相关(P<0.01)。结果表明,在形成实验性动脉粥样硬化的过程中,高胆固醇食物及高胆固醇血症可引起血清Zn降低,又通过锌铜拮抗,使血清Cu升高。     

沈阳地区正常人血清铜,铁,锌含量测定及其与血型关系

本文报道了沈阳地区148例正常人血清铜、铁、锌含量,Cu/Zn比值、Fe/Cu比值及其与性别、居住地区、居住年限和血型之间的关系。经统计分析结果表明:性别间血清铜、锌含量及Cu/Zn比值无显著性差异。血清铁及Fe/Cu比值有显著性差异,男高于女。市区与市郊血清铁、锌及Cu/Zn比值有显著性差异。居住年限的四个年龄组间血清锌含量有显著性差异,血清铜、铁含量无显著性差异。不同血型之间的血清铜、铁、锌含量变化无显著性差异.     

心脏病患者血清铜、锌、锰、铬、硒含量测定的临床意义

作者应用原子吸收光谱法和原子荧光光谱法测定了人血清铜、锌、锰、铬、及全血硒。测定对象分正常对照(40例),冠心病(36例),风湿性心脏瓣膜病(27例),扩张型心肌病(34例)4组。结果表明,正常人平均血铜值1.227±0.213μg/ml,锌1.0±0.149μg/ml,铬8.945±5.464ng/ml,锰12.163±4.21ng/ml,硒0.0625±0.03μg/ml,与文献报道值接近。其余三组心脏病人血铜值(1.448μg/ml,1.740μg/ml、1.746μg/ml)均显著升高(P<<0.001),血锌在冠心病、风心病组降低(P<0.01),铬三组无变化,锰仅在风心病组降低(P<0.01),硒在冠心病组增高(P<0.05),在扩张型心肌病组则显著降低(P<0.0001)。急性心肌梗塞(13例),血铜升高,而锌降低;心衰时血铜显著升高。以上变化对三种心脏病及急性心肌梗塞的诊断与鉴別、判断心脏的功能可能有一定意义。特别是扩张型心肌病呈现出特异性血硒降低,可能是该病的致病因素之一。     

人发锌、铜比与动脉硬化的关系

本实验采用原子吸收分光光度法测定321人头发中锌,铜含量,其中青年健康组65人(男35,女30);中老年健康组90人(男72,女18);动脉硬化组104人(男84,女20),脑血栓组31人(男23,女8),脑血栓对照组31人(男23,女8)。结果:动脉硬化病人发中Zn/Cu明显高于各健康对照组。用Feisher判别分析法比较各易患因素在动脉硬化中的作用,舒张压贡献率为75.02％,Zn/Cu为16.32％,诊断符合率达82％以上。     

产妇和新生儿血清脂类、脂蛋白和锌铜含量及相关关系的研究

本实验对53例正常分娩产妇和61例新生儿血清脂类及脂蛋白和血清锌、镉的含量及其相关关系做了初步的研究。结果表明:产妇血中TG、 TC、 HDL-CLDL-C、 LDL-C/HDL-C及铜均比正常对照组高,但血清锌较低(0.41mg/L)。除LDL-C/HDL-C比值无差异外,各项指标及Zn/Cu比值均有显著差异(P<0.001)。母血中TG、 TC、 HDL-C、 LDL-C、 LDL-C/HDL-C及铜均比脐带血高,且均有显著差异(P<0.001),但Zn和Zn/Cu比值明显低于脐带血(P<0.001),其中HDL-C、AI、LDL-C/HDL-C均有明显相关(P<0.001)。实验结果表明:孕产妇存在高TG、 TC血症;同时,存在血清锌低水平,且与脐带血中HDL-C、AI、LDL-C/HDL-C均有明显正相关。     

职业性白细胞减少症血清Cu,Zn及Cu／Zn比值变化的研究

职业性白细胞减少症(简称职白减,下同)与血清铜(Cu)、锌(Zn)及其它微量元素之间的关系,报道较多。为了进一步探讨其变化及与Cu/Zn比值的关系。对医用X线及苯系化合物作业人员引起的白细胞减少症进行了血清Cu、Zn及Cu/Zn比值的     

子宫颈鳞癌放疗前后血清铜锌变化的分析

目的 :检测子宫颈鳞癌患者放疗前后血清铜、锌的变化 ,并与正常人血清铜、锌水平进行对比分析。方法 :采用三电极直流等离子原子发射光电直读光谱仪法检测。结果 :子宫颈鳞癌患者血清铜 (SCu)、铜锌比值(Cu/Zn)显著高于正常对照组 (P <0 0 0 1) ,Ⅲ期患者又显著高于Ⅱ期患者 (P <0 0 0 1) ,放疗后癌灶完全消退者 (CD)SCu、Cu/Zn明显下降 (P <0 0 1) ,部分消退者 (PD)二值仍处于高水平。结论 :SCu和Cu/Zn可以检测放疗效果 ,评估预后 ,具有一定临床价值     

血清锌铜含量和铜蓝蛋白活性变化对肝癌诊断价值的研究

用原子吸收仪 ,酶氧化法测定了 62例原发性肝癌患者血清 Zn、Cu含量及铜蓝蛋白活性 ,并以 79例正常人作对照。结果表明 ,肝癌患者血清 Cu含量升高 ,血清 Zn含量明显低于对照组 ( P<0 .0 1 ) ,Cu/Zn比值明显高于对照组 ( P<0 .0 1 )。肝癌患者铜蓝蛋白活性高于对照组( P<0 .0 1 )。提示原发性肝癌患者体内微量元素代谢异常 ,并影响酶系统 ,对肝癌的发生可能起到一定的作用     

晕船对血清钙、磷、镁、铁、铜、锌的影响

目的探讨晕船对血清钙、磷、镁、铁、铜、锌的影响.方法以30名20～22岁男学员为研究对象,用全自动生化分析仪及原子吸收分光光度计测定出航前与晕船发生后的血清钙、磷、镁、铁、铜、锌.结果出航前受试者血清钙、磷、镁、锌、铁的含量依次为(2.17±0.03)、(0.88±0.03)、(0.93±0.01)mmol/L、(10.60±0.33)、(20.48±0.96)μmol/L,航行时,晕船发生后上述血清元素浓度分别为(2.44±0.08)、(1.42±0.05)、(1.13±0.03)mmol/L、(11.98±0.44)、(9.68±0.66)μmol/L,统计学比较差异有显著性;血清铜含量在航行前后分别为(14.29±1.10)和(13.67±0.56)μmol/L,无统计学差异.结论晕船对血清矿物质含量有显著影响,表现为血清钙、磷、镁、锌升高,血清铁下降,血清铜含量变化不显著.     

喂养方式与1～3月龄婴儿血清锌铜含量的观察

本文比较了母乳和牛乳两种不同喂养方式的1～3月龄婴儿的血清锌铜含量。86名成都市区婴儿(1～3月)经配对后分为母乳喂养组和牛乳喂养组。两组婴儿生后一直采用同一种方式喂养。结果母乳组婴儿血清锌含量为15.47±3.95μmol/L,血清铜为17.27±6.36μmol/L。牛乳组血清锌为13.57±4.21μmol/L,明显低于母乳组(P<0.05);血清铜为17.21±6.20μmol/L,与母乳组差异无显著性(P>0.05)。母乳组锌摄入量(mg/d)从1～3月分别为2.35±0.71,1.47±0.61,0.86±0.17,均低于牛乳组(3.82±1.22);母乳组铜摄入量(mg/d)从1～3月分别为0.29±0.11,0.18±0.07,0.15±0.04均高于牛乳组(0.10±0.07)。两组婴儿的血清锌铜含量与乳汁锌铜摄入量间无相关性。结果提示:婴儿早期的锌营养状况与喂养方式有关。母乳喂养儿的锌营养状况优于牛乳喂养儿,可能与母乳锌的生物利用度较好有关。而婴儿早期的铜营养状况与喂养方式关系不大,可能主要依赖于体内的铜储存量及其动用。     

血清Cu Zn浓度及其比值在肝硬化患者中的诊断效率

目的:探讨血清Cu、Zn浓度及其Cu/Zn比值肝硬化患者中的诊断价值。方法:测定了67例肝硬化患者和32例健康对照血清Cu、Zn浓度及其Cu/Zn比值,并对肝硬化患者进行了Child-Pugh分级统计处理。用ROC曲线分析评价了Cu、Zn元素及其Cu/Zn比值对肝硬化的诊断性能。结果:肝硬化患者血清Cu(t=5.656,P=0.000)和Cu/Zn比值(t=10.741,P=0.000)均明显高于健康受试者,而血清Zn则明显低于健康受试者(t=19.931,P=0.000)。经Child-Pugh分级后,血清Cu、Zn浓度及其Cu/Zn比值在各亚组间没有统计学差异。血清Cu、Zn浓度及其Cu/Zn比值肝硬化患者有无脑病并发间有明显差异。ROC曲线分析显示,难以找到一个合适的判断线,以使血清Cu对诊断肝硬化有较好的灵敏度和特异性。血清Zn的诊断效率较血清Cu好,若以16.23μmol/L为判断线,其Se=100.0%,Sp=85.1%。相比之下Cu/Zn比值有最佳诊断效率,当判断线为0.89时,其Se=98.5%,Sp=100.0%。AUC(95%可信限)指示ROC曲线的总的诊断效率:Cu是0.789(0.677~0.901)、AUC是0.952(0.916~0.989)、AUC是0.999(0.995~1.002)。结论:血清Cu、Zn浓度及其Cu/Zn比值可能是肝硬化的辅助诊断指标,但真正有诊断价值的指标是Cu/Zn比值。     

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.     

葡萄糖酸锌对人体内环境锌铜水平影响的研究

目的:探讨高锌摄入对血压、心率及人体内环境锌铜水平的影响。方法:选择饮食结构及饮食习惯相同的健康成人38例口服葡萄糖酸锌(50 mg/d),连续8周,于服葡萄糖酸锌前、后4、8周及停锌后4周4次查体,同时取血、尿、发测定锌、铜含量。结果:服锌后收缩压降低,停药后恢复到原来水平,血、尿、发锌含量明显升高(P<0.01),并且随锌摄入量的增加持续升高,Zn/Cu增大(P<0.05~0.01),停药后血、发锌含量仍高于服前水平(P<0.05~0.01),铜含量无变化(P>0.05)。结论:口服葡萄糖酸锌后内环境锌铜代谢失衡,停锌后短期内不能恢复原来水平。     

矽尘接触者血脂质过氧化与微量元素铜、锌的相关分析

作者测试了１１６名矽尘接触者和８９名对照者血中脂质过氧化作用指标［丙二醛（ＭＤＡ）、过氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）］和血清铜、锌含量。结果显示，ＭＤＡ、ＳＯＤ、ＧＳＨ－Ｐｘ矽尘组分别为（５．５３１±１．８７２）μｍｏｌ／Ｌ、（２３９６±４１３）μｍｏｌ／（ｍｉｎ·ｇ）、（３５．０６±８．９４）μｍｏｌ／（ｍｉｎ·ｇ），均显著高于对照组。血清铜、锌、铜／锌比值矽尘组分别为（２４．８０±６．５６）μｍｏｌ／Ｌ、（１３．１１±４．６６）μｍｏｌ／Ｌ、２．２１±０．８７，血清铜、铜／锌比值明显高于对照组，而血清锌两组无显著差异。各指标间相关分析表明，ＭＤＡ与Ｃｕ、ＭＤＡ与Ｃｕ／Ｚｎ；ＳＯＤ与Ｃｕ、ＳＯＤ与Ｃｕ／Ｚｎ以及Ｃｕ与Ｃｕ／Ｚｎ呈正相关。其他指标之间无相关关系。作者认为生物膜的脂质过氧化和铜代谢在ＳｉＯ２所致的肺纤维化的病理机制中起重要作用，是肺纤维化有意义的指标，对判断肺损伤可能具有一定的价值。     

Dietary Copper/Zinc Ratio and Type 2 Diabetes Risk in Women: The E3N Cohort Study

The serum copper (Cu) to zinc (Zn) ratio could be an important determinant of Type 2 diabetes (T2D) risk, but prospective epidemiological data are scarce. We aimed to investigate the association between T2D incidence and the dietary Cu/Zn ratio. A total of 70,991 women from the E3N cohort study were followed for 20 years. The intakes of copper and zinc were estimated at baseline using a validated food frequency questionnaire. We identified and validated 3292 incident T2D cases. Spline analysis showed that a Cu/Zn ratio < 0.55 was associated with a lower risk of T2D. Subgroup analyses comparing women in the highest versus the lowest quintile of Cu/Zn ratio showed the same pattern of association for obese women and those with zinc intake ≥8 mg/day. However, for women with zinc intake <8 mg/day, higher Cu/Zn ratio appeared to be associated with higher T2D risk. Our findings suggest that a lower dietary Cu/Zn ratio is associated with a lower T2D risk, especially among obese women and women with zinc intake >8 mg/day. Further studies are warranted to validate our results.     

血清铜锌硒与卵巢癌关系的研究

对 40例卵巢癌患者进行血清铜、锌、硒及铜 /锌比值测定 ,并以 48例健康成年女性为对照。测定结果进行单因素分析和非条件 Logistic多因素分析。单因素分析结果表明 ,卵巢癌患者血清锌、硒低于正常组 ,铜 /锌比值升高 ,而血清铜无显著差异 ;有负荷患者铜 /锌比值明显高于无负荷患者 ,而血清锌、硒无显著差异。回归多因素分析表明 ,硒、锌是卵巢癌发病的保护因素 ,揭示锌、硒在卵巢癌预防及辅助治疗上均有一定价值。     

Distribution and Determinants of Serum Zinc,Copper, and Selenium Levels among Children under Five Years from Popokabaka,Democratic Republic of Congo: A Cross-Sectional Study

Information about essential trace elements among children in many African countries, including the Democratic Republic of Congo (DRC), is limited. We aimed to measure the distribution and determinants of serum zinc (Zn), copper (Cu), and selenium (Se) concentrations in a representative sample of children under five years old. We conducted a community-based cross-sectional study in Popokabaka, DRC. Blood samples were drawn from 412 children. The serum concentrations of minerals were measured using inductively coupled plasma–mass spectrometry. The median concentrations (P25–P75) of Zn, Cu, and Se were 61.9 µg/dL (52.8–70.2), 145.5 (120.0–167.0) µg/dL and 5.3 (4.3–6.3) µg/dL. The CRP-adjusted prevalence of serum Se deficiency was 84.1% (95% confidence interval [CI] 81.4–87.0) and of Zn deficiency was 64.6% (95% CI 59.8–69.1%). Only a few children were Cu deficient [1.5% (0.6–3.2)]. Evidence of inflammation (C-reactive protein, >5 mg/L) was associated with a lower Se concentration and higher Cu concentration. Furthermore, serum Se concentration was positively associated with linear growth. The average Cu/Zn molar ratio (2:1) was twice that recommended. Children in western Popokabaka had higher Zn and Se levels than their eastern neighbors. Zinc and selenium deficiencies are common among children in Popokabaka and require attention and prioritization.     

Dietary Habits,Selenium, Copper,Zinc and Total Antioxidant Status in Serum in Relation to Cognitive Functions of Patients with Alzheimer’s Disease

Oxidative stress plays a crucial role in the neurodegenerative process and can impair cognitive functions. In the prevention of Alzheimer’s disease (AD), an adequate consumption of dietary antioxidants may be a major factor. The objective of the study was to estimate selenium (Se), copper (Cu), zinc (Zn), and total antioxidant status (TAS) in the serum of patients with AD in relation to their cognitive functions and dietary habits. A total of 110 patients (aged 54–93 years) with early or moderate AD, as well as 60 healthy people (aged 52–83 years) were studied. The severity of the disease was assessed using the mini-mental state examination (MMSE) scale. Food-frequency questionnaires were implemented to collect the dietary data. The concentrations of Se, Cu and Zn in the sera were determined by the atomic absorption spectrometry method. TAS was estimated spectrophotometrically using ready-made kits (Randox). Significantly lower concentrations of Se, Zn and TAS, and higher Cu:Zn ratio in the serum of patients with AD, compared to healthy people, were observed. A low correlation between the MMSE score and TAS in the serum of AD patients and significantly higher MMSE values in patients with TAS above the reference range were also noted. In patients with serum Cu concentration above the norm, significantly lower MMSE values were found. Selected dietary habits such as the frequency of consumption of various food products had a significant impact on the concentration of the assessed parameters in the serum of people with AD.