从“松侨老人傅山稿”看《傅青主女科》的著作权归属

《傅青主女科》的著作权人是否傅青主,长期以来在中医界存在争议。一些学者认为《傅青主女科》与陈士铎《辨证录》高度重合,是从《辨证录》中析出的,其作者应该是陈士铎。也有学者认为《辨证录》是陈士铎托名仙授,原作者就是傅青主,所以《傅青主女科》的著作权人理应是傅青主。山西博物院藏“松侨老人傅山稿”的发现,为《傅青主女科》的著作权归属问题,提供了有力的文献文撑。经文献对勘发现,“松侨老人傅山稿”与《傅青主女科》和《辨证录》“调经”部分内容高度重合,三者同出一源,有着共同的祖本,即清顺治间抄本。但《傅青主女科》不出自《辨证录》,两者之间没有誊抄关系。     

《傅青主女科》辨伪

署名傅山的《傅青主女科》等医书是不是傅山本人撰写,向有争议。《傅青主女科》与陈士铎《辨证录》文多雷同,或称陈士铎的医著本为傅山所作。而经考证,陈士铎从未见过傅山,其著作非得自傅山。或称傅山因反清斗争需要,在医书中隐去了自己姓名。其实傅山行医从不隐姓埋名。《傅青主女科》是对《辨证录》稍加语句调整而成书的,其抄本又屡经增删改易,并曾用他名。辨别《傅青主女科》的真伪,需通过傅山的其他著作进行文风的比较研究,才能得出可靠的结论。     

傅青主与《傅青主女科》

本文简述了傅青主的生平,及其代表性的医学著述。着重分析了《傅青主女科》的真伪,介绍了《傅青主女科》主要学术思想及其用药特点,并对中医妇科学的发展的贡献亦有所描述。     

从《傅青主女科》肥胖不孕浅析肥胖型多囊卵巢综合征所致不孕机制研究

目的 浅析《傅青主女科》肥胖不孕的论治对肥胖型多囊卵巢综合征（polycystic ovarian syndrome，PCOS ）所致不孕机制作用研究。方法 通过研读《傅青主女科·种子》中“肥胖不孕”的论述内容，分析傅青主对其病因病机的认识，总结其治疗肥胖不孕的治则治法及遣方用药，并加医案以佐证。结果 《傅青主女科·种子》中“肥胖不孕”认为导致女子不孕的病因病机之一为脾虚痰湿，与肥胖型PCOS所致女性不孕症的病机有异曲同工之处。结论 傅青主对治疗肥胖不孕的内容体例、用方遣药完备，对后世治疗本病具有重要指导意义，为临床诊治提供新思路。     

《傅青主女科》与《辨证录》内容及语言考察

本文就《傅青主女科》与《辨证录》两书的内容、结构、语词等方面进行了考证,认为《傅青主女科》乃是录自于《辨证录》。     

《傅青主女科》对鬼胎的辨识与治疗

《傅青主女科》对鬼胎的辨识与治疗郑其昌指导：尤昭玲李克湘（１９９５级硕士研究生长沙４１０００７）关键词《傅青主女科》鬼胎中医治则中国图书分类号Ｒ２７１．１Ｒ７３７．３《傅青主女科》为清代傅山编撰，历来深受医界重视，书中对鬼胎的论述和治疗与现代医学中的...     

傅青主带下病诊治学术思想分析

《傅青主女科》是中医文化宝库中对后世具有深远影响的妇产科专著之一,带下病作为《傅青主女科》中首篇,其重要性不言而喻.本文通过对傅氏带下病治疗思想、辨证、用药特色进行探讨,以期为临床更好地辨证应用提供思路.     

浅谈荆芥穗在《傅青主女科》中治疗经带胎产疾病的应用

《傅青主女科》是中医妇科医生在临床学习中的重要专著之一。本文作者通过研读《傅青主女科》,发现含有荆芥穗的方剂共21首,傅山巧用本为辛温解表的荆芥穗,利用其性辛散,入肝、肺经的药物特性,配伍柴胡以疏肝解郁;荆芥穗炒黑后,增强了其止血的功效,配伍黑姜等药物以引血归经,活血化瘀。通过研读和归纳总结《傅青主女科》中荆芥穗的应用,以指导我们临床用药。     

学习《傅青主女科》治疗崩漏的体会

傅青主是明末清初的杰出医学家,他一生献身于祖国的医学事业,精通医理,对于临床医学很有研究,以擅长妇科见称,对治疗妇科疾病方面作出了贡献。著有《傅青主女科》,(以下简称女科),他的一些见解和经验,至今还指导着中医妇科的临床实践。就我学习《傅青主女科》治疗崩漏的论述,谈谈点滴体会。     

浅析《傅青主女科》中黄芪之应用

《傅青主女科》所载80证中,应用黄芪者18证,可见傅山将黄芪应用于治疗妇科诸疾中颇有见解.本文通过总结《傅青主女科》中黄芪的配伍规律及用量特点,阐述其在月经病、妊娠病、产后病及种子中的灵活应用,以飨同道.     

益智健脑颗粒联合针灸对阿尔茨海默病大鼠学习记忆的影响

目的观察益智健脑颗粒联合针灸对阿尔茨海默病（Alzheimers disease,AD）大鼠学习记忆的影响。方法将大鼠随机分为假手术组（A组）、模型组（B组）、针灸组（C组）、益智＋针灸组（D组）各10只,B、C、D 3组分别以海马CA1区注射β淀粉样蛋白25-35（Aβ25-35）造模,A组注射等量的双蒸水,各组分别治疗20 d后行Morris水迷宫试验,观察大鼠学习记忆能力变化。结果B组较A组的平均潜伏期明显延长,差异具有统计学意义（P〈0.05）;与B组比较,C组、D组的平均潜伏期明显缩短,过台次数增多,差异具有统计学意义（P〈0.05,P〈0.01）;与C组比较,D组的潜伏期缩短,过台次数增多,差异具有统计学意义（P〈0.05）。结论益智健脑颗粒联合针灸能够提高Aβ25-35介导的AD模型大鼠的学习记忆能力。     

表皮生长因子受体酪氨酸激酶抑制剂在非小细胞肺癌应用的瓶颈——获得性耐药

以表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI）分子靶向治疗研究为肇始,转化性研究使基础实验和临床实践间的鸿沟迅速填平,改变着人们认识治疗肺癌的视角。无可否认,EGFR-TKI上市后极大地延伸了肿瘤学家治疗肺癌的手段,但不管从临床经验、临床研究数据、分子生物学层面还是文献计量学的角度,     

WHO西太区与“世界中医药学会联合会”中医名词术语国际标准比较研究：精、神、气、血、津、液部分

精、神、气、血、津、液是中医理论中6个非常重要的概念，有关术语在《WHO西太区传统医学国际标准名词术语》中一共收录了59条，“世界中医药学会联合会”（以下简称世中联）《中医基本名词术语中英对照国际标准》中收录了58条。血、津、液的内涵较为具体，有一定的物质基础，理解并不困难。翻译上虽有差异，但亦不难统一。精、神、     

Liuwei Dihuang,a traditional Chinese herbal formula,suppresses chronic inflammation and oxidative stress in obese rats

OBJECTIVE： To investigate the anti-inflammatory, anti-oxidative stress, and adipokine-ameliorating effects of Liuwei Dihuang （LWDH）, a traditional Chinese herbal formula, in obese rats. METHODS： After 2 weeks of acclimation with free access to regular rodent chow and water, obese-prone-caesarean-derived （OP-CD） rats were fed a modified AIN-93G diet containing 60% energy from fat. Treatment was performed twice daily by gavage feeding with 500, 1 500, or 3 500 mg/kg body weight LWDH suspended in water （n=12 rats per group）. Twelve obese-resistant-CD （OR-CD） rats were fed the atherogenic diet and gavaged with water, and served as the normal control. Blood biomarkers of inflammation, oxidative stress and adiponectin were measured post-sacrifice and used to determine the treatment effect of LWDH and assess the suitability of OR/OP-CD rats for studying these parameters. RESULTS： After 9 weeks of treatment, LWDH lowered serum C-reactive protein （CRP） and tumour necrosis factor-α （TNF-α） levels. Serum interleukin-6 （IL-6） levels showed a tendency towards reduction, but were not significantly different from the OP-CD control. Liver superoxide dismutase （SOD） activity was increased in response to all three doses of LWDH, while the levels of reduced （GSH） and oxidized glutathione （GSSG） and thiobarbituric acid reactive substances （TBARS） were unchanged. Serum adiponectin levels were increased in response to oral administration of LWDH at the dose of either 500 or 1 500 mg/kg body weight. In addition, comparisons between OR-CD and OP-CD rats revealed differential, and for some biomarkers, conflicting characteristics of high-fat diet-fed OP-CD rats in reference to obese human subjects in terms of inflammatory and oxidative stress biomarkers and circulating adiponectin levels. CONCLUSION： The results show, for the first time, the anti-inflammatory, anti-oxidative stress and adiponectin-ameliorating effects of LWDH in obese rats. The suitability of the OP-JOP-CD rat model as     

New Mechanism of Herb-herb Interaction between Ginseng and Trogopterus Based on CYPs in Rat Livers

The study was designed to investigate the potential mechanism of herb-herb interaction between ginseng and Trogopterus （Trg） based on Cytochrome P450 isozymes （CYPs） in rat livers. We estimated the influence on CYP1A2, CYP2E1, and CYP3A1/2 activity caused by ginseng and Trg used in combination. The CYP1A2 and CYP2E1 enzyme activity were induced by ginseng and Trg used in combination. And this induction effect was caused via inducing CYP1A2 and CYP2E1 protein expression which was supposed caused by inducing the gene expression of CYP1A2 and CYP2E1.     

中医疗法治疗运动性疲劳的研究进展

随着竞技体育的发展，运动员经常承受着大负荷、超强度的体力训练，因此极易产生运动性疲劳。疲劳的出现使肌内压增高，局部缺血，造成氧化代谢、H^＋排出率与pH值降低，血乳酸增高，从而影响肌纤维神经传导速度和肌内收缩力量，减弱了肌肉保护能力。致使较多的冲击力传到骨骼上，故易导致疲劳骨折的发生,严重影响了运动员的训练和比赛成绩，对运动员身心产生不必要的伤害。运动性疲劳消除手段的研究一直是竞技体育工作和运动医学关注和研究的焦点。     

Effects of tacrolimus and cyclosporine treatment on metabolic syndrome and cardiovascular risk factors after renal transplantation: a meta-analysis

Background The therapeutic success of renal transplantation has been largely attributable to the development of effective and balanced immunosuppressive treatment regimens.This study provides a meta-analysis of a series of randomized controlled trials that compared the effects of tacrolimus and cyclosporine on metabolic syndrome （MetS） and cardiovascular risk factors after renal transplantation.Methods We searched various electronic databases and bibliographies,including MEDLINE,the Cochrane Central Register of Controlled Trials,and EMBASE,for relevant studies published prior to October 2012.Results Our meta-analysis included five randomized controlled trials that examined a total of 923 patients.The tacrolimus group and the cyclosporine group exhibited no significant differences in MetS incidence after renal transplantation; risk ratio （RR）：1.06,95％ confidence interval （C/）：0.73-1.55,P=0.76.Cyclosporine treatment was associated with a higher incidence of hyperlipidemia （RR：0.50,95％ CI：0.39-0.64,P ＜0.01）.Although there were no statistically significant differences,cyclosporine treatment was associated with a higher incidence of hypertension （RR：0.91,95％ CI：0.83-1.00,P=0.06） after renal transplantation compared to tacrolimus treatment,and tacrolimus treatment was associated with a higher incidence of diabetes after renal transplantation （RR：1.79,95％ CI：0.98-3.27,P=0.06） compared to cyclosporine treatment.Conclusions Compared to tacrolimus treatment,cyclosporine treatment was associated with a higher incidence of hyperlipidemia.Future large-scale studies are expected to be conducted to further confirm our findings.     

程丑夫教授论治情志病验案举隅

程丑夫是国家级名老中医,湖南中医药大学第一附属医院主任医师、教授、博士生导师,享受政府特殊津贴专家,出身于中医世家,从医40余年,经验丰富,对于内科系统及疑难杂症的治疗颇有心得,笔者有幸跟师学习,聆听教诲,受益匪浅,现将程师论治情志病的经典验案略陈一二。1思虑伤脾案患者肖某,女,27岁。初诊：2014年5月20日。半年前因婚变后出现忧心忡忡,多思多虑,近1月来反复腹部胀满,刻诊：腹胀,食后为甚,呃逆,无反酸,通气后可减轻,无腹痛,不欲食,夜寐不安,二便调。舌红苔厚白腻,脉弦,BP：110／70mmHg。     

补肾活血方对PCOS大鼠模型卵巢中PAI-1mRNA表达的影响

目的探讨补肾活血方对大鼠PCOS模型卵巢局部纤溶酶原激活物抑制因子-1（PAI—1mRNA）表达的影响。方法选用未成年24d龄SD雌性大鼠60只,随机分为模型组、克罗米酚组、补肾活血方高剂量组、补肾活血方低剂量组、正常对照组5组。用Bogovich法建立大鼠多囊卵巢病理模型。以克罗米酚为对照。用原位杂交法观察补肾活血方对多囊卵巢大鼠局部PAI—1mRNA的影响。结果模型组卵巢局部PAI—1mRNA存在卵泡膜间质细胞显著增高,用补肾活血方高、低剂量与克罗米酚药后,卵巢局部PAI-1mRNA的表达明显降低．差异具有统计学意义（P〈0．05、P〈0．01）。补肾活血方高剂量组与克罗米酚组比较,差异具有显著统计学意义（P〈0．01）;低荆量组与克罗米酚组比较差异无统计学意义（P〉0．05）,补肾活血方高、低剂量组比较,低剂量组卵泡膜间质细胞上PAI-1的基因表达增高更明显,但二者差异无统计学意义（P〉0．05）。结论PAI-1mRNA可能与多囊卵巢综合征的发病机制有关。以补肾活血立法的补肾活血方能降低多囊卵巢大鼠局部PAI—1mRNA的显著增高表达．降低PAI—1mRNA卵巢局部的作用。提示补肾活血方可能通过PAI—1mRNA途径促进卵巢排卵的机制。     

UniPron is A Fully Effective Non-hormonal Reversible Contraceptive in Baboon Model （Papio Anubis）

Objective To determine the safety and efficacy of UniPron as a reversible contraceptive.
Methods Vaginal swabs were obtained before and after UniPron administration, cultured onto appropriate culture media and bacteria identification was done based on type of media used, Gram stain reactions, colony morphology and biochemical tests. Vaginal biopsy tissues were processed using paraffin wax method, stained with hematoxylin and eosin and examined under light microscopy to determine the effect of the product on vaginal tissues. The effect of UniPron on sperm was examined by mixing the product with electroejaculated spermatozoa in vitro at different concentrations. For efficacy studies, male baboons of proven fertility were mated with UniPron treated or untreated females of proven fertility during the fertile stages.
Results All the five females （100%） that were treated with UniPron did not conceive and they regained total fertility when the treatment was stopped while all the controls conceived. At a concentration of 40%, UniPron completely immobilized spermatozoa in an in-vitro system. UniPron mechanism of action was by lowering the vaginal pH and on application in baboon, the pH was lowered for at least 3 h after which it went back to normal.
Conclusions As we plan for a study to test UniPron as a microbicide to prevent STIs including HIV, our current study has established that this novel product is effective in contraception and harmless to vaginal tissues and vaginal microbial flora in a baboon model （Papio anubis）.