口服息斯敏联合穴位注射泼尼松龙治疗荨麻疹疗效观察

我院 2 0 0 0年 3月至 2 0 0 1年 12月 ,采用口服息斯敏联合醋酸泼尼松龙穴位注射治疗荨麻疹 4 6例 ,现报告如下。1　临床资料1.1　一般资料 :14 0例荨麻疹患者均为我科门诊患者 ,所有患者均符合诊断标准 [1 ] 。将 14 0例荨麻疹患者分为 A、B、C 3组。 A组 (口服息斯敏组 ) 5 0例 ,男 2 7例 ,女 2 3例 ;年龄 15～63岁 ,平均 (3 2 .6± 9.94 )岁 ,病程 2 d至 15年 ,平均 (2 3 .2 3± 3 9.18)个月 ,其中急性荨麻疹 2 0例 ,慢性荨麻疹 3 0例。 B组 (穴位注射醋酸泼尼松龙组 ) 4 4例 ,男 2 1例 ,女 2 3例 ,年龄18～ 5 8岁 ,平均 (3 3 .4± 10…     

皿治林治疗慢性荨麻疹41例的疗效观察

荨麻疹 (urticaria)病因多样 ,发病机理复杂 ,尤其是慢性荨麻疹 (chronicurticaria ,CU)往往难以找到真正病因 ,故治疗较难 ,目前大多数情况下是对症治疗[1] 。 2 0 0 1年 7～ 12月 ,我们在随机开放性临床试验中采用皿治林 (mizolastine ,咪唑斯汀 ,西安杨森公司出品 )治疗 4 1例CU患者 ,疗效显著 ,现报告如下。1　临床资料1.1　病例情况　 4 1例病例均符合CU诊断标准[1] 。发病具体时间及长短各异。其中男 19例 ,女2 2例。年龄 2 2～ 5 5岁 ,平均 (35 .2± 10 .8)岁。病程 2～ 31月 ,平均 10 .2月。所有调查对象不包括妊娠或哺乳期妇女…     

咪唑斯汀治疗慢性荨麻疹60例疗效观察

20 0 1年 1 2月至 2 0 0 2年 3月 ,我们应用咪唑斯汀治疗慢性荨麻疹 6 0例 ,取得满意疗效 ,现报告如下。1　资料和方法1 .1　一般资料 :选择慢性荨麻疹患者 6 0例 ,随机将病人分为两组 ,治疗组 30例 (男 1 2例 ,女 1 8例 ) ,年龄 1 5～ 6 0岁 ,平均 34.7岁 ,病程 6个月至 3年 ,平均 1 2个月。对照组 30例 (男 1 3例 ,女 1 7例 ) ,年龄 1 6～ 6 4岁 ,平均 35 .2岁 ,病程 4个月至 4年 ,平均 1 0个月。两组患者一般情况比较 ,差异无统计学意义 (P >0 .0 5 )。1 .2　病例入选标准 :1年龄 1 2～ 70岁 ,性别不限 ;2病程超过 1个月 ;3治疗前 1个月…     

玉屏风散联合咪唑斯汀治疗慢性荨麻疹的临床疗效观察

目的:研究玉屏风散联合咪唑斯汀治疗慢性荨麻疹的临床疗效.方法:将68例患者随机分成两组,治疗组36例给予中药汤剂玉屏风散,1剂/d,同时口服咪唑斯汀片10mg,1次/d;对照组32例给予咪唑斯汀片10mg,1次/d.3周为1个疗程,均连用6周.结果:治疗组痊愈率38.89%、有效率86.11%,对照组痊愈率15.63%、有效率62.50%,2组差异均有显著性意义(P＜0.05).结论:玉屏风散联合咪唑斯汀治疗慢性荨麻疹疗效显著.     

咪唑斯汀治疗慢性荨麻疹188例报告

咪唑斯汀是近年出现的新一代具有中枢选择性、无镇静作用的苯并咪唑类H1-受体拮抗剂。为了进一步了解咪唑斯汀对慢性荨麻疹的疗效和安全性,共治疗观察了188例慢性荨麻疹患者,现将结果报告如下。资料与方法病例选择:共治疗慢性荨麻疹患者188例,其中男96例,女92例;平均年龄37.4岁(15~70岁),平均病程13个月(4周~8年)。治疗前1个月内未应用长效皮质类固醇制剂,5天内未应用阿司咪唑(息斯敏)及皮质类固醇制剂;无严重心、肺、肾、胃等器官及系统疾病。用药及观察方法:咪唑斯汀10mg,每日1次口服,至临床症状、体征缓解或连续服用14天后停药评价。观…     

咪唑斯汀治疗慢性荨麻疹疗效观察

咪唑斯汀 (皿治林 ,Ｍｉｚｏｌａｓｔｉｎｅ)是一种具有抗组胺和抗过敏性炎症双重作用的新型抗组胺药。为了解咪唑斯汀对慢性荨麻疹的疗效和安全性 ,我们治疗观察了 4 0例患者 ,现将结果报告如下 :1　对象与方法1 1　病例 :临床确诊的患者 ,风团反复发作 ,病程在4周以上 ,收集的 4 0例均为我科门诊慢性荨麻疹患者 ,其中男 17例 ,女 2 3例 ,平均年龄 35 - 5 3岁 (14 -70 ) ,病程平均 2月。1 2　治疗方法 :咪唑斯汀 10ｍｇ ,每日一次口服 ,疗程 14天。1 3　观察项目及指标 :治疗前及治疗后 7天、14天各观察记录 1次 ,治疗前后均由同一位医生观…     

咪唑斯汀与雷尼替丁联用治疗慢性特发性荨麻疹疗效与不良反应探究

目的 研究咪唑斯汀和雷尼替丁联合治疗慢性特发性荨麻疹的疗效和安全性.方法 方便选取该院2015年2月—2016年6月期间收治的80例慢性特发性荨麻疹患者作为研究对象,将其随机分为对照组和观察组,每组40例.对照组单一采用咪唑斯汀进行治疗,观察组在对照组基础上联合雷尼替丁进行治疗.对比两组疗效和不良反应发生率.结果 治疗结束后,两组症状评分均明显下降(P<0.05),观察组下降(1.33±0.27)分,对照组下降(0.83±0.18)分,观察组评分下降幅度显著优于对照组(P<0.05);观察组有效率为97.5%,对照组有效率为80.0%,观察组疗效远优于对照组,治疗有效率对比差异有统计学意义(P<0.05);观察组不良反应率为5.0%,对照组为27.5%,两组患者在不良反应发生率方面对比差异无统计学意义(P>0.05).结论 在治疗慢性特发性荨麻疹的过程中,采用咪唑斯汀联合雷尼替丁治疗方法具有更好效果,在安全性方面也更具优势,建议推广至临床.     

慢性荨麻疹120例疗效分析

自2004年起,我科采用咪唑斯汀(皿治林)联合复方甘草酸苷(美能,深圳建安有限公司)治疗慢性荨麻疹120例,疗效显著,并设对照组110例,现报道如下. 1 临床资料 入选的慢性荨麻疹患者共230例,年龄12-27岁,平均36.8岁,病程2个月-7年,平均15.6个月,男104例,女126例.入选标准:①年龄≥12岁.②皮肤风团、瘙痒反复发作6周以上.③治疗前一个月未用过长效糖皮质激素或免疫抑制剂,前一周未用过其他抗组胺药物.④无严重的系统性疾病.     

皿治林治疗慢性荨麻疹34例疗效观察

慢性荨麻疹是皮肤科常见病 ,皮疹反复发作 ,长达数月或若干年之久 ,多数患者病因不明 ,多种抗组织胺药均有效 ,但停药后易复发。我院应用新型抗组织胺药皿治林 (咪唑斯汀 )治疗并随访 3 4例 ,取得满意疗效 ,现报道如下。资料与方法1　临床资料　入选病例共 64例 ,均为门诊确诊为慢性荨麻疹的病人 ,年龄 1 2岁～ 60岁 ,病程 1个月～ 4年 ,随机分为两组 ,治疗组 3 4人 ,其中男 1 1人 ,女 2 3人 ;对照组 3 0人 ,其中男 1 0人 ,女 2 0人 ,两组性别、年龄、病程经统计学处理差异均无显著性。所有患者治疗前 1月内未服用长效糖皮质激素 ,4天内未服…     

咪唑斯汀治疗慢性荨麻疹80例疗效观察

目的：探讨咪唑斯汀(皿治林)治疗慢性荨麻疹的疗效。方法：对慢性荨麻疹80例患者给予口服咪唑斯汀10mg，每日1次，治疗14天。结果：在治疗后第7天有效率为88．75％，在第14天有效率为92．5％。结论：使用咪唑斯汀治疗慢性荨麻疹具有起效快，持续时间长，安全有效特点。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.