Cardiorespiratory function is significantly improved following corrective surgery for severe pectus excavatum. Proposed treatment guidelines

BACKGROUND: Pectus excavatum is a congenital chest abnormality which may become more marked during childhood and teenage growth. Young teenagers with severe PE deformities often become short of breath during strenuous exercise and complain of becoming easily fatigued. The pathophysiologic effects of PE remain controversial because they have been difficult to measure, especially in young children. Symptomatic patients often have significant subjective improvement during exercise following PE repair and there is a major cosmetic impact on teenagers with severe deformities. This study was designed to measure pulmonary and cardiac function with exercise before and after corrective surgery. METHODS: Pulmonary function testing and incremental exercise testing were performed in 36 adolescents with pectus excavatum (PE) and 10 age-matched, healthy control subjects. Six months after corrective surgery was performed, 15 of these PE patients and 6 control subjects were re-evaluated for pulmonary function. RESULTS: Before surgery, PE subjects had a lower forced vital capacity (FVC) than controls; there was no change in FVC after surgery. Before surgery, 58% of PE patients had subjective complaints of exercise limitation; 66% of the patients were significantly improved after surgery. PE subjects exercised at a similar workload to controls. Respiratory parameters during exercise were similar between the two groups before surgery, indicating that exercise was not limited by restrictive lung disease. After surgery, PE subjects exercised longer and had a higher oxygen pulse than before surgery, whereas controls showed no such changes. Although some PE subjects showed mild restrictive lung function, surgical repair did not influence this mild degree of restriction. CONCLUSIONS: After corrective surgery, PE patients have increased exercise tolerance and a higher oxygen pulse. Oxygen pulse is a measure of cardiac output. Results suggest that PE repair improves cardiopulmonary function during vigorous exercise. Based upon these studies, and our experience in the treatment of more than 700 surgical patients with pectus excavatum over a 40-year period, guidelines for the diagnosis and management of children with pectus excavatum are proposed.     

Acute pain — guidelines for care

Canadian Journal of Anesthesia/Journal canadien d'anesthésie -     

Proposed guidelines for increasing the reliability and validity of Letournel classification system

The aim of this study was to improve the reliability of Letournel classification system using a guideline algorithm protocol. The study was conducted upon two groups of orthopaedic surgeons with different experience and was consisted of two observation sessions (A and B). In session A, every observer studied, with no instructions or guidelines, a particular set of acetabular fractures on AP and Judet oblique views. In session B the observers had to examine the same set of radiographs by taking into account a guideline algorithm protocol. The unweighted kappa coefficient was utilised to estimate the observers’ agreement arising from the examination of the given X-rays. Finally, the agreement of the observers, related to the intraoperative diagnosis was estimated. The main finding of the herein study lies on the improvement of the agreement rate experienced within both groups, in session B over session A. It is reasonable to assume that the main reason behind this result is the provision of the guideline algorithm protocol in the second session. The total agreement rate was increased from 59.9% in session A to 72.1% in session B, (p value = 0.0267).Our findings confirm the reliability of Letournel classification system and the proposed guideline algorithm protocol further improve the ability to classify the most complex acetabular fractures types.     

The development of practice guidelines for independent living donor advocates

The practice recommendations discussed here are based on the findings of the national survey as well as the opinions of the authors. The recommendations that are proposed here are not exhaustive and are aspirational in intent and are likely to evolve with time. Practice guidelines are recommended for legal and regulatory issues (e.g., state or federal laws), consumer or public benefit (e.g., improving service delivery, avoiding harm to the patient, decreasing disparities in underserved or vulnerable populations), and for professional guidance (e.g., new role, professional risk management issues, advances in practice). Without such practice guidelines, donors, and indirectly the candidates, may be at increased risk for possible bias or undue harm.     

Proposed guidelines for re-evaluation of patients on the waiting list for renal cadaver transplantation

Transplant candidates are extensively evaluated before being wait-listed for cadaver transplantation. Yet many wait a number of years before being transplanted. We propose guidelines for regular cardiac re-evaluation for patients on the waiting list.     

Proposed practice guidelines for nonoperative anterior cruciate ligament rehabilitation of physically active individuals

Nonoperative management of anterior cruciate ligament (ACL) rupture has not been a successful option for those who participate in high-level physical activity. However, there are instances when patients may want to attempt to return to physically demanding activities with nonoperative rehabilitation for an ACL injury. The purpose of this commentary is to describe guidelines for nonoperative management of physically active individuals with ACL injuries who wish to return to preinjury levels of physical activity. The guidelines are based on the results of 2 clinical studies that improved the overall success of nonoperative management of physically active individuals with ACL ruptures. A decision-making process for selecting appropriate candidates for nonoperative management (rehabilitation candidates) is described. Individuals are classified as rehabilitation candidates if they have no concomitant ligament or mensical damage associated with the ACL injury, have a unilateral ACL injury, and meet all 4 of the following criteria: (1) timed hop test score of 80% or more of the uninjured limb, (2) Knee Outcome Survey Activities of Daily Living Scale score of 80% or more, (3) global rating of knee function of 60% or more, and (4) no more than 1 episode of giving way since the incident injury to the time of testing. Individuals meeting the criteria of a rehabilitation candidate undergo an intensive rehabilitation program before returning to high-level activity. The rehabilitation program consisting of lower extremity muscle strength training, cardiovascular endurance training, agility and sport-specific skill training, and a training program using balance perturbations is described.     

Recommendations for mechanical ventilation during donor care

The organ procurement coordinator usually directs adjustments to the mechanical ventilator during donor care. It is often difficult to achieve optimal oxygen uptake and carbon dioxide removal while avoiding barotrauma or undesirable effects on the cardiac output. Interrelationships among a variety of ventilator parameters must be understood in order to achieve the desired goal of providing the best organs possible. These recommendations review the key ventilator parameters of tidal volume; positive end-expiratory pressure; auto-positive end-expiratory pressure; fraction of inspired oxygen; and flowrate and frequency and their interactions in controlling peak, plateau, and mean and end-expiratory airway pressures.     

Wound care guidelines and formulary for community nurses

Community nursing is experiencing significant change as a result of developments such as improved technology, care in the community and earlier discharge of patients from hospital. Because of this, increasingly complex clinical care is required in the community, and it has been noted that community nurses are 'under considerable pressure' and show 'evidence of high stress and low morale'. Wound care is one area in which community nurses constantly battle to keep abreast of continual change. Growing product availability and diversity of use, changes in dressing techniques and the ever-increasing costs associated with wound care mean decision-making in wound care is often a complex task. In the Grampian region, a handbook of evidence-based practice guidelines with a product formulary was developed and distributed to all community nurses. The handbook was designed to ease the decision-making process by evaluating evidence-based practice and local preferences to recommend and guide nurses towards effective clinical practice and cost efficiency. All grades of district nurse in the region have been issued with their own copy of the handbook. It is presented in an A5 ring-binder format to make it easy to carry and to facilitate updating using loose-leaf inserts. The use of logos, extra information boxes and colour coding makes it easy for users to find specific areas of interest in the handbook. The success of the handbook has led to debate on the potential for development of a similar resource for use by practice nurses and in local community hospitals.     

Overview of treatment guidelines for epilepsy

Opinion statement The selection of an antiepileptic drug (AED) for the newly diagnosed patient is a critical decision because patients who are successfully treated usually respond to the first medication tried and changing the medication when treatment has been successful usually is avoided. However, the evidence needed to choose an AED wisely is incomplete, which is demonstrated by multiple practice guidelines that have been produced using systematic reviews of the medical literature. No individual AED or group of AEDs has been found to have superior efficacy for seizure control, nor can any AED or group of AEDs be considered first-line therapy. Nevertheless, the AEDs differ in their efficacy for different seizure types. Therefore, initial treatment should be based in part on the seizure type diagnosis or, at least, on whether the epilepsy syndrome is focal or generalized. The AEDs also differ in their safety, tolerability, and potential for pharmacologic interactions. These issues and the patient’s comorbid conditions are additional bases for AED selection. The failure of AEDs to produce complete seizure control should lead to consideration of epilepsy surgery, especially for patients with mesial temporal lobe epilepsy. However, consensus does not exist regarding how many AEDs should be tried before determining the condition to be pharmacoresistant. Vagus nerve stimulation is an alternative treatment for patients who have pharmacoresistant epilepsy and choose not to have epilepsy surgery or have undergone unsuccessful epilepsy surgery. Infantile spasms are a seizure type requiring their own specific treatment. At present, the best evidence supports treatment with adrenocorticotropic hormone or vigabatrin.     

Proposed new method for nonoperative treatment of urethral stones

Urethral calculi is a common clinical problem in the Middle and Far East. Different endoscopic and operative techniques have been used in the treatment of impacted urethral stones. We report a noninvasive procedure to treat this condition. Intraurethral instillation of 2% lidocaine jelly was followed by spontaneous expulsion of the stone in 14 of 18 patients. The indications and limitations of the method are outlined.     

Cardiac dysrhythmias during donor care

Organ procurement coordinators must treat various cardiac dysrhythmias (arrhythmias), including rhythm disturbances that may cause or follow a cardiac arrest, in about 15% to 50% of donors. Treatment decisions should be based on the particular dysrhythmia and its effect on donor blood pressure. Medications selected should be effective but short acting. In this article, data available in publications located through a PubMed search are reviewed and specific dysrhythmias that are likely to occur during donor care are described. Treatment recommendations are based on guidelines from the American Heart Association.