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We report on a 39-year-old man with neurofibromatosis-Noonan syndrome and longstanding infertility. Comprehensive testing did not uncover any significant endocrine abnormalities, but the testicular seminiferous epithelium was found to be severely compromised. While the occasional association of neurofibromatosis with signs of Noonan syndrome has been reported, reproductive failure has not been previously described in this condition. © 1993 Wiley-Liss, Inc. 相似文献
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