易贝滴眼液治疗过敏性结膜炎后干眼症临床观察

目的观察易贝滴眼液(重组人表皮生长因子滴眼液)治疗过敏性结膜炎后干眼症的疗效。方法选择90例过敏性结膜炎后确诊为干眼症患者并将其随机分成两组,治疗组45例(90眼)使用易贝滴眼液,每日5次,每次1滴;对照组45例(90眼)使用玻璃酸钠滴眼液,每日5次,每次1滴。用药后对2周进行眼主观症状、BUT、Sit、FL的评价。结果治疗组的有效率明显高于对照组(P<0.01)。结论易贝滴眼液治疗过敏性结膜炎后干眼症疗效显著,可优先选用。     

咪唑斯汀治疗过敏性结膜炎临床分析

本院自 2 0 0 1年 5月～ 2 0 0 2年 5月采用咪唑斯汀 (皿治林 )治疗过敏性结膜炎 5 2例 ,现作以下分析。1　资料与方法1.1　一般情况　共接治过敏性结膜炎 5 2例 ,女 2 2例 ,男30例。年龄 14～ 6 7岁。病因 :药物过敏 19例 ,占 36 .5 % ,其中各种眼药膏 6例 ,氯霉素 3例 ,利副平 2例 ,阿托品 4例 ,氧氟沙星 2例 ,美洛西林 2例。染发 9例 ,占 17.3%。春季卡他性结膜炎 11例 ,占 2 1.1%。不明原因 7例 ,占13.4 %。装饰材料 6例 ,占 11.5 %。1.2　临床表现　药物过敏及染发过敏者发病急 ,表现为眼痒、畏光、流泪、眼睑水肿、结膜充血水肿 ,严重…     

儿童过敏性结膜炎临床研究

目的：研究儿童过敏性结膜炎的临床表现和治疗手段。方法：对2011年3月~2013年3月患有儿童过敏性结膜炎的126名患者进行具体的分析和研究。结果：儿童过敏性结膜炎通常都具有过敏史,而针对儿童过敏性结膜炎的有效治疗方法就是尽可能早期并且正确地使用具有抗过敏性的药物。结论：儿童眼科的相关医生要根据儿童过敏性结膜炎的主要临床表现和具体的治疗手段,对患有儿童过敏性结膜炎的患者进行正确及时的治疗。     

"候鸟式"旅居老年患者过敏性结膜炎导致干眼症的临床研究

目的 分析候鸟式旅居老年患者过敏性结膜炎(AC)导致干眼症的检测情况.方法 选取2015年3月至2019年3月海南省万宁市人民医院确诊为AC的候鸟式旅居老年患者42例(84只眼)为观察组,同时选取性别、年龄相匹配且无全身疾病和眼表疾病的老年患者42例(84只眼)作为对照组.采用泪液分泌试验(SIt)、角膜荧光素...     

过敏性结膜炎是可以治好的

福建省南平占读者来信说,他儿子6岁时,因服用解热止痛药过敏,导致全身水泡,剥脱性皮炎,经输血、激素治疗15天才挽救了生命.     

季节性过敏性结膜炎过敏原特点分析及临床意义

目的研究季节性过敏性结膜炎过敏原的特点及临床意义。方法收集2011年1月1日~2015年12月31日就本中心的175例季节性过敏性结膜炎患者病历资料,分析其过敏原结果特征和临床表现特点。结果季节性过敏性结膜炎中花粉过敏者比例最高,多合并呼吸道过敏性疾病,且多价过敏原过敏患者比例明显高于单价过敏原过敏患者(χ2=8.681,P0.05)。结论季节性过敏性结膜炎临床过敏原特点对疾病的临床诊断和治疗方案的选择有重要意义。     

过敏性结膜炎的药物治疗与手术治疗

过敏性结膜炎是由于接触过敏性抗原引起的结膜过敏反应,它主要是由IgE介导的I型变态反应。凡对特异性抗原有遗传的或体质上易感的人,在接触这种抗原时,可导致速发型或迟发型过敏性结膜炎,常伴有过敏性鼻炎等。药物抗过敏治疗只能控制过敏症状,很难彻底治愈过敏性结膜炎,这也是过敏性结膜炎久治不愈的原因之。     

Comparison of Azelastine Eye Drops with Levocabastine Eye Drops in the Treatment of Seasonal Allergic Conjunctivitis

Summary

A randomised, multicentre parallel group study was undertaken to compare the efficacy and safety of 0.05% azelastine eye drops (101 patients) in an open manner with 0.05% levocabastine eye drops (103 patients) and in a double-blind manner with placebo (103 patients) during a 14-day treatment period involving patients with seasonal allergic conjunctivitis. The three main eye symptoms, scored on a four-point scale, were itching, lacrimation and conjunctival redness; the primary efficacy variable was the responder rate on day 3. Responders were patients whose sum score of the three main eye symptoms decreased by at least three points from a baseline score of at least six points. In addition to these main symptoms, five other symptoms were recorded on days 0, 3, 7 and 14, and patients kept daily diaries of the three main eye symptoms and swollen eyelids. The responder rate after 3 days of treatment was 69% in patients treated with azelastine, 59% in patients treated with levocabastine and 51% in the placebo group. Only the difference in responder rates between azelastine and placebo eye drops was statistically significant (p = 0.02). The improvements in other ocular symptoms and entries in the patients’ diaries closely reflected the changes reported by the investigators. No serious adverse events occurred throughout the study. Nine patients (three in the azelastine, five in the levocabastine and one in the placebo group) terminated the study prematurely due to poor tolerability. Adverse drug reactions, mainly a mild, transient irritation and a bitter or unpleasant taste, were reported in 37% of patients receiving azelastine eye drops, 31% of patients receiving levocabastine and 9% of placebo patients. Overall tolerability was assessed as very good or good in 86% of azelastine- and levocabastinetreated patients, and in 95% of the patients receiving placebo. The results of this study indicate that azelastine possesses a tolerability profile at least comparable to that of levocabastine eye drops, but additionally appears to have a slightly quicker onset of effect, and confirm the therapeutic potential of azelastine eye drops in the treatment of allergic conjunctivitis.     

鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎的临床研究

目的探讨鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎的临床效果。方法选取2016年3月—2018年6月重庆北碚爱尔眼科医院收治的急性细菌性结膜炎患儿126例,随机分成对照组(63例)和治疗组(63例)。对照组眼睑内滴入妥布霉素滴眼液,1滴/次,6次/d。治疗组在对照组基础上眼睑内滴入鱼腥草滴眼液,1滴/次,6次/d。两组均治疗7d后。观察两组患者临床疗效,同时比较治疗前后两组患者眼部症状评分及血浆C反应蛋白(CRP)、白细胞介素-6(IL-6)水平。结果治疗后,对照组临床有效率为84.1%,显著低于治疗组的95.2%,两组比较差异具有统计学意义(P0.05)。治疗后,两组眼部症状评分及总分均显著降低(P0.05),且治疗组这些眼部症状评分明显低于对照组(P0.05)。治疗后,两组患儿血浆CRP、IL-6浓度显著降低(P0.05),且治疗组患儿血浆CRP和IL-6水平明显低于对照组(P0.05)。结论鱼腥草滴眼液联合妥布霉素滴眼液治疗儿童急性细菌性结膜炎,可明显改善患儿症状,抑制炎症反应,减轻机体炎性损伤。     

鱼腥草滴眼液联合奥洛他定滴眼液治疗过敏性结膜炎的临床观察

目的:观察鱼腥草滴眼液联合奥洛他定滴眼液治疗过敏性结膜炎的临床疗效和不良反应。方法:选取过敏性结膜炎患者160例眼,按照随机数字表法分为对照组和观察组,各80例眼。对照组予以奥洛他定滴眼液进行治疗,观察组在对照组的基础上加用鱼腥草滴眼液(两药间隔时间>10 min)。两组均连续治疗14d。分别于治疗前、治疗后14d随访观察两组患者的症状体征并进行评分,计算两组患者临床有效率,并观察不良反应发生情况。结果:与治疗前比较,两组患者的症状评分和体征评分均有所下降,差异有统计学意义(P<0.01或P<0.05),且观察组的症状评分和体征评分较对照组下降更多,组间比较差异有统计学意义(P<0.01);对照组和观察组治疗后的有效率分别为37.50%和77.50%,组间比较差异有统计学意义(P<0.05)。结论:鱼腥草滴眼液联合奥洛他定滴眼液可明显改善过敏性结膜炎患者的临床症状与体征,显著提高疗效,且未出现明显不良反应。     

中西医结合治疗干眼症的临床观察

目的观察中西医结合治疗干眼症的临床效果。方法选择我院2009年10月至2010年5月诊治的干眼症患者107例,遵照知情同意原则分为两组,对照组53例采用单纯西医治疗,给予玻璃酸钠,观察组54例在对照组的基础上给予杞菊地黄丸治疗,比较两组的治疗效果及不良反应发生情况。结果观察组的总有效率为98.1%,明显高于对照组的83.0%,组间差异有统计学意义(χ2=5.5509,P<0.05);两组不良反应症状均较轻微,且能够自行缓解,不影响治疗。结论中西医结合治疗干眼症疗效满意,且无严重不良反应发生,值得临床推广应用。     

Evaluation of the effects of olopatadine ophthalmic solution, 0.2% on the ocular surface of patients with allergic conjunctivitis and dry eye*

ABSTRACT

Purpose: Olopatadine hydrochloride 0.2% (Pataday^?, Alcon, Fort Worth, USA) is a topical ocular anti-allergic agent that has shown high rates of efficacy in treating ocular itching, the primary symptom of allergic conjunctivitis, and allows for once-daily dosing. Since some patients suffer from signs or symptoms of dry eye in addition to ocular allergy, this study was designed to evaluate the safety of olopatadine 0.2% in a population of patients with both allergic conjunctivitis and dry eye.

Methods: This was a single-center, 3-visit, double-masked, randomized study. Fifty-two patients diagnosed with ocular allergy and mild-to-moderate dry eye were evaluated. After a run-in period, patients were randomized to receive either olopatadine hydrochloride 0.2% or a tear saline, and self-dosed once-daily for 1 week. Outcome measures included tear film break-up time, corneal and conjunctival staining, tear volume and flow as measured by fluorophotometry, Schirmer's test, injection, and symptom evaluations.

Results: No significant differences between the treatment groups were observed (?p > 0.05). No serious adverse events occurred during the trial. Variability in the presentation of dry eye can hinder the observation of treatment effects. Although the study design facilitated the comparison of olopatadine 0.2% against an agent that was certain to not exacerbate dry eye, future comparison of olopatadine 0.2% against other agents in its drug class would provide useful information about relative drug tolerabilities.

Conclusion: As there were no significant changes in the signs and symptoms of dry eye, olopatadine hydrochloride 0.2% is safe to use in ocular allergy patients with mild-to-moderate dry eye.     

左旋氧氟沙星滴眼液治疗细菌性结膜、角膜炎的临床疗效

目的 :了解国产0 3 %左旋氧氟沙星滴眼液治疗急性细菌性结膜炎、角膜炎的临床疗效。方法 :确诊病例分层随机加入试验组及对照组 ,对照药物为0 3 %氧氟沙星滴眼液 ,对比观察疗效及毒副作用并作统计学分析。结果 :1998年4月～12月共观察132例 ,其中试验组67例 ,对照组65例。各组细菌培养阳性率均为80 %以上 ,两组的痊愈率及有效率无显著性差异 ,但左旋氧氟沙星的最低抑菌浓度更低 ,角膜炎病例中试验组的平均治愈日数明显少于对照组。结论 :0 3 %左旋氧氟沙星滴眼液对细菌性角膜炎、结膜炎疗效好、疗程短 ,无明显不良反应 ,有临床应用价值。     

8例变态反应性支气管肺曲霉菌病的临床分析

目的研究变态反应性支气管肺曲霉菌病（ABPA）的的诊断和治疗方法,并总结其临床特点。方法回顾性分析本人在省人民医院进修期间收集8例ABPA患者的临床表现,血清学结果,胸部放射学,病理检查结果,总结其临床特点,结果ABPA的临床表现主要包括哮鸣音、咳嗽、咳痰、咯血、呼吸困难和发热。所有病例血清IgE水平（3040±306）U／mL和外周血嗜酸性粒细胞计数（0．19±0．02）均升高。6例患者曲霉抗原皮肤测试阳性。CT可见中心支气管扩张,支气管壁增厚。、黏液或痰栓、游走性片状、结节状或肿块状肺浸润。所有患者均进行皮质类固醇与抗真菌治疗结合治疗。结论ABPA的临床特征包括哮喘病史,血清总IgE水平升高,曲霉IgE抗体的存在,外周血嗜酸性粒细胞增高,特异性CT表现等。曲霉抗原皮肤测试、血清总IgE水平和胸部CT扫描对ABPA的诊断有重要意义。口服糖皮质激素和抗真菌的药物是有效的治疗方法。     

过敏性支气管肺曲菌病的临床分析及HRCT表现

目的提高对过敏性支气管肺曲霉菌病（ABPA）的认识和诊断准确率。方法回顾性分析9例经临床和实验室诊断的ABPA的CT表现。结果 9例患者均见中心性支气管扩张,4例为单侧,5例为双侧;上叶支气管受累11处,下叶支气管受累5处。8处扩张支气管呈囊状、串珠状改变,12处扩张支气管呈牙膏样、指套样改变,内见粘液栓充填,其中9处粘液栓呈高密度。扩张支气管周围见马赛克灌注、小叶中心结节、树芽征;2例见肺不张。结论中心性支气管腔扩张并周边支气管变细为ABPA相对特征性的HRCT表现,结合实验室化验检查可确定诊断。     

环孢素滴眼液治疗干眼症20例

目的评价0.05%环孢素滴眼液治疗干眼症的临床疗效。方法干眼症患者40例(80只眼)，随机分为治疗组和对照组各20例。治疗组每日给予0.05%环孢素滴眼液点眼2 次，萘扑维滴眼液点眼4次;对照组用萘扑维滴眼液每日点眼4 次。连续治疗1个月后评价疗效。分别检查、记录治疗前后Schirmer-1试验、泪液膜破裂时间(BUT)及荧光素染色结果以及治疗后患者干眼症状的改善程度。结果治疗组Schirmer 1试验结果、BUT、角膜荧光素染色分级及临床症状的改善均明显优于对照组(P＜0.01)。结论0.05%环孢素滴眼液对干眼症有显著疗效，且无明显不良反应。