大力加强烧伤转化医学与再生医学研究

Translational medicine and regenerative medicine are presently the hottest areas in medical research. Translational medicine is regarded as a two-way model of medical research, I. E. Bench to bedside and bedside to bench. The purpose of translational research is to test novel therapeutic strategies developed through experimentation in human beings, and to facilitate the transformation of findings resulting from basic research to clinical practice. Regenerative medicine is to search for effective biotherapy methods to promote self repair and regeneration ; or to construct new tissues and organs to improve or restore the function of the injured tissues and organs. To strengthen researches on translational medicine and regenerative medicine in burns may promote the application of new clinical therapeutic strategies, and supply effective therapeutic measures for treatment of severe burns.     

大力加强烧伤转化医学与再生医学研究

1 转化医学研究模式体现了烧伤医学研究的最终目标 近年来,基因组、蛋白质组等分子生物学技术的不断创新和生物信息学在生命科学中的广泛应用,一方面为生命科学研究带来了前所未有的深度和广度;另一方面却使基础研究和临床研究的距离增大.生命科学研究的成果没有被及时应用到临床,没有真正体现生命科学研究的价值.     

大力加强烧伤转化医学与再生医学研究

1 转化医学研究模式体现了烧伤医学研究的最终目标 近年来,基因组、蛋白质组等分子生物学技术的不断创新和生物信息学在生命科学中的广泛应用,一方面为生命科学研究带来了前所未有的深度和广度;另一方面却使基础研究和临床研究的距离增大.生命科学研究的成果没有被及时应用到临床,没有真正体现生命科学研究的价值.     

干细胞、组织工程与再生医学

在上世纪80年代提出的组织工程概念、90年代发现成体干细胞的可塑性之后,在研究中逐渐认识到细胞、支架材料、生物活性因子、干细胞在促进组织、器官愈合与再生治疗中的重要作用.     

淋巴系统再生医学与组织工程的研究进展

各种原因导致的淋巴系统损害仍然是临床亟待解决的难题。再生医学和组织工程技术的发展为淋巴系统修复开辟了重要的途径。近年来,对淋巴系统生理的理解逐渐深入,淋巴系统再生医学展现出许多新的重要进展,包括细胞因子的应用、支架系统的开发、细胞疗法、组织工程淋巴系统的构建等。本文将对淋巴系统再生医学、组织工程的现状及其最新进展进行综述。     

生物材料和再生医学的进展

目的综述生物材料和再生医学的研究与进展情况.方法广泛查阅近年有关生物材料及再生医学的文献,总结生物材料的发展历程,分析其发展方向.结果生物材料经历了从第一、二代到第三代的发展过程.再生医学是利用人类的自然治愈能力,使受到巨大创伤的机体组织或器官获得自己再生能力为目的的医学,主要包括干细胞与克隆技术、组织工程、组织器官代用品、异种器官移植.结论第三代生物材料具有生物活性和降解两种性能,在植入体内后可促进机体的再生能力,从而达到治疗效果.组织工程学提出了复制"组织"、"器官"的思想,为再生医学的崛起开辟了道路.     

组织再生是烧伤组织修复的重要手段

Regenerative medicine is presently one of the hottest areas in medical research. Regenerative medicine is to search for effective biotherapeutic strategies to promote self-repair and regeneration, or to construct new tissues and organs hopefully to improve or restore the function of the injured tissues and organs. Regenerative repair, including constructural and functional repair, may be classified into exogenous and endogenous regenerative repair when considering its cellular or molecular origin. To strengthen researches on regenerative medicine may precipitate the application of new clinical therapeutic strategies, and supply effective therapeutic means for treatment of severe burns.     

对组织再生和再生医学发展的再思考

Research in the field of tissue regeneration is a new focus in life science and medicine in the 21st century,hereby I express my personal expectations of its research and translational application in the future.     

再生医学与干细胞在美容整形外科的研究与应用

笔者于2008年报道了"无创或微创美容医学技术的最新进展"[1],其中主要包括物理方面、化学方面和生物学方面.笔者现将生物学方面再生医学--脂肪来源干细胞这一项微创技术的研究与应用进展进行报道.再生医学即再生一个有生命力的组织、器官以修复各种原因引起的受损组织和器官,继而延续生命的医学,是当今新兴的一门跨学科领域的医学.     

再生医学与转化研究

一、再生医学的内涵和重要性 再生医学广义上讲是一门研究如何促进组织、器官创伤或缺损生理性修复,以及如何进行组织、器官再生与功能重建的学科,即任何与再生修复有关的内容都可以包含在再生医学范畴内。     

Tissue engineering and regenerative medicine: from first principles to state of the art

This lecture updates pediatric surgeons on the state of the science of tissue engineering and regenerative medicine.     

转化医学理念促进我国烧伤医学的发展

This article endeavours to reiterate the advances in six vital aspects of burn injury,i.e.shock/ischemiahypoxia,infection/sepsis,inhalation injury,regenerative medicine/tissue engineering and wound rep...     

An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing

The global burden of disease associated with wounds is an increasingly significant public health concern. Current treatments are often expensive, time‐consuming and limited in their efficacy in chronic wounds. The challenge of overcoming current barriers associated with wound care requires innovative management techniques. Regenerative medicine is an emerging field of research that focuses on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function. This article provides an overview of the pathophysiology of wound healing and reviews the latest evidence on the application of the principal components of regenerative medicine (growth factors, stem cell transplantation, biomaterials and tissue engineering) as therapeutic targets. Improved knowledge and understanding of the pathophysiology of wound healing has pointed to new therapeutic targets. Regenerative medicine has the potential to underpin the design of specific target therapies in acute and chronic wound healing. This personalised approach could eventually reduce the burden of disease associated with wound healing. Further evidence is required in the form of large animal studies and clinical trials to assess long‐term efficacy and safety of these new treatments.     

Regenerative Medicine in Bladder Reconstructive Surgery

This article explores the options for bladder reconstructive surgery and the role of regenerative medicine and tissue engineering. The indications for bladder reconstructive surgery are explored to complement medical management, which remains the first line for bladder dysfunction. Different strategies for research in tissue engineering of the bladder are discussed.Patient summaryOptions for bladder reconstructive surgery are discussed, including regenerative medicine and tissue engineering.     

Regenerative medicine: a surgeon's perspective

More than 200 million incisions are made in the world each year on children and adults. They all end up with a scar unless there is an unusual situation where we are operating on an early gestation fetus. The question is, “why do we not regenerate?” and “why do we always heal with either a ‘normal amount of scarring’ or, approximately 15% of the time, with a pathologic amount of scarring (hypertrophic scar or keloid)?”     

加快创面处理领域的干细胞研究

The restoration of destroyed skin tissue in extensive deep burn injury has been perplexing burn surgeons for a long time due to impossibility of de novo formation of true skin in the process of burn wound healing with the current treatment methods. Stem cells possess the capacity to repair the damaged tissue through regeneration of the original structure and function,and it is considered as the expected ideal outcome of burn wound healing and also the final goal of multidisciplinary wound managements. In the skin tissue, the resident stem cells do exist,and they retain an autonomous self-renewal potential, and they respond to guiding signals to differentiate in repairing burn wound. Besides, the remote mesenchymal stem cells and the adjacent adipose-derived stem cells have been shown to be involved in burn wound healing. The basic studies demonstrated that the microenvironmental feature or extracellular regulators, the selective activation of intracellular signaling pathways, and the expression of specific genes have a significant influence on the proliferation, differentiation or function of stem cells in wound repair. Therefore, further investigation and manipulation of the molecular mechanisms by which stem cells could participate well in regenerating skin tissue would be a valuable and promising way in burn wound treatment. The recent discovery of reprogramming a mature body cell into a pluripotent stem cell, which can then be converted to any type of human body cell sheds a new light to regenerative medicine. Stem cell-based regeneration is offering the next coming frontier of medical therapy by yielding new treatment through delivery of pluripotent stem cells to achieve structural and functional repair in the damaged tissues or organs due to trauma or chronic diseases. Therefore, it is a pressing task for us to expedite the study on the role and utility of stem cells in burn wound treatment, especially aiming to explore the possibility in regenerating skin appendages or even the entire structure of the normal skin, and avoiding the formation of hypertrophic scar or chronic wound after burn.