超声评价下肢动脉粥样硬化性疾病患者股动脉僵硬度与心功能关系的初步研究

目的 探讨下肢动脉粥样硬化性疾病(LEAD)患者股总动脉僵硬度与心功能间的关系.方法 选取LEAD患者33例与健康志愿者37例,应用QIMT和QAS技术自动测量左侧股总动脉的内中膜厚度(IMT)、管径、扩张性(DC)、顺应性(CC)、僵硬度参数(α、β)和脉搏波传导速度(PWVβ);应用超声心动图测量室间隔舒张末期厚度(IVSd)、左室舒张末期内径(LVDd)、左室质量(LVM)、射血分数(EF)、E/A、E'/A'、E/E'和Tei指数.对比两组的测量结果,并将股动脉僵硬度参数与左室功能参数进行相关分析.结果 ①LEAD组IMT增厚,α、β和PWVβ高于对照组,DC、CC低于对照组,差异有统计学意义(P＜0.05).②LEAD组IVSd、LVM和E/E'高于对照组,差异有统计学意义(P＜0.05);两组的E/A、E'/A'及Tei指数差异无统计学意义.③E/E'与CC呈负相关,与α、β和PWVβ呈不同程度的正相关(P＜0.05～0.01);E'/A'与IC和CC呈正相关,与α、β和PWVβ呈不同程度的负相关(P＜0.05～0.01);收缩功能参数、Tei指数与股动脉僵硬度各参数相关性均无统计学意义(P＞0.05).结论 LEAD患者左侧股动脉内中膜增厚,动脉僵硬度增高,左室舒张功能受损;股动脉硬化与早期左室舒张功能受损有一定相关.     

2型糖尿病合并高脂血症患者颈动脉内膜-中层厚度与动脉弹性的相关性研究

目的 应用血管内中膜分析技术(QIMT)和动脉僵硬度分析技术(QAS)评价2型糖尿病合并高脂血症患者颈动脉内膜-中层厚度与弹性的相关性.方法 随机选取2型糖尿病合并高脂血症患者56例作为病例组,48例同期健康志愿者为对照组.应用QIMT和QAS技术对颈动脉进行检查,获得颈动脉的内膜-中层厚度(IMT)、顺应性系数(CC)、扩张性系数(DC)、僵硬度系数(β).病例组再根据IMT分组;IMT＜0.9 mm为病例1组,IMT≥0.9 mm为病例2组.结果 对照组、病例1组、病例2组的β、甘油三酯(TG)、低密度脂蛋白(LDL)、胆固醇(Ch)、糖化血红蛋白(GHb)、颈动脉IMT等指标差异有统计学意义(P＜0.05),对照组＜病例1组＜病例2组.对照组、病例1组、病例2组的DC、CC差异有统计学意义(P＜0.05),对照组＞病例1组＞病例2组.病例组的β与年龄、GHb、LDL和颈动脉IMT呈明显正相关,β与年龄r=0.811,P=0.000;β与GHbr=0.764,P:0.000;β与LDLr=0.732,P=0.000;β与颈动脉IMT r=0.729,P=0.000.结论 QIMT可较准确地测量颈动脉IMT,QIMT与QAS技术联合应用使颈动脉的解剖结构成像与功能成像有机地结合,可成为深入研究颈动脉早期结构和功能改变的有效手段.     

超声技术评价中老年男性代谢综合征患者颈动脉僵硬度、左室功能及心室-动脉耦联情况

目的应用超声技术评估中老年男性代谢综合征(MetS)患者颈动脉血管壁僵硬度、左室功能及心室-动脉耦联情况。方法选取在广西医科大学第一附属医院确诊的中老年男性MetS患者86例,分为射血分数(EF)正常者52例(EF≥50%,MetS N组)和EF减低者34例(EF50%,MetS A组);另选同期50例健康男性为对照组。比较各组颈动脉血管壁僵硬度指标[扩张系数(DC)、杨氏弹性模量(YEM)、僵硬指数(SI)]、左室功能指标(Tei指数和EF),以及左心系统心室-动脉耦联参数:左室收缩末弹性(Ees)、有效动脉弹性(Ea)及心室-血管耦联指数(VVI)。结果①颈动脉血管壁僵硬度指标比较:与对照组比较,MetS N组、MetS A组DC减低,YEM、SI增高,差异均有统计学意义(均P0.05);MetS N组与MetS A组比较差异均无统计学意义;②左室功能指标:MetS A组Tei指数高于MetS N组,MetS N组Tei指数高于对照组,差异均有统计学意义(均P0.05);③与对照组比较,MetS N组、MetS A组Ea增高,差异均有统计学意义(均P0.05),MetS N组与MetS A组比较Ea差异无统计学意义;MetS N组Ees增高,MetS A组Ees减低,差异均有统计学意义(均P0.05);MetS A组VVI高于MetS N组,差异有统计学意义(P0.05),对照组与MetS N组VVI比较差异无统计学意义。简单线性回归分析示:MetS A组VVI与Tei指数呈正相关(b=2.72,P=0.000),拟合线性回归的决定系数(R2)=0.565(P0.05)。结论中老年男性MetS患者颈动脉血管壁僵硬度增高;左室整体功能减低,以射血分数降低者更为明显;MetS A患者心室-动脉失耦联,且心室-动脉失耦联情况随左室整体功能的下降而恶化。应用超声技术能够无创、敏感、准确地评估其心血管功能。     

单心动周期实时三维超声心动图评价冠心病患者左心室舒张同步性

目的 应用单心动周期实时三维超声心动图(sRT-3DE),评价冠心病患者左室舒张同步性.方法 71例冠心病患者依据冠脉造影直径狭窄率(r)分为A (50％＜r＜ 75％)、B(r≥75％)两组,健康人为对照组(Con组).测量左室舒张同步性参数,并进行统计学分析.获取左室17节段容积-时间曲线(VTC)及达到最大容积-时间牛眼图,并观察分析图像特点.结果 A组左房内径(LAD)、E/e'及舒张不同步参数较Con组增大,e'减少.B组LAD、左室内径、左室容积及舒张不同步参数,E/e较其他组增大,曲减少.病例组中舒张失同步指数(DDI)与LAD、E/e'均呈正相关(r1 =0.317,P1=0.021;r2=0.359,P2 =0.008),与e'呈负相关(r=-0.459,P=0.001).应用DDI诊断r＞50％和r＞75％的冠脉狭窄,舒张末期离散度(DISPED)诊断r＞75％的冠脉狭窄,分别以9.3、10.95和34.05为截点值,有良好的灵敏度和特异度.结论 sRT-3DE能够评价冠心病左室心肌舒张同步性,DDI、DISPED对冠脉狭窄程度的预测有重要的临床价值.     

应用超声射频血管内中膜分析和血管硬度定量技术评价睡眠呼吸暂停患者颈动脉结构和功能

目的 应用超声射频信号血管内中膜分析(RFQIMT)技术和血管硬度定量分析(RFQAS)技术评价阻塞性睡眠呼吸暂停综合征(OSAS)患者颈动脉结构和功能,并探讨其心血管危险因素.方法 113例因打鼾疑为OSAS的患者根据呼吸暂停低通气指数(AHI)＜5、5～20、20～40、＞40次/h分为对照组及OSAS轻度、中度、重度4组,应用RFQIMT和RFQAS技术检测颈总动脉内中膜厚度(IMT)、内径(D)、内径变化幅度(Dis)、扩张系数(DC)、顺应系数(CC)、脉搏波传导速度(PWV)及僵硬度α、β,观察4组间参数的差异,并应用多重线性回归分析其危险因素.结果 ①一般临床资料:4组间比较,血压逐渐升高(P＜0.05).平均血氧饱和度(SO2)、最低血氧饱和度(SO2 min)在OSAS轻、中、重组逐渐减小,氧饱和度低于90％的时间占睡眠时间百分比(T90)、氧解离指数(ODI)逐渐增大(P＜0.05).②颈动脉QIMT及斑块:4组间差异有统计学意义(P＞0.05).③颈动脉QAS参数:与对照组比较,OSAS轻度组Dis增大,中度组PWV、α、β增大(P＜0.05).与OSAS轻度组比较,中度组PWV、α、β增大(P＜0.05).与OSAS中度组比较,重度组α、β增大(P＜0.05).④多重线性回归结果提示:年龄是影响IMT、Dis、DC、CC、PWV、α、β的主要因素(P＜0.05);夜间收缩压下降率是D、DC、CC、PWV的影响因素(P＜0.05),白天收缩压、夜间收缩压、白天脉压是影响D的主要因素(P＜0.05),SO2是影响PWV的显著因素(P＜0.05),脉压(PP)是影响PWV、α、β的显著因素(P＜0.05);吸烟是斑块形成的预测因素(P＜0.05).结论 ①随着OSAS病情加重,颈动脉弹性显著减低,但结构指标无差异,提示OSAS患者颈动脉弹性异常早于形态学的改变.②PP、夜间收缩压下降率及SO2是影响OSAS颈动脉弹性功能的显著因素,提示昼夜血压变化及低氧是影响颈动脉弹性的重要因素.     

肾移植患者左室舒张功能指标与颈动脉弹性参数的相关性分析

目的探讨肾移植患者颈动脉硬化指标与左心室舒张功能参数之间的相关性。方法依据颈动脉内中膜厚度（IMD）的变化将103例肾移植患者分为三组：IMT≤0．11cm为A组（51例）;IMT〉0．11cm,无斑块为B组（39例）;IMT〉0．11cm,有斑块为c组（13例）。正常对照为D组（30例）。超声心动图检查测量左室舒张功能指标二尖瓣E峰／组织多普勒E峰（E／Era）、二尖瓣E峰／左室血流传导速度（E／vp）、二尖瓣E峰／A峰（E／A）、E峰减速时间（DT）、肺静脉反流速度（PVAR）。高频线阵探头测量颈动脉IMT、扩张系数（DC）、僵硬度指数（SI）、脉压差（PP）。结果A、B、C组肾移植患者左室舒张功能指标E／Em、E／Vp、E／A、DT和PVAR与对照组比较,差异有统计学意义（P均〈0．05）;A、B、C三组之间两两比较差异亦有统计学意义（P均〈0．05）。左室舒张功能指标E／Em、E／Vp与颈动脉DC呈负相关（r=-0．876,P=0．000;r=-0．814,P=0．ooo）,E／Era与颈动脉SI、IMT及PP呈正相关（r=0．887,P=0．000;r=0．690,P=0．016;r=0．529P=0．046）,E／Vp与颈动脉SI、IMT及PP亦呈正相关（r=0．811,P=0．000;r=0．674,P=0．015;r=0．0537,P=0．040）;左室舒张功能指标PVAR与颈动脉DC呈负相关（r=-0．601,P=0．011）,与颈动脉IMT、颈动脉SI、PP呈正相关（r=0．635,P=0．031;r=0．611,P=0．023;r=0．601,P=0．030）;左室舒张功能指标E／A、DT与颈动脉各参数之间没有明显的相关性（r均为0．000,P均〉0．05）。结论肾移植后反映左室舒张功能的指标E／Era、E／Vp与颈动脉弹性参数DC、SI具有相关性。     

射频超声评价亚临床甲状腺功能减退症颈动脉弹性的临床价值

目的应用射频超声技术检测亚临床甲状腺功能减退症(SCH)患者颈动脉弹性功能。方法 SCH患者93例,据促甲状腺激素(TSH)水平分为SCH1组(TSH 4.2~10.0 m U/L)46例,SCH2组(TSH10.0 m U/L)47例,体检健康者50例为对照组。检测其血清总胆固醇、甘油三酯、低密度脂蛋白。射频超声检测其颈动脉弹性参数:内—中膜厚度(IMT)、顺应性系度(CC)、膨胀系数(DC)、弹性系数(α、β)、脉搏波速度(PWV)及动脉反射波增强指数(AIx)。结果 SCH2组总胆固醇、低密度脂蛋白高于对照组(P0.05)。与对照组相比,SCH1组DC、β、PWV、AIX均增高(P0.05),SCH2组IMT、CC、DC、α、β、PWV、AIx均增高(P0.05)。SCH2组IMT、α、β、PWV、AIX高于SCH1组(P0.05)。DC与IMT、α、β、PWV呈负相关(P0.01)。CC与IMT、α、β、PWV呈负相关,与DC呈正相关(均P0.01)。AIX与IMT呈正相关,与DC呈负相关(均P0.01)。结论射频超声能尽早发现颈动脉弹性改变,为评估SCH患者大动脉损害提供重要的检测方法。     

应用动脉弹性新参数评价2型糖尿病患者双侧颈动脉硬化差异的初步研究

目的应用动脉弹性新参数评价2型糖尿病患者颈动脉段硬化差异的初步研究。方法 2型糖尿病患者88例(DM组),对照组70例。应用超声射频技术获取受检者左、右侧颈动脉顺应系数(CC)和脉搏波速度(PWV),计算左、右侧两参数值之比,获取CCratio、PWVratio新参数,并在组内采用左右侧比较,在组间采用同侧比较。分析影响CCratio、PWVratio值的相关因素。结果 1DM组,左侧颈动脉PWV高于右侧(P﹤0.05);对照组,CC和PWV在左右侧对比差异无统计学意义;2与对照组比较,DM组患者左右侧颈动脉PWV和右侧颈动脉CC均大于对照组(均P﹤0.05);3PWVratio在两组间差异有统计学意义(P﹤0.05)。PWVratio与糖尿病病程和收缩压呈正相关(r=0.334和r=0.460,P﹤0.05),而与年龄、身高、体重不相关。CCratio在两组间差异无统计学意义(P﹥0.05)。结论 2型糖尿病患者双侧颈动脉僵硬度不同,这种差异与病程和血压有关,新参数可评价双侧颈动脉僵硬的差异。     

血管回声跟踪技术定量评价2型糖尿病患者颈动脉弹性的研究

目的 应用血管回声跟踪(ET)技术评价2型糖尿病患者颈动脉弹性参数的变化.方法 应用ET技术检测44例被首次确诊的2型糖尿病患者及31例健康者为对照组的颈动脉压力-应变弹性系数(Ep)、僵硬度参数(β)、顺应性(AC)、单点脉搏波传导速度(PWVβ),并分析其与空腹血糖、糖化血红蛋白之间的关系.结果 2型糖尿病组的Ep、β、PWVβ高于对照组(P＜0.01),AC则低于对照组(P＜0.01).Ep、β、PWVβ与空腹血糖、糖化血红蛋白呈正相关,AC与空腹血糖、糖化血红蛋白呈负相关(P＜0.05).结论 2型糖尿病患者颈动脉弹性明显减低,减低程度与空腹血糖、糖化血红蛋白相关;应用ET技术有助于评估2型糖尿病患者颈动脉弹性的功能改变.     

血管内径追踪和矢量应变技术评价糖尿病患者颈总动脉弹性的价值

目的 探讨血管内径追踪和矢量应变技术在评价颈总动脉血管弹性中的价值.方法 病例组选择单纯糖尿病患者38例,与病例组年龄、性别匹配的健康志愿者37例作为对照组.应用血管内径追踪和矢量应变技术测量颈总动脉弹性指标:脉搏波传导速度(PWV)、顺应性系数(CC)、僵硬指数(β),内膜环向应变、应变率、应变时间,外膜环向应变、应变率、应变时间,径向应变、应变率、应变时间.分析两组间参数的显著性差异及相关性.结果 糖尿病组颈总动脉PWV、β较对照组显著增高(P＜0.05),CC较对照组明显减低(P＜0.05);内外膜环向应变、应变率和径向应变、应变率指标较对照组显著减低(P＜0.05),相对应的应变时间较对照组延长(P＜0.05);两组间纵向应变指标差异无统计学意义.糖尿病组CC与PWV呈显著负相关(r=-0.872,P＜0.001),年龄、收缩压、β与PWV正相关(分别r=0.322,P=0.005;r=0.384,P=0.001; r =0.927,P＜0.001).结论 血管内径追踪技术所测量的硬度及顺应性指标和矢量应变技术所获得的环向及径向应变指标能够直观地反映糖尿病患者血管弹性的变化.     

Determination of creatine kinase isoenzyme MB activity in serum using immunological inhibition of creatine kinase M subunit activity. Activity kinetics and diagnostic significance in myocardial infarction.

This is a new method for the determination of creatine kinase isoenzyme MB activity in serum. The method uses direct activity measurement of creatine kinase B subunit activity after blocking of CK-M subunit activity by inhibiting antibodies. The test takes no longer than 15 min. The method yields an intra-serial C.V. of 2.0-12.9%, and a C.V. from day to day of 5.5%. The detection limit is 3.4 U/l creatine kinase MB. In the 95 cases with proven myocardial infarction several types of creatine kinase MB activity kinetics could be determined. The percentage of creatine kinase MB of peak CK-total is 6-25%, with a mean of 11.1%. The amount of creatine kinase MB with respect to total CK activity after reinfarction is higher than the amount after initial infarction.     

Dissociable correlates of two classes of retrieval processing in prefrontal cortex

Although substantial evidence suggests that the prefrontal cortex (PFC) implements processes that are critical for accurate episodic memory judgments, the specific roles of different PFC subregions remain unclear. Here, we used event-related functional magnetic resonance imaging to distinguish between prefrontal activity related to operations that (1) influence processing of retrieval cues based on current task demands, or (2) are involved in monitoring the outputs of retrieval. Fourteen participants studied auditory words spoken by a male or female speaker and completed memory tests in which the stimuli were unstudied foil words and studied words spoken by either the same speaker at study, or the alternate speaker. On "general" test trials, participants were to determine whether each word was studied, regardless of the voice of the speaker, whereas on "specific" test trials, participants were to additionally distinguish between studied words that were spoken in the same voice or a different voice at study. Thus, on specific test trials, participants were explicitly required to attend to voice information in order to evaluate each test item. Anterior (right BA 10), dorsolateral prefrontal (right BA 46), and inferior frontal (bilateral BA 47/12) regions were more active during specific than during general trials. Activation in anterior and dorsolateral PFC was enhanced during specific test trials even in response to unstudied items, suggesting that activation in these regions was related to the differential processing of retrieval cues in the two tasks. In contrast, differences between specific and general test trials in inferior frontal regions (bilateral BA 47/12) were seen only for studied items, suggesting a role for these regions in post-retrieval monitoring processes. Results from this study are consistent with the idea that different PFC subregions implement distinct, but complementary processes that collectively support accurate episodic memory judgments.     

俯卧位通气对高海拔地区肺复张治疗无效急性呼吸窘迫综合征患者氧合的影响

目的 探讨俯卧位通气对高海拔地区肺复张术(RM)治疗无效急性呼吸窘迫综合征(ARDS)患者的治疗作用.方法 从海拔2260m的地区医院筛选RM治疗无效的41例ARDS患者[平均氧合指数( PaO2/FiO2)较RM前升高＜20％视为RM无效],依不同病因分为肺内源性ARDS组(ARDSp组)和肺外源性ARDS组(ARDSexp组),每组再按信封法随机分为俯卧位组和仰卧位组,即ARDSp俯卧位组(11例)、ARDSp仰卧位组(9例)、ARDSexp俯卧位组(10例)、ARDSexp仰卧位组(11例).在通气前及通气1、2、3、4h监测动脉血氧分压( PaO2)、PaO2/FiO2、静态顺应性(Cst)、气道阻力(Raw)的变化.结果 通气lh时,ARDSexp俯卧位组PaO2/FiO2( mm Hg,l mm Hg=0.133 kPa)即较通气前显著升高(157.4±40.6比129.3±48.7,P＜0.05),并随通气时间延长呈持续增高趋势,4h达峰值(219.1 ±41.1);且ARDSexp俯卧位组通气3h内PaO2/FiO2较其他3组显著增高,另3组间则差异无统计学意义.ARDSp俯卧位组、ARDSexp俯卧位组通气4h时PaO2/FiO2均较相应仰卧位组显著增高(208.8±39.7比127.4±47.1,219.1±41.1比124.9±50.8,均P＜0.05).4组通气前后Cst无显著改变,各组间差异也无统计学意义.ARDSp俯卧位组通气4h时Raw(cmH2O·L-1·s-1)较通气前显著降低(6.8±1.7比10.7±1.8,P＜0.05),且明显低于其他3组;其他3组各时间点Raw组内及组间比较差异均无统计学意义.结论 俯卧位通气作为ARDS机械通气重要策略之一,可以改善RM无效高原ARDS患者的氧合,为抢救患者赢得宝贵的时间.     

Digital imaging among medical facilities

The Department of Veterans Affairs (VA) in the USA operates a network of 172 medical centres which all utilize a hospital information system (HIS) which has been developed and is currently maintained by the VA. During the past several years, an image management and communication module has been developed, installed and clinically utilized at the Washington DC and Maryland VA Medical Centres. This image management and communication system, referred to as the decentralized hospital computer program (DHCP) imaging system, is fully integrated with a commercial picture archiving and communication system (PACS). The system is utilized to capture, archive, and display all images generated within the hospital including radiology, nuclear medicine, pathology, endoscopy, bronchoscopy, and dermatology, intraoperative photographs, ECG data, and a limited number of paper documents. The ultimate goal of the project is to have all patient text and image data available at any clinical workstation to any authorized user anywhere within the network of medical centres. Clinical requirements for an imaging workstation include ease of use, rapid and reliable access to the complete set of patient information, and images which are of acceptable quality to meet the requirements of the user and the subspecialty. Patient confidentiality and data security must be safeguarded at all times. Integration of the images with the remainder of the patient's database was found to be critical to the success of the project. The experience at the Washington and Maryland facilities suggests that an imaging system that is successfully integrated with a hospital information system can provide substantial clinical and economic benefits both within and among medical centres. Clinical acceptance and utilization of the system has been excellent, particularly in diagnostic radiology where DHCP Imaging has been interfaced to a commercial PAC system. Based upon this initial experience, the VA has begun to deploy the system throughout its large network of medical centres.     

Myocardial elastography at both high temporal and spatial resolution for the detection of infarcts

Myocardial elastography is a novel method for noninvasively assessing regional myocardial function, with the advantages of high spatial and temporal resolution and high signal-to-noise ratio (SNR). In this paper, in-vivo experiments were performed in anesthetized normal and infarcted mice (one day after left anterior descending coronary artery [LAD] ligation) using a high-resolution (30 MHz) ultrasound system (Vevo 770, VisualSonics Inc., Toronto, ON, Canada). Radiofrequency (RF) signals of the left ventricle (LV) in longitudinal (long-axis) view and the associated electrocardiogram (ECG) were simultaneously acquired. Using a retrospective ECG gating technique, 2-D full field-of-view RF frames were acquired at an extremely high frame rate (8 kHz) that resulted in high-quality incremental displacement and strain estimation of the myocardium. The incremental results were further accumulated to obtain the cumulative displacements and strains. Two-dimensional and M-mode displacement images and strain images (elastograms), as well as displacement and strain profiles as a function of time, were compared between normal and infarcted mice. Incremental results clearly depicted cardiac events including LV contraction, LV relaxation and isovolumetric phases in both normal and infarcted mice, and also evidently indicated reduced motion and deformation in the infarcted myocardium. The elastograms indicated that the infarcted regions underwent thinning during systole rather than thickening, as in the normal case. The cumulative elastograms were found to have higher elastographic SNR (SNR(e)) than the incremental elastograms (e.g., 10.6 vs. 4.7 in a normal myocardium, and 6.0 vs. 2.4 in an infarcted myocardium). Finally, preliminary statistical results from nine normal (m = 9) and seven infarcted (n = 7) mice indicated the capability of the cumulative strain in differentiating infracted from normal myocardia. In conclusion, myocardial elastography could provide regional strain information at simultaneously high temporal (>/=0.125 ms) and spatial ( approximately 55 microm) resolution as well as high precision ( approximately 0.05 microm displacement). This technique was thus capable of accurately characterizing normal myocardial function throughout an entire cardiac cycle, at the same high resolution, and detecting and localizing myocardial infarction in vivo.     

手转胎头术失败的原因与分娩结局临床分析

目的 探讨手转胎头术失败的原因与分娩结局.方法 选择2008年1月至2010年12月于我院住院分娩的持续性枕横位、枕后位产妇198例,根据行手转胎头术后结果分为成功组126例、失败组72例.比较两组分娩结局,对比分析失败原因.结果 失败组胎儿体质量≥3500 g的发生率[76.4％(55/72)]明显高于成功组[31.7％(40/126)],差异有统计学意义(x2=30.177,P=0.001)、失败组宫缩乏力发生率[58.3％(42/72)]高于成功组[38.1％ (48/126)],差异有统计学意义(x2=7.569,P=0.006)、失败组骨盆临界或轻度狭窄发生率[38.9％ (28/72)]高于成功组[23.8％(30/126)],差异有统计学意义(x2 =5.030,P=0.002)、失败组手转胎头时机不当(宫口开大＜6 cm、胎头位于坐骨棘上及宫口开大8～10 cm、胎头位于坐骨棘下≥2 cm)发生率[61.1％(44/72)]高于成功组[38.9％(49/126)],差异有统计学意义(x2=9.084,P=0.003).失败组母儿并发症(产后出血、产褥病率、胎儿窘迫、新生儿窒息)发生率高于成功组(x2 =9.586,P=0.002、x2=9.334,P=0.002、x2=5.910,P=0.015、x2=5.240,P=0.022)、失败组剖宫产发生率[72.2％(52/72)]明显高于成功组[34.1 ％(43/126),x2=26.641,P=0.001)].结论 手转胎头术能使难产变顺产,降低剖宫产率,减少母儿并发症,但须积极预防、处理导致手转胎头术失败的原因,对矫正失败后继续矫正及试产应慎重.