The Number of Fungiform Papillae,Taste Sensitivity and Smell Functions of Children Aged 11–15

Differences in the ability to identify and perceive tastes and smells might influence food consumption and, ultimately, chronic nutrition-related conditions such as overweightness and obesity. This study aimed to investigate the associations between taste sensitivity and odour function, anthropometry, and quantity of fungiform papillae in children at age 11–15. Taste strips (4 base tastes), U-Sniff sticks (12 selected smells), and a filter paper strip impregnated with 6-n-propylthiouracil (PROP) were used. The photographic method was used to estimate the number of fungiform papillae (FP) on the tongue. The results showed that the quantity of FP was not related to anthropometry or gender. The taste test total scores were higher for girls, for whom the median score was 14 (12.0–15.0), than for boys, for whom the median score was 12 (9.0–13.0). Of the children, 13.9% had some difficulty in identifying odours. The Mann–Whitney U test showed that children who were most sensitive to bitter taste had more FP (p = 0.0001). The median score for this group (score = 4) was 34.0 (27.0–37.0). For those who had some problems with correctly assessing all bitter taste strips (score = 0–3), the median score was 24.0 (20.0–31.0). Higher numbers of FP were also observed in tasters, that is, people sensitive to PROP, than in nontasters. Only some measures of the taste function correlated with each other, but not very significantly. We concluded that there are multiple perceptual phases of taste, with no single measure able to entirely represent the sense of taste.     

The Association between Fat Taste Sensitivity,Eating Habits,and Metabolic Health in Menopausal Women

The aim of our study was to evaluate the associations between sensitivity to fat taste, eating habits and BMI value in a sample of menopausal Polish women. In a population of 95 women, fat taste thresholds with oleic acid were determined, allowing us to classify each woman as a hypersensitive or hyposensitive taster. Eating habits were assessed using a validated KomPAN questionnaire for food frequency. Dietary intake was evaluated based on a food diary. Selected biochemical parameters were measured using a Konelab20i biochemical analyzer. Anthropometric parameters and blood pressure were also measured. Twenty-two menopausal women were classified as hyposensitive to fat taste and 73 as hypersensitive. The hyposensitive tasters were significantly older (p = 0.006), with the majority of them (92%) being postmenopausal (p < 0.001); this group had significantly higher BMI values (p < 0.001) and other adiposity indicators compared to their hypersensitive counterparts. The hyposensitive tasters had higher blood pressure (systolic blood pressure; SBP p = 0.030; diastolic blood pressure; DBP p = 0.003), glucose (p = 0.011) and triacylglycerols levels than the hypersensitive tasters (p = 0.031). Almost half of them had diagnosed metabolic syndrome. Daily eating occasions were associated with low oral fatty acid sensitivity, irrespective of age (p = 0.041) and BMI value (p = 0.028). There were also significant associations between frequency of consumption of meats and eggs, as well as snacks and fast foods and low oral fatty acid sensitivity before adjustment for potential confounders (both associations p < 0.05), which remained after adjustment for age (both associations p < 0.05), but not after adjustment for BMI. A multivariate logistic regression analysis showed that higher BMI value (p = 0.003), along with postmenopausal status (p = 0.003), were associated with low fat taste sensitivity irrespective of age and consumed percentage energy from fat. Postmenopausal status and BMI are associated with low fat taste sensitivity. Fat hyposensitivity may also play a role in eating habits, leading to increased eating occasions and favoring certain types of food. These eating habits may determine increased body weight and the occurrence of metabolic syndrome in mid-life women, especially those who have undergone menopause and have been exposed to the physiological changes which are conducive to these relationships.     

Associations between Sweet Taste Sensitivity and Polymorphisms (SNPs) in the TAS1R2 and TAS1R3 Genes,Gender, PROP Taster Status,and Density of Fungiform Papillae in a Genetically Homogeneous Sardinian Cohort

Individual differences in sweet taste sensitivity can affect dietary preferences as well as nutritional status. Despite the lack of consensus, it is believed that sweet taste is impacted by genetic and environmental variables. Here we determined the effect of well-established factors influencing the general taste variability, such as gender and fungiform papillae density, specific genetic variants (SNPs of TAS1R2 and TAS1R3 receptors genes), and non-specific genetic factors (PROP phenotype and genotype), on the threshold and suprathreshold sweet taste sensitivity. Suprathreshold measurements showed that the sweet taste response increased in a dose-dependent manner, and this was related to PROP phenotype, gender, rs35874116 SNP in the TAS1R2 gene, and rs307355 SNP in the TAS1R3 gene. The threshold values and density of fungiform papillae exhibited a strong correlation, and both varied according to PROP phenotype. Our data confirm the role of PROP taste status in the sweet perception related to fungiform papilla density, show a higher sweet sensitivity in females who had lower BMI than males, and demonstrate for the first time the involvement of the rs35874116 SNP of TAS1R2 in the sweet taste sensitivity of normal weight subjects with body mass index (BMI) ranging from 20.2 to 24.8 kg/m². These results may have an important impact on nutrition and health mostly in subjects with low taste ability for sweets and thus with high vulnerability to developing obesity or metabolic disease.     

The Associations Between Life Satisfaction and Health-related Quality of Life, Chronic Illness, and Health Behaviors among U.S. Community-dwelling Adults

The primary purpose of this article was to examine the associations between life satisfaction level and health-related quality of life (HRQOL), chronic illness, and adverse health behaviors among adults in the U.S. and its territories. Data were obtained from the 2005 Behavioral Risk Factor Surveillance System, an ongoing, state-based, random-digit telephone survey of the noninstitutionalized U.S. population aged ≥18 years. An estimated 5.6% of U.S. adults (about 12 million) reported that they were dissatisfied/very dissatisfied with their lives. As the level of life satisfaction decreased, the prevalence of fair/poor general health, disability, and infrequent social support increased as did the mean number of days in the past 30 days of physical distress, mental distress, activity limitation, depressive symptoms, anxiety symptoms, sleep insufficiency, and pain. The prevalence of smoking, obesity, physical inactivity, and heavy drinking also increased with decreasing level of life satisfaction. Moreover, adults with chronic illnesses were significantly more likely than those without to report life dissatisfaction. Notably, all of these associations remained significant after adjusting for sociodemographic characteristics. Our findings showed that HRQOL and health risk behaviors varied with level of life satisfaction. As life satisfaction appears to encompass many individual life domains, it may be an important concept for public health research. Disclaimer: The findings and conclusions in this article are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.     

Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL)

The World Health Organization (WHO) has undertaken a project to develop an instrument (the WHOQOL) for measuring quality of life. Quality of life is defined as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns. It is a broad ranging concept affected in a complex way by the person's physical health, psychological state, level of independence, social relationships, and their relationship to salient features of their environment.The instrument will be developed in the framework of a collaborative project involving numerous centres in different cultural settings. In addition, it will have proven psychometric properties of validity, responsiveness and reliability and will be sensitive to the cultural setting in which it is applied, whilst maintaining comparability of scores across different cultural settings.This paper outlines the characteristics of the planned instrument and the study protocol governing work on its development. To date steps 1 through 5 have been completed and work is progressing on step 6. It is anticipated that the instrument will be available for piloting in July 1993 and a final version available for use in June 1994.The study protocol for the WHO project to develop a Quality of Life assessment instrument reported here is based on the work and experience of a panel of consultants, as well as the collaborating investigators in each of the field sites. The collaborating investigators in this study are: Prof. H. Herrman, University of Melbourne, Melbourne, Australia; Ass. Prof. Z. Metelko and Prof. S. Szabo, Institute of Diabetes, Endocrinology and Metabolic Diseases, University of Zagreb, Zagreb, Croatia, Dr S. Rajkumar and Mrs Shuba Kumar, Madras Medical College, Madras, India, Prof. Dr G. Van Heck, and Mrs J. De Vries, Tilburg University, Tilburg, Netherlands, Prof. Arroyo Sucre, University of Panama, Panama, Prof. Kabanov, Dr Lomachenkov and Dr Burkovsky, Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia, Prof Sompotch Sukwatana and Mr Kitikorn Meesapya, Department of Medical Services, Bangkok, Thailand, Dr S. Skevington, University of Bath, Bath, United Kingdom; Dr D. Patrick and Ms M. Martin, University of Washington, Seattle, USA and; Dr J. Mutambirwa, University of Zimbabwe, Harare, Zimbabwe. The project team at the Division of Mental Health, WHO, Geneva is Dr N. Sartorius, Dr J. Orley and Dr W. Kuyken.Technical support and funds for carrying out this study have been provided by the World Health Organization, by the participating centres themselves and by grants from the Upjohn Company, Kalamazoo, USA, and the Carnegie Corporation, New York, USA.     

修订的糖尿病生命质量量表(A-DQOL)信度与效度初探

目的：通过对修订的专用糖尿病生命质量量表（Ａ－ＤＱＯＬ）信度和效度进行评价,旨在国内推广应用糖尿病生命质量评价的专用量表。方法：采用相关分析和因子分析对Ａ－ＤＱＯＬ的信度和效度进行评价。结果：Ａ－ＤＱＯＬ的重测信度为０．８２３６,折半信度为０．７９６３,克朗巴哈α系数为０．８６９９,θ系数为０．９０６０,Ω系数为０．９１６３;规定提取３个公因子,利用主因子因子分析法进行分析表明,Ａ－ＤＱＯＬ具有良     

支气管哮喘患者的生活质量及情绪状况分析

目的调查支气管哮喘患者的生活质量及情绪状况,分析不同人口学特征及医学变量的支气管哮喘患者生活质量的差异,探讨情绪与患者生活质量的关系。方法使用一般情况调查表、5分制成人哮喘生活质量评估表(AQLQ)及简明心境问卷—简式(POMS-SF)对769名支气管哮喘患者进行了问卷调查。结果 AQLQ总均分为(113.00±25.85)分;每题均分为3.23分,处在5点量表的中间位置。门诊患者的生活质量总分高于住院患者,差别有统计学意义(P0.001);男性、年龄30岁、大学及以上文化程度、病程少于5年的支气管哮喘患者相对于其他患者来说生活质量相对较好,负性情绪的得分较低;工人及农民、经济状况较差、病情较严重的支气管哮喘患者生活质量较差,负性情绪的得分也相对较高,差别均有统计学意义(P0.05)。同时,相关分析的结果表明,AQLQ总分与POMS-SF总分呈负相关(r=-0.50),AQLQ各维度与POMS-SF各分量表也存在着不同程度的相关,均有统计学意义(P0.001)。结论支气管哮喘患者的生活质量偏差,存在较多的负性情绪,不同性别、年龄、文化程度、职业、经济状况、病情及病程的支气管哮喘患者生活质量及情绪状况存在差异。     

芜湖市大学生生活质量调查研究

目的了解在校大学生生活质量现状及其影响因素。方法采用世界卫生组织生活质量测定量表简表(WHOQOL-BREF)对芜湖市3所高校700名大学生进行问卷调查。结果大学生生活质量总体水平居中,总的生活质量随年级增高呈逐步下降趋势并存在显著的年级差异,心理健康状况与大学生生活质量关系密切。结论相关部门应重视大学生的生活质量状况,有区别地针对不同性别、健康状况、不同专业及来源的大学生加强教育,以改善大学生的生活质量。     

Quality of Life in the General Norwegian Population, Measured by the Quality of Life Scale (QOLS-N)

The main aim of the present study was to derive norms or reference values from the general Norwegian population for the Norwegian version of the Quality of Life Scale (QOLS-N). In addition, associations between socio-demographic and health variables on the level of quality of life were examined. The sample consisted of 1893 subjects from a total of 4000 randomly selected Norwegian citizens representative of the entire Norwegian population, aged 19-81. The subjects received a mailed questionnaire containing the QOLS-N. Results show that the mean quality of life score was 84.1 (SD 12.5). Women reported a higher quality of life than men. People with higher levels of education reported a higher quality of life. Those who were married or cohabitating reported the highest quality of life and those who were unemployed reported a lower quality of life than those who worked. In addition, people reporting long-term diseases or health problems scored significantly lower on quality of life. These results could serve as reference values for the level of quality of life, as measured by the QOLS-N in the Norwegian population.     

The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): Validation Study of the Thai Version

The objective of this study was to assess the psychometric properties of the Thai version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) version 3.0. The questionnaire was completed by 310 cancer patients during their follow-up at 2 teaching hospital oncology clinics. About 70% of participants had advanced stage of cancer and 72% had been receiving chemotherapy. Cronbach’s α coefficients of the six scales were above 0.7, except for cognitive and social function scales. All test–retest reliability coefficients were high. Multitrait scaling analysis showed that all item-scale correlation coefficients met the standards of convergent and discriminant validity. Most scales and items could discriminate between subgroups of patients with different clinical status assessed with the Eastern Cooperative Oncology Group (ECOG) scale. The results suggested that the EORTC QLQ-C30 and the Functional Assessment of Cancer Therapy – General (FACT-G) measured different aspects of quality of life and should be independently used. Testing psychometric properties of the EORTC QLQ-C30 in heterogeneous diagnostic group yield similar results as found in homogeneous group. These results support that the EORTC QLQ-C30 (version 3.0) has proven to be a reliable and valid measure of the quality of life in Thai patients with various types of cancer.     

农村脑卒中患者家庭陪护人生命质量的研究

目的了解脑卒中致农村家庭负担，为今后降低脑卒中对家庭的危害性提供依据。方法以SF-36量表作为测量工具，采用人户的方式对71名脑卒中的家庭陪护人进行调查。结果脑卒中患者及其家庭陪护人在8个维度的评分比较，经t检验，差别均无统计学意义（P〉0．05）。男女性家庭陪护人在8个维度的评分上均低于四川省40～59岁农村人口，差别有统计学意义（P〈0．01）。结论脑卒中在严重影响患者自身生命质量的同时，给农村家庭造成的负担不容忽视。     

The Relation between Resistin (−420C/G) Single Nucleotide Variant,Resistin Serum Concentration,Carbohydrate, and Lipid Parameters and Fried Food Taste Preference in Patients with Hypertriglyceridemia

Background: Resistin is a proinflammatory adipokine involved in metabolic disorders. Its interplay with hypertriglyceridemia remains to be elucidated. We aimed to evaluate the relationship between resistin (−420C/G) single nucleotide variant (SNV) and metabolic parameters and preference for fried food consumption in hypertriglyceridemia. Methods: The study enrolled 179 hypertriglyceridemic (HTG) and 182 normotriglyceridemic (NTG) patients. Anthropometric measurements, serum resistin, insulin and fasting glucose concentration, a homeostatic model assessment—insulin resistance (HOMA-IR), triglycerides (TG), cholesterol concentration, and fried food taste preference (FP) or other cooking methods preference (OP) were assessed in the study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Results: HTG and NTG groups did not differ significantly in serum resistin concentration; HTG individuals demonstrated significantly increased serum levels of TG, glucose, total cholesterol (TCH), and HOMA-IR and decreased HDL cholesterol. Resistin, insulin, glucose, HOMA-IR, and cholesterol fractions were similar among particular resistin genotypes in HTG, NTG, FP, or OP groups. TG and TCH concentrations differ significantly among CG and CC genotypes in the FP group. Considering the FP group, GG and CG genotypes appeared more frequently in hyperlipidemic (OR 2.6 95% CI; 1.16–5.82; p = 0.01; significant after Bonferroni correction) than in NTG patients. Multivariable logistic regression models showed that the G allele and CG genotype of SNV (−420C/G), adjusted for selected confounders such as fried food preference, increased the odds of hypertriglyceridemia about twofold. Conclusions: Allele G and CG genotype of resistin SNV (−420C/G) are linked with the preference for fried food taste in hypertriglyceridemic patients.     

郴州市大学生生活质量研究

目的 了解大学生生活质量及其影响因素。方法 采用世界卫生组织生存质量测定量表简表(WHOQOL-BREF)对郴州市两所高校687名大学生进行问卷调查。结果 男生在社会关系领域得分高于女生，在环境领域得分低于女生；自述健康大学生在总的生存质量和总的健康状况及其它各领域得分均高于自述非健康学生；来自城市的学生在社会关系领域、环境领域得分高于农村学生；医学生在生理领域得分低于师范生。结论 大学生的生活质量存在差异，应采取针对性措施改善大学生的生活质量。     

手术室男护士职业认同与工作压力、生活质量的相关性研究

目的探讨手术室男护士职业认同、工作压力、工作相关生活质量相关性。方法于2019年9月10日-11月10日选取山西省10所医院265名手术室男护士进行调查,采用SPSS l7.0软件进行统计分析。结果调查对象职业认同水平中等偏上(105.63±15.93)分、工作压力为中等(88.69±18.83)分、工作相关生活质量水平中等偏下(85.67±12.57)分;多元线性回归分析显示,子女数量（t=2.434,P=0.015）、薪酬满意度（t=2.852,P=0.005）、职称（t=3.335,P=0.001）     

Association between Sour Taste SNP KCNJ2-rs236514, Diet Quality and Mild Cognitive Impairment in an Elderly Cohort

Differences in sour-taste thresholds have been identified in cognition-related diseases. Diet is a modulator of cognitive health, and taste perception influences dietary preferences and habits. Heritable genetics and polymorphisms in the KCNJ2 gene involved in the transduction of sour taste have been linked to variations in sour taste and non-gustatory functions. However, relationships between sour taste genetics, mild cognitive impairment, and diet quality are yet to be elucidated. This study investigated the associations between the presence of the KCNJ2-rs236514 variant (A) allele, diet quality indices, and mild cognitive impairment evaluated by the Mini-Mental State Examination (MMSE), in a secondary cross-sectional analysis of data from the Retirement Health & Lifestyle Study. Data from 524 elderly Australians (≥65y) were analyzed, using standard least squares regression and nominal logistic regression modeling, with demographic adjustments applied. Results showed that the presence of the KCNJ2-A allele is associated with increased proportions of participants scoring in the range indicative of mild or more severe cognitive impairment (MMSE score of ≤26) in the total cohort, and males. These associations remained statistically significant after adjusting for age, sex, and diet quality indices. The absence of association between the KCNJ2-A allele and cognitive impairment in women may be related to their higher diet quality scores in all indices. The potential link between sour taste genotype and cognitive impairment scores may be due to both oral and extra-oral functions of sour taste receptors. Further studies are required on the role and relationship of neurotransmitters, sour taste genotypes and sour taste receptors in the brain, and dietary implications, to identify potential risk groups or avenues for therapeutic or prophylactic interventions.     

The Significance of Importance: An Evaluation of Ferrans and Powers’ Quality of Life Index

Ferrans and Powers’ Quality of Life Index (QLI) defines and assesses quality of life (QoL) in terms of importance-weighted life satisfaction. This study assessed the value of such weights and explored the relationship between weighted and unweighted (satisfaction only) scores and single-item rated overall life satisfaction (LS) and QoL. Data were collected by a postal survey to 81 Parkinson’s disease patients (88% response rate). Correlations between weighted and unweighted QLI scores were ≥0.96, except for one subscale (r_s = 0.85). Item non-response rates ranged between 4.2 and 45.1% and 1.4 and 38% for the weighted and unweighted QLI, respectively. Cronbach’s α exceeded 0.7 for weighted and unweighted versions of two out of the four subscales and the total score. Scaling success rates were similar for weighted and unweighted scores and did not support the current subscale structure. Unexpectedly, weighted total scores correlated stronger with LS than with QoL, and unweighted scores displayed the opposite pattern. This study found no advantages by using importance-weighted satisfaction scores. The correlational pattern with overall LS and QoL challenges the QLI approach to QoL, although these observations may relate to the use of multiplicative item weights. This study has implications also beyond the QLI regarding, e.g., the use of multiplicative weights and the relationship between life satisfaction and QoL.     

Comparison of the psychometric properties of the Asthma Quality of Life Questionnaire (AQLQ) among 115 Asthmatic Adults assessed during Acute Hospitalization and as Outpatients

Health status instruments designed for outpatient settings may not perform as intended when applied to hospitalized patients. In this study, we assessed similarities and differences between the psychometric properties of the Asthma Quality of Life Questionnaire (AQLQ) in-hospital and during an outpatient visit 6 months later, in a cohort of 115 patients. No ceiling or floor effects were present at either visit. At both visits, all scales except for `environment' had internal consistency coefficients >0.7 (Environment: 0.69 – hospitalization; 0.68 – outpatient). On both occasions, over 75% of item-scale correlation scores were >0.4 and over 80% correlated to a greater degree with their own scale total than with the other three scales. However, at both visits, the AQLQ standard activity items had a higher correlation with the environment scale than with respondent-defined activity items; this finding re-occurred during exploratory factor analysis. Finally, the AQLQ performed similarly in construct validity tests in the two settings. In conclusion, this study provides evidence that the AQLQ has similar psychometric properties during an acute hospitalization and subsequently in an outpatient setting. This revised version was published online in July 2006 with corrections to the Cover Date.     

氟西汀治疗高血压合并抑郁症患者的疗效及对患者生活质量的影响

目的:探究氟西汀治疗高血压合并抑郁症患者的疗效及对患者生活质量的影响。方法:择取80例高血压伴抑郁症患者,随机性分成试验组与对照组,各40例。对照组应用硝苯地平控释片进行治疗;试验组在此基础上联合氟西汀加以治疗。结果:试验组总有效率大于对照组,P<0.05;对照组的汉密尔顿抑郁量表(HAMD)评分高于比较组,P<0.05;比较组在生活质量方面得分均高于对照组,P<0.05。结论:高血压合并抑郁症患者应用氟西汀治疗,能够有效改善抑郁情况、降低血压并提高生活质量。     

Associations between Pregnancy-Related Symptoms,Serum 25(OH)D,and Physical Quality of Life in Pregnant Women

Vitamin D deficiency has been associated with pregnancy-related symptoms including fatigue, poor sleep quality, and musculoskeletal pain. Pregnant Black and Hispanic women are more likely to have vitamin D deficiency compared with pregnant non-Hispanic White women. Data are limited on the association of vitamin D deficiency with quality of life (QOL) among pregnant women. This study examined the association of serum 25(OH)D and pregnancy-related symptoms with QOL among pregnant predominantly minority women. Using a cross-sectional design, 119 pregnant Black and Hispanic women completed surveys and had blood drawn for serum 25(OH)D levels between 24–32 weeks gestation. Hierarchical regression analysis indicated that total pregnancy-related symptoms and serum 25(OH)D level were significant predictors of QOL, while controlling for covariates. Higher total pregnancy-related symptoms and lower serum 25(OH)D predicted poorer physical QOL. Screening for pregnancy-related symptoms and vitamin D levels among childbearing women might be important nursing interventions to improve physical QOL.     

Responsiveness,longitudinal- and cross-sectional construct validity of the Pediatric Asthma Quality of Life Questionnaire (PAQLQ) in Dutch children with asthma

Objective: Health-related quality of life is an important measure in evaluations of the management of childhood asthma. In this study, we assessed psychometric properties, responsiveness, and longitudinal and cross-sectional construct validity of the Dutch version of the 23-item Pediatric Asthma Quality of Life Questionnaire (PAQLQ). Methods: The study group consisted of 238 6–18-year olds with asthma, with complete respiratory symptom diaries in the course of one winter season; each child had one (or more) PAQLQ measurement(s) concerning one (or more) week(s) with relatively many symptoms (n=238). Each child also had one PAQLQ measurement concerning another week with relatively few symptoms (n=238). The PAQLQ scores of the 238 children for a week with few symptoms (the symptom diary scores remained below a predefined level everyday) were compared with their PAQLQ scores for another week with many symptoms (on day 1 of that week, symptom diary scores had been above the predefined level). Additionally, in a subgroup of the study group that had experienced two or more `weeks with many symptoms' (n=101), we compared the PAQLQ-scores for two different weeks with many symptoms of these children. Results: Only the domain Emotions showed a ceiling effect (> 25% had the maximum score). All Cronbach's α's of the PAQLQ total score and domains were >0.70, except for Activities (α=0.54). Mean PAQLQ-scores were significantly different (p<0.01; n=238) between one week with few symptoms and another week with many symptoms. Contrary, in the subgroup of children with PAQLQ-measurements regarding more than one week with many symptoms (n=101), mean PAQLQ-scores did not differ significantly (p≥ 0.05) between 1week with many symptoms and another week with many symptoms. These results indicate responsiveness. (Changes in) lower respiratory tract symptoms, indicative of asthma severity, correlated better with (changes in) PAQLQ scores than (changes in) upper respiratory tract␣symptoms, which supports the longitudinal and cross-sectional construct validity. Conclusion: The assessed properties of the PAQLQ linguistic validation into Dutch were similar to those originally established for the PAQLQ in Canada. This study showed that the Dutch PAQLQ has adequate psychometric properties, excellent responsiveness, and that the longitudinal and cross-sectional construct validity is supported.