肺癌术后化疗病人癌因性疲乏相关因素调查分析

[目的]探讨肺癌术后化疗病人癌因性疲乏的影响因素。[方法]采用Piper疲乏修订量表对100例肺癌术后化疗病人进行调查。[结果]癌因性疲乏在肺癌术后化疗病人中普遍存在,其中86％是中重度疲乏;化疗副反应、化疗方案、疼痛、经济状况等是癌因性疲乏的主要影响因素。[结论]肺癌术后化疗病人癌因性疲乏的发生率较高,应采取相应的干预措施,降低病人癌因性疲乏的程度。     

乳腺癌术后辅助化疗患者癌因性疲乏与社会支持相关性的研究

目的调查乳腺癌术后辅助化疗患者癌因性疲乏的状况,并分析乳腺癌术后辅助化疗患者癌因性疲乏与社会支持的相关性。方法采用Piper疲乏量表和社会支持评定量表对某市3所三级甲等医院的203例乳腺癌术后辅助化疗患者进行问卷调查。结果 95.57%的患者存在癌因性疲乏,处于中度疲乏程度;社会支持及主观支持、对社会支持的利用度与整体疲乏及各维度呈负相关,客观支持与情感维度呈负相关(P<0.01或P<0.05)。结论乳腺癌术后辅助化疗患者癌因性疲乏的发生率较高,应提高对癌因性疲乏的重视,加强社会支持,提高患者的生活质量。     

乳腺癌新辅助化疗病人癌因性疲乏状况的调查研究

目的调查乳腺癌新辅助化疗病人随着化疗疗程进展的癌因性疲乏状况。方法应用中文版Piper疲乏修订量表调查70例乳腺癌病人在新辅助化疗前和化疗1个疗程后、2个疗程后、3个疗程后的癌因性疲乏状况。结果本组乳腺癌病人完成新辅助化疗1、2、3个疗程后的RPFS总分及各维度得分均较化疗前增加,差异有统计学意义（P〈0.01）,而新辅助化疗后3个疗程之间的RPFS总分及各维度得分之间的差异无统计学意义（P〉0.05）。本组乳腺癌病人接受新辅助化疗前的癌因性疲乏的发生率为15.7%,而完成1、2、3个疗程后的癌因性疲乏发生率分别为82.9%、80%、80%,化疗后的癌因性疲乏发生率较化疗前增加,差异有统计学意义（P〈0.01）;而新辅助化疗后3个疗程之间的癌因性疲乏发生率的差异无统计学意义（P〉0.05）。结论本组乳腺癌病人多数在新辅助化疗后出现了癌因性疲乏,但化疗后病人的癌因性疲乏程度及发生率并未随着化疗疗程的进展而加重。     

护理干预对乳腺癌化疗病人癌因性疲乏与生活质量的影响

[目的]研究护理干预对乳腺癌化疗病人癌因性疲乏与生活质量的影响。[方法]将60例乳腺癌术后化疗病人随机分为对照组和干预组。对照组采用常规护理,干预组给予系统化护理干预,应用简易疲乏量表与生活质量调查问卷表分析干预前后两组病人的癌因性疲乏与生活质量。[结果]干预后干预组病人生活质量、功能状况及癌因性疲乏程度明显优于对照组,差异均有统计学意义（P〈0.05）;癌因性疲乏与病人生活质量呈负相关。[结论]乳腺癌化疗病人癌因性疲乏与生活质量互相影响,系统化护理干预可消除或减轻癌因性疲乏,提高乳腺癌病人术后化疗的生活质量。     

乳腺癌化疗患者癌因性疲乏及影响因素分析

目的 探讨乳腺癌化疗患者癌因性疲乏状况及其影响因素.方法 随机选取接受化疗前3个疗程的符合乳腺癌诊断患者110例,于化疗前1～2 d、化疗中5～7 d、化疗后5～7 d 3个时间点进行癌因性疲乏的测量.结果 化疗中和化疗后,乳腺癌患者的癌因性疲乏属于中等程度,化疗前、中、后的疲乏程度差异有统计学意义(F=45.19,P＜0.01),化疗后5～7 d疲乏最重.化疗前、中、后疲乏程度的发生率差异有统计学意义(Hc=52.0625,P＜0.01).影响癌因性疲乏的因素化疗前有医疗方式(t=2.24,P＜0.05)、化疗方案(t=2.18,P＜0.05)和疗程(t=3.59,P＜0.01);化疗后有医疗方式(t=2.53,P＜0.05)和化疗方案(t=2.21,P＜0.05).结论 护理人员应关注和重视癌因性疲乏,尤其是应加强对化疗中5～7 d患者癌因性疲乏的关注和指导,使护理干预更有依据和针对性.     

护理干预对乳腺癌化疗病人癌因性疲乏与生活质量的影响

[目的]研究护理干预对乳腺癌化疗病人癌因性疲乏与生活质量的影响.[方法]将60例乳腺癌术后化疗病人随机分为对照组和干预组.对照组采用常规护理,干预组给予系统化护理干预,应用简易疲乏量表与生活质量调查问卷表分析干预前后两组病人的癌因性疲乏与生活质量.[结果]干预后干预组病人生活质量、功能状况及癌因性疲乏程度明显优于对照组,差异均有统计学意义(P＜0.05);癌因性疲乏与病人生活质量呈负相关.[结论] 乳腺癌化疗病人癌因性疲乏与生活质量互相影响,系统化护理干预可消除或减轻癌因性疲乏,提高乳腺癌病人术后化疗的生活质量.     

癌因性疲乏对乳腺癌病人化疗期间生活质量的影响

目的调查乳腺癌病人化疗期间的癌因性疲乏及生活质量状况并分析癌因性疲乏对生活质量的影响。方法应用Piper疲乏修订量表(中文版)及SF-36健康状况量表调查了98例乳腺癌病人门诊化疗期间的癌因性疲乏状况及其生活质量状况。结果本组乳腺癌化疗病人存在疲乏的有63例,占64.29%,其中,中至重度疲乏的有39例,占39.80%。乳腺癌病人化疗期间SF-36生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能共7个维度得分均低于国内正常人群(P0.01)。经多元逐步回归分析发现,年龄、疲乏状况总分及癌因性疲乏行为及严重性、情绪和认知、情感3个维度对于除精神健康外的生活质量的7维度有影响(P0.01)。结论乳腺癌病人化疗期间的生活质量低于正常人群,癌因性疲乏为其化疗期间的常见症状。年龄、癌因性疲乏是导致本组乳腺癌病人生活质量降低的主要因素。     

运动干预对乳腺癌化疗病人癌因性疲乏和睡眠质量的影响

[目的]观察运动干预对乳腺癌化疗病人癌因性疲乏和睡眠质量的影响。[方法]将69例乳腺癌改良根治术后病人采用双盲法分为观察组34例和对照组35例,对照组术后采用常规护理,观察组在常规护理的基础上按照运动方案进行规律运动锻炼8周。术后第1天、术后第8周采用修订的Piper疲乏量表与匹兹堡睡眠质量指数表(PSQI)观察两组病人干预前后癌因性疲乏得分与睡眠质量情况。[结果]观察组病人干预后Piper疲乏量表评分与PSQI评分均低于对照组,差异有统计学意义(P0.05)。[结论]运动干预可以有效缓解乳腺癌化疗病人术后癌因性疲乏、改善睡眠质量。     

乳腺癌化疗患者癌因性疲乏及影响因素分析

目的 探讨乳腺癌化疗患者癌因性疲乏状况及其影响因素。方法 随机选取接受化疗前3个疗程的符合乳腺癌诊断患者110例，于化疗前1～2d、化疗中5～7d、化疗后5-7d3个时间点进行癌因性疲乏的测量。结果 化疗中和化疗后，乳腺癌患者的癌因性疲乏属于中等程度，化疗前、中、后的疲乏程度差异有统计学意义（F=45．19，P〈0．01），化疗后5～7d疲乏最重。化疗前、中、后疲乏程度的发生率差异有统计学意义（Hc=52．0625，P〈0．01）。影响癌因性疲乏的因素化疗前有医疗方式（t=2．24，P〈0．05）、化疗方案（t=2．18，P〈0．05）和疗程（t=3．59，P〈0．01）；化疗后有医疗方式（t=2．53，P〈0．05）和化疗方案（t=2．21，P〈0．05）。结论 护理人员应关注和重视癌因性疲乏，尤其是应加强对化疗中5～7d患者癌因性疲乏的关注和指导，使护理干预更有依据和针对性。     

早期有氧锻炼对乳腺癌术后化疗患者疲乏的影响

目的探讨早期有氧锻炼对乳腺癌术后化疗患者癌因性疲乏的影响。方法将60例乳腺癌患者按床号单、双号分为观察组和对照组,观察组在术后化疗前1周开始有氧锻炼,对照组在化疗开始后进行有氧锻炼。应用简易疲乏量表对两组在化疗前1周和化疗后2周的癌因性疲乏进行评估。结果两组在化疗前1周疲乏程度无明显差异,化疗后2周观察组疲乏程度明显低于对照组,资料经秩和检验-H检验法,Hc=4.301,P<0.05,有统计学意义。结论早期有氧锻炼可减轻乳腺癌术后化疗患者的癌因性疲乏。     

Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates.

This study investigated the characteristics, course, and correlates of fatigue in women receiving adjuvant chemotherapy for breast cancer. Fifty-four patients were assessed before the start of chemotherapy and during the first three treatment cycles. An age-matched sample of women with no cancer history was assessed at similar time intervals for comparison purposes. Results indicated that breast cancer patients experienced worse fatigue than women with no cancer history. These differences were evident before and after patients started chemotherapy. In addition, fatigue worsened among patients after treatment started. More severe fatigue before treatment was associated with poorer performance status and the presence of fatigue-related symptoms (e.g., sleep problems and muscle weakness). Increases in fatigue after chemotherapy started were associated with continued fatigue-related symptoms and the development of chemotherapy side effects (e.g., nausea and mouth sores). These findings demonstrate the clinical significance of fatigue in breast cancer patients before and during adjuvant chemotherapy treatment. Results also suggest that aggressive management of common side effects, such as nausea and pain, may be useful in relieving chemotherapy-related fatigue.     

乳腺癌患者内分泌治疗相关症状的调查研究

目的 调查乳腺癌患者内分泌治疗相关症状的发生情况,并探讨其影响因素。方法 采用方便抽样方法,应用一般情况调查表、乳腺癌内分泌治疗知识和态度问卷、乳腺癌患者生命质量测定-内分泌症状量表,于2019年11月—2020年4月在上海市2所三级甲等医院及1所抗癌康复俱乐部的患者随访平台对正在接受内分泌治疗的乳腺癌患者进行在线调查。结果 共回收有效问卷613份,患者内分泌症状量表评分总分为（18.99±11.43）分,其中容易烦躁或易怒、情绪波动、对性生活失去兴趣、潮热、关节痛、性交疼痛或不适是发生率和严重程度较高的症状。多元线性回归结果显示,年龄、自费、内分泌治疗药物种类、既往手术、既往化疗、内分泌治疗态度是症状发生的独立影响因素（P<0.05）,可解释总变异的19.1%。结论 乳腺癌患者内分泌治疗相关症状的发生率高,症状负担重,年龄小、自费、使用选择性雌激素受体调节剂、既往手术、既往化疗、内分泌治疗态度差的患者症状负担更重。     

Fatigue in patients with breast cancer receiving adjuvant chemotherapy: a review of the literature

The aim of this literature review was to evaluate the prevalence and course of fatigue in patients with breast cancer undergoing adjuvant chemotherapy and to examine factors relating to fatigue. Fatigue is one of the most common side effects of chemotherapy. High and fluctuating prevalence rates of fatigue have been found not only during but also after adjuvant chemotherapy. The intensity of fatigue seems to be stable throughout the treatment cycles, despite the common perception that more chemotherapy treatments lead to greater fatigue. The first two days after a chemotherapy treatment seem to be the worst period.The influence of factors such as pain, impaired quality of sleep, and depression are be highly consistent across several studies, although it is often not clear whether it is the symptoms that cause the fatigue or vice versa. The outcomes of the studies indicate that several symptoms are interrelated in a network of symptoms. Factors such as changes in weight, menopausal symptoms, coping, social support, and biochemical changes have been mentioned in the literature as potentially contributing to fatigue. Results have been conflicting and need further study.     

Assessment of fatigue in and care needs of Turkish women with breast cancer

Using Piper's Integrated Fatigue Model, this research project was planned to determine the level of fatigue experienced by Turkish women with breast cancer undergoing adjuvant chemotherapy, to discover the factors affecting fatigue, and to provide a reference by means of which an effective nursing care for such patients could be planned. In assessing the level of fatigue and factors affecting it, a patient information form, the Piper Fatigue Scale, and the Rotterdam Symptom Checklist were used. The reliability tests performed afterwards showed that the scales are appropriate tools for use in Turkish women with breast cancer. Before treatment, psychological symptoms' distress was higher than physical symptoms' distress. However, following treatment, the latter was found to be closer to the former. When pretreatment and posttreatment physical and psychological symptoms were compared, it was noticed that fatigue, nausea, anorexia, vomiting, constipation, depression, and loss of hope for the future were among the symptoms observed to increase the most in the posttreatment period. Different from the other studies, we determined that all of the patients experienced fatigue 7 to 10 days after the chemotherapy cycle and the sensory/affective fatigue scores were high. Breast cancer patients undergoing chemotherapy experienced a moderate level of fatigue, which was influenced by level of income, stage of disease, and symptoms related to chemotherapy, showing compliance with similar studies. Following up patients individually and keeping the treatment-related symptoms under control were noticed to help prevent fatigue.     

乳腺癌新辅助化疗病人生活质量状况及其相关因素分析

目的 调查乳腺癌新辅助化疗病人的生活质量状况及其相关因素.方法 应用自设问卷及SF-36健康状况量表对88例乳腺癌病人在新辅助化疗结束后1周内的化疗副反应及其生活质量状况进行调查.结果 本组乳腺癌病人完成新辅助化疗后的SF-36各维度得分中,生理机能（72.90±23.55）分、生理职能（28.98 ±37.31）分、躯体疼痛（71.50±21.91）分、一般健康状况（53.67±21.72）分、精力（61.19±28.39）分、社会功能（61.08±28.39）分、情感职能（52.27±43.71）分共7个维度得分均低于国内正常人群（P＜0.01）.多元逐步回归分析显示,化疗副反应的数量、厌食、疲乏、年龄、文化程度对于生活质量有影响（P＜0.05）.结论 新辅助化疗后本组乳腺癌病人的生活质量降低,化疗副反应中的厌食、疲乏等是导致本组病人生活质量降低的主要因素,同时年龄越大的病人生理机能越差,而文化程度越高的病人社会功能越差.     

Women's perceptions of home-based exercise performed during adjuvant chemotherapy for breast cancer

PurposeTo describe women's perceptions of a home-based exercise intervention in which they participated while receiving adjuvant chemotherapy for breast cancer.Methods and sampleParticipants were 8 women who were involved in a home-based exercise program while receiving 24 weeks of adjuvant chemotherapy for breast cancer. They were asked about their exercise program every 2 weeks by telephone, and completed a feasibility and acceptability questionnaire at the end of the study. The two principal investigators performed a content analysis on the resulting data.Key resultsParticipants highly valued the exercise program. The content analysis resulted in two major categories: exercise challenges and exercise facilitators and strategies. The most common exercise challenges were side effects of chemotherapy, particularly fatigue and pain. The women overcame challenges in many ways, most notably adapting the routine, internal motivation and external support. Their comprehension of breast cancer and its treatment, reinforced by expert advice and resources on exercise, helped them develop successful strategies to maintain the exercise program.ConclusionsIn spite of challenges, women in this study perceived that a customized, flexible, home-based exercise program was beneficial while they were undergoing adjuvant chemotherapy for breast cancer. Resource material and regular guidance helped them implement strategies to maintain the exercise program.