共查询到18条相似文献,搜索用时 78 毫秒
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巴西甘薯叶黄酮类成分的研究 总被引:13,自引:1,他引:13
目的:研究巴西甘薯叶Ipomoea batatas的黄酮类成分.方法:乙醇提取后分别以氯仿、醋酸乙酯和正丁醇萃取,醋酸乙酯部位用硅胶柱色谱,Sephadex LH-20凝胶柱色谱等色谱法分离;通过理化性质和波谱方法鉴定结构.结果:分离并鉴定了5个黄酮类化合物:银椴苷(tiliroside)(Ⅰ),紫云英苷(astragalin)(Ⅱ),鼠李柠檬素(rhamnocitrin)(Ⅲ),鼠李素(rhamnetin)(Ⅳ),山柰酚(Ⅴ).结论:上述黄酮类成分均首次从该植物中分得. 相似文献
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目的对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法采用硅胶柱色谱、葡聚糖凝胶LH-20及HPLC等色谱技术进行分离纯化,并利用NMR等波谱学手段对化合物进行结构鉴定。结果从醋酸乙酯层分离得到7个单体化合物,分别鉴定为苯甲酰芍药苷(1)、白芍苷R1(2)、paeonidanin A(3)、4-甲氧基苯甲酰基芍药苷(4)、paeonidanin B(5)、4-O-methylgalloylpaeoniflorin(6)、paeoniflorin B(7);从正丁醇层中分离得到4个化合物,分别鉴定为isomaltopaeoniflorin(8)、芍药苷(9)、羟基芍药苷(10)、芍药内酯苷(11)。结论化合物1~8为首次从该复方中分离得到,化合物1~11均为芍药苷类化合物。 相似文献
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目的研究黑果悬钩子Rubus caesius茎叶的化学成分及其对蛋白酪氨酸磷酸酶1B(PTP1B)的抑制活性。方法利用硅胶柱色谱、Sephadex LH-20柱色谱、半制备液相等色谱方法进行分离纯化,根据核磁共振波谱鉴定化合物结构,利用酶标仪测定不同萃取部位和单体化合物的PTP1B抑制活性。结果从黑果悬钩子茎的醋酸乙酯部位分离得到5个化合物,分别鉴定为柚皮苷(1)、芹菜素-7-O-β-D-吡喃葡萄糖苷(2)、异槲皮苷(3)、金丝桃苷(4)、(-)-表儿茶素3-O-没食子酸(5);从叶的醋酸乙酯部位分离得到2个化合物,分别鉴定为类叶升麻苷(6)、鞣花酸(7)。结论所有化合物均为首次从黑果悬钩子中分离得到。不同的萃取部位均有一定的PTP1B抑制活性,化合物6表现出较好的PTP1B抑制活性,IC_(50)为(27.41±0.61)μg/m L,推测该化合物可能是叶的醋酸乙酯部位中主要活性成分。 相似文献
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毛白杨化学成分研究 总被引:2,自引:0,他引:2
目的:对毛白杨雄株干皮进行化学成分的分离鉴定。方法:毛白杨的新鲜干皮用甲醇提取,所得浸膏用水混悬后依次用石油醚、醋酸乙酯、正丁醇萃取,对醋酸乙酯和正丁醇部分采用各种柱色谱进行分离纯化,根据理化性质并通过波谱数据的解析进行结构鉴定。结果:从醋酸乙酯和正丁醇部分获得12个化合物,分别鉴定为苯甲酸(1),胡萝卜苷(2),苯甲酰水杨苷(3),鼠李柠檬素(4),樱花素(5),7-O-甲基香橙素(6),异大齿杨苷A(7),siebolside B(8),樱花苷(9),micranthoside(10),α-D-葡萄糖(11),蔗糖(12)。结论:化合物4~12为首次从该植物中分离得到,其中化合物10为首次从该属植物中得到。 相似文献
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蒙药列当的化学成分研究 总被引:1,自引:0,他引:1
目的:研究蒙药列当(Orobanche coerulescens Steph)的化学成分,为进一步明确其中的有效成分奠定基础。方法:利用普通硅胶柱色谱、大孔树脂柱色谱、Sephadex LH-20色谱技术及重结晶等方法进行分离、纯化,并利用波谱技术和理化性质确定了化合物的结构。结果:从中分离得到9个化合物,分别鉴定为:甘露醇①,β-谷甾醇②,豆甾醇③,二十烷酸-1-甘油酯④,β-胡萝卜苷⑤,琥珀酸⑥,Crenatoside⑦,麦角甾苷⑧,D-松醇⑨。结论:其中化合物③,④,⑦,⑧,⑨为首次从该植物中获得。 相似文献
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目的研究傣药倒心盾翅藤Aspidopterys obcordate的化学成分。方法采用硅胶柱色谱、Sephadex LH-20柱色谱、ODS等色谱分离技术,对倒心盾翅藤茎醇提物的醋酸乙酯相和正丁醇相进行分离纯化,经现代波谱技术及物理常数测定等方法对所分离的化学成分进行结构鉴定。结果从倒心盾翅藤95%乙醇提取物中分离得到8个化合物,分别鉴定为3,4-二羟基苯甲酸-3-O-α-L-鼠李糖苷(1)、3,4-二羟基苯酚乙酸酯(2)、3,4-二羟基苯甲酸(3)、儿茶素(4)、β-谷甾醇(5)、胡萝卜苷(6)、cinnacasolide C(7)、尿囊素(8)。结论所有化合物均为首次从倒心盾翅藤中分离。其中,化合物1为新化合物,命名为倒心盾翅藤苷。 相似文献
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Lidia Osuna Hector Ponce-Monter María G. Campos Jos A. Rojas Mariana Meckes 《Phytotherapy research : PTR》1996,10(3):257-259
A methanol extract (MEII) obtained from the seeds of Ipomoea intrapilosa and its isolated crude alkaloid fraction (ALKII) were tested as possible blockers of the serotonergic response in the rat uterus in vitro . The results obtained showed an unsurmountable non-selective inhibition of the contractile response induced by serotonin on isolated uterine smooth muscle. 相似文献
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A. Navarro-Ruiz Garzn P. de la Mora M. T. Villanueva-Michel J. R. Dominguez-Rodriguez B. E. Bastidas-Ramirez J. D. Quezada-Arellano B. Ruiz-Madrigal 《Phytotherapy research : PTR》1996,10(3):242-244
The anticonvulsant activity of aqueous (AQ), ethanol (E-OH) and chloroform (CHL) extracts of Ipomoea stans root was demonstrated in adult male Wistar rats following ad libitum ingestion of the aqueous extract over 7 days, or a single oral dose of 100 mg/kg ethanol or chloroform extract. Maximal electroshock seizure inducing test (MES) and subcutaneously injected metrazole (METsc) were the experimental epilepsy models used. Maximum protection exhibited to MES were 80%, 36% and 57%; and in the case of METsc, 15%, 41% and 50% when AQ, E-OH or CHL extract was administered, respectively. 相似文献
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U. Pongprayoon L. Bohlin P. Soonthornsaratune S. Wasuwat 《Phytotherapy research : PTR》1991,5(2):63-66
The antiinflammatory activity of an extract from the leaves of Ipomoea pes-caprae (L.) R. Br., used as a traditional remedy for different types of inflammation, was investigated using experimental models of acute inflammation. Topical application of the extract inhibited carrageenan-induced paw oedema and ear oedema induced in rats by arachidonic acid or ethyl phenylpropiolate. In vitro prostaglandin formation was inhibited by the extract in a concentration-dependent manner, with a potency equal to that of aspirin but considerably less than that of indomethacin. This study shows that Ipomoea pes-caprae has a significant antiinflammatory activity, probably due to a reduction of prostaglandin and leukotriene formation. Thus, in addition to earlier results, this work further supports the use of Ipomoea pes-caprae as an antiinflammatory agent in traditional medicine. 相似文献
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Malalavidhane TS Wickramasinghe SM Perera MS Jansz ER 《Phytotherapy research : PTR》2003,17(9):1098-1100
Ipomoea aquatica Forsk is a common green leafy vegetable consumed in many parts of the world. The present study was designed to investigate the oral hypoglycaemic activity of Ipomea aquatica in streptozotocin induced diabetic Wistar rats, and Type II diabetic patients. Experimental diabetes was induced with streptozotocin in Wistar rats. The rats were then divided into test and control groups. In addition to the standard feed given to both groups the test was fed with the shredded leaves of Ipomoea aquatica (3.4 g/kg) for one week. Type II diabetic patients were subjected to a glucose challenge before and after a single dose of blended I. aquatica. Patients acted as their own controls. The results revealed that consumption of the shredded, fresh, edible portion of I. aquatica for one week, effectively reduced the fasting blood sugar level of streptozotocin-induced diabetic rats (p = 0.01). When subjected to a glucose challenge, the Type II diabetic subjects showed a significant reduction (p = 0.001) in the serum glucose concentration 2 h after the glucose load. However, it was not significantly reduced at 1 h (p < 0.09) post glucose load. There was a 29.4% decrease in the serum glucose concentration of the diabetic patients when treated with the plant extract. 相似文献
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目的研究药用滨海植物厚藤[Ipomea pes-caprae(Linn.)Sweet]的化学成分。方法采用硅胶柱色谱和Sephadex LH-20凝胶柱色谱从厚藤的正丁醇提取物中分离到7个化合物,经理化常数和波谱分析确定这7种化合物的结构。结果这7种化合物分别为:山柰酚(1)、槲皮素(2)、杨梅黄酮(3)、胡萝卜苷(4)、山柰苷(5)、栎皮苷(6)和槲皮素-7-O-β-D-葡萄糖苷(7)。结论其中化合物杨梅黄酮、胡萝卜苷、山柰苷、栎皮苷和槲皮素-7-O-β-D-葡萄糖苷为首次从该种植物中分离得到。 相似文献