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1.
磁共振成像动态增强对乳腺癌血管生成的研究 总被引:6,自引:0,他引:6
目的: 研究乳腺癌组织中微血管密度(MVD)及其分布、乳腺癌动态增强磁共振成像强化、腋淋巴结转移之间的相关性. 方法: 38例乳腺癌病例,手术前均行动态增强磁共振成像检查观察病灶中心、边缘的早期强化率(△SI)以及强化表现.对术后病理证实的乳腺癌31例,以正常乳腺组织为对照,采用免疫组化法检测MVD值在肿瘤中心及其边缘的分布,分析MRI△SI与MVD的相关性.根据MRI乳腺癌的强化表现分为边缘强化组、非边缘强化组,结合各组腋窝淋巴结转移率,分析乳腺癌不同MRI强化形式与预后的关系. 结果: 乳腺癌MVD边缘>MVD中心,△SI 边缘>△SI中心△SI随MVD值增高,△SI与MVD值有明显相关性.MRI边缘强化的11例,病灶边缘部分MVD高于中心部分,差异有显著性意义(P<0.01),非边缘性强化组20例,虽然病灶边缘部分MVD高于中心部分,但二者差异无显著性意义.边缘强化组淋巴结转移率为72%(8/11),非边缘强化组淋巴结转移率为35%(7/20),差异有显著性意义(P<0.01). 结论: MVD值的大小和分布与MR动态增强早期强化率和强化均匀性密切相关,在一定程度上反映了乳腺肿瘤血管生成特性及其预后. 相似文献
2.
BACKGROUND: Assessment of pectoralis muscle invasion is important for treatment planning for breast cancer. We evaluated the usefulness of breast magnetic resonance (MR) imaging for the detection of tumor invasion of the pectoralis muscle in breast cancer patients. MATERIALS AND METHODS: A total of 306 breast MR examinations were performed preoperatively. Three-dimensional gradient echo sequences, at a section thickness of 1.5 or 2 mm were obtained with administration of gadolinium-DTPA. All patients underwent surgery. RESULTS: In 33 breasts, disruption of the fat plane between tumor and muscle was noted. Seven of 33 cases showed muscle enhancement contiguous to enhanced tumors. Pathology reports indicated that 5 of 7 of the tumors involved muscle invasion. Of the 2 false positive cases, one showed muscle enhancement because of a previous biopsy, and the other was incorrectly interpreted as showing muscle enhancement. Of the 26 breasts which did not demonstrate muscle enhancement, none were found at surgery to have tumor involvement. CONCLUSION: Enhancement of the pectoralis muscle correlates well with muscle invasion, but there are a few potential pitfalls. Disruption of the fat plane between tumor and muscle, without muscle enhancement, might not indicate tumor involvement of the pectoralis muscle. 相似文献
3.
Zhang Y Fukatsu H Naganawa S Satake H Sato Y Ohiwa M Endo T Ichihara S Ishigaki T 《Breast cancer (Tokyo, Japan)》2002,9(3):231-239
PURPOSE: The aim of this study was to assess the impact of preoperative magnetic resonance mammography (MRM) on the surgical determination of breast conservation treatment for breast cancer patients. METHODS: From September 1997 to March 2000, 57 consecutive breast conservation treatment candidates were prospectively evaluated with conventional imaging studies (mammography and ultrasonography) and preoperative MRM. RESULTS: In 47 of 54 (87% ) breast cancer patients breast conservation surgery (BCS) was indicated on the basis of mammography (MMG) and ultrasonography (US). However in 40 of the 54 (74% ) patients BCS was indicated on the basis of MRM. Thirty-eight of the 40 patients ultimately underwent BCS and only 1 showed a positive margin. There were 7 patients whose MRM findings suggested that more aggressive treatment than BCS was needed but for whom US/MMG suggested that BCS was appropriate. Five of the 7 patients underwent mastectomy rather than BCS based on the MRM findings, which were justified by post-surgical histological findings. Of the 2 remaining patients who underwent BCS, one had a positive histological margin and one had recurrence, both of which resulted in salvage mastectomy. CONCLUSION: Our study suggests that high resolution preoperative MRM provides more accurate information compared with US and MMG for selecting candidates for BCS. Using MRM as a routine staging tool may reduce unnecessary repeated excisions. A larger study will be required to confirm these findings and to define the patients most likely to benefit from breast MR imaging. 相似文献
4.
Uematsu T 《Breast cancer (Tokyo, Japan)》2011,18(3):161-164
Little is known about the MR imaging features of triple-negative breast cancer (TNBC), but TNBC has a worse prognosis because
it has no effective therapeutic targets, such as estrogen receptor for endocrine therapy and human epidermal growth factor
receptor 2 (HER2) for anti-HER2 therapy. MR findings of a unifocal lesion, mass lesion type, smooth mass margin, rim heterogeneous
enhancement, persistent enhancement pattern, and very high signal intensity on T2-weighted images are typical features of
breast MR imaging associated with TNBC. Although TNBC can mimic a benign morphology, the early MR imaging recognition of TNBC
could assist in both the pretreatment planning and the prognosis, as well as adding to our understanding of the biological
behavior of TNBC. 相似文献
5.
Buadu AA Buadu LD Murakami J Murayama S Hashiguchi N Masuda K 《Breast cancer (Tokyo, Japan)》1998,5(3):285-289
Objective To evaluate patterns of enhancement in the nipple-areolarcomplex (NAC) on contrast-enhanced MRI.
Methods We reviewed the MR images of 37 patients in which enhancement of the NAC was demonstrated on gadolinium-enhanced dynamic fast
radiofrequency spoiled gradient recalled echo (fast-SPGR) images. Time intensity profiles derived from signal intensity values
were constructed, and findings correlated with histological results.
Results Three types of curve were observed. In the first type seen in adenoma of the nipple, rapid initial increase in signal intensity
with an early peak (1 min) occurred followed by gradual washout. In the second type seen in direct invasion from carcinoma,
subareolar intracystic papilloma, or Paget’s disease, rapid initial increase in signal intensity followed by a more gradual
increase or plateau was seen. In the third type seen in carcinoma without nipple invasion, fibrocystic disease and fibroadenoma,
a gradual increase in signal intensity was observed throughout the examination period.
Conclusion Early and prominent enhancement of the NAC on contrast-enhanced MRI may indicate the presence of a primary lesion in the NAC
or secondary involvement by a primary tumor elsewhere in the breast. 相似文献
6.
Akashi-Tanaka S Shien T Tsukagoshi S Funabasama S Miyagawa K Terada K Yoshida M Hojo T Kinoshita T Moriyama N 《Breast cancer (Tokyo, Japan)》2009,16(1):62-67
Background The aim of this study was to apply perfusion techniques to breast tumors using a prototype 256-row multislice computed tomography
(CT) scanner (which allows a wide range of 128 mm to be scanned and can provide whole-breast perfusion maps without any dead
angles) to improve contrast and assess the possibility of precisely depicting the extent of breast cancer.
Patients and methods The study group included seven patients with breast cancer who were scheduled to undergo radical surgery and radiotherapy.
Dynamic scanning was performed using a 256-row multislice CT scanner during normal respiration. Volume perfusion images of
the entire breast were obtained using the maximum slope method. Perfusion map images and early-phase breast CT images at 54 s
were compared by means of pathological examination.
Results All breast cancers could be distinguished from normal mammary glands based on the perfusion value. The extent of cancer depicted
in perfusion images showed excellent agreement with the pathology findings for invasive ductal carcinoma and ductal carcinoma
in situ. In three patients, all ductal spread, parts of which were not visualized by early-phase CT, were depicted in volume
perfusion images. Simulation analysis suggested that perfusion maps could be generated with fewer scanning points.
Conclusion The results of the present study suggest that volume perfusion imaging may be useful for depicting the extent of breast cancer,
with excellent sensitivity. Further research is needed to determine the clinical relevance of these findings. 相似文献
7.
BackgroundInternational guidelines do not recommend magnetic resonance imaging (MRI) for all breast cancer patients at primary diagnostics. This study aimed to understand which patient or tumor characteristics are associated with the use of MRI. The role of MRI among other preoperative imaging methods in clinically node negative breast cancer was studied.Material and methodsPatient and tumor characteristics were analyzed in association with the use of MRI by multivariable logistic regression analysis in 461 patients. Primary tumor size was compared between MRI, mammography (MGR), ultrasound (US) and histopathology by Spearman correlation. The delays in surgery and diagnosis were analyzed among patients with or without MRI, and axillary reoperations were evaluated.ResultsAge (p < 0.0001), primary operation method (p < 0.0001), tumor histology (p < 0.0001) and HER2 status (p = 0.0064) were associated with the use of MRI. Spearman correlations between tumor size in histopathology and the difference in tumor size between histopathology and imaging methods were 0.52 in MGR, 0.66 in US and 0.36 in MRI (p < 0.0001 for all). A seven-day delay in surgical treatment was observed among patients with MRI compared to patients without MRI (p < 0.0001). Axillary reoperation rates were similar in patients with or without MRI (p = 0.57).ConclusionPatient selection through prearranged characterization is important in deciding on optimal candidates for preoperative MRI among breast cancer patients. MRI causes moderate delays in primary breast cancer surgery. Preoperative MRI is useful in the evaluation of tumor size but might be insufficient in detecting lymph node metastases. 相似文献
8.
Tozaki M Yamashiro N Suzuki T Kawano N Ozaki S Sakamoto N Abe S Ogawa T Katayama N Tsunoda Y Fukuma E 《Breast cancer (Tokyo, Japan)》2009,16(2):121-125
Background In the United States and Europe, MR-guided vacuum-assisted biopsy (VAB) is required for MR-only visible suspicious lesions
that cannot be identified with mammography or ultrasonography. However, it is controversial as to whether MR-guided VAB is
essential or not in Japan. The purpose of this study was to clarify the frequency of malignancy among the patients that underwent
MR-guided VAB, and to discuss the need for this technique in Japan.
Methods This study was approved by the Institutional Review Board of our hospital. A retrospective review was performed of 30 consecutive
patients who had undergone MR-guided 11-gauge VAB. The biopsies were performed on a 1.5 T MR scanner using a commercially
available biopsy system. All lesions seen with MRI could not be detected by mammography and second-look ultrasonography.
Results All 30 lesions were assessed as category 4 or 5. The average lesion size of a mass enhancement before biopsy was 0.7 cm, and
the average lesion size of a non-mass-like enhancement was 2.3 cm. The average number of cores of VAB was 19. The median time
required to perform the VAB procedure was 35 min. The biopsy was successfully performed without important side effects in
all patients. Histopathological findings were invasive ductal carcinoma in one (3%); ductal carcinoma in situ (DCIS) in seven
(23%); and benign in 22 (73%). In one case, atypical ductal hyperplasia at VAB was upgraded to DCIS at surgical excision.
Conclusion MR-guided VAB can be performed safely and it is needed for MR-only visible suspicious lesions in Japan. 相似文献
9.
Yumi Kojima Yoichi Aoki Hiroaki Kase Shoji Kodama Kenichi Tanaka 《International journal of clinical oncology / Japan Society of Clinical Oncology》1998,3(3):143-146
Background The purpose of this study was to assess the accuracy of contrast-enhanced magnetic resonance imaging (dynamic MR imaging)
in the evaluation of preinvasive and early invasive cancer of the cervix.
Methods Twenty-nine women with untreated squamous cell carcinoma of the cervix with either no stromal invasion or early stromal invasion
underwent pretreatment MR imaging and dynamic MR imaging within 4 weeks of surgical evaluation. The images were evaluated
for tumor detection and compared with results of histologic examination of the surgical specimens.
Results The lesions in 17 cases with histologically proven stromal invasion of 4 mm or greater were detected with dynamic MR imaging,
whereas lesions in only 8 of these cases were detected with T2 imaging. In 9 cases with stromal invasion between 4.0 mm and
5.0 mm, lesions were represented as early phase focal enhancement on dynamic MR images, but not detected on T2-weighted images.
In the 12 cases with less than 4 mm stromal invasion, no lesions were visualized on either T2-weighted images or dynamic MR
images, except in 1 case of glandular involvement without stromal invasion that appeared as enhancement on early-phase dynamic
MR imaging.
Conclusion Dynamic MR imaging detected more lesions of early stromal invasion in pretreatment imaging for cervical cancer than nonenhanced
MR imaging. 相似文献
10.
N. Biglia V.E. BounousL. Martincich E. PanuccioV. Liberale L. OttinoR. Ponzone P. Sismondi 《European journal of surgical oncology》2011,37(3):199-204
Aims
The role of magnetic resonance imaging (MRI) in the local staging of breast cancer is currently uncertain. The purpose of this prospective study is to evaluate the accuracy of preoperative MRI compared to conventional imaging in detecting breast cancer and the effect of preoperative MRI on the surgical treatment in a subgroup of women with dense breasts, young age, invasive lobular cancer (ILC) or multiple lesions.Methods
Between January 2006 and October 2007, 91 patients with newly diagnosed breast cancer underwent preoperative clinical breast examination, mammography, bilateral breast ultrasonography and high-resolution breast MRI. All patients had histologically verified breast cancer. The imaging techniques were compared using the final pathological report as gold standard.Results
The sensitivity of MRI for the main lesion was 98.9%, while for multiple lesions sensitivity was 90.7% and specificity 85.4%. After preoperative MRI, 13 patients (14.3%) underwent additional fine needle/core biopsies, 9 of whom had specimen positive for cancer. Preoperative MRI changed the surgical plan in 26 patients: in 19.8% of the cases breast conservative surgery was converted to mastectomy and in 7.7% of the patients a wider excision was performed. At a mean follow-up of 48 months, 2 local recurrences occurred (local failure rate = 2.5%).Conclusions
Enhanced sensitivity of breast MRI may change the surgical approach, by increasing mastectomy rate or suggesting the need of wider local excision. MRI can play an important role in preoperative planning if used in selected patients with high risk of multifocal/multicentric lesions. However, the histologic confirmation of all suspicious findings detected by MRI is mandatory prior to definite surgery. 相似文献11.
The purpose of the present paper was to evaluate the utility of perfusion MRI in cerebral gliomas showing imperceptible contrast enhancement on conventional MRI, and to evaluate the relationships of perfusion MRI and magnetic resonance (MR) spectroscopic results in these tumours. Twenty‐two patients with histopathologically proven cerebral gliomas and showing insignificant contrast enhancement on conventional MR were included in the present study. All patients underwent perfusion MRI and MR spectroscopy on a 1.5‐T MR system. Significant differences of the relative cerebral blood volume (rCBV) values and the choline : creatine ratios were noted between low‐grade and anaplastic gliomas (P < 0.01). Good correlation was found between the rCBV values and the choline : creatine values (y = 0. 532x + 1.5643; r = 0.67). Perfusion MRI can be a useful tool in assessing the histopathological grade of non‐contrast‐enhancing cerebral gliomas. Along with MR spectroscopic imaging it can serve as an important technique for preoperative characterization of such gliomas, so that accurate targeting by stereotactic biopsies is possible. 相似文献
12.
Bhavika K. Patel Naziya Samreen Yuxiang Zhou Jun Chen Kathy Brandt Richard Ehman Kay Pepin 《Clinical breast cancer》2021,21(1):e102-e111
Recognizing that breast cancers present as firm, stiff lesions, the foundation of breast magnetic resonance elastography (MRE) is to combine tissue stiffness parameters with sensitive breast MR contrast-enhanced imaging. Breast MRE is a non-ionizing, cross-sectional MR imaging technique that provides for quantitative viscoelastic properties, including tissue stiffness, elasticity, and viscosity, of breast tissues. Currently, the technique continues to evolve as research surrounding the use of MRE in breast tissue is still developing. In the setting of a newly diagnosed cancer, associated desmoplasia, stiffening of the surrounding stroma, and necrosis are known to be prognostic factors that can add diagnostic information to patient treatment algorithms. In fact, mechanical properties of the tissue might also influence breast cancer risk. For these reasons, exploration of breast MRE has great clinical value. In this review, we will: (1) address the evolution of the various MRE techniques; (2) provide a brief overview of the current clinical studies in breast MRE with interspersed case examples; and (3) suggest directions for future research. 相似文献
13.
《Clinical breast cancer》2021,21(4):352-359
BackgroundWe assessed the long-term oncologic safety of nipple-sparing mastectomy (NSM) compared to skin-sparing mastectomy (SSM) for primary breast cancer patients with immediate reconstruction.Patients and MethodsData of stage 0-III primary breast cancer patients undergoing NSM (n = 190) or SSM (n = 729) from June 2006 to December 2012 were retrospectively collected. Nipple–tumor distance (NTD) was measured on pretreatment mammography, magnetic resonance imaging, or ultrasonography findings. NSM patients with NTD < 1 cm were excluded. Locoregional recurrence (LRR) rates were compared between groups. Disease-free survival (DFS) and overall survival (OS) according to surgical procedure were assessed.ResultsThe median (range) follow-up period for NSM and SSM was 71 (10-131) months and 79 (9-140) months, respectively. LRR developed in 11 patients with invasive ductal carcinoma (5.8%) for NSM and 44 (42 in patients with invasive ductal carcinoma and 2 in patients with ductal carcinoma-in-situ) (6.0%) for SSM. Hormone receptor and HER2 status were not associated with LRR in either group. DFS and OS rates did not differ between groups (DFS: 89.3% for NSM, 89.3% for SSM, P = .87; OS: 98.4% for NSM, 94.5% for SSM, P = .43).ConclusionNSM with immediate reconstruction was as safe as SSM for primary breast cancer with respect to prognosis and local control, regardless of the presence of invasive carcinoma or breast cancer subtype. 相似文献
14.
Jinguji M Kajiya Y Kamimura K Nakajo M Sagara Y Takahama T Ando M Rai Y Sagara Y Ohi Y Yoshida H 《Breast cancer (Tokyo, Japan)》2006,13(1):64-73
BACKGROUND: There is little evidence regarding associations between magnetic resonance imaging (MRI) features and other important histopathological prognostic factors of breast cancer. The purpose of our study was to investigate the relationship between rim enhancement on MRI and common histopathological prognostic factors of breast cancers. METHODS: We reviewed the contrast-enhanced MR images of 106 consecutive women with histopathologically verified invasive breast carcinomas. Three radiologists assessed the images of each lesion for the presence of rim enhancement on early and delayed images, which were classified into four patterns. Statistical analyses were performed to explore the associations of these patterns with common histopathological prognostic factors and patient age. RESULTS: Positive ratios of lymph node metastasis and blood vessel invasion and negative ratios of hormone receptors were higher in the invasive cancers with rim enhancement than those without rim enhancement. Rim enhancement was more frequent in invasive ductal cancers with a higher histological grade and larger invasive cancers. The pattern of rim enhancement with centripetal progression showed a significantly increased risk of lymph node metastasis and was associated with a larger size of invasive lesion when compared with the other patterns. Invasive cancers with rim enhancement and little change between the early and delayed images and with centrifugal progression showed significantly less hormone receptor positivity than those without rim enhancement. CONCLUSIONS: Rim enhancement patterns of breast cancers on contrast-enhanced MRI are related to common histopathological prognostic factors and these patterns may be valuable in the preoperative evaluation of breast cancers. 相似文献
15.
Inge-Marie A. Obdeijn Claudette E. Loo Adriana J. Rijnsburger Martin N. J. M. Wasser Elisabeth Bergers Theo Kok Jan G. M. Klijn Carla Boetes 《Breast cancer research and treatment》2010,119(2):399-407
In order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging.
In the Dutch MRI screening study (MRISC), a non-randomized prospective multicenter study, women with high familial risk or
a genetic predisposition for breast cancer were screened once a year by mammography and MRI and every 6 months with a clinical
breast examination (CBE). The false-negative MR examinations were subject of this study and were retrospectively reviewed
by two experienced radiologists. From November 1999 until March 2006, 2,157 women were eligible for study analyses. Ninety-seven
malignant breast tumors were detected, including 19 DCIS (20%). In 22 patients with a malignant lesion, the MRI was assessed
as BI-RADS 1 or 2. One patient was excluded because the examinations were not available for review. Forty-three percent (9/21)
of the false-negative MR cases concerned pure ductal carcinoma in situ (DCIS) or DCIS with invasive foci, in eight of them
no enhancement was seen at the review. In six patients the features of malignancy were missed or misinterpreted. Small lesion
size (n = 3), extensive diffuse contrast enhancement of the breast parenchyma (n = 2), and a technically inadequate examination (n = 1) were other causes of the missed diagnosis. A major part of the false-negative MR diagnoses concerned non-enhancing DCIS,
underlining the necessity of screening not only with MRI but also with mammography. Improvement of MRI scanning protocols
may increase the detection rate of DCIS. The missed and misinterpreted cases are reflecting the learning curve of a multicenter
study. 相似文献
16.
Q.R.J.G. Tummers F.P.R. Verbeek B.E. Schaafsma M.C. Boonstra J.R. van der Vorst G.-J. Liefers C.J.H. van de Velde J.V. Frangioni A.L. Vahrmeijer 《European journal of surgical oncology》2014
Background
Despite recent developments in preoperative breast cancer imaging, intraoperative localization of tumor tissue can be challenging, resulting in tumor-positive resection margins during breast conserving surgery. Based on certain physicochemical similarities between Technetium(99mTc)-sestamibi (MIBI), an SPECT radiodiagnostic with a sensitivity of 83–90% to detect breast cancer preoperatively, and the near-infrared (NIR) fluorophore Methylene Blue (MB), we hypothesized that MB might detect breast cancer intraoperatively using NIR fluorescence imaging.Methods
Twenty-four patients with breast cancer, planned for surgical resection, were included. Patients were divided in 2 administration groups, which differed with respect to the timing of MB administration. N = 12 patients per group were administered 1.0 mg/kg MB intravenously either immediately or 3 h before surgery. The mini-FLARE imaging system was used to identify the NIR fluorescent signal during surgery and on post-resected specimens transferred to the pathology department. Results were confirmed by NIR fluorescence microscopy.Results
20/24 (83%) of breast tumors (carcinoma in N = 21 and ductal carcinoma in situ in N = 3) were identified in the resected specimen using NIR fluorescence imaging. Patients with non-detectable tumors were significantly older. No significant relation to receptor status or tumor grade was seen. Overall tumor-to-background ratio (TBR) was 2.4 ± 0.8. There was no significant difference between TBR and background signal between administration groups. In 2/4 patients with positive resection margins, breast cancer tissue identified in the wound bed during surgery would have changed surgical management. Histology confirmed the concordance of fluorescence signal and tumor tissue.Conclusions
This feasibility study demonstrated an overall breast cancer identification rate using MB of 83%, with real-time intraoperative guidance having the potential to alter patient management. 相似文献17.
Purpose To determine pulmonary metastasis, video assisted thoracoscopic surgery (VATS) was performed on the patients who had undergone
breast cancer surgery.
Patients and Methods p Nineteen patients with a history of breast cancer underwent VATS, because of subsequent abnormal pulmonary
shadows on chest computed tomograms (CT). All patients were suspected to have pulmonary metastasis from breast cancer.
Results The VATS procedure showed 10 (52%) patients to have pulmonary metastasis, but, 9 (48%) had primary lung cancers or benign
lesions. In the patients of pulmonary metastasis, 7 had nodular lesions (5 had a single nodule and 2 had two nodules with
a median diameter of 8.5 mm), and 3 patients had pleural dissemination. The follow-up period of the patients with pulmonary
metastasis ranged from 3 to 28 months. Three patients died of brain metastasis and respiratory failure, 3 suffered recurrence
and 4 were free from disease after VATS.
Conclusion VATS was useful for distinguishing small metastatic lesions from other diseases and a minimally invasive surgical approach
in the follow-up of breast cancer patients suspected of pulmonary metastasis. 相似文献
18.
Tozaki M 《Breast cancer (Tokyo, Japan)》2008,15(3):218-223
Magnetic resonance imaging (MRI) of the breast has emerged as a highly sensitive modality. In addition to morphologic and
kinetic analysis obtained from contrast-enhanced breast MRI, functional information has been needed for diagnosis of breast
disease. In vivo proton (hydrogen 1 [1H]) MR spectroscopy of the breast has demonstrated that choline (Cho) can be detected in breast cancers, whereas Cho is generally
undetectable in normal breast tissue. Thus, breast MR spectroscopy has shown great promise as a way to differentiate between
benign and malignant lesions and to gauge the effect of chemotherapeutic agents in patients with locally advanced breast cancer.
Prior studies performed on 1.5-T MR imagers have reported sensitivities of 70–100% (average 89%; 149/168) and specificity
of 67–100% (average 87%; 97/112) for breast MR spectroscopy. Moreover, the presence of a Cho peak in breast cancer may reflect
the increased cell proliferation, with a decrease in this peak after treatment reflecting decreased viability of the tumor.
With further development and the assessment of Cho quantity in the tumor, breast MR spectroscopy may be helpful in the elucidation
of the biology of breast cancer. 相似文献
19.
P. Mariani V. Servois Y. De Rycke S.P. Bennett J.G. Feron M.M. Almubarak F. Reyal B. Baranger J.Y. Pierga R.J. Salmon 《European journal of surgical oncology》2013
Aim
To determine whether, in a highly selected patient population, medical treatment combined with surgical resection of liver metastases from breast cancer is associated with improved survival compared with medical treatment alone.Patients and methods
Between 1988 and 2007, 100 liver resections for metastatic breast cancer were performed at Institut Curie, 51 of which met the criteria for inclusion in this case-control study. With the exception of bone metastases, patients with other distant metastasis sites were excluded. Surgery was only performed in patients with stable disease or disease responding to medical treatment evaluated by imaging evaluation. Surgical cases were individually matched with 51 patients receiving medical treatment only. All patients had 4 or fewer resectable liver metastases. The study group was matched with the control group for age, year of breast cancer diagnosis, time to metastasis, TNM stage, hormone receptor status and breast cancer tumour pathology.Results
Univariate analysis confirmed a survival advantage for patients lacking bone metastases and axillary lymphadenopathy at the time of breast cancer diagnosis and for surgically treated patients. Multivariate analysis indicated that surgery and the absence of bone metastases were associated with a better prognosis. A multivariate Cox model adapted for paired data showed a RR = 3.04 (CI: 1.87–4.92) (p < 0.0001) in favour of surgical treatment.Conclusion
Surgical resection of liver metastases from primary breast cancer appears to provide a survival benefit for highly selected patients. 相似文献20.
Yilmaz MH Ozguroglu M Mert D Turna H Demir G Adaletli I Ulus S Halac M Kanberoğlu K 《Medical oncology (Northwood, London, England)》2008,25(3):257-263
Purpose The goal of this study was to compare the sensitivity of MRI and scintigraphy for detecting metastatic bone disease involving
the axial skeleton. Patients and Methods A total of 59 patients (58 women and 1 man, age range 28–83 years, mean age 53.0 years) with histopathologically proven breast
cancer during a 15-month period (between April 2003 and January 2004) were included in the study. All the patients underwent
scintigraphy and MRI examinations for staging, follow-up, or evaluation of bone pain. Results MR imaging revealed 59 metastases in 59 patients (sensitivity, 95%; specificity, 100%; positive predictive value, 100%).
Four lesions detected by MRI were classified as of uncertain origin (grade 2) and 36 lesions were regarded as definitely benign
(grade 1). Scintigraphy revealed 44 metastases in 59 patients (sensitivity, 70%; specificity, 94%; positive predictive value,
95%). A total of 29 lesions were considered as of uncertain origin (grade 2), and 26 lesions were regarded as definitely benign
(grade 1). About five lesions were graded as grade 2 in scintigraphy, while MRI graded them as degeneration or benign compression
(Grade 1). For 11 lesions the same grade was regarded in both MRI and scintigraphy. Two lesions graded as grade 3, and eleven
lesions graded as grade 2 in scintigraphy demonstrated no pathological signal intensity in MRI. In total, 18 lesions with
no activity in scintigraphy were graded as grade 3 lesions in MRI. Conclusion MRI is more sensitive than scintigraphy in the detection of bone metastases. MRI appears to be able to screen patients more
effectively than scintigraphy if the spine and pelvis are included because metastases merely outside the axial skeleton are
rare. 相似文献