共查询到19条相似文献,搜索用时 109 毫秒
1.
联立方程组新解法测定氯柳酊的含量 总被引:2,自引:0,他引:2
目的 测定氯柳酊中二组分的含量。方法 采用新Vierordt法不经分离直接测定氯柳酊中氯霉索及水杨酸的含量,测定波长分别为278nm及297nm。结果 平均回收率及RSD:氯霉素为99.6%,0.87%和水杨酸为100.6%,1.13%。结论 本法操作简便、快速,准确,适用于医院制剂分析。 相似文献
2.
目的:介绍氯柳酊的制备、质量控制。方法:制备氯柳酊,采用紫外分光光度法测定氯霉素的含量。结果:氯霉素在278nm处有最大吸收,水杨酸在278nm和322.2nm有吸收点。平均回收率为99.2%,RSD为0.37%。结论:本制剂处方合理,含量测定方法简便准确。可作为该制剂的质量控制方法。 相似文献
3.
目的 :建立氯柳酊中氯霉素和水杨酸含量测定方法。方法 :采用紫外分光光度法 ,利用吸收度的加和性 ,不经分离直接进行含量测定。结果 :氯霉素的测定波长为 2 78nm ,平均回收率为 10 0 .75 % (RSD=0 .70 % ,n =5 ) ;水杨酸的测定波长为 2 30 nm,平均回收率为 99.4 8% (RSD=0 .2 9% ,n =5 )。结论 :本法简便、快速 ,结果准确。 相似文献
4.
目的本文建立一种同时测定制剂中多组分含量的分光光度法。方法应用联立方程分光光度法,不经分离直接测定氯柳酊中氯霉素和水杨酸的含量。测定波长为278.4nm和296.3nm。结果氯霉素的平均回收率及RSD为99.5%,0.48%;水杨酸的平均回收率及RSD为99.1%,0.58%。结论本法快速、简便、结果准确,适宜于医院制荆分析。 相似文献
5.
系数倍率法测定氯柳酊的含量 总被引:2,自引:0,他引:2
目的 建立氯柳酊中二组分的含量测定方法。方法 采用系数倍率法消除组分间干扰直接测定含量。结果 以278nm、297nm为测定波长,氯霉素和水杨酸的平均回收率及RSD分别为99.3%,0.9%和99.5%。结论 本法简便、快速、准确。 相似文献
6.
7.
8.
9.
双波长光谱法测定复方氯霉素酊中氯霉素与水杨酸的含量 总被引:3,自引:0,他引:3
目的:对复方氯霉素酊的含量测定进行研究。方法:采用双波长光谱法不经分离直接测定复方氯霉素酊中氯霉素与水杨酸的含量。选定氯霉素的测定波长为274.5nm,参比波长为326nm;水杨酸的测定波长为290nm,参比波长为260nm。结果:平均回收率:氯霉素为99.4%,RSD为1.8%(n=6),水杨酸为100.1%,RSD为2.1%(n=6)。结论:该方法简便、快速,准确可靠,适用于该制剂的含量测定。 相似文献
10.
11.
目的 :测定复方氟罗沙星栓及复方氟罗沙星滴耳液中2组分含量。方法 :采用联立方程组新解法不经分离直接测定复方氟罗沙星栓及复方氟罗沙星滴耳液中氟罗沙星、替硝唑及氟罗沙星、甲硝唑的含量。结果 :以286、317nm分别为复方氟罗沙星栓中2组分的测定波长 ,以蒸馏水为空白 ,氟罗沙星和替硝唑的平均回收率及RSD分别为100 17 %、0 44 %和99 96 %、0 37 % ;以286、318nm分别为复方氟罗沙星滴耳液中2组分的测定波长 ,以蒸馏水为空白 ,氟罗沙星和甲硝唑的平均回收率及RSD分别为100 65 %、0 65 %和99 92 %、0 21 %。结论 :本法操作简便快速 ,重现性好 ,可消除各处方中2组分的相互干扰 ,结果满意 相似文献
12.
Simple, rapid and reliable spectroscopic methods (absorbance ratio and Vierordt) were compared with HPLC for quantitative determination in dissolution tests of benazepril-HCl (BNZ) and hydrochlorothiazide (HCT) in commercial tablets. A 249 nm wavelength was chosen as the isosbestic point in the absorbance ratio method, and the absorbance ratios A236/A249 nm for BNZ and A269/A249 nm for HCT were used for calculation of regression equations. For the Vierordt method, A1(1) values (%1.1 cm) obtained at 236 and 269 nm for both substances were used for quantitative analyses of BNZ and HCT. In the HPLC method, simultaneous determination of BNZ and HCT from dissolution medium was achieved using the mobile phase containing phosphate buffer (0.01 M, pH 6.2) and acetonitrile (65:35) on a Supelcocil LC-18 (4.6 x 250, 5.6 mm) reversed phase column. Dissolution tests of commercial tablets were carried out according to USP XXII paddle method in 0.1 N HCl at 50 rpm at 37 +/- 0.5 degrees C. Comparison of the dissolution data from the HPLC and two spectroscopic methods indicated that spectroscopic and HPLC methods were in good correlation with each other. Therefore, it was concluded that both spectroscopic methods as well as HPLC can be used in routine analyses of BNZ and HCT in dissolution tests of commercial tablets. 相似文献
13.
Two spectrophotometric methods have been developed for the simultaneous determination of diloxanide furoate and tinidazole in combined dosage formulations without prior separation. The first method is based on the measurement of the absorbance of a methanolic solution of the sample at 259 and 311 nm and application of a simplified Vierordt equation for the determination of diloxanide furoate, whereas tinidazole is determined by direct spectrophotometry. The second method is a difference spectrophotometric procedure based on measurement of the absorbance of the sample solution in water relative to that of an acidic or alkaline solution of identical concentration at the appropriate wavelength of maximum difference absorption. The results are calculated by reference to standard absorptivity values. 相似文献
14.
A rapid method for the determination of naphazoline in antazoline- naphazoline drops is discussed. The method depends upon precipitating antazoline by a solution of sodium carbonate. Naphazoline is determined in the filtrate using (i) the modified Vierordt method and (ii) Glenn's method of orthogonal functions to correct for the unprecipitated fraction of antazoline. 相似文献
15.
Three spectrophotometric methods, based on a spectral analysis, are proposed for quantification of ranitidine hydrochloride (RHCl) in the presence of its decomposition product (R-ox) without isolation from the matrix. One of them is a zero-crossing derivative-spectrophotometry. A value of the first derivative at 332 nm generated by the Savitzky-Golay algorithm (delta lambda = 22 nm and the first polynomial degree) allows for quantification of RHCI in the concentration range 0.5-35.1 microg/mL. The second proposed spectrophotometric procedure, called Vierordt method, utilizes an additivity of the absorbance. The assay of studied compound was realized by the direct reading of absorbance at 312 nm and 202 nm for ranitidine hydrochloride and its decomposition product, respectively. The quantitative results were obtained by resolving of an appropriate system of equations. The third method is based on the bivariate calibration algorithm. The absorbance values were measured at optimum wavelengths found by Kaiser method at 228 nm and 202 nm and used for the quantification of RHCI in the presence of its decomposition product. The Beer's law was obeyed in the concentration range 0.5-35.1 microg/mL for RHCl. The discussion of applicability of all elaborated methods is presented. The proposed methods were applied for assay of ranitidine hydrochloride contents in its preparation Ranigast and for investigation of kinetics of its reaction with hydrogen peroxide. 相似文献
16.
双波长分光光度法测定复方阿昔洛韦搽剂中阿昔洛韦的含量 总被引:4,自引:0,他引:4
本文采用双波长分光光度法,不经分离直接测定复方阿昔洛韦搭剂中阿昔洛韦的含量。测定波长为251.5nm,参比波长为307nm,平均回收率为100.56%,RSD为0.5%。本法快速,简便,结果准确。 相似文献
17.
目的利用联立方程组新解法考察注射用头孢噻肟钠和维生素B6注射液与木糖醇注射液配伍的稳定性。方法用联立方程组新解法计算注射用头孢噻肟钠与维生素B6注射液的含量。分别在25℃和37℃条件下,观察6h内注射用头孢噻肟钠和维生素B6配伍液的外观、pH值及紫外光谱的变化。结果 6h内,注射用头孢噻肟钠和维生素B6与木糖醇注射液配伍液的外观、pH值、紫外光谱及含量无明显变化。结论应用联立方程组新解法测定头孢噻肟钠和维生素B6注射液与木糖醇注射液配伍的稳定性,方法简便、准确,实用性强。 相似文献
18.
高效液相色谱法测定双扑伪麻片中扑热息痛、盐酸伪麻黄碱、扑尔敏的含量 总被引:7,自引:0,他引:7
用高效液相色谱法,同时分离测定双扑伪麻片中扑热息痛、盐酸伪麻黄碱和扑尔敏的含量.线性范围:扑热息痛020~080g/L,r=09995;盐酸伪麻黄碱0012~0048g/L,r=09996;扑尔敏000072~000288g/L,r=09992.平均回收率(x±rsd)%分别为:扑热息痛(1002±17)%;盐酸伪麻黄碱(996±14)%;扑尔敏(984±26)%. 相似文献
19.
几种中草药中痕量锗的同步荧光法测定 总被引:15,自引:1,他引:14
目的:测定中草药中痕量锗。方法:采用同步荧光分析法。在乙醇介质中,以磷酸调节试液酸度,桑色素乙醇溶液为络合剂。结果:Ge-桑色素络合物的最佳峰位λex=427nm,Δλ=70nm。在0~200ng·mL-1浓度范围内线性关系良好(r=09996),最低检出限为05ng·mL-1。结论:实验证明,该法用于中草药中痕量锗的测定灵敏方便,几个实样测定结果满意 相似文献