Enzymology of intracellular membrane fusion

Summary A combination of cell-free biochemical and morphological studies has revealed that a coated bud-coated vesicle transport system shuttles newly synthesized proteins through the successive processing compartments of the Golgi apparatus. These Golgi coated vesicles operate in a manner formally analogous to the clathrin coated pitcoated vesicle system responsible for receptor-mediated endocytosis; however Golgi coated vesicles do not contain clathrin.Abbreviations ER endoplasmic reticulum - VSV vesicular stomatitis virus - TGN trans Golgi network - GCVs Golgiderived coated vesicule - NEM N-ethylmaleimide - NSF NEM-sensitive fusion protein - SNAP soluble NSF-attachment protein(s) - ARF ADP-ribosylation factor - AlF₄ aluminumfluoride     

Clinical Psychology: Beyond Psychopathology and Clinical Interventions

As clinical psychology addresses an increasingly wide spectrum of problems, the discipline's dominant emphasis on psychopathology must be integrated with an equivalent understanding of psychosocial problems. Such a balance is viewed as improving work done in relation to all problems addressed by clinical psychology and the mental health field. In support of these views, this article explores the importance of going beyond psychopathology with respect to (a) classifying behavioral, emotional, and learning problems and (b) conceiving intervention models.     

Clinical myiasis

Human clinical myiasis is a rare entity in temperate zones, but it is of frequent occurrence among indigenous populations in tropical countries. The physician in practice in temperate zones, especially in urban areas, will generally see cases in those who have returned from rural travel or duty tours in tropical countries.