微创技术结合中药三期辨证治疗拇外翻42例临床体会

目的:探讨微创技术结合中药三期辩证治疗拇外翻的疗效。方法:自2010年1月-2012年6月微创技术结合中药三期辩证治疗拇外翻42例(51足),男性7例,女性35例,年龄38-73岁,平均年龄56.3岁;双足发病9例,单足发病33例,共51足;拇趾外翻角(HAV角)13-45,平均29.4,第1、2跖骨间夹角(IMA角)10-21,平均14.2。结果:一期:优35足,良11足,差5足,优良率为90.2%;二期:优37足,良10足,差4足,优良率为92.2%;三期:优41足,良7足,差3足,优良率为94.1%。结论:微创技术结合中药三期辩证是治疗拇外翻的一种良好方法,其优点是对软组织及骨组织破坏小,畸形矫正好、功能恢复快,可早期下地活动,术后不易复发等,便于基层医院推广应用。     

微创技术治疗拇外翻畸形344例的疗效观察

目的观察微创治疗拇外翻畸形患者的治疗效果.方法采用局麻下微创手术治疗拇外翻畸形344例,使用温氏微型动力系统专用器械微创截骨,配合小针刀断开拇内收肌,手法矫形、复位、绷带外固定.结果优325例545足,良12例13足,差7例8足,优良率98.33%.结论微创手术治疗拇外翻具有损伤小、痛苦少、术后恢复快、安全性高、手术效果可靠、简单易行的特点,可作为矫正拇外翻畸形的较好方法.     

拇趾外翻的术式选择

目的 探讨拇趾外翻的手术方式的选择原则.方法 对49例62足采用不同方法进行手术治疗.结果 所有病例均或随访,时间0.5年-13年,平均4.1年,采用胥氏标准进行疗效评定,优48足,良8足,差6足.结论 根据拇趾外翻的主要病理变化选择适当的手术方法.     

足拇外翻的治疗

目的 探讨微创手术治疗拇外翻的效果及注意事项.方法 本组23例(42足)拇外翻均采用微创手术治疗,行第1跖趾关节囊外侧松解,第1跖骨头内侧骨赘切除,跖骨头颈斜形截骨,术后"8"字绷带包扎,生活可自理.结果 优20例37足,良2例4足,差1例1足,优良率976%.结论 微创手术治疗拇外翻具有损伤小、痛苦少、术后恢复快、安全性高的特点.     

微创手术治疗拇外翻的疗效观察

目的 探讨微创手术治疗拇外翻的临床效果及优缺点.方法 对我院近3年收治的845例(1467足)拇外翻患者采用微创手术治疗,回顾性分析治疗的效果.结果 1467足均在术后8周一期愈合,内侧皮神经损伤19足.拇趾僵硬12足,第一跖趾关节痛、畸形矫正不良8足(均为重度拇外翻患者),转移性跖骨痛6足,足中部不适6足,均对症治疗效果满意.结论 拇外翻微创治疗适合于轻中度拇外翻患者,术后可在短期内愈合,并发症少.     

微创手术治疗拇外翻23例（42足）

目的探讨微创手术治疗拇外翻的效果及注意事项。方法本组23例（42足）拇外翻均采用微创手术治疗,行第1跖趾关节囊外侧松解,第1跖骨头内侧骨赘切除,跖骨头颈斜形截骨,术后“8”字绷带包扎,生活可自理。结果优20例37足,良2例4足,差1例1足,优良率976％。结论微创手术治疗拇外翻具有损伤小、痛苦少、术后恢复快、安全性高的特点。     

微创技术治疗拇外翻临床应用报告

目的：研究采用微创技术小切口手术,结合手法治疗拇外翻的方法,总结其疗效。方法：报告13例（26足）拇外翻合并拇囊炎,采用小切口结合手法治疗,行骨赘削磨、跖骨头颈截骨、手法矫正畸形、“8”字绷带、粘膏外固定方法,术后病人穿硬底、前开口的拖鞋,可适当下床活动,6周后去除外固定。随访时间为7～18个月,平均12月。结果：优11例,良2例,差0例。优良率达100％。结论：微创技术小切口手术结合手法治疗拇外翻是一种矫形满意、畸形不易复发、痛苦少、术后生活能自理、恢复快、无明显合并症,深受患者欢迎的新方法。     

拇外翻术后113例并发症分析

目的 探讨拇外翻术后并发症的起因及防治方法.方法 于1998-03/2008-02选择大连大学附属中山医院骨科手术治疗的拇外翻畸形患者113例(186足)进行回顾性分析,其中选择Keller术式67例,Macbfide术式56例,Mitchell术式12例.wilson术式18例.Scafe术式4例,Loison术式20例,跖趾关节融合术9例.分析并发症原因,参照原术式症状严重程度和患者要求采取针对性措施.首先保守治疗,无效则再次手术治疗.保守治疗包括理疗、按摩、主被动功能锻炼和支具固定等.手术参照并发症原因采取针对性措施.所有患者按美国足踝外科协会Maryland评分系统中拇跖趾关节评分标准评分,其中疼痛占40分,功能占45分(包括日常生活及体育活动10分,穿鞋情况10分,跖趾关节活动5分,趾间关节活动5分,关节稳定性5分,拇趾有无胼胝5分),外观占15分;90～100分为优.80-89分为良,70-79分为可,低于70分为差.结果 术后2.5-41个月,平均13个月出现并发症,其中拇外翻复发6例,拇内翻3例.转移性跖骨痛10例.截骨处延迟愈合或不愈合3例,第1跖骨头坏死2例及第1趾列活动受限21例.该组患者首次术后评估,优97足(52%),良45足(24%),可31足(17%),差13足(7%),优良率为76%.针对并发症采取保守治疗38例,手术治疗7例,治疗后评估,优111足(60%),良61足(33%),可12足(6%),差2足(1%),优良率为93%.结论 制定个性化治疗方案,出现并发症后进行针对性的康复治疗,可明显提高疗效.     

微创手术治疗踇外翻的临床效果

目的分析采用微创手术治疗踇外翻患者的临床效果。方法选取周口协和骨科医院2015年10月至2018年10月收治的踇外翻患者52例83足,均行微创手术治疗,随访1～36个月,观察患者畸形纠正情况、临床疗效及并发症发生情况。结果随访1～36个月,末次随访时测量第1～2跖骨间夹角为3°～14°,平均(7.69±2.12)°;踇外翻角为6°～24°,平均(14.25±3.10)°。本研究52例83足中,优60足,良18足,优良率为93.98%(78/83)。随访期间,2足于早期截骨部位皮肤切口出现感染,经对症治疗后1足症状消退,另1足继发深部感染,经静脉滴注抗生素治疗2周后消退,其他患者均一期愈合,1足出现踇趾麻木。所有患者均未发生踇内翻畸形及截骨部位骨不连等情况,6个月内骨性愈合,外观无明显瘢痕。结论微创手术治疗踇外翻可有效纠正畸形,创伤小、并发症少,疗效显著。     

Keller手术治疗老年女性拇外翻畸形临床分析

目的：探讨采用Keller手术治疗老年女性拇外翻畸形的临床疗效。方法：2004年3月－2008年6月采用Keller手术治疗踇外翻畸形女性患者24例,共39足。结果：术后评价,优31足,良8足,术后无切口感染、畸形复发、跖骨头无菌性坏死等并发症。结论：采用Keller手术治疗老年女性踇外翻畸形的疗效令人满意。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.