中西医结合治疗肾阴亏虚型原发性高血压40例

目的观察中西医结合治疗肾阴亏虚型原发性高血压的临床疗效。方法将诊断为肾阴亏虚型原发性高血压的80例患者随机分为2组。对照组40例给予西药联合治疗,治疗组40例在对照组治疗基础上给予左归丸加减治疗。治疗2个月后比较两组疗效。结果治疗组总有效率92.5%,对照组总有效率77.5%,两组比较差异有统计学意义(P0.05)。结论左归丸加减并辅助西药联合降压治疗肾阴亏虚型原发性高血压能有效改善患者临床症状,值得推广应用。     

二仙汤合当归芍药散加减治疗围绝经期高脂血症的随机对照试验

[目的]评价二仙汤合当归芍药散加减治疗围绝经期高脂血症(肾阴阳两虚型)的临床疗效.[方法]将68例围绝经期高脂血症(肾阴阳两虚型)患者随机分为对照组和治疗组,每组各34例.对照组给予口服阿托伐他汀治疗,治疗组在对照组基础上给予二仙汤合当归芍药散加减治疗,疗程为4周.观察2组患者治疗前后中医证候积分、更年期综合征自我评定...     

定坤丹结合谷维素治疗围绝经期综合征临床观察

[目的]观察定坤丹结合谷维素治疗围绝经期综合征的临床疗效.[方法]54例患者,随机分为治疗组和对照组,每组27例,对照组常规使用谷维素治疗,治疗组在对照组的基础上采用定坤丹口服,疗程为3个月.对比两组临床疗效及治疗前后性激素水平.[结果]治疗组总有效率为85.2％,对照组总有效率为63.0％,治疗组疗效明显高于对照组(P＜0.05).[结论]定坤丹结合谷维素治疗围绝经期综合征的疗效显著.     

紫参颗粒治疗围绝经期综合征临床研究

目的:观察紫参颗粒治疗肾阴阳两虚型围绝经期综合征的疗效.方法:60例围绝经期综合征患者随机分成治疗组(用紫参颗粒治疗)和对照组(用尼尔雌醇治疗),每组30例.观察临床总疗效及主要症状积分变化,治疗前后检测性激素水平.结果:两组临床治愈率、显效率、有效率、总有效率比较,差异无显著性(P＞0.05).治疗组头晕目眩、尿频、少寐、虚烦的症状积分下降值明显优于对照组(P<0.05).结论:紫参颗粒对阴阳两虚型围绝经期综合征有显著疗效,对头晕目眩、尿频、少寐、虚烦症状的疗效明显优于尼尔雌醇.     

三原胶囊3号治疗肾阴亏虚型早期糖尿病肾病(DN)的临床研究

目的 观察三原胶囊3号治疗肾阴亏虚型早期糖尿病肾病(DN)的临床疗效.方法 将符合标准的肾阴亏虚型早期糖尿病病人典型病例60例,按随机原则分成对照组、治疗组各30例.其中对照组30例在严格控制血糖的同时,联合应用血管紧张素转换酶抑制荆(ACEI);治疗组30例在前述基础上加服我院糖尿病专科研制的三原胶囊3号.1个月为一个疗程,2个疗程结束后观察两组疗效.结果 对照组30例早期糖尿病肾病(DN)病人经过2个疗程的治疗,结果总有效率为76.7%;治疗组30例早期糖尿痛肾病(DN)病人经过2个疗程加服三原胶囊3号的治疗,结果总有效率为93.3%.结论 三原胶囊3号治疗肾阴亏虚早期糖尿病肾病(DN)疗效可靠.     

补肾固齿丸配合牙周基础治疗对肾阴亏虚型牙周炎的疗效观察

目的观察补肾固齿丸配合牙周基础治疗对肾阴亏虚型牙周炎的临床疗效。方法将50例肾阴亏虚型牙周炎患者随机分为2组,治疗组30例采用中成药补肾固齿丸加牙周基础治疗,对照组20例采用西药甲硝唑加牙周基础治疗。结果对照组总有效率为85．0％,治疗组为96．7％,2组比较差异有统计意义（P〈0．05）。结论补肾固齿丸配合牙周基础治疗对肾阴亏虚型牙周炎疗效显著,值得推广。     

针刺治疗围绝经期综合征的临床观察

[目的]观察针刺治疗围绝经期综合征的疗效.[方法]将70例围绝经期综合征患者随机分为针刺组和对照组各35例.对照组予尼尔雌醇1 mg/d口服,针刺组予针刺治疗,取肾俞、肝俞、肺俞、脾俞、心俞、百会、四神聪、神门、内关、足三里、三阴交、太冲等穴,治疗4周后观察治疗前后Kupperman评分及临床疗效.[结果]治疗组治疗前后Kupperman评分分别为35.45±5.86和7.83±3.87,对照组分别为36.57±6.16和16.22±5.11,两组治疗前后自身比较均有显著改善(P＜0.01);治疗后的Kupperman评分以治疗组为佳(P＜0.01).临床疗效观察显示治疗组总有效率为91.4%,对照组为68.6%,治疗组疗效尤佳(P＜0.05).[结论]针刺治疗围绝经期综合征的疗效较好.     

三原胶囊3号治疗肾阴亏虚型早期糖尿病肾病(DN)的临床研究

目的观察三原胶囊3号治疗肾阴亏虚型早期糖尿病肾病(DN)的临床疗效。方法将符合标准的肾阴亏虚型早期糖尿病病人典型病例60例,按随机原则分成对照组、治疗组各30例。其中对照组30例在严格控制血糖的同时,联合应用血管紧张素转换酶抑制剂(ACEI);治疗组30例在前述基础上加服我院糖尿病专科研制的三原胶囊3号。1个月为一个疗程,2个疗程结束后观察两组疗效。结果对照组30例早期糖尿病肾病(DN)病人经过2个疗程的治疗,结果总有效率为76.7%;治疗组30例早期糖尿病肾病(DN)病人经过2个疗程加服三原胶囊3号的治疗,结果总有效率为93.3%。结论三原胶囊3号治疗肾阴亏虚早期糖尿病肾病(DN)疗效可靠。     

逍遥丸结合针刺治疗围绝经期综合征肝郁型观察

目的:观察逍遥丸结合针刺治疗围绝经期综合征肝郁型临床疗效.方法:将40例患者随机分治疗组20例和对照组20例.治疗组口服中药逍遥丸及针刺疗法;对照组口服谷维素、倍美力片,两组治疗15d后观察临床疗效.结果:治疗组显效率50％,总有效率90％;对照组显效率30％,总有效率65％.两组疗效比较,治疗组疗效明显优于对照组.结论:逍遥丸结合针刺治疗围绝经期综合征肝郁型效果显著,无明显不良后果.     

中西医结合治疗围绝经期综合征的心理护理

目的 观察滋阴平肝清心法治疗围绝经期综合征的效果.方法 选择确诊为围绝经期综合征的患者60例,随机分为两组.治疗组(30例)以滋阴平肝清心法为原则组方,随证加减,每日1剂,水煎服,每日2次,连服20d.对照组(30例)口服更年康,连服20d观察疗效.结果 治疗组:显效23例(76.67%),有效6例(20.00%),无效1例(3.33%),总有效率96.67%.对照组:显效13例(43.33%),有效14例(46.67%),无效3例(10.00%),总有效率90.00%.治疗组与对照组比较(P<0.05),有统计学意义,说明治疗组总有效率、显效率均高于对照组,有显著性差异.结论 滋阴平肝清心法是治疗围绝经期综合征更为有效的方法.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.