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董文斌 《国际生物制品学杂志》2018,41(6):306-309
含有4-氨基-2,4-戊二烯酸的环缩酚酸肽类天然产物是一类包含酯键的环状多肽次级代谢产物,通常具有抗肿瘤、抗病原体等生物活性。此文根据国内外最新研究现状,介绍了这类物质的来源、结构、制备现状、生物活性以及开发前景。 相似文献
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生物活性肽是一类天然存在于动、植物和微生物等生物体内,或动、植物蛋白质经蛋白酶酶解以及人工化学合成或生物工程方法而得,且具有特殊生理活性的生物物质,具有较显著的抗肿瘤作用。此文介绍了生物活性肽的分类与特性、抗肿瘤作用,并简述了生物活性肽增强机体特异性和非特异性免疫功能、抗自由基与辐射损伤、诱导肿瘤细胞凋亡和直接作用于肿瘤细胞等多种作用机理,并简述了生物活性肽实现抗癌以及临床抗肿瘤药用等内容。 相似文献
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Enopeptin A是一种缩酚酸肽类化合物,具有抗菌、抗病毒等生物活性。以本实验室保藏的链霉菌SIIA-H7264为出发菌,通过紫外(UV)照射、甲基磺酸乙酯(EMS)诱变、亚硝基胍(NTG)诱变以及常压室温等离子体(ARTP)诱变,获得1株高产突变株A-21,其发酵产物Enopeptin A的产量较出发菌株提高了3倍。对发酵条件、发酵培养基组分进行单因素及响应面优化试验,最终Enopeptin A的产量达到1750μg/mL,较初始工艺提高了2.98倍。 相似文献
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王莹 《国外医学(药学分册)》1999,(4)
大量的天然产物被用于抗肿瘤细胞的有丝分裂和干扰微管的正常功能。这一类天然产物或其衍生物如长春花碱、紫杉醇等已被用于临床治疗肿瘤。但是多药耐药性限制了这类药物的应用,而cryptophycin家族中的新抗肿瘤制剂对P糖蛋白(Pgp)介导的多药耐药性机制敏感性低。cryptophycin是一种缩酚酸肽类抗肿瘤制剂。这一类药物的先导化合物cryptophycin1是从念珠蓝细菌属(Nostocsp.)中分离出来的,最初作为抗真菌药物,随后发现它具有对抗肿瘤细胞的细胞毒性,cryptophycin52是… 相似文献
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内皮素是1988年日本学者Yanag sawa发现的一类由内皮细咆合成的生物活性肽。随后有人证实神经胶质细咆也产生内皮素(ET),并以旁分泌的方式对神经胶质细胞和神经元发挥作用。这说明ET可能是一种潜在的神经调节因子,内皮素以其强大的缩血管作用而引起人们广泛关注,近几年来有关内皮素与腑血管病的研究已有较多报道。但对脑外伤后脑脊液及血浆ET含量的 相似文献
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Ellagitannins as active constituents of medicinal plants 总被引:5,自引:0,他引:5
Isolation and structure determination, accompanied by measurement of various biological activities of each isolated tannin, particularly of ellagitannins, have brought about a marked change in the concept of tannins as active constituents of medicinal plants. Their biological activities should now be discussed on the basis of the structural differences among each tannin, in a way similar to that of the other types of natural organic compounds. The anti-tumor activity exclusively exhibited by several oligomeric ellagitannins, and their anti-HIV activities are examples of such biological activities. The inhibitory activity against lipid peroxidation, which is different in the strength among tannins of various structures, is exhibited in general more strongly by ellagitannins than by the other types of tannins of similar structures. The radical-scavenging activities of tannins as the mechanism of their inhibition, which is regarded to participate in several biological activities of tannins, have been supported by the ESR spectral measurements. Other biological activities, i.e., inhibition of mutagenicity of carcinogens, inhibition of tumor promotion, etc., have been found for tannins including ellagitannins. 相似文献
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Acharan sulfate (AS) is a glycosaminoglycan (GAG) prepared from the giant African snail, Achatina fulica. In this study, some biological activities of AS were evaluated on the basis of structural similarities to heparin/heparan sulfate and the biological functions of GAGs. We demonstrated that it exhibited strong immunostimulating activities as measured by carbon clearance test in mice and in vivo phagocytosis. It also exhibited a significant hypoglycemic activity in epinephrine (EP)-induced hyperglycemia as well as antifatigue effects by weight-loaded forced swimming test. And it showed hypolipidemic activities in cholesterol-rich mixture induced hyperlipidemia in rats. The above results indicate that AS has diverse biological activities and suggest therapeutically important target molecules. 相似文献
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The topologically derived, nonempirical molecular connectivity index, chi, for several classes of compounds is shown to be parabolically related to the biological activities of these compounds. Similar nonlinear relationships were previously shown between the octanol-water partition coefficients, expressed as log P, of the compounds and their biological activities. These and previous studies indicate that many physiochemical properties presently used in structure-activity studies may be intermediaries between the nonempirical molecular structure encoded in chi and measured biological activities. 相似文献
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Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds 总被引:11,自引:2,他引:9
Hendrich AB 《Acta pharmacologica Sinica》2006,27(1):27-40
Flavonoids are found ubiquitously in higher plants and constitute an important component of the majority of people daily diets. The biological activities of flavonoids cover a very broad spectrum, from anticancer and antibacterial activities through to inhibition of bone resorption. In the present paper, the interactions between flavonoids and lipid bilayers as well as biological membranes and their components are reviewed, with special emphasis on the structure-activity relationships and mechanisms underlying the biological activity of flavonoids. 相似文献
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Natural products are regarded as vital key source of lead compounds for drug discovery due to their structural diversity and broad array of biological activities. Phenylpropanoid sucrose esters are naturally occurring compounds isolated from various plants and are structurally characterized by a sucrose core connected to one or more Ph-CH=CH-CO- moieties through an ester linkage. These compounds were extensively used in folk medicine and are found to possess many biological activities such as antitumor, antibacterial, antioxidant, antiviral, anti-inflammatory, neuro-protective and glycosidase inhibitory activities. This extensive review, which is the first of its kind on phenylpropanoid sucrose esters, aims to provide an up-to-date account of naturally occurring known phenylpropanoid sucrose esters with special focus on their sources, structures, biological and pharmacological activities. 相似文献
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Preeti Arora Rakesh Narang Surendra Kumar Nayak Sachin Kumar Singh Vikramjeet Judge 《Medicinal chemistry research》2016,25(9):1717-1743
Thiazoles are important heterocyclics exhibiting boundaryless biological activities, such as antibacterial, antifungal, anti-inflammatory, antitumor, antitubercular, antidiabetic, antiviral, and antioxidant. Substituents on a particular position of the thiazole ring affect the biological outcomes to a great extent. Therefore, researchers have synthesized compounds containing the thiazole ring with variable substituents as target structures, and evaluated their biological activities. The present review describes the biological importance of recently developed 2,4-disubstituted thiazole derivatives. Moreover, we have thrown light on various targets of 2,4-disubstituted thiazoles through which they induce biological effects, which will be helpful to those who are working on the design and structure–activity relationship of bioactive molecules. 相似文献