股骨头髓芯减压带旋髂深血管蒂髂骨骨瓣植骨治疗股骨头缺血性坏死

目的　探讨股骨头髓心减压带旋髂深血管蒂髂骨骨瓣植骨术治疗股骨头缺血坏死的疗效及手术适应证。　方法　 1995年 10月～ 2 0 0 0年 8月共进行 18例 (2 6髋 )股骨头髓心减压带旋髂深血管蒂髂骨骨瓣植骨术。根据Harris髋关节评分系统进行关节功能评价 ,根据ARCO分期分型系统进行影像学评价。　结果　随访 16例 2 3髋 ,平均 3 1 5个月。Harris评分由术前平均 61 7改善为随访时 76 0分。 13髋 (5 6% )随访时Harris评分 >80 0分 (内侧型 8髋 ,中央型 3髋 ,外侧型 2髋 ) ,根据ARCO分期分型系统进行分类随访时优良率 ,内侧型 80 % ,中央型 60 % ,外侧型 2 5 %。 8髋分期发生进展。塌陷及失败率内侧型 2 0 % ,中央型 40 % ,外侧型 75 %。　结论　股骨头髓芯减压带旋髂深血管蒂髂骨骨瓣植骨术适用于ARCO分期分型系统中ⅠA中央型、ⅠB内侧型、ⅡA中央型、ⅡB内侧型股骨头缺血性坏死 ,并具有良好的近、中期疗效。对坏死范围较大的股骨头不能防止病程的进展 ,但可缓解症状 ,延缓全髋关节置换的时间     

Analysis of long‐term outcomes of double‐strut bone graft for osteonecrosis of the femoral head

Objective: To analyze the long‐term effect of double‐strut bone graft for osteonecrosis of the femoral head (ONFH). Methods: A total of 366 adult patients with ONFH in 466 hips underwent double‐strut bone graft from March 1988 to January 1999. Of them, 186 patients with 206 hips and an average age of 32.2 years (range, 20–60 years) were followed up for more than five years, up to January 2006. Based on the Association Research Circulation Osseous (ARCO) classification, there were 36 hips in stage IIB, and 30, 40, 40, 32 and 28 in stage IIC, IIIA, IIIB, IIIC and IV, respectively. The functional results of affected hips were evaluated by the hundred forked method. Results: Hip pain in all patients disappeared or alleviated greatly after the operation. The height of the femoral head improved to various extents, and the range of motion of the hip joint increased. The patients were followed up for 5–16 years, (average 10.5 years). The total scores increased significantly postoperatively (P < 0.01). The rate of excellent and good results was 83.3%, 80.0%, 75.0%, 65.0%, 40.6% and 28.6% in stage IIB, IIC, IIIA, IIIB, IIIC and IV, respectively (63.6% for the whole group). Conclusion: The long–term effect of double‐strut bone graft for ONFH is satisfactory in relation to staging of ONFH. Favorable results can be expected in young ONFH patients in stage IIB, IIC, and IIIA, IIIB.     

Treatment of early stage osteonecrosis of the femoral head with autologous implantation of bone marrow-derived and cultured mesenchymal stem cells

Background

Treatment of early-stage osteonecrosis of the femoral head (ONFH) with autologous implantation of iliac crest bone marrow-derived mononuclear cells, which contain tens of thousands of bone marrow mesenchymal stem cells (BMMSCs), recently achieved a promising outcome.

Methods

One hundred patients with early-stage ONFH were recruited and randomly assigned to BMMSC treatment or core decompression (CD) treatment. Each BMMSC-treated hip received femoral head (FH) implantation of 2 × 10⁶ autologous subtrochanteric bone marrow-derived and ex vivo expanded BMMSCs. The radiographic stage of ONFH according to the Association Research Circulation Osseous classification, Harris hip score (HHS), and the volume of the necrotic lesion or the low signal intensity zone (LowSIZ) in the FH were assessed before and 6, 12, 24, and 60 months after the initial operation.

Results

Sixty months after the operation, only 2 of the 53 BMMSC-treated hips progressed and underwent vascularized bone grafting. In CD group, 7 hips lost follow-up, and 10 of the rest 44 hips progressed and underwent vascularized bone grafting (5 hips) or total hip replacement (5 hips). Compared with the CD group, BMMSC treatment significantly improved the HHS as well as decreased the volume of femoral head LowSIZ of the hips preoperatively classified at stage IC, IIB, and IIC (P < 0.05, respectively; stage IIA, P = 0.06, respectively). No complication was observed in both treatment groups.

Conclusions

Ex vivo expansion of autologous BMMSCs can reliably provide a greater number of BMMSCs for FH implantation. This intervention is safe and effective in delaying or avoiding FH collapse, which may necessitate total hip replacement.     

Analysis of outcome of avascular necrosis of femoral head treated by core decompression and bone grafting

Background

Femoral head is the most common bone affected by avascular necrosis. Core decompression procedure, when done in the initial stages, before collapse, may arrest or reverse the progress of avascular necrosis and thereby may preserve the normal femoral head. Hence, we have analysed the clinical, functional and radiological outcome of core decompression and bone grafting in patients with Osteonecrosis of the femoral head (ONFH) upto stage IIB (Ficat & Arlet).

Materials and method

A study was undertaken at our institute from June 2010 to June 2013 wherein 20 patients (28 hips) of ONFH upto grade II B (Ficat & Arlet) were treated with core decompression and the outcomes were studied. Patients were subjected to core decompression of the affected hip. All the patients were operated in lateral position. In 26/28 hips, cancellous grafting was done after harvesting graft from the posterior iliac crest. In 2 patients cortical non-vascularised fibular graft was used.

Results

Functional outcome was assessed by Harris hip score, wherein 19 hips (67.85%) had good or excellent outcome; 1 hip (3.57%) had fair out come. However, 8 hips (28.57%) showed poor result. For stage I, 12/13 hips (92.3%) improved, whereas for Stage IIA, 6/11 hips (54.54%) showed improvement and for stage IIB, only 2/4 hips (50%) showed improvement. Less than 25% of the hips required a replacement or salvage procedure. Strict non weight bearing was complied by 23 hips (82.14%), whereas 5 hips (17.85%) were not compliant. If we exclude non compliant patients, our success rate was 92.3% for grade I, 100% for grade IIA and 50% for grade IIB.

Conclusion

Core decompression and bone grafting provide satisfactory outcome when patients are carefully selected in early stages of the disease, before the stage of collapse.     

股骨头骨折后并发股骨头缺血性坏死的治疗

目的 探讨股骨头骨折内固定术后并发股骨头缺血性坏死的治疗.方法 对单侧股骨头骨折内固定术后股骨头缺血性坏死采用带血运骨瓣转移术治疗的26例临床资料进行回顾分析.21例数字减影血管造影(DSA)检查明确股骨头及其周围骨的血供后行内固定物取出、带血运骨瓣转移术.1例内固定物取出后行全髋置换术.结果 施行带血运骨瓣转移术的术后平均随访23个月(12～38个月),根据Harris髋关节功能评分标准进行临床评价.根据手术前后Ficat分期改变进行影像学评价.对其中15例进行术后DSA检查以明确坏死股骨头血运重建情况.术后2髋改行人工全髋关节置换.股骨头得到重建的病例,术后Harris髋关节功能评分提高至平均86.2分(术前平均54分),其中临床成功率为92.0%,影像学成功率为84.0%.15例重建股骨头手术后DSA评估提示血管蒂充盈好,骨瓣血运丰富.结论 股骨头骨折内固定术后股骨头坏死发生率较高(可达40%).在取出内固定物同时行带血运骨瓣转移治疗股骨头缺血性坏死、股骨头血运重建良好,早期疗效满意.     

浓缩自体骨髓移植治疗非创伤性股骨头坏死的临床研究

目的探讨富含单个核细胞的浓缩骨髓血移植治疗非创伤性股骨头坏死的临床疗效。方法应用自体骨髓血浓缩技术,在术中完成骨髓血采集、含有骨髓基质干细胞（BMSCs）的骨髓浓集,通过细针多孔减压手术回植入股骨头坏死区,治疗非创伤性股骨头坏死45例（59髋）,男36例,女9例;年龄16—56岁,平均37．5岁,其中根据国际骨循环学会（ARCO）分期,Ⅰ期2髋,Ⅱ期48髋,ⅢA期9髋,激素性20例（29髋）,酒精性18例（22髋）,特发性7例（8髋）。对浓集集前后包含BMSCs的骨髓单个核细胞（BMMCs）计数,分析年龄、性别、病种对BMMCs的影响;平均随访27．64个月（12—40个月）,结合Harris评分和影像学检查综合评定临床疗效。结果平均抽取骨髓血（126±15）ml,经浓集后BMMCs数量从（12．23±3．2）×10^6／ml增加到了（35．23±12）×10^6／ml。BMMCs细胞数量与年龄,病因和性别有一定相关性,酒精性患者要多于激素性患者,40岁以上患者细胞数量降低。临床总体成功率为79．66％（影像学有效率为76．27％）,其中Ⅰ期100％,U期87．5％,ⅢA期成功率44％,激素性坏死患者预后较差。Harris评分手术前后比较有统计学意义（P〈0．05）。结论富含单个核细胞的浓缩骨髓血移植技术是一种快速、简便、安全的临床细胞治疗手段,与髓心减压技术一起可以有效缓解各期的股骨头坏死患者症状,并在一定程度上防止股骨头塌陷或进展。     

Treatment of osteonecrosis of the femoral head in lymphoma patients by free vascularised fibular grafting

The purpose of this study was to assess the outcomes of treatment of femoral head osteonecrosis using free vascularised fibular grafting in patients with Hodgkin’s disease and non-Hodgkin’s lymphoma. We retrospectively reviewed seven patients (14 hips) with lymphoma who underwent free vascularised fibular grafting for osteonecrosis of the femoral head, evaluating pre- and postoperative Harris hip scores, visual analog scale (VAS) pain scores, hip range of motion and radiographs. Patients were followed up for a minimum of 1.5 years (mean, 3.3 years). All these patients exhibited good recovery without severe life-threatening complications. The mean Harris hip score improved from 69 to 88, while average VAS pain score decreased from 54 to 18. At the latest follow-up, we found improvement or unchanged radiographs in all three hips with initial Steinberg stage II osteonecrosis and in nine of 11 hips with stage III or IV osteonecrosis. No hips failed treatment and underwent total hip arthroplasty. The clinical data demonstrated that free vascularised fibular grafting can slow or even halt progression of necrosis, and improve the function of the hip and quality of life in lymphoma patients.     

Clinical and radiological outcomes of treatment of avascular necrosis of the femoral head using autologous osteochondral transfer (mosaicplasty). Preliminary report

Purpose

The purpose of this study was to evaluate clinical and radiological outcomes of autologous osteochondral transfer (OATS) for femoral head osteonecrosis.

Methods

Twenty-one hips in 20 patients (one woman and 19 men), average patients' age at the time of surgery of 35.4 (range 20–56) years, were treated with OATS for osteonecrosis of the femoral head (ONFH). Seven patients at pre-collapse ARCO stages IIA and IIB were treated with OATS alone. Thirteen patients with large pre-collapse ARCO IIC and post-collapse ARCO III and IV were treated with OATS and morselised bone allografts (OATS/allograft). Harris hip score (HHS) was used for clinical evaluation of outcomes; X-rays were performed to examine the evolution of the disease. Kaplan-Meier survival curves were used to determine the failure of the procedures with conversion to THR defined as endpoint.

Results

Follow-up of patients treated with OATS alone was 46.14 (range 18–75) months with HHS improvement from a preoperative mean of 42 to 87.85 points at the latest follow-up examination. Only one patient in this group needed a revision operation with THR. The survival for this group of patients was 85.71 % at four years. Follow-up of patients treated with AOTS/allograft was 32.7 (range 7–84) months with HHS improvement from a preoperative mean of 35.2 to 65.7 points at the latest follow-up examination. One patient died six months after the surgery. There were five conversions to THR because of femoral head collapse in this group of patients with survival of 61.54 % at three years.

Conclusion

The use of osteochondral grafts offers the possibility of successful treatment for ONFH at small and medium pre-collapse stages. The outcomes of large pre-collapse and post-collapse stages were below our expectations. OATS is a time buying procedure for young patients as it may defer total hip replacement.     

Treatment of osteonecrosis of the femoral head with core decompression and human bone morphogenetic protein

A retrospective evaluation was done of 15 patients (17 hips) with symptomatic osteonecrosis of the hip treated with core decompression combined with an allogeneic, antigen-extracted, autolyzed fibula allograft and 50 mg of partially purified human bone morphogenetic protein and noncollagenous proteins. The average duration of clinical followup of the patients was 53 months (range, 26-94 months). The osteonecrotic involvement of the hip was classified by plain radiographs using a modification of the Ficat staging system and MRI evaluations. Fifteen hips were classified as Ficat Stage IIA, one hip (one patient) was classified as Ficat Stage IIB, and one hip (one patient) was classified as Ficat Stage III. Fourteen hips had involvement of 50% or less of the femoral head and 2/3 or less involvement of the weight-bearing surface of the femoral head, based on a magnetic resonance imaging evaluation. The procedures were a clinical success in 14 of 15 hips (93%; 13 patients) with Stage IIA disease. Three of 17 hips (three patients) had radiographic progression (Ficat Stages IIA, IIB, and III) of the femoral head and were converted to total hip replacements. Only one of seven hips (six patients) with 50% or less involvement of the femoral head and between 1/3 and 2/3 of the weightbearing surface of the femoral head developed radiographic progression of the femoral head. There was no radiographic progression in the 3 hips with less than 1/3 involvement of the weightbearing surface of the femoral head. Further evaluation of the potential efficacy of bone morphogenetic protein is required in randomized trials.     

Core decompression in combination with nano-hydroxyapatite/polyamide 66 rod for the treatment of osteonecrosis of the femoral head

Background

The aim of this study was to investigate the effectiveness of core decompression in combination with a nano-hydroxyapatite/polyamide 66 (n-HA/PA66) rod and a porous bioglass bone graft for the treatment of osteonecrosis of the femoral head (ONFH).

Methods

Sixty-four patients (84 hips) with ONFH were allocated to a program of either core decompression (CD) in combination with a n-HA/PA66 rod and a porous bioglass bone graft (treatment group) or CD with an autologous cancellous bone graft (control group). Clinical and radiographic retrospective follow-ups were performed on all patients with the prospectively collected data.

Results

The overall clinical failure rate in the treatment group (9/38, 23.68 %) was lower than that of the control group (24/46, 52.17 %) (p < 0.05). Harris hip scores (HHS) were significantly increased in both groups post-surgery (p < 0.05). There was a significant difference between the two groups on HHS improvement for Steinberg IIC and IIIA (p < 0.05 and p < 0.001, respectively). The visual analogue scale (VAS) was significantly decreased in both groups post-surgery (p < 0.05). Especially, significant difference in the VAS improvement was observed between the groups for IIB, IIC and IIIA (p < 0.05, p < 0.05 and p < 0.01, respectively).

Conclusions

Core decompression combined with the implantation of a n-HA/PA66 rod and a bioglass bone graft can significantly decrease hip pain, improve hip function, and prevent the collapse of the femoral head in patients with ONFH. As the effectiveness of this approach appears to vary with Steinberg stage, we suggest that this treatment procedure may be suitable for patients with early to middle stage ONFH.     

Sartorius muscle-pedicle bone graft for osteonecrosis of the femoral head

Purpose

This study summarises the clinical efficacy of sartorius muscle-pedicle bone graft in osteonecrosis of the femoral head.

Methods

A total of 58 patients, including 53 men (61 hips) and five women (6 hips) with osteonecrosis of the femoral head, underwent sartorius muscle-pedicle bone grafting. Association Research Circulation Osseous (ARCO) staging was performed.

Results

The ARCO staging revealed 23 hips of stage I, 36 hips of stage II and eight hips of stage III. The average surgical duration was 65 minutes (range 45–90 minutes). A total of 55 (64 hips) of the 58 patients undergoing surgery were followed up, with a mean follow-up duration of 34.48 months (range, 24–48 months) and a median of 34 months. The outcome was excellent in 27, good in 24, normal in two, and poor in 11 hips, with a total good rating of 79.68 %. The Harris score of the hip joints in the last follow-up was significantly improved compared with pre-surgical scores (P?<?0.01). Imaging results showed that 21 hips were improved, 31 hips were stabilized and 12 hips were aggravated (of which 9 hips underwent total hip replacement). The survival rate of femoral head was 81.25 %.

Conclusion

Sartorius muscle-pedicle bone graft significantly promotes repair of osteonecrosis of the femoral head, improves the Harris score of the hip joints, with good clinical efficacy. It effectively improves the survival rate of femoral head, delaying or preventing artificial hip replacement.

     

Treatment of osteonecrosis of the femoral head by using the greater trochanteric bone flap with double vascular pedicles

The use of the bone flap transfer has been reported to be successful in treatment of patients with early to medium stage (Ficat and Arlet stage I‐III) osteonecrosis of the femoral head (ONFH). We examined the vascular anatomy and blood supply of the greater trochanter area and evaluated the feasibility of revascularization of the femoral head by using the bone flap pedicled with transverse and gluteus medius branches of the lateral circumflex femoral artery. Based on the anatomy study, from January 2002 to May 2004, 32 ONFH patients were treated with the greater trochanteric bone flap pedicled with double blood vessels. Fifteen femoral heads were Ficat and Arlet stage II and 17 were stage III. The mean follow‐up was 99.5 months. Two of the 32 patients required a total hip replacement due to severe hip pain after surgery. The overall Harris hip score improved from a mean of 55.2 points to 85 points. Our data suggest the procedure is relatively easy to perform, less donor‐site morbidity and useful for young patients with stages II to III disease with or without mild collapse of the femoral head. © 2013 Wiley Periodicals, Inc. Microsurgery 33:593–599, 2013.     

高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死

 目的 探讨高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死的近期疗效。方法 2009 年 1 月至 2011 年12月采用高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死 26例（35髋）,男 11例,女 15例;年龄 18~65岁,平均 37.4岁。股骨头坏死 ARCO分期ⅡA期 6髋、ⅡB期 13髋、ⅡC期 16髋。采用高位股骨头颈开窗植骨支撑术治疗,开窗位置位于股骨头颈交界处靠近股骨头方向,累及部分股骨头软骨。术后第 1个月及以后每 3个月定期门诊随访,依据 Harris髋关节评分及优良率评估疗效。结果 25例 33髋获得随访,失访 1例 2髋。随访时间 18~32个月,平均 24个月。随访期间未出现感染及神经损伤等并发症。总体 Harris 髋关节评分由术前（73.42±7.30）分提高至末次随访的（85.85±11.63）分;其中ⅡA 期患者由（74.50±1.76）分提高至（91.17±1.60）分;ⅡB 期患者由（73.92±8.03）分提高至（86.00±10.49）分;ⅡC 期患者由（72.60±8.29）分提高至（83.60±14.29）分。总体优良率由术前 36.4%提高至 84.9%;ⅡA 期患者由 33.3%提高至 100.0%;ⅡB 期患者由 41.7%提高至 91.7%;ⅡC 期患者由 33.3%提高至 73.3%。手术前后 Harris 髋关节评分及优良率的差异均有统计学意义。结论 高位股骨头颈开窗植骨支撑术治疗早期股骨头坏死近期疗效好,能促进坏死修复,改善髋关节症状。     

Umbrella-shaped, memory alloy femoral head support device for treatment of avascular osteonecrosis of the femoral head

Purpose

Avascular necrosis (AVN) of the femoral head is a common orthopaedic disease that is difficult to treat. The purpose of this study was to explore the preliminary efficacy of a self-designed umbrella-shaped memory alloy femoral head support device in the treatment of adult patients with avascular osteonecrosis of the femoral head.

Methods

The minimally-invasive approach involved curettage of the necrotic tissue of the femoral head, and a self-designed umbrella-shaped, memory alloy femoral head support device was implanted into the collapsed necrotic area to support the collapsed femoral head. Autologous iliac bone and artificial bone were implanted into the support device for the treatment of adult patients with avascular osteonecrosis of the femoral head.

Results

The clinical device was used in ten patients and 18 hip joints. The support device failed in one hip joint, which subsequently underwent joint replacement surgery, and the remaining 17 implanted devices were followed up for four to 19 months. The 17 postoperative hip joints were evaluated using the percent-efficacy evaluation method for avascular osteonecrosis of the femoral head in adult patients, and the efficacy rate was 82.35 %.

Conclusion

The umbrella-shaped femoral head support device can be used in Ficat stage I, stage II, and stage III adult patients with avascular osteonecrosis of the femoral head.     

Clinical outcome and survivorship analysis of core decompression for early osteonecrosis of the femoral head

Thirty-three hips in 23 patients (followed for 5.3 years) were treated with core decompression for early osteonecrosis of the femoral head (Ficat and Arlet I, IIA, IIB). When the clinical endpoint of severe pain was used for survivorship, 76% of hips survived 1 year, 52% survived 2 years, and 44% survived 5 years. When the radiographic endpoint of progression to stage III disease was used, no progression was found in 72% of hips at 1 year, 61% at 2 years, and 37% at 5 years. When total hip arthroplasty was used as an endpoint, 90% of hips survived 1 year, 70% survived 2 years, and 61% survived 5 years. Lower radiographic stage was associated with a better result. Patients who weighed less than 79.4 kg (175 lb.) (P = .03) or whose bone stock was good (femoral index < 0.56, P < .001) had significantly improved survival. Outcome evaluation documented a 70% overall patient satisfaction rate in patients not undergoing total hip arthroplasty.     

Degeneration of the acetabular cartilage in osteonecrosis of the femoral head: histopathologic examination of 15 hips

Acetabular cartilage with subchondral bone was taken from the superior dome from 15 hips of 13 patients undergoing total hip arthroplasty due to osteonecrosis of the femoral head. The mean age of the patients was 40 years. There were 10 hips ARCO stage IIIA, and 5 hips stage IIIB. 3 of the cases were mild, 12 moderate, and 1 had severe arthrosis. The degree of collapse of the femoral head was significantly related to the degeneration of the acetabular cartilage on histological examination. Our observations support the view that patients with an ARCO Stage III hip do not benefit from head-preserving procedures. They may also explain why bipolar prosthesis gives poorer results than total hip arthroplasty, in cases of osteonecrosis of the femoral head.     

Degeneration of the acetabular cartilage in osteonecrosis of the femoral head: Histopathologic examination of 15 hips

Acetabular cartilage with subchondral bone was taken from the superior dome from 15 hips of 13 patients undergoing total hip arthroplasty due to osteonecrosis of the femoral head. The mean age of the patients was 40 years. There were 10 hips ARCO stage IIIA, and 5 hips stage IIIB. 3 of the cases were mild, 12 moderate, and 1 had severe arthrosis. The degree of collapse of the femoral head was significantly related to the degeneration of the acetabular cartilage on histological examination. Our observations support the view that patients with an ARCO Stage III hip do not benefit from head-preserving procedures. They may also explain why bipolar prosthesis gives poorer results than total hip arthroplasty, in cases of osteonecrosis of the femoral head.     

Degeneration of the acetabular cartilage in osteonecrosis of the femoral head: Histopathologic examination of 15 hips

Acetabular cartilage with subchondral bone was taken from the superior dome from 15 hips of 13 patients undergoing total hip arthroplasty due to osteonecrosis of the femoral head. The mean age of the patients was 40 years. There were 10 hips ARCO stage IIIA, and 5 hips stage IIIB. 3 of the cases were mild, 12 moderate, and 1 had severe arthrosis. The degree of collapse of the femoral head was significantly related to the degeneration of the acetabular cartilage on histological examination. Our observations support the view that patients with an ARCO Stage III hip do not benefit from head-preserving procedures. They may also explain why bipolar prosthesis gives poorer results than total hip arthroplasty, in cases of osteonecrosis of the femoral head.     

小孔径多通道髓芯钻孔减压治疗早中期股骨头坏死

目的 回顾性分析小孔径多通道髓芯钻孔减压技术治疗股骨头坏死.并探讨其疗效及适应证.方法 2000年3月至2004年12月,共55例(85髋)早期股骨头坏死患者行股骨头髓芯减压术.所有病例入院时均按宾夕法尼亚大学分期法分期并行患髋Harris评分.所有患者均在"C"型臂X线机透视下采用直径3.2 mm空心环钻经大转子下向股骨头外上钻孔,平行3个通道钻孔减压.术后1、2、3、6个月门诊随访,以后每年门诊随访至少1次.随访观察比较患髋Harris评分变化,影像学进展及是否行人工髋关节置换术.术后评价:股骨头塌陷视为钻孔减压失败,疼痛缓解、股骨头未塌陷视为有效.结果 49例(79髋)患者获得随访,术后平均随访4.8(3.5-9.2)年.Ⅰ C期11髋,Harris评分由术前平均75分提高到末次随访时85分,1例(1个股骨头)术后1年发生塌陷;Ⅱ A期15髋,Harris评分由术前平均75分提高到85分,3例(3个股骨头)分别于术后1、2年发生塌陷;Ⅱ B期24髋,Harris评分由术前平均72分提高到83分,5例(6个股骨头)分别于术后1、2、4年发生塌陷;Ⅱ C期29髋,Harris评分由术前平均73分提高到82分,7例(9个股骨头)分别于术后1、2、3年发生塌陷.所有患者术后1个月疼痛均明显缓解,无明显手术并发症发生.结论 小孔径多通道髓芯钻孔减压技术治疗早中期、轻中度股骨头坏死,具有良好的近中期疗效,而且无明显手术并发症.     

Treatment of osteonecrosis of the femoral head by percutaneous decompression and autologous bone marrow mononuclear cell infusion

Osteonecrosisfrequentlycausesfemoralheadcollapseanddisablingarthritis,whichultimatelyleadstototaljointreplacement.Ahighfailurerateofjointreplacementunderscoresthejoint preservingprocedures.Varioussurgicaltechniques havebeenusedasatherapyforosteonecrosisofthe femoralhead,whichincludecoredecompressionalone orwithnonvascualrizedorvascularizedbonegraft(DBM,IBG,vascularizedfibulaetc.).1Sofar,the mechanismoftheosteonecrosisisstillunclear(except traumatic),andthereisnouniversalmethodforit especiall…