人附红体的电镜特点及附红体病的临床治疗观察

附红细胞体 (Ｅｐｅｒｙｔｈｒｏｚｏｏｎ简称附红体 )是寄生于人和动物红细胞表面、血浆及骨髓中的一群多形态的微生物。192 8年Ｓｃｈｉｌｌｉｎｇ和Ｄｉｎｇｅｒ首次在啮齿类动物中查到了附红体。以后相继在其它动物和家畜中也证实了有附红体感染的存在[1～ 3 ] ,。迄今为止     

人巨细胞病毒感染家庭聚集性的初步研究

骨髓移植治疗白血病常常由于感染人巨细胞病毒导致移植失败。在对骨髓移植ＨＬＡ配型血术前检测同时进行人巨细胞病毒染检测发现，通过套式ＰＣＲ特异扩增人巨细胞病毒即刻早期基因外显示４的ＤＮＡ片段，在２９个骨髓移植家庭供受体的外周血中，有的家庭中所有成员均有人细胞病毒感染，而有的家庭成员中却根本不存在人巨细胞病毒感染。     

人附红细胞体病2例报道附文献复习

附红细胞体病是一种人畜共患疾病,它是由附红细胞体寄生于人、畜红细胞表面、血浆和骨髓中而引起的.它是传染性疾病,广泛存在于马、牛、羊、猪、狗、兔、猫、鸡等多种畜禽中.但人类附红细胞体病报告并不多见,近年来呈增多趋势,作者对我院发现的2例人附红细胞体病及近年各类文献报道的人附红细胞体病进行了分析和研究.     

附红细胞体病的调查

附红细胞体病的调查侯金凤，陈必珍，闫美荣，杜跃峰，张福仁附红细胞体病是一种人畜共患的传染性疾病。目前，随着经济的发展，人和家畜密度的增加，城乡间与国际间交往的增多，以及诊断水平的提高，有关本病的报道日渐增多。据有关资料表明，我国台湾，辽宁、吉林以及内...     

布鲁氏菌病患者家庭聚集性及其流行病学意义

疾病在流行中,通常将发生两个以上病例的家庭称为多发家庭,在一个病区内这样的家庭占有相当比例时,便称为家庭多发性,即家庭聚集性。家庭聚集性的研究,对查明布鲁氏菌病的病因、传播途径和制定防治措施,可提供重要的流行病学依据。国外Dalrpmple和Champneg二氏报道,983例布鲁氏菌病患者中仅有7家是属于同一家中出现2例以上病人。在国内,王书义等报道,105户发生布鲁氏菌病的家庭中,同一家庭发病2例以上者有17户,最多一户发生7例急性布鲁氏菌病患者。布鲁氏菌病是否具有家庭聚集性的特点,尚未见统计学处理报告。作者对近年来几次布鲁氏菌病暴发流行资料做了家庭聚集性泊松分布     

云南发现人附红细胞体病

附红细胞体病（Eperythrozoonsis简称附红体病）是由附红细胞体（Eperythrozoon简称附红体）寄生在人、畜红细胞表面、血浆和骨田中而引起的一种人畜共患的疾病。我国于1981年首次发现家兔感染附红体，1992年，冯立明、裴标等又相继发现了人附红体病’‘，’‘，近年来，该病已引起人兽医的关注，尚德秋等’‘’“对部分省区人、畜的流行病学调查结果表明，附红体在我国分布广泛，人畜感染率高，严重危害着人畜健康。目前，云南还未见有关报告，笔者将1996年11月至1997年3月在玉溪地区发现的2例人附红体病和对部分人群的流行病学调查结果报…     

几起家庭聚集性布鲁氏菌病发病报告

我国近年来由于农牧区的经济发展 ,畜牧业繁荣 ,牲畜交易频繁 ,加上有些地区布病防治失控 ,检疫免疫措施实施不力 ,传染源得不到及时的发现和有效的控制 ,致使人畜间布病疫情有回升态势 ,局部地区疫情活跃 ,有散发病例 ,个别地区出现流行蔓延趋势。新疆和全国一样 ,有导致布病疫情死灰复燃的可能 ,现将新疆流行区发现的家庭聚集性发病的调查情况介绍如下。例一发生在阿勒泰地区布尔津县哈萨克牧民赛尔江家中。赛尔江家住在布尔津县杜来提乡阿合塔木村 ,该县是 1999年全国布病监测县。通过本年的监测了解到 ,杜来提乡目前布病疫情比较严重 ,…     

新疆一起家庭聚集性人间布鲁氏菌病暴发疫情调查

目的掌握新疆某村人间布鲁氏菌病疫情发生原因、波及范围,查明传染源,采取有效的综合防治措施,及时控制当地布鲁氏菌病疫情蔓延。方法按照病例定义开展病例搜索,采用现场流行病学调查方法,调查每例病例,同时检测畜间布鲁氏菌病感染情况。结果该村共发现确诊病例10例和疑似病例2例,年龄中位数38岁(10～75岁);以低文化程度者为主、占83.3%,集中发生在第四村组A家庭;处理流产及流产物(OR=11.0, 95%CI为1.7～69.1)是本次暴发的危险因素;羊血清学阳性率为6.7%。结论该村发生的是一起由处理流产及流产物而引起的家庭聚集性人间布鲁氏菌病暴发事件;应加强布鲁氏菌病的联防联控工作,避免传染源继续驻留或转移其他地区而发生再次暴发或流行。     

福建省首例人附红细胞体病报告

患者,女,47岁,2004年7月去内蒙古,10月28日到九寨沟旅游,回来1周后出现畏冷、发热、出汗,体温38℃上下,伴有恶心、呕吐、腹泻和头痛症状。自服“感冒药”治疗数天,症状无缓解,休温升至39.3℃,于11月23日入住福建医科大学附属第一医院,抗感染治疗无明显效果,     

沙依瓦克病家庭聚集性分析

本文报告沙瓦克病具有明显的家庭聚集性，其遗传倾向较高，原因与遗传因素有关。同时提示沙依瓦克病的家庭聚集性与周围环境，饮水、饮食结构、居住条件、近亲婚配等因素无关。     

乙型肝炎病毒在家庭内的传播现状

1日常生活的密切接触已成为目前乙型肝炎的主要传播途径之一2003年,Balter、陈安海等[1,2]采用酶联免疫吸附实验和聚合酶链反应检测发现,在慢性乙型肝炎(乙肝)患者的胃液中HBsAg、HBeAg及HBVDNA的检出率分别为51.7%、12.1%和34.4%,而部分血清HB-sAg、HBeAg及HBV DNA阴性者,胃液     

Acute Toxoplasma infection among family members of patients with acute lymphadenopathic toxoplasmosis

Studies were performed to determine how frequently acute infections with Toxoplasma gondii occur among family members of patients with acute acquired lymphadenopathic toxoplasmosis. In five of the nine families studied, more than one family member had serologic evidence of recent acute infection with T gondii. In three of the families, the immunoglobulin M and immunoglobulin G antibody titers to T gondii among infected family members were similar irrespective of whether lymphadenopathy was present. Lymphadenopathy developed in one family member in each of two families (families VIII and IX) three and eight months after lymphadenopathy had developed in the index case (proband). These results suggest that common-source outbreaks occur with surprising frequency among family members of patients with lymphadenopathic toxoplasmosis and that the humoral response is similar with different manifestations of the infection.     

The forgotten members of the glucagon family

From proglucagon, at least six final biologically active peptides are produced by tissue-specific post-translational processing. While glucagon and GLP-1 are the subject of permanent studies, the four others are usually left in the shadow, in spite of their large biological interest. The present review is devoted to oxyntomodulin and miniglucagon, not forgetting glicentin, although much less is known about it. Oxyntomodulin (OXM) and glicentin are regulators of gastric acid and hydromineral intestinal secretions. OXM is also deeply involved in the control of food intake and energy expenditure, properties that make this peptide a credible treatment of obesity if the question of administration is solved, as for any peptide. Miniglucagon, the C-terminal undecapeptide of glucagon which results from a secondary processing of original nature, displays properties antagonistic to that of the mother-hormone glucagon: (a) it inhibits glucose-, glucagon- and GLP-1-stimulated insulin release at sub-picomolar concentrations, (b) it reduces the in vivo insulin response to glucose with no change in glycemia, (c) it displays insulin-like properties at the cellular level using only a part of the pathway used by insulin, making it a good basis for developing a pharmacological workaround of insulin resistance.     

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

Interactions of the Bcl-2 protein with itself and other members of the Bcl-2 family, including Bcl-X-L, Bcl-X-S, Mcl-1, and Bax, were explored with a yeast two-hybrid system. Fusion proteins were created by linking Bcl-2 family proteins to a LexA DNA-binding domain or a B42 trans-activation domain. Protein-protein interactions were examined by expression of these fusion proteins in Saccharomyces cerevisiae having a lacZ (beta-galactosidase) gene under control of a LexA-dependent operator. This approach gave evidence for Bcl-2 protein homodimerization. Bcl-2 also interacted with Bcl-X-L and Mcl-1 and with the dominant inhibitors Bax and Bcl-X-S. Bcl-X-L displayed the same pattern of combinatorial interactions with Bcl-2 family proteins as Bcl-2. Use of deletion mutants of Bcl-2 suggested that Bcl-2 homodimerization involves interactions between two distinct regions within the Bcl-2 protein, since a LexA protein containing Bcl-2 amino acids 83-218 mediated functional interactions with a B42 fusion protein containing Bcl-2 amino acids 1-81 but did not complement a B42 fusion protein containing Bcl-2 amino acids 83-218. In contrast to LexA/Bcl-2 fusion proteins, expression of a LexA/Bax protein was lethal to yeast. This cytotoxicity could be abrogated by B42 fusion proteins containing Bcl-2, Bcl-X-L, or Mcl-1 but not those containing Bcl-X-S (an alternatively spliced form of Bcl-X that lacks a well-conserved 63-amino acid region). The findings suggest a model whereby Bax and Bcl-X-S differentially regulate Bcl-2 function, and indicate that requirements for Bcl-2/Bax heterodimerization may be different from those for Bcl-2/Bcl-2 homodimerization.     

Intrafamilial transmission of symptomatic Epstein-Barr virus infection among six adult members of one family

The contagiousness of Epstein-Barr virus (EBV) is low, and transmission of the disease from infected persons within a family or to other contacts is rare. We report of 6 adult members of 1 family who over a period of 6 months showed symptoms and laboratory findings compatible with acute EBV infection. Four patients examined for EBV specific antibodies had serology typical of primary EBV infection. Three of the 6 patients--1 of them serologically confirmed--were 60 years old or more, an age in which acute EBV infection is very rare.     

Plasmid transfer into members of the family Legionellaceae

The plasmids RP4 and pPH1JI::Mu::Tn5 were transferred with moderate frequency from Escherichia coli to Legionella pneumophila (strain Bloomington 2) and Fluoribacter (Legionella) bozemanae (strain WIGA). The frequency of transfer to Tatlockia (Legionella) micdadei (strain Tatlock) was much lower. In these transconjugant strains the plasmids were maintained following at least 10 nonselective passages. However, the introduced plasmids could not be transferred from these strains to several other strains of Legionella or Tatlockia with a detectable frequency, yet they could be transferred to a restriction-modification deficient (rm-) E. coli strain with moderate frequency. This suggests not only that the expression of transfer genes may be repressed but that the legionellae are poorer recipients than are the rm- E. coli.     

Cotrimoxazole prophylaxis by HIV-infected persons in Uganda reduces morbidity and mortality among HIV-uninfected family members

BACKGROUND: The effect of cotrimoxazole prophylaxis taken by persons with HIV on community health and antimicrobial resistance is unknown. OBJECTIVE: To assess the effect of cotrimoxazole prophylaxis taken by persons with HIV on morbidity, mortality, and antimicrobial resistance of diarrheal pathogens infecting their HIV-negative family members. DESIGN: Prospective cohort in rural Uganda. METHODS: A total of 879 persons with HIV and 2771 HIV-negative family members received weekly home-visits. After 5 months, persons with HIV received daily cotrimoxazole prophylaxis and households were followed for an average of 17 additional months. FINDINGS: During the study, 224 participants with HIV (25%) and 29 household members (1%) died. Mortality among HIV-negative family members < 10 years old was 63% less during the cotrimoxazole period than before [hazard ratio, 0.37; 95% confidence interval (CI), 0.14-0.95; P = 0.04]. Malaria among family members was less common during cotrimoxazole treatment [incidence rate ratio (IRR), 0.62; CI, 0.53-0.74; P < 0.0001], as were diarrhea (IRR, 0.59; CI, 0.45-0.76; P = 0.0001), and hospitalizations (IRR, 0.57; CI, 0.36-0.92; P = 0.02). Death of a parent with HIV was associated with a threefold increase in mortality among HIV-negative children < 10 years old (hazard ratio, 2.9; CI, 1.1-8.1; P = 0.04). Of 134 bacterial isolates from family members before cotrimoxazole treatment, 89 (66%) were resistant to cotrimoxazole; of 75 recovered during cotrimoxazole treatment, 54 (72%) were resistant (P = 0.41). INTERPRETATION: Cotrimoxazole prophylaxis taken by persons with HIV was associated with decreased morbidity and mortality among family members. Antimicrobial resistance among diarrheal pathogens infecting family members did not increase. Concerns regarding the spread of bacterial resistance should not impede implementation of cotrimoxazole programs.