幽门螺杆菌及其相关毒素与口腔扁平苔藓关系的研究

目的 探讨口腔扁平苔藓与幽门螺杆菌及其相关毒素CagA和VacA之间的关系.方法 快速尿素酶检测法检测口腔扁平苔藓患者与正常对照组龈下菌斑中幽门螺杆菌的表达.酶联免疫吸附试验法检测口腔扁平苔藓患者与正常对照组血清中幽门螺杆菌及相关毒素CagA和VacA的表达.结果 60例扁平苔藓患者龈下菌斑中Hp的阳性表达数明显高于正常对照组(P＜0.05),差异有统计学意义;60例扁平苔藓患者血清中Hp-IgG抗体、CagA-HpIgG抗体、VacA-HpIgG抗体阳性表达数明显高于正常对照组(P＜0.05),差异有统计学意义.结论 口腔扁平苔藓的发生与可能与Hp感染及CagA、VacA基因相关.     

丙型肝炎病毒在口腔扁平苔藓发病中的意义

目的：探索丙型肝炎病毒在口腔扁平苔藓发病中的意义。方法：应用ＰＣＲ技术对６０例口腔扁平苔藓患者进行了丙型肝炎病毒ＲＮＡ的检测。结果：在６０例口腔扁平苔藓患者中，其中７例丙型肝炎病毒ＲＮＡ阳性，与对照组相比具有显著性差异（Ｐ＜０．０５）；且丙型肝炎病毒ＲＮＡ阳性患者的损害均表现为白纹伴糜烂。结论：在口腔扁平苔藓中，尤其是在糜烂伴白纹的口腔扁平苔鲜患者中，应用敏感的ＰＣＲ技术检测血液中的丙型肝炎病毒ＲＮＡ，不仅对于防治慢性肝炎，而且对于探索口腔扁平苔藓的病因与治疗均具有重要意义。     

口腔扁平苔藓与肝病关系的病例对照研究

目的：探讨口腔扁平苔藓与慢性肝病的关系。方法：回顾性分析４７６例口腔扁平苔藓的肝病、肝功能异常发生情况，并与年龄、性别配对的４７６例其它口腔粘膜病及１７１１名健康人比较。结果：口腔扁平苔藓患者慢性肝病发生率６５％，１项肝功能异常发生率为２３．９％，二项或二项以上为５．３％。上述指标均较疾病对照组和正常对照组为高（Ｐ＜０．０１），其中尤以反映间质反应的指标如血清蛋白、ＴＴＴ、ＺｎＴＴ的异常改变较为明显。结论：口腔扁平苔藓与肝病有一定的关系，其所伴发的肝病以慢性肝病疾患为主。     

口腔扁平苔藓患者幽门螺杆菌感染状况分析

目的 分析口腔扁平苔藓患者幽门螺杆菌感染状况,探索口腔扁平苔藓与幽门螺杆菌感染的相关性.方法 收集口腔扁平苔藓患者(扁平苔藓组)69例和口腔黏膜慢性炎症患者(慢性炎症组)28例,在初诊时进行14C-尿素呼气试验,其中32例患者(扁平苔藓组23例,慢性炎症组9例)同时检测血清抗幽门螺杆菌(Helicobacter pylori,Hp)抗体.结果 扁平苔藓组14C-尿素呼气试验阳性率为68.12%,慢性炎症组14C-尿素呼气试验阳性率为46.43%,扁平苔藓组高于慢性炎症组,差异有统计学意义(x2=3.970,P=0.046).23例口腔扁平苔藓患者中抗Hp抗体阳性检出率为52.17%,9例口腔黏膜慢性炎症患者Hp抗体阳性检出率为22.22%,差异无统计学意义(x2=2.358,P=0.125).结论 口腔扁平苔藓患者幽门螺杆菌感染率较高,口腔扁平苔藓与幽门螺杆菌感染可能有关.     

黑龙江地区口腔扁平苔藓患者丙型肝炎病毒感染的检测

目的 检测黑龙江地区口腔扁平苔藓(OLP)患者丙型肝炎病毒(HCV)的感染率,并讨论两者之间的关系。方法 采用双抗夹心酶联免疫吸附试验(ELISA)对本地区62例OLP患者和61例非OLP黏膜病患者及22例健康志愿者进行血清丙型肝炎病毒抗体(HCV-Ab)的检测。结果 口腔扁平苔藓组HCV感染率(9.7%)明显高于非OLP黏膜病组(1.6%)和健康组(0%)HCV感染率(P<0.05)。结论 黑龙江地区OLP的发病与HCV感染存在一定的关系。     

口腔扁平苔藓与丙型肝炎病毒感染的关系研究

目的 :探讨口腔扁平苔藓与丙型肝炎病毒感染的关系。方法 :应用酶联免疫测定法和PCR技术分别对 80例口腔扁平苔藓患者、80例非扁平苔藓粘膜病患者及 80例健康人进行血液抗 -HCV和HCV -RNA检测。结果 :80例口腔扁平苔藓中 ,17例抗 -HCV阳性 ,明显高于疾病对照组 ( 4例 ) (P <0 .0 1) ,明显高于正常对照组 ( 2例 ) (P<0 .0 1) ;13例HCV -RNA阳性 ,明显高于疾病对照组 ( 4例 ) (P <0 .0 5 ) ,明显高于正常对照组 ( 2例 ) (P <0 .0 1) ;且 13例HCV -RNA阳性患者的损害均表现为白纹伴糜烂。结论 :OLP患者存在较高的HCV感染率 ,OLP的发病可能与患者体内HCV的存在和复制有一定的关系     

口腔扁平苔藓患者抗上皮抗体与丙肝病毒感染的相关性研究

口腔扁平苔藓(OLP)为一种常见的慢性炎症,可能与丙肝病毒(HCV)感染有关。有文献报道,丙肝患者自身免疫反应有增强趋势。 本研究通过常规的间接免疫荧光方法检测丙肝病毒阳性患者血清中的抗上皮的循环抗体。实验分4组:第一组,感染了HCV又同时患有OLP的患者14例;第二组,无HCV感染的OLP患者14例;第三组,感染了HCV未患有OLP的患者21例;第四组,健康对照组18例。结果显示:第一组有8例血清抗复层鳞状上皮抗体为阳性。根据染色的位置不同,抗体分3种:6例     

口腔糜烂型扁平苔藓与慢性肝病的临床研究

本研究对３２例口腔糜烂型扁平苔藓患者的肝酶学及病原学进行检测，结果发现，有７例患者（２１．８８％）的血清谷丙转氨酶（ＡＬＴ）和／或血清谷草转氨酶（ＡＳＴ）值升高，且这７例患者中有５例ＨＢｓＡｇ、ＨＢｅＡｇ和抗ＨＢＣ阳性。另有１例患者ＨＢｓＡｇ、ＨＢｅＡｇ和ＨＢＣ阳性。２例患者抗ＨＣＶ阳性，而血清酶水平未见升高。本研究提示对口腔糜烂型扁平苔藓患者，除应注意询问相关病史外，还就常规进行功能和肝炎病毒检     

EB病毒感染与口腔鳞状细胞癌关系的研究

目的探讨EB病毒感染与口腔鳞癌发生、发展的关系.方法采用酶联免疫法检查234例住院患者血液中EBV抗体,对28例口腔癌病灶标本用多聚酶链反应技术(PCR)检测EBV基因组核抗原1区.结果 234例住院患者的血液的EBV抗体阳性13例,阳性率5.55%.28例口腔癌病灶标本EBV核抗原1区阳性2例,阳性率7.1%(P＞0.05).结论 EBV感染与口腔鳞癌的发生无明显关系.     

口腔扁平苔藓与上皮抗原IgG循环抗体无相关性

一些研究表明:扁平苔藓(lichen planus,LP)是一种T细胞介导的损害,人类免疫功能在LP发生和持续存在过程中起着作用,并有学者在LP损害中发现了抗上皮抗体。最近,有学者在丙型肝炎病毒(hepatitis C virus,HCV)相关性口腔LP患者血清中发现了猴食管上皮成分的IgG抗体。本文对非HCV感染之口腔LP患者中这种上皮抗体的存在情况进行了调查。     

Oral lichen planus and hepatitis C virus (HCV) infection: is there a relationship? A report of 10 cases

Ten patients are reported suffering from oral lichen planus (OLP) associated with chronic liver diseases linked to HCV. All patients were affected by varieties of erosive oral lichen planus. In six of these 10 patients the diagnosis of HCV was made as a result of the OLP diagnosis and four of them had unknown, but severe, chronic liver disease. These preliminary data support the possible existence of a relationship between oral erosive lichen planus and HCV infection.     

Hepatitis C virus infection in Italian patients with oral lichen planus: a prospective case-control study

To assess the aetiology of liver disease associated with lichen planus, we prospectively studied 70 consecutive newly diagnosed patients with oral lichen planus (OLP) living in northwest Italy (Piemonte) and 70 controls matched for age and sex with other oral keratoses coming from the same district. Twenty-two patients with OLP (3.4%) and 9 controls (12.9%) were found to be affected by chronic liver disease (CLD) ( P =0.014). In sixteen of the 22 OLP patients with CLD the liver disease was hepatitis C virus (HCV)-related. whereas 2 of the 9 controls had a HCV-related CLD ( P =0.016). In another OLP case, liver damage was related to a combination of HCV and alcohol abuse. The prevalence of HCV antibodies in the whole OLP group (27.1%) was significantly higher than in controls (4.3%) ( P =0.014). whereas no difference was found between the OLP and control groups regarding hepatitis B virus markers and other common causes of CLD. HCV infection was more frequently found in patients with erosive OLP (58.8%) than in patients with non-erosive OLP (13.2%) ( P =0.004). Serum HCV-RNA was detected by polymerase chain reaction (RT-PCR) in the majority (93.7%) of OLP patients who had HCV antibodies. Excluding OLP and control patients with HCV markers, there was no difference between the two groups regarding frequency of CLD. Our data show that HCV is probably the main pathogenic factor in liver disease of Italian patients with OLP. and suggests that HCV could be involved in the pathogenesis of OLP.     

Hepatitis C virus-associated oral lichen planus: no influence from hepatitis G virus co-infection

There is a variable geographic distribution in the prevalence of hepatitis C virus (HCV)-related oral lichen planus (OLP), which appears unrelated to either HCV genotype or HCV epidemiology. The present study investigated whether hepatitis G virus (HGV) co-infection may be a feature of patients with HCV-related OLP, which might explain these phenomena. HGV co-infection was detected in 6 of 39 Italian patients with HCV-related OLP, but the presence of HGV did not influence the clinical presentation of OLP. It is concluded that HGV co-infection is unlikely to influence the clinical detection of HCV-related OLP.     

Lack of evidence of hepatitis in patients with oral lichen planus in China: A case control study

Background

China has been one of the countries with high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) liver disease. And lichen planus is an extrahepatic manifestation of patients with chronic HCV infection. This case-control study was conducted to investigate the relationship between oral lichen planus (OLP) and HBV/HCV infection in China.

Material and Methods

A total of 776 patients, including 150 patients with OLP (Group OLP), 429 inpatients from the Trauma Ward of Oral and Maxillofacial Surgery Department (Group A), 110 patients with other oral mucosal diseases, but without a reported association with HCV infection (Group B) and 87 patients with oral lichenoid lesion (Group OLL), were compared with their seroprevalence of anti-HCV antibody (HCVAb), hepatitis B surface antigen (HBsAg) and the parameters of liver functions. Moreover, the clinical characteristics of OLP were also observed, such as gender, age, chief complaint, course of the disease, clinical type, sites involved and so on.

Results

The positive rates of HCVAb and HBsAg in OLP patients were 0.7% and 4%, respectively. Neither HCVAb nor HBsAg was associated with OLP as demonstrated by both the univariate and the multivariate analyses. The clinical features and liver functions of OLP patients with negative or positive HBsAg were nearly the same.

Conclusions

Our findings verify that there is no association between OLP and hepatitis and there is no need to run a screening test for HCV or HBV in OLP patients in China. Key words:Oral lichen planus, hepatitis C virus, hepatitis B virus.     

热休克蛋白60、70在口腔扁平苔藓中表达的研究

目的　探讨热休克蛋白 (heatshockprotein ,HSP) 60和HSP70在口腔扁平苔藓病变中的作用。方法　对 62例口腔扁平苔藓、1 0例正常口腔粘膜、2 1例慢性盘状红斑狼疮、1 0例粘膜良性淋巴组织增生病 ,46例白斑进行免疫组织化学SP法染色 ,分析HSP60、HSP70在口腔扁平苔藓中的表达 ;对 1 2例口腔扁平苔藓和 5例正常粘膜进行逆转录PCR实验 ,观察HSP60、HSP70mRNA的变化。结果　HSP60在口腔扁平苔藓病损区的表达较其他各组显著增强 ,差异有显著性 (P <0 0 0 1 )。HSP70在糜烂型口腔扁平苔藓病损区的表达下调。RT PCR结果显示 ,HSP60、HSP70mRNA表达增强。结论　HSP60及HSP70在口腔扁平苔藓的发病中起重要作用     

口腔扁平苔藓合并食道扁平苔藓的诊治及相关文献复习

目的总结分析口腔扁平苔藓（OLP）合并食道扁平苔藓（ELP）的临床发生率、诊出方法、治疗和恶变倾向。 方法对236例OLP确诊患者,根据主诉及问诊有胸部不适、胸前灼痛、烧灼感、吞咽困难、食道狭窄、进食不畅等症状,获得知情同意后进一步进行食道胃镜检查及病理活检,筛选合并ELP,进行规范治疗和追踪。 结果18例出现了ELP病损,OLP合并出现ELP发生率为7.6%（18/236）。其中2例11.1%（2/18）早于OLP出现食道非典型增生,1例5.5%（1/18）已早于OLP出现恶变为食道鳞状细胞癌。 结论扁平苔藓是全身性疾病,ELP和OLP均属于黏膜的慢性炎症性疾病,两者间存在关联性。口腔科医生接诊OLP患者时,应该关注其全身其他部位的病损,尽早发现其他部位早期而隐匿的恶变,以免造成误诊和漏诊。     

Hepatitis C virus infection and oral lichen planus: a report from the Netherlands

The reported frequency of anti-hepatitis C virus (HCV) antibodies in groups of cutaneous lichen planus (CLP) and/or oral lichen planus (OLP) patients varies from about 4% to 65%. Most of these studies have been performed in countries with a high overall prevalence of HCV infection in the general population, such as the southern European countries and Japan. Limited data are available from areas with a low prevalence of HCV infection. Therefore, we investigated the prevalence of HCV infection in a series of 55 patients with OLP in the Netherlands, which apparently has a low prevalence of HCV infection. None of the 55 patients revealed serological evidence of antibodies to HCV. The present data suggest that HCV infection in OLP patients in the Netherlands is probably not very common. A larger study group with a sex- and age-matched control group is required to advise against routine serological examination for HCV infection in Dutch OLP patients.     

丙型肝炎病毒感染与口腔粘膜扁平苔藓关系的初探

目的 本研究对４０例口腔扁平苔藓（ＯＬＰ）患者及４０名对照组患者分别用于干湿全自动生化分析仪,酶链免疫吸附试验（ＥＬＺＳＡ）及多聚酶链反应（ＰＣＲ）检测外周血ＡＬＴ,抗－ＣＨＶ物ＨＣＶ－ＲＮＡ,以探讨ＨＣＶ感染与ＯＬＰ之间的关系。结果 ４０名ＯＬＰ患者中,１０例（２５．０％）有ＡＬＴ异常,８例（２０．０％）抗－ＨＣＶ阳性,７例（１７．５％）ＨＣＶ－ＲＮＡ阳性、经统计学处理有显著性差异（Ｐ〈０．０－