癣药2号与联苯苄唑乳膏配合治疗手足癣200例临床观察

目的 观察癣药2号对手足癣的疗效.方法 将200例手足癣患者随机分为两组.治疗组给予癣药2号与1%联苯苄唑乳膏配合治疗,对照组单用1%联苯苄唑乳膏治疗,两组用药2个疗程后,分别观察疗效.结果 癣药2号与1%联苯苄唑乳膏配合治疗手足癣治愈率90.0%,单用1%联苯苄唑乳膏治愈率67.0%(P＜0.05),两组间差异具有显著性.结论 癣药2号与1%联苯苄唑乳膏配合治疗手足癣,疗效确切,治愈率高.     

伊曲康唑胶囊联合联苯苄唑乳膏治疗足癣

目的 观察口服伊曲康唑胶囊联合外用联苯苄唑乳膏治疗足癣的疗效.方法 将180例足癣患者随机分为三组,治疗组60例,口服伊曲康唑胶囊1周,联合外用联苯苄唑乳膏2周;对照Ⅰ组62例,仅口服伊曲康唑胶囊1周;对照Ⅱ组58例,仅予联苯苄唑乳膏外用连用4周.结果 用药后8周治疗组有效率为88.33%,真菌清除率为85%;对照Ⅰ组有效率为75.81%,真菌清除率为77.42%;对照Ⅱ组有效率为68.96%,真菌清除率为53.45%,两对照组有效率与治疗组相比差异有统计学意义.结论 口服伊曲康唑联合外用联苯苄唑乳膏治疗足癣,在缩短疗程、减少费用、提高依从性和疗效、降低复发率等方面有明显优势.     

1％联苯苄唑溶液治疗花斑癣、体股癣临床观察

目的：观察1％联苯苄唑溶液治疗花斑癣、体股癣的疗效和安全性。方法：临床试验观察50例病人（男33例，女17例，平均年龄39．7岁。花斑癣22例。体癣10例、股癣18例）。外用涂搽于皮损处每晚一次，7天为一个疗程，连续用药3个疗程。结果：总有效率为97。6％，痊愈率分别为花斑癣78％，体癣77％和股癣77％＇o结论：1％联苯苄唑溶液治疗花斑癣、体股癣的临床疗效确切，安全性好。     

他克莫司联合皮炎汤Ⅰ号治疗面部激素依赖性皮炎的疗效观察

目的：探讨他克莫司联合皮炎汤Ⅰ号治疗面部激素依赖性皮炎的临床疗效。方法选取2012年10月至2013年8月该院皮肤科诊治的面部激素依赖性皮炎患者152例,并随机分为治疗组患者和对照组各76例,治疗组患者给予0．1％的他克莫司软膏外用,并口服中药皮炎汤Ⅰ号;对照组给予3％硼酸溶液外敷,并口服中药皮炎汤Ⅰ号,两个月后观察并比较两组患者的治疗效果。结果治疗组76例患者中痊愈39例,痊愈率为51．32％,显效29例,显效率为38．16％,好转8例,好转率为10．52％,无效0例,治疗总有效率为89．48％;对照组76例患者中痊愈14例,痊愈率为18．42％,显效30例,显效率为39．47％,好转32例,好转率为42．11％,无效0例,治疗总有效率为57．89％。治疗组总有效率明显高于对照组,差异有统计学意义（ P＜ 0．05）;治疗组患者不良反应的发生率为7．89％,对照组为6．58％,两组不良反应发生率相比,差异无统计学意义（ P＞0．05）。结论他克莫司联合皮炎汤Ⅰ号治疗面部激素依赖性皮炎的临床疗效显著,安全可靠,值得临床推广应用。     

莫匹罗星软膏和醋酸地塞米松乳膏联合外用治疗亚急性湿疹疗效观察

[目的]观察莫匹罗星软膏和醋酸地塞米松乳膏联合外用治疗亚急性湿疹的临床疗效.[方法]将123例亚急性湿疹患者随机分为两组,其中莫匹罗星软膏和醋酸地塞米松乳膏联合外用治疗组63例,单用醋酸地塞米松乳膏对照组60例.两组均治疗两周后判定疗效.[结果]治疗组总显效率为90.5%,而对照组总显效率为66.6%,两组比较有明显差异(P＜ 0.01).[结论]莫匹罗星软膏和醋酸地塞米松乳膏联合外用临床疗效明显优于单用醋酸地塞米松乳膏.     

腹腔灌注联合中药治疗慢性盆腔炎临床观察

目的：观察综合治疗慢性盆腔炎的疗效。方法：将126例患者随机分为治疗组与对照组各63例,治疗组用腹腔灌注抗菌药联合中药口服治疗。对照组仅用抗炎治疗。3个疗程后观察对比两组疗效。结果：治疗组痊愈率和总有效率分别为55．56％、93.65％,对照组痊愈率和总有效率分别为30．15％、73．02％,两组痊愈率、总有效率比较,差异均有统计学意义（P〈0．01）,复发率治疗组为11．11％;对照组为26．67％,治疗组低于对照组（P〈0．01）。结论：腹腔灌注联合中药治疗慢性盆腔炎疗效较好,值得推广。     

芳香维A酸乙酯联合丙酸氯倍他索治疗掌跖脓疱病疗效观察

目的：观察芳香维A酸乙酯联合丙酸氯倍他索治疗掌跖脓疱病的疗效。方法：治疗组采用内服芳香维A酸乙酯胶囊联合丙酸氯倍他索乳膏局部封闭;对照组采用口服四环素片和雷公藤多甙片,局部对症处理,共治疗8周。结果：治疗组痊愈率37.50%,有效率81.25%;对照组痊愈率20.00%,有效率57.14%。两组有效率比较差异有统计学意义（P〈0.05）。治疗组痊愈和显效患者中,3个月复发1例,半年内复发2例;对照组痊愈和显效患者中,3个月内复发5例,半年内复发10例。结论：口服芳香维A酸乙酯联合丙酸氯倍他索乳膏局封治疗掌跖脓疱病是一种有效的方法。     

中药陈醋离子导入治疗慢性咽炎

将符合诊断标准的400例慢性咽炎患者分为两组各200例，治疗组采用中药陈醋离子导入，对照组运用碘离子导入，2个疗程后评定疗效。治疗组痊愈106例，显效90例，好转4例，痊愈显效率98．0％，总有效率100．0％；对照组痊愈48例，显效67例。好转59例，无效26例，痊愈显效率57．5％，总有效率87．0％。中药陈醋离子导入治疗慢性咽炎疗效明显。     

自拟养血祛风汤治疗老年皮肤瘙痒症患者36例的临床研究

目的探讨自拟养血祛风汤治疗老年皮肤瘙痒症的临床疗效。方法36例老年皮肤瘙瘁症患者随机分为治疗组（n=18）和对照组（n=18）。治疗组给予自拟养血祛风汤治疗,对照组给予氯苯那敏、维生素C,另用酯酸去炎松软膏外涂。两个疗程后对两组疗效进行比较。结果治疗组中,痊愈9例,显效8例,总有效率达94．44％;对照组中,痊愈3例,显效9例,总有效率为66．67％。治疗组的痊愈率和总有效率均明显高于对照组,差异有统计学意义（P〈0．05）。结论自拟中药养血祛风汤治疗老年皮肤瘙痒症疗效好,值得临床推广应用。     

中西医结合治疗念珠菌性阴道炎的临床观察

目的：观察中西医结合治疗念珠菌性阴道炎的临床疗效。方法：60例念珠菌患者随机分为治疗组和对照组。对照组单用达克宁栓阴道塞药，治疗组在达克宁栓外用的基础上口服中药汤剂完带汤，治疗1周后观察疗效，1个月后随访复发情况。结果：治疗组痊愈率50％。有效率93．3％。复发率12．1％；对照组痊愈率30％。有效率80％，复发率34．8％。治疗组与对照组的近期疗效与远期疗效有显著性差异（P〈0．05）。结论：完带汤化裁合西药治疗念珠菌性阴道炎较单纯使用西药有明显优势。     

Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis

Studies were conducted to assess the bioequivalence of a new antimycotic formulation, ciclopirox olamine lotion 1%, to an established compound, ciclopirox olamine cream 1%. Results of in vitro studies, using skin samples from human cadavers and domestic pigs, demonstrated that the two formulations equally penetrate all layers of the stratum corneum and inhibit the growth of Trichophyton mentagrophytes and Candida albicans. In vivo studies in guinea pigs and in human volunteers demonstrated the comparable therapeutic efficacy of the lotion and the cream in experimental trichophytosis. In addition, a multicenter, double-blind clinical trial was undertaken to compare ciclopirox olamine lotion 1% with the vehicle alone in the treatment of patients with tinea pedis. Patients with plantar, interdigital, or vesicular tinea pedis were enrolled in the studies. Patients were treated for 28 days. Clinical and mycological responses were determined during treatment and two weeks posttreatment. Ciclopirox olamine lotion 1% was found to be significantly more effective than its vehicle in the treatment of patients with common tinea pedis. Minor localized side effects (pruritus, burning sensation) were reported in 2% of 89 patients treated with ciclopirox olamine lotion 1%. The results demonstrate the bioequivalence of ciclopirox olamine lotion 1% and ciclopirox olamine cream 1% and confirm the clinical effectiveness and safety of the lotion in the treatment of tinea pedis, a generally recalcitrant fungal infection. It is concluded that ciclopirox olamine lotion 1% can be used as an alternative to ciclopirox olamine cream 1% for treatment of tinea pedis, tinea versicolor, tinea cruris, tinea corporis, and cutaneous candidiasis when the convenience and/or cosmetic elegance of a lotion is desired.     

Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent

Oxiconazole nitrate (1%) cream became available in the United States in 1989 for the once-daily treatment of tinea pedis, tinea cruris, and tinea corporis. It has also proved valuable in the once-daily treatment of tinea (pityriasis) versicolor. In vitro oxiconazole is highly effective against many dermatophytes, including Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans, and Epidermophyton floccosum. After application to the skin, oxiconazole is rapidly absorbed into the stratum corneum, maximum concentrations often being attained within 100 minutes. Fungicidal concentrations are maintained in the epidermis, upper corium, and deeper corium for at least five hours, and levels exceeding the minimum inhibitory concentrations of susceptible fungi are present in the corneum, epidermis, upper corium, and the hair follicle for over 16 hours. Applied once daily for four weeks in the treatment of tinea pedis or for two weeks in the treatment of tinea corporis, tinea cruris, and tinea versicolor, 1% oxiconazole cream has produced mycologic and clinical cures in at least 80% of patients. In plantar-type tinea pedis caused primarily by T rubrum, once-daily oxiconazole cream resulted in a mycologic cure in 76% of patients. The efficacy of once-daily and twice-daily regimens is similar. In comparative clinical trials of various types of dermatophytoses, oxiconazole was shown to be as effective as or more effective than miconazole, clotrimazole, and tolnaftate creams, and as effective as econazole and bifonazole creams. Tolerability of oxiconazole and the other antifungal creams was similar; in irritation studies oxiconazole was better tolerated than econazole. Oxiconazole cream exerts no detectable systemic effect since only a negligible amount is absorbed from the skin. Once-daily use of oxiconazole cream could be valuable in patients with a history of noncompliance with multiple-daily regimens of other topical antifungal agents.     

Short-term therapy with luliconazole, a novel topical antifungal imidazole, in guinea pig models of tinea corporis and tinea pedis

Luliconazole is a novel topical antifungal imidazole with broad-spectrum and potent antifungal activity. The drug is under clinical development in the United States for management of dermatophytosis with a short-term treatment regimen. The present study was undertaken to investigate the clinical benefit of short-term therapy with luliconazole cream in guinea pig models of tinea corporis and tinea pedis induced with Trichophyton mentagrophytes. The dose-dependent therapeutic efficacy of topical luliconazole cream (0.02 to 1%), measured by macroscopic improvement of skin lesions and by fungal eradication as determined by a culture assay, was demonstrated using a tinea corporis model. The improvement in skin lesions seen with luliconazole cream was observed even at a concentration of 0.02%, and its efficacy at 0.1% was equal to that of 1% bifonazole cream. The efficacy of short-term therapy with 1% luliconazole cream, which is used for clinical management, was investigated using the tinea corporis model (4- and 8-day treatment regimens) and the tinea pedis model (7- and 14-day treatment regimens). The 1% luliconazole cream completely eradicated the fungus in half or less of the treatment time required for 1% terbinafine cream and 1% bifonazole cream, as determined by a culture assay for both models. These results clearly indicate that 1% luliconazole cream is sufficiently potent for short-term treatment for dermatophytosis compared to existing drugs. Luliconazole is expected to be useful in the clinical management of dermatophytosis.     

Once-daily luliconazole cream 1% for the treatment of interdigital tinea pedis

Luliconazole is an imidazole antifungal agent with a unique chemical structure. In this article, we summarize the in vitro data, animal studies and clinical trial data relating to the use of topical luliconazole cream 1% in the treatment of tinea pedis. Preclinical studies have demonstrated potent activity against dermatophytes. Luliconazole has strong fungicidal activity against Trichophyton spp., similar to that seen with terbinafine. Evidence from clinical trials in tinea pedis have shown once-daily application of luliconazole cream 1% for 14 days to be effective and well tolerated.     

疏肝活血汤联合中药祛斑霜治疗肝郁血瘀型黄褐斑疗效观察

目的观察疏肝活血汤联合中药祛斑霜治疗肝郁血瘀型黄褐斑疗效。方法肝郁血瘀型黄褐斑女性患者77例,随机分为观察组(中药治疗)与对照组(西药治疗),比较两组皮损面积和严重程度指数(MASI)评分、匹兹堡睡眠质量指数(PSQI)及生活质量量表(SF-36)评定。结果治疗后观察组MASI评分、PSQI评分均低于对照组(P<0.05);在SF-36情感、精神、社会三个维度评分高于对照组(P<0.05)。结论中药内服外用治疗黄褐斑效果满意,并能显著改善患者生活质量。     

中西医结合治疗慢性乙型肝炎肝纤维化及早期肝硬化的临床分析

目的分析研究中西医结合治疗慢性乙型肝炎肝纤维化及早期肝硬化的疗效。方法临床上诊断明确的慢性乙型肝炎肝纤维化及早期肝硬化患者100倒,将患者分为对照组50例,治疗组50例。对照组采用仅一干扰素治疗;治疗组在采用西医治疗的基础上,根据中医辨证论治,选用有特别疗效的中药方剂。经过治疗一个疗程后,观察两种疗效。结果治疗组总有效率90．0％高于对照组的54．0％,组间疗效差异具有明显统计学意义（P〈0．05）。治疗后症状和体征,各项肝功能、纤维化指标变化和腹部超声下影像改善情况治疗组均优于对照组,差异均具有显著性（P〈0．05）。结论中西医结合是治疗慢性乙型肝炎肝纤维化及早期肝硬化的有效办法,经济实用,副作用少,值得在临床上推广。     

Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.

The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea pig model of tinea pedis. Each agent was topically applied once a day for 3 or 7 consecutive days, starting on day 10 postinfection, and a culture study was conducted on day 5 after the last treatment with each agent. The 1% cream of lanoconazole was as highly effective as the 1% cream of terbinafine in terms of eradicating the fungi from the infected feet.     

盐酸布替萘芬乳膏治疗体股癣临床疗效观察

目的探讨盐酸布替萘芬乳膏和盐酸特比萘芬乳膏治疗体股癣的临床疗效。方法将190例体股癣患者随机分为2组,治疗组96例,外用盐酸布替萘芬乳膏;对照组94例,外用盐酸特比萘芬乳膏。2组疗程均为2周,在治疗结束及停药后2周随访时记录症状、体征积分及真菌学检查结果。结果治疗组2周停药时及停药2周后的治疗组2周停药时的痊愈率、总有效率均高于对照组,但差异均无统计学意义。2组用药后真菌直接镜检转阴率和真菌培养转阴率均为100%。结论盐酸布替萘芬乳膏治疗体股癣安全有效,值得临床推广应用。     

中药结合针刺治疗坐骨神经痛36例疗效观察

目的研究中药结合针刺方法治疗坐骨神经痛的临床疗效。方法 73例坐骨神经痛患者随机分为两组。对照组患者仅采用针刺方法治疗,研究组患者采用针刺结合中药调理方法,用药时间2个疗程。对两组患者的疗效进行比较分析。结果研究组患者显效率(30.55%)、总有效率(86.11%)明显高于对照组(14.71%、67.65%),均具有显著差异(P<0.05)。结论中药结合针刺方法治疗坐骨神经痛具有较好的效果,能够提高疗效,适合于临床推广。     

温经通络中药药枕联合颈复康颗粒治疗神经根型颈椎病的临床研究

目的: 探讨温经通络中药药枕联合颈复康颗粒对于颈椎病（神经根型）的治疗效果。方法: 随机选取80位符合CSR诊断标准的患者,将其均分为2组,对照组给予单纯颈复康颗粒治疗,而治疗组在其基础上联合温经通络药枕治疗。两组总的治疗时间均为一月。所有患者在治疗前、治疗半月、治疗一月时分别进行指标检测,进行疗效评价。结果: 两组患者在治疗一个疗程后,统计分析发现,单纯服用中药组治愈率20%、有效率87.5%;而联合治疗组治愈率35%、有效率97.5%,联合治疗组疗效明显优于单纯服用中药组。结论: 温经通络中药药枕联合颈复康颗粒在治疗颈椎病（神经根型）方面疗效明显,可为临床治疗提供新的思路与参考。