深圳市南山区学龄前单纯性肥胖儿童血脂、脂蛋白及载脂蛋白的变化

目的通过对单纯性肥胖儿童血脂、脂蛋白及载脂蛋白的研究,初步了解其脂质代谢紊乱的状况,探讨其致动脉粥样硬化危险性增加的可能机制。方法对39名肥胖儿童和39名对照儿童空腹12小时以上抽静脉血检测甘油三脂（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白AI（APoAI）和载脂蛋白B（APoB）。结果单纯性肥胖儿童血清TG、LDL-C、APoB显著高于对照组（P〈0.05）,而TC、HDL-C、APoAI肥胖组与对照组无显著性差异（P〉0.05）。结论单纯性肥胖儿童脂质代谢出现紊乱,其发生动脉粥样硬化（AS）的危险性增加。     

中老年人肥胖对血脂,脂蛋白及载脂蛋白A1,B水平的影响

中老年人肥胖对血脂、脂蛋白及载脂蛋白Ａ＿１、Ｂ水平的影响赵瑞祥，周向东，郑霞荣，张弘（空军杭州疗养院，杭州，３１０００７）关键词：肥胖，血脂，脂蛋白，载脂蛋白为探讨中老年人肥胖与血脂、脂蛋白及载脂蛋白（ＡＰＯ）Ａ１、Ｂ水平的关系，我们自１９８８年以来...     

单纯性肥胖儿童血脂、脂蛋白、载脂蛋白的研究

目的：通过对单纯性肥胖儿童的血脂、脂蛋白、载脂蛋白进行研究，探讨其发生动脉粥样硬化（AS）的危险性。方法：对54名肥胖儿童和60名正常体重儿童分别测定其血清脂质、脂蛋白、载脂蛋白，同时测定腰围、臀围、皮褶厚度，计算腰臀围比（WHR）、体脂百分比（％BF）、脂肪组织（FM）。结果：肥胖组儿童血清甘油三酯（TG）、低密度脂蛋白胆固醇（LDL－C）、极低密度脂蛋白胆固醇（VLDL－C）和载脂蛋白B100(apoB100)的浓度高于非肥胖组（P＜0．05），而高密度脂蛋白胆固醇（HDL－C）、载脂蛋白AI（apoAI)的浓度却低于非肥胖组，差异有显著性（P＜0．05），肥胖组与非肥胖组儿童总胆固醇（TC）浓度差异没有显著性（P＞0．05）。结论：单纯性肥胖儿童脂质代谢出现紊乱，肥胖儿童发生AS的危险性增加。     

胆囊胆固醇结石患者血脂、脂蛋白、载脂蛋白水平研究

目的 观察胆囊胆固醇结石患者血脂、脂蛋白和载脂蛋白特点及其临床意义,探讨与胆囊胆固醇结石形成的机制.方法 检测胆囊胆固醇结石组和对照组血清总胆固醇（TCH）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、载脂蛋白AI（Apo-AI）、载脂蛋白B（Apo-B）、载脂蛋白E（Apo-E）浓度.结果 胆囊胆固醇结石组的血清HDL及LDL低于正常对照组;Apo-B高于正常对照组.结论 胆囊胆固醇结石患者血清具有低HDL、低LDL、高Apo-B的特点.HDL、LDL及Apo-B可能可作为胆囊胆固醇结石的预示指标,对这些指标的干预可能会对胆囊胆固醇结石的形成有所抑制.     

牧民冠心病患者血清脂蛋白载脂蛋白和血脂测定的临床意义

为探讨蒙古族物民血脂、载脂蛋白及脂蛋白（ａ）与冠心病的关系,测定了１２６例牧区蒙古族冠心病患者及１０５例牧区蒙古族健康人（对照组）血清脂质及脂蛋白含量。蒙古族冠心病患者血清甘油三脂、胝密度脂蛋白胆固醇、载脂蛋白Ｂ１００、脂蛋白（ａ）显著高于对照组;冠心病组血清高密度脂蛋白胆固醇、载脂蛋白ＡＩ显著低于对照组;冠心病组血清胆固醇含量与对照组比较无显著差异。脂蛋白（ａ）、甘油三脂、低密度脂蛋白胆固醇、载     

脑血管病患者血脂、脂蛋白及载脂蛋白AI、B100测定的临床意义

目的 研究脑血管病患血脂，脂蛋白及载脂蛋白AI（apo AI），载脂蛋白B100（apoB100)测定的临床意义。方法 脑血管病人及健康人均晨起空腹静脉抽血，血清TC，TG及HDL－C采用酶法试剂盒及生化仪测定；apoAI,B100和免疫周围扩散法；LDL－C用Friedewald公式计算，即LDL-C=TC-(1/5TC＋HDL－C）。结果 脑动脉硬化组及脑梗死组与健康对照组的血脂，脂蛋白及apoAI,B100含量的比较，经过统计学处理，均有显差异至极显差异（P＜0．05－0．001）。脑出血组除TG有显差异（P＜0．05）外，其余均无显差异（P＞0．05）。结论 载脂蛋白测定对脑血管疾病预测的敏感度远比血脂及脂蛋白高。     

高锌摄人对机体血脂 脂蛋白及载脂蛋白代谢的影响

目的：观察健康人高锌摄入对血脂、脂蛋白及栽脂蛋白代谢的影响，为合理用锌提供依据。方法：选择长清县五峰乡当地居民38例，服葡萄糖酸锌(0.2g，含锌50mg／d)，每次专人送药，连服8周。在服药前、服药后4、8周3次查体，描记心电图，测定血压。3次查体同时取静脉血，测定胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL—C)、高密度脂蛋白胆固醇(HDL—C)、载脂蛋白AI(apoA1)、载脂蛋白B100(apoB100))含量，观察动态变化。结果：服锌4周时TC升高，8周持续升高，TG4周时升高，8周时处稳定状态，8周时LDL—C升高，4周时apoB100升高，8周时apoA1降低，apoA1／apoB100值变小。结论：健康人摄入锌50mg／d时，引起脂类代谢紊乱，临床应谨慎使用锌制剂。     

妊娠高血压综合征与血脂、载脂蛋白及脂蛋白（a）的关系

目的探讨妊娠高血压综合征（简称妊高征）患者血脂代谢水平的变化及其，临床意义。方法测定正常孕妇及妊高征患者的血清甘油三脂（TG）、总胆固醇（TC）、载脂蛋白AI（ApoAI）、载脂蛋白B（ApoB）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）及脂蛋白（a）水平。结果妊高征组血清TG（P〈0．01）、ApoB（P〈0．01）、LDL—c（P〈0．05）及LP（a）（P〈0．05）较正常孕妇显著升高，ApoAI、HDL—C则显著降低（P〈0．05），TC在两组间差别无显著性意义（P〉0．05）。在轻、中、重妊高征患者之间，ApoAI（P〈0．05）及HDL—C（P〈0．01）依次降低，组间比较有显著性意义，LDL—C（P〈0．01）及LP（a）（P〈0．01）依次升高，组间有极显著性差异。TG、TC和ApoB组间比较，差别无显著性意义。结论血脂代谢异常可能在妊娠高血压疾病的发病中起一定作用。     

脑血管病患者血脂、脂蛋白及载脂蛋白AI、B100测定的临床意义

目的研究脑血管病患者血脂、脂蛋白及载脂蛋白AI(apo AI)、载脂蛋白B100(apo B100)测定的临床意义.方法脑血管病人及健康人均晨起空腹静脉抽血,血清TC、TG及HDL-C采用酶法试剂盒及生化仪测定;apoAI、B100测定用免疫周围扩散法;LDL-C用Friedewald公式计算,即LDL-C=TC-(1/5TC+HDL-C).结果脑动脉硬化组及脑梗死组与健康对照组的血脂、脂蛋白及apoAI、B100含量的比较,经过统计学处理,均有显著差异至极显著差异(P＜0.05～0.001).脑出血组除TG有显著差异(P＜0.05)外,其余均无显著差异(P＞0.05).结论载脂蛋白测定对脑血管疾病预测的敏感度远比血脂及脂蛋白高.     

高锌摄入对机体血脂脂蛋白及载脂蛋白代谢的影响

目的 :观察健康人高锌摄入对血脂、脂蛋白及载脂蛋白代谢的影响 ,为合理用锌提供依据。方法 :选择长清县五峰乡当地居民 38例 ,服葡萄糖酸锌 (0 .2 g ,含锌 5 0mg/d) ,每次专人送药 ,连服 8周。在服药前、服药后 4、8周 3次查体 ,描记心电图 ,测定血压。 3次查体同时取静脉血 ,测定胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL -C)、高密度脂蛋白胆固醇 (HDL -C)、载脂蛋白AI(apoA1)、载脂蛋白B10 0(apoB10 0 ) )含量 ,观察动态变化。结果 :服锌 4周时TC升高 ,8周持续升高 ,TG 4周时升高 ,8周时处稳定状态 ,8周时LDL -C升高 ,4周时apoB10 0升高 ,8周时apoA1降低 ,apoA1/apoB10 0值变小。结论 :健康人摄入锌 5 0mg/d时 ,引起脂类代谢紊乱 ,临床应谨慎使用锌制剂。     

Genotype by sex interaction in measures of lipids,lipoproteins, and apolipoproteins

Genotype by sex (GxS) interaction in a quantitative trait indicates that the sexual dimorphism exhibited in that trait is heritable. GxS interaction has implications for the modeling of traits in segregation analyses and for the assessment of disease risk in males and females. Thirteen quantitative measures of lipids, lipoproteins, and apolipoproteins from 203 to 301 individuals in 25 to 27 kindreds were examined for evidence of GxS interaction. These measures included serum concentrations of total cholesterol, triglycerides, LDL-C, HDL-C, apo B, and apo AI, and peak LDL particle diameter, small LDL mass, large LDL mass, IDL mass, VLDL mass, HDL, mass, and HDL, mass. GxS interaction was indicated for transformed values of LDL-C and small LDL mass by an additive genetic correlation between males and females significantly less than 1.0, and GxS interaction was indicated for transformed values of HDL, mass and HDL, mass by males and females having significantly different additive genetic variances. © 1993 Wiley-Liss, Inc.     

血清NT-proBNP与IL-6在川崎病患儿中的水平变化及临床意义

目的探讨血清N末端B型脑钠肽原(NT-proBNP)、白细胞介素-6(IL-6)在川崎病(KD)患儿中的表达水平及临床意义。方法收集2014年8月-2016年12月沧州市中心医院收治的KD患儿为病例组(n=50),并根据是否合并冠脉损伤将其分为冠脉损伤组(n=17)和非冠脉损伤组(n=33),并于同期选取因发热性疾病入院治疗的非KD患儿为对照组(n=50)。采用电化学发光法检测血清NT-proBNP水平,酶联免疫吸附法检测血清IL-6水平。结果病例组患儿血清NT-proBNP、IL-6水平均高于对照组,差异有统计学意义(P<0.05)。冠脉损伤组患儿血清NT-proBNP、IL-6水平均高于非冠脉损伤组,差异有统计学意义(P<0.05)。经Pearson积差相关分析,病例组患儿血清NT-proBNP与IL-6呈正相关关系(r=0.639,P<0.05)。NT-proBNP的ROC曲线下面积AUC为0.862(95%CI:0.755~0.970),最佳临界值为1.07μg/L,灵敏度为89.21%,特异性为92.24%;IL-6的ROC曲线下面积AUC为0.904(95%CI:0.813~0.995),最佳临界值为58.21 ng/ml,灵敏度为93.41%,特异性为89.16%;NT-proBNP联合IL-6对KD的AUC为0.915(95%CI:0.837~0.993),灵敏度为96.27%,特异度为92.24%。结论 NT-proBNP、IL-6在川崎病患儿血清中明显升高,早期联合检测可作为辅助诊断川崎病的重要指标。     

川崎病的早期诊断及治疗体会

目的总结川崎病住院患儿的临床特点。方法对23例川崎病患儿的临床表现和辅助检查及诊治过程进行分析。结果本组早期临床表现发热（100％），唇和口腔粘膜变化（95.65％），双眼结膜充血（82，6％），肛周皮肤潮红脱皮（69.56％），四肢末梢脱皮（65.2％），肛周皮损较四肢变化早；多形皮疹（65．2％），颈淋巴结肿大（73.9％），心脏彩超异常（39％）。结论增强对川崎病的认识，早诊断，早治疗。     

Serum lipids, lipoproteins and apolipoproteins in black patients with angiographically defined coronary artery disease

The association between angiographically defined coronary artery disease (CAD) and serum lipids, lipoproteins, and apolipoproteins was evaluated in 151 black men and 245 black women. Patients with 70% or greater narrowing of at least one coronary artery or greater than or equal to 50% stenosis of the left main coronary artery (n = 179) were compared to those with lesions of less than 50% stenosis (n = 217) for total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), LDL-C/HDL-C, triglycerides, apolipoprotein A-I, apolipoprotein B, and apolipoprotein A-I/B. A consistently more atherogenic pattern of lipids, lipoproteins, and apolipoproteins occurred only among the women. Using stepwise selection multiple logistic regression analysis, the ratio of apolipoprotein A-I/B (odds ratio = 0.38, 95% confidence limits 0.24-0.61) was the only statistically significant association of CAD in women, after adjusting for the effects of age, body mass index, and histories of smoking, hypercholesterolemia, hypertension, and diabetes. When stratified by median of total cholesterol, the ratio of apolipoprotein A-I/B was the most strongly associated with the presence of CAD in the lower half of the total cholesterol distribution (less than 208 mg/dl), whereas in the upper half of the total cholesterol distribution the total cholesterol/HDL-C ratio was more strongly associated with CAD. None of the variables studied was associated with CAD in men. These results support other studies suggesting that apolipoproteins may be better predictors of CAD.     

冠心病患者血脂、血清胆红素、总胆汁酸水平变化的临床研究

目的:研究冠心病(CHD)患者血脂、血清胆红素及总胆汁酸(TBA)水平变化及它们之间的相关性。方法:198例健康体检者为对照组,252例经临床确诊的CHD患者为观察组,采用全自动生化分析仪检测血脂、血清胆红素水平及TBA浓度,并进行统计学分析。结果:观察组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、TG/HDL-C、LDL-C/HDL-C、TBA水平明显高于对照组,差异有统计学意义(P<0.01);而血清高密度脂蛋白胆固醇(HDL-C)、总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)均明显低于对照组,差异有统计学意义(P<0.01),且与冠脉病变程度相关。结论:血脂异常、TBA水平升高和血清胆红素水平降低与CHD密切相关,提示血脂异常、高TBA及低水平胆红素是CHD发病的危险因素,早期干预有可能预防心血管事件的发生、发展。     

CRP和VEGF在川崎病患儿血清中的表达和临床意义

目的:动态研究川崎病(KD)患儿血清中C-反应蛋白(C-reactive protein,CRP)和血管内皮生长因子(vascular endothelial growth factor,VEGF)在小儿川崎病血管损伤中的作用机制,寻找其与冠状动脉(简称冠脉)损伤之间直接关系的依据。方法:应用酶联免疫吸附实验(ELISA)和免疫乳胶比浊法检测47例川崎病患儿、19例发热疾病患儿(对照组)血清中的CRP和VEGF水平,并将KD患儿分为急性期、亚急性期、恢复期;有冠脉损伤(CAL)组和无冠脉损伤(NCAL)组。结果:KD患儿急性期、亚急性期和恢复期的CRP、VEGF水平均高于发热组,两组间差异有统计学意义(P<0.01);CAL组CRP、VEGF水平明显高于NCAL,差异有统计学意义(P<0.01)。CRP的高峰期在急性期,VEGF的高峰期在亚急性期。结论:CRP和VEGF水平在KD患儿组急性期和亚急性期升高,可能在川崎病患儿血管损伤的病理生理发生机制中发挥重要作用。CRP和VEGF具有预示KD患儿CAL潜在的可能性。     

Heterogeneity in multifactorial inheritance of plasma lipids and lipoproteins in ethnically diverse families in Jerusalem

Genetic and cultural determinants of total cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), and HDL-C/TC were estimated utilizing a path model in a random sample of nearly 4,000 families examined in the Jerusalem Lipid Research Clinic. The analyses were done separately in each of the ethnic groups categorized according to the parents' country of birth (Europe, Asia, North Africa, and Israel/mixed origin) in order to identify the nature and sources of any heterogeneity among the groups. Both genetic (h2) and cultural (c2) components of inheritance were significant for all lipid variables in each of the ethnic groups. Under the most parsimonious model, estimates of h2 in the ethnic groups were .40-.55, .40-.51, .45-.50, .41-.48, and .42-.78 for TC, LDL-C, HDL-C, HDL-C/TC, and TG, respectively. The c2 ranged from 3% to 5% for TC and LDL-C and from 4% to 10% for HDL-C, HDL-C/TC, and TG. The major parameters of the path model were generally homogeneous across the origin groups. The h2 appeared to be higher in the Asian and c2 was slightly greater in the European group. The stronger sibling environmental effect in the Asia group, the somewhat lower transmission of environment in the North African group, and the lower correlation between spouse environments in the North African group were the major sources of the origin heterogeneity. Within this population, genetic factors appear to be the major determinants of lipid variations, suggesting relative homogeneity of the distribution of environmental determinants of plasma lipids.     

老年冠心病患者血脂与胆红素水平的研究

目的探讨血脂水平及血清胆红素与冠心病的关系。方法96例经临床确诊的老年冠心病患者为观察组,82例老年健康体检者为对照组,采用全自动生化分析仪检测血脂水平及血清胆红素浓度。结果观察组的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平高于对照组,差异有统计学意义;而血清高密度脂蛋白胆固醇(HDL-C)、总胆红素(TB il)、直接胆红素(DB il)、间接胆红素(IB il)均低于对照组,差异有统计学意义。结论老年冠心病患者血脂水平较高,而血清胆红素水平较低,提示高血脂及低水平胆红素是冠心病发病的危险因素。     

Effect of altered feeding patterns on serum lipids and lipoproteins in adult males

Effects of a three meal per day versus a six meal per day feeding pattern on selected serum lipids and lipoproteins in 17 males were examined. After a two week acclimatization period, subjects were randomly assigned to one of two groups. Each group followed a three meal per day pattern for six weeks and a six meal per day pattern for another six weeks. Serum total cholesterol and LDL-cholesterol levels were not significantly affected by the altered feeding patterns. There was a significant decrease in the triglyceride levels of one group, but not the other, during the six meal per day pattern. For both groups the HDL-cholesterol levels differed significantly (P≤0.05) between the two feeding patterns. However, the findings were dissimilar in that for one group the HDL-cholesterol was higher after the six meal per day pattern and, for the other group, the opposite was true. Only during Phase I, the acclimatization period when both groups were consuming three meals per day, were any significant differences in dietary intakes noticed. Specifically, subjects in Group I consumed significantly more total fat and saturated fat (P=0.01 and P=0.04, respectively). Throughout the study there were no significant differences between the two groups relative to polyunsaturated to saturated fat (P/S) ratios of the diets.     

陕西省川崎病流行病学调查研究

了解陕西省川崎病的实际发病情况,分布及流行病学现状。方法采用日本中国川崎病流行病学调查组１９９８年东京会议制定的统一标准,对１００张床位以上的二级甲等医院的１５０家儿科发出统一制定的流行病学调查表,选择１９９３年１月－１９９７年１２月儿科住院的川崎病初诊患儿进行登记调查。