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Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland 总被引:9,自引:0,他引:9
Postiglione MP Parlato R Rodriguez-Mallon A Rosica A Mithbaokar P Maresca M Marians RC Davies TF Zannini MS De Felice M Di Lauro R 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(24):15462-15467
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Furuya F Shimura H Suzuki H Taki K Ohta K Haraguchi K Onaya T Endo T Kobayashi T 《Endocrinology》2004,145(6):2865-2875
Iodide uptake by the thyroid is mediated by the sodium/iodide symporter. Upon iodide uptake, thyroperoxidase catalyzes iodination of tyrosine residues in thyroglobulin, retaining iodide within thyroid follicles. Dedifferentiation-induced loss of these functions in cancers, rendering them unresponsive to radioiodide, occurs with most poorly differentiated and anaplastic tumors. We focused on the histone deacetylase (HDAC) inhibitors (HDACI) as a way to induce differentiation of thyroid cancer cells. We assessed re-expression of thyroid-specific genes mRNA induced by HDACI using quantitative RT-PCR and immunostaining in poorly differentiated papillary and anaplastic thyroid cancer cells. HDACI induced expression of thyroid-specific gene mRNAs and proteins, and accumulation of radioiodide through iodination of generic cellular proteins were detected. HDACI-treated tumors could specifically accumulate (125)I as revealed by imaging experiments and radioiodide concentration in vivo. In an attempt to determine the mechanism by which these gene expressions occurred, we detected the inhibition of protein synthesis by cycloheximide, which up-regulated the expression of thyroperoxidase and thyroglobulin mRNA in HDACI-treated cells and down-regulated that of sodium/iodide symporter mRNA. Together, our results suggest that HDACI-induced expression of thyroid-specific genes, some of which is mediated by some protein synthesis, may contribute to development of novel strategy against thyroid cancer. 相似文献
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BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism 总被引:3,自引:0,他引:3
Durante C Puxeddu E Ferretti E Morisi R Moretti S Bruno R Barbi F Avenia N Scipioni A Verrienti A Tosi E Cavaliere A Gulino A Filetti S Russo D 《The Journal of clinical endocrinology and metabolism》2007,92(7):2840-2843
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Decreased expression of thyrotropin receptor gene suggests a high-risk subgroup for oncocytic adenoma 总被引:1,自引:0,他引:1
Mirebeau-Prunier D Guyétant S Rodien P Franc B Baris O Rohmer V Reynier P Tourmen Y Malthièry Y Savagner F 《European journal of endocrinology / European Federation of Endocrine Societies》2004,150(3):269-276
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