M型彩色多普勒超声心动图对原发性高血压和冠心病患者左室舒张功能的评估作用

背景：左室舒张功能障碍的评价对于患者的心功能分级、诊断与治疗，具有重要的意义。但对不同收缩功能状态及E／A比值假性正常化时的左室舒张功能的研究少见有报道。目的：探讨M型彩色多普勒超声心动图在研究原发性高血压和冠心病患者左室舒张功能中的作用，并与传统方法进行比较。设计：以诊断为依据的病例对照研究。地点、对象和方法：收集2001-11／2002-05中山大学附属三院门诊和住院患者，对照组为门诊正常体检者，自愿参加本研究。在超声心动图室收集资料。36例正常人为对照组，74例原发性高血压(essential hypertension，HTN)患者(HTN组)和33例冠心病患者(冠心病组)进行了研究。采用M型彩色多普勒超声心动图进行研究。左室容量用Teichholz公式由舒张末和收缩末容积估计，然后计算射血分数和缩短分数。主要观察指标：①HTN患者、正常人、冠心病患者从二尖瓣到心尖的早期充盈峰速传播速率(1ate of propagation of peak early filling flow velocity，vp)。②早期充盈峰速时间(time delay rate of propagation of peak early filling flow velocity，TD)和Vp／E比值。③左室舒张早期、晚期跨二尖瓣血流峰速(E峰和A峰)、早期和晚期血流峰速比(E／A)和舒张晚期跨二尖瓣血流峰速时间。④肺静脉收缩期血流速度、舒张期血流速度、肺静脉返流速度和返流时间。⑤舒张期末和收缩期末左室内径、舒张期末室间隔厚度和后壁厚度。结果：根据EF值将患者分成EF≤60％组(收缩功能障碍组)和EF&;gt;60％组(收缩功能正常组)。收缩功能障碍组与收缩功能正常组的所有传统舒张功能参数差异无显著性意义，但收缩功能障碍组与收缩功能正常组Vp分别为(37．6&;#177;12．1)和(46．0&;#177;19．1)cm／s(P&;lt;0．05)，TD分别为(86．2&;#177;26．1)和(66．8&;#177;19．4)ms(P&;lt;0．05)，Vp／E分别为0．65&;#177;0．29和0．73&;#177;0．26(P&;lt;0．01)。对10例收缩功能障碍患者(EF≤60％)而E／A值正常(大于1)(假性正常化)的研究结果显示，在假性正常化患者和对照组Vp分别为(34．9&;#177;8．3)和(59．9&;#177;21．3)cm／s(P&;lt;0．01)，TD分别为(91．0&;#177;29．6)和(56．9&;#177;18．9)m8(P&;lt;0．01)、Vp／E分别为0．56&;#177;0．24和0．85&;#177;0．28，差异有非常显著性意义(P&;lt;0．01)，而其他舒张功能参数差异无显著性意义。结论：原发性高血压和冠心病患者存在舒张功能障碍；M型彩色多普勒超声心动图测定的早期充盈峰速传播速率和时间(Vp，TD和Vp／E)是评价左室舒张功能更精确和更可靠的参数，可以区别假性正常化的跨二尖瓣血流类型。     

M型彩色多普勒超声心动图评价冠心病和高血压病的左室舒张功能

目的：研究冠心病（CAD）和原发性高血压（EH）患的左室舒张功能。方法：采用M型彩色多普勒超声心动图研究了36例正常人（I组），33例冠心病患（Ⅱ组）和74例原发性高血压患（Ⅲ组）。测定了从二法瓣到心尖的早期充盈峰速传播速率（Vp），早期充盈峰速时间（TD）和Vp/E比值，同时测定左室舒张早期、晚期跨二尖瓣血流峰速（E峰和A峰）、早晚期血流峰速比（E／A）和舒张晚期跨二尖瓣血流速度时间（AD），并测定左室结构与收缩功能。结果：3组在性别、年龄和心率方面无统计学差异。Ⅱ组、Ⅲ组与Ⅰ组比较，E、A、E／A，Vp、TD和Vp/E差异有统计学意义（P＜0．05）或P＜0．01）；Ⅱ组与Ⅰ组比较，左室内经（LVID）、左室质量指数（LVMI）、射血分数（EF）、缩短分数（SF）差异有统计学意义（P＜0．01）；Ⅱ组与Ⅲ组比较，LVID、EF、SF差异有统计学意义（P＜0．01）。结论：冠心病和原发性高血压患存在左室功能障碍，M型彩色多普勒超声心动图测定的Vp、TD和Vp/E参数是评价左室舒张功能更敏感的指标。     

高血压病患者左室舒张功能的研究

本文采用二维脉冲多普勒技术对40例高血压病患者的左室舒张功能进行了研究,并与同年龄正常人对照。结果显示,高血压病患者心脏二尖瓣口血流,舒张早期充盈速度(E峰速)与E峰减速率明显低于正常人;而二尖瓣口舒张晚期充盈速度(A峰速)与A/E值明显高于正常人。证实了高血压病患者可出现左室舒张功能障碍。经分组对照显示,左室壁出现明显增厚时,其舒张功能的障碍更加严重。     

多普勒组织成像评价冠心病左室舒张功能的价值

目的:探讨多普勒组织成像(DTI)评价冠心病(CAD)左室舒张功能的价值。方法:应用DTI技术对54例临床确诊(其中22例经冠脉造影证实)的冠心病患者和26例正常对照组二尖瓣环侧壁舒张早期及晚期(e峰、a峰及e/a比率)运动速度进行测定,并与二尖瓣血流舒张早期及晚期峰值速度比E/A、肺静脉血流收缩与舒张早期峰值速度比S/D进行对照分析。结果:1.左室充盈减低时,E/A<1,e/a较正常组减低(P<0.01),S/D较正常组减低(P<0.01);2.左室充盈假性正常化时,E/A>1,e/a较正常组减低(P<0.01),S/D较正常组减低(P<0.01);3.左室限制性充盈异常时,E/A≥2,S/D较正常组减低(P<0.01),e峰、a峰较正常组减低(P<0.01),e/a与正常组比较无显著性差异。结果:DTI技术测定二尖瓣环e峰、a峰及e/a比率,可评价CAD左室舒张功能,弥补常规多普勒超声心动图的不足。     

冠心病患者颈动脉超声参数与左室舒张功能的相关性分析

[目的]探讨冠心病患者颈动脉超声参数与左室舒张功能的相关性。[方法]收集2019年1月至2020年3月在本院诊治的24例心肌梗死患者作为A组,并收集同期在本院诊治的30例不稳定性心绞痛患者(B组)和26例稳定性心绞痛患者(C组),三组患者均接受颈动脉超声检查和左室舒张功能检测。对比三组患者的颈动脉超声参数[颈总动脉硬化度(β)、颈动脉顺应性(AC).弹性系数(EP)、脉搏波传导速度(PEVβ)]和左室舒张功能[二尖瓣E峰/组织多普勒E峰(E/Em)、二尖瓣E峰/左室血流传导速度(E/Vp)、二尖瓣E峰/A峰(E/A)、肺静脉反流速度(PVAR).E峰线速时间(DT)]情况;分析颈动脉超声参数与左室舒张功能的关系。[结果]A组患者β、AC、EP、PEVβ.IMT、E/Em、E/A.DT、E/Vp.PVAR值均显著高于B组和C组,且B组上述参数值也显著高于C组,其差异均有统计学意义(P<0.05);相关性分析结果显示:冠心病患者颈动脉超声参数与左室舒张功能各参数水平间两两均呈正相关(P<0.05)。[结论]冠心病患者的颈动脉超声参数与左室舒张功能参数呈显著相关性,颈动脉超声各参数越高可能提示左室舒张功能越差。临床可依据颈动脉超各参数变化预判冠心病患者的左室舒张功能变化。     

彩色多普勒超声心动图评价冠心病左室舒张功能的临床价值

目的应用彩色多普勒超声心动图测定冠心病左室舒张功能，为临床提供可靠的诊断及治疗依据。方法分别测定冠心病组及对照组的左室舒张功能：二尖瓣口左室快速充盈峰值血流速度即E峰；左室舒张晚期峰值速度即A峰；E／A值，左室等容舒张时间（IVRT），E峰减速时间（DT），二尖瓣前叶E峰与室间隔左室面的距离（EPSS）。结果冠心病组与正常对照组相比，E峰明显降低，A峰相对较高，E／A值明显降低，IVRT明显延长，EPSS有所延长。结论彩色多普勒超声心动图评价冠心病左室舒张功能具有临床诊断价值。     

彩色M-型多普勒评价左室舒张功能的临床研究

目的　探讨应用 M-型彩色多普勒测量左室内血流播散速度评价左室舒张功能的临床价值。方法　研究 6 0例扩张型心肌病患者和 6 0例正常人的左室舒张早期血流播散速度 (Vp)和 E峰与 Vp的比值 (E/ Vp)等指标。结果　扩张型心肌病患者不论是 E/ A>1还是 E/ A≤ 1,其 Vp和 E/ Vp与正常对照组相比均明显异常 (P<0 .0 1)。结论　 Vp和 E/ Vp无伪正常充盈现象 ,其评价左室舒张功能较二尖瓣血流频谱更可靠。     

评估冠心病左室舒张功能多普勒几项技术的对比研究

目的　探讨二尖瓣口血流多普勒、肺静脉血流多普勒及组织多普勒成像技术评价左室舒张功能 ,并对该三种多普勒技术进行对比性研究。方法　对 166例冠心病患者的舒张功能进行检测 ,分别探测二尖瓣口血流舒张早期与心房收缩期峰值速度E A比值、肺静脉血流收缩期与舒张早期峰值速度S D比值以及二尖瓣环室间隔、侧壁、前壁、下壁四个壁舒张早期及晚期运动速率比值的平均值e a比值。结果　在冠心病患者左室舒张功能轻度不全时 (E A <1) ,二尖瓣环DTI测值e a <1的阳性率最高 ,为 10 0 % ,肺静脉血流S D >1.5比值的阳性率为 98%。在二尖瓣口血流频谱多普勒显示假性正常时 ( 2 >E A >1) ,二尖瓣环DTI测值e a <1的阳性率为 93 % ,而肺静脉血流频谱多普勒S D <1的阳性率仅为 76%。在二尖瓣口血流频谱多普勒显示限制性充盈时 (E A >2 ) ,二尖瓣环DTI测值e a <1的阳性率则为 5 8% ,而肺静脉血流频谱多普勒S D <1的阳性率为 83 %。结论　在舒张功能减退的早期 ,二尖瓣环DTI测值阳性率最高。在二尖瓣口血流频谱多普勒显示假性正常时 ,二尖瓣环DTI明显优于肺静脉血流频谱。在限制性充盈时 ,二尖瓣环e a的阳性率反而不及肺静脉血流     

急性心肌梗死后左室舒张功能的超声心动图评价

目的　应用彩色多普勒超声心动图对发生急性心肌梗死（AMI）的患者左室舒张功能进行观察。方法　于心尖四腔切面检测舒张期二尖瓣血流频谱获得左室舒张早期最大流速（E）、左室舒张晚期最大流速（A）、E／A、E峰减速时间（DT）值;检测肺静脉血流频谱（PVFP）获得收缩期脉静脉血流频谱最大速度（S）、舒张早期脉静脉血流频谱最大速度（D）、S／D、舒张晚期肺静脉逆向血流的最大速度（Ar）值;测定主动脉瓣血流频谱结束到二尖瓣血流频谱开始之间的时间,即左室等容舒张时间（IRT）,将病例组所测值与正常对照组进行比较。结果 47例病例与46例正常对照组比较,病例组中有27例二尖瓣血流频谱E／A〈1,DT,左室等容舒张时间（IRT）值增高,肺静脉血流频谱的S值显著增高,D值降低,S／D值显著增高;有13例二尖瓣血流频谱2≥E／A〉1,肺静脉血流频谱S／D值显著降低,余各值差异无显著性;有7例二尖瓣血流频谱E／A〉2,DT,IRT值减低,肺静脉血流频谱S值显著减低,S／D值显著减低。结论 彩色多普勒超声心动图二尖瓣血流频谱及肺静脉血流频谱可以对AMI后左室舒张功能进行较准确的评价。     

左室舒张性心力衰竭的左心形态及舒张功能的超声评价

目的探讨左室舒张性心力衰竭(LVDHF)的左心形态及舒张功能的超声心动图特点。方法 LVDHF组60例,健康体检30例为对照组,超声心动图测量左房内径(LAD)、左室内径(LVD)、舒张期室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室射血分数(LVEF)、二尖瓣口舒张早期流速峰值(E)、肺静脉反向血流速度(Ar)、彩色M型血流传播速度(Vp)、二尖瓣瓣环舒张早晚期速度比(Ea/Aa)、E/Ea及心室收缩期与舒张期正向波峰速比(S/D)。结果与对照组比较,LVDHF组LAD、IVST、LVPWT、E/Ea及Ar均增加,Ea/Aa、Vp及S/D均减小,差异均有统计学意义(P<0.05)。结论超声心动图能正确判断左室舒张功能,是目前临床通用的诊断左室舒张性心力衰竭的最佳办法。     

彩色血流传播速度对二尖瓣置换术后左心室舒张功能的定量评估

目的 探讨彩色M型多普勒(CMM)评价二尖瓣置换术(MVR)后患者左室舒张功能的临床价值.方法 52例接受MVR术后3个月以上患者为病例组,另选取年龄、性别相匹配的30例正常人为对照组.测量左房室腔大小、机械瓣口流速、射血分数(EF)等常规超声心动图指标;应用CMM测量舒张期左室内彩色血流传播速度(Vp),计算二尖瓣位机械瓣口血流速度(E)与Vp比值(E/Vp);应用组织多普勒测量二尖瓣环舒张期峰值速度(Em),计算均值Em'和E/Em'.结果 ①MVR组Vp、Em较对照组明显减低,E/Vp、E/Em'较对照组明显增高,差异有统计学意义(P<0.001).E/Vp与E/Em'相关性良好,r=0.86,P <0.01;②Vp受左窜收缩功能和心律的影响,当EF≤50%或者心房颤动时,Vp减低更明显(P<0.01),而E/Vp受EF及心房颤动的影响较小(P>0.05);③绘制ROC曲线,以E/Vp≥2.00为最佳截断值,预测E/Em'≥15的敏感性为92.31%,特异性为83.65%,曲线下面积0.954.结论 CMM可用于评价MVR术后左室舒张功能;E/Vp与E/Em具有良好的一致性,可作为评价MVR术后左室舒张功能的有效指标.     

Diagnosis of left-ventricular diastolic dysfunction in patients with predialysis chronic renal failure

AIM: To specify effectiveness of different methods for assessment of diastolic function in patients with pre-dialysis chronic renal failure (CRF). MATERIAL AND METHODS: Forty non-diabetic pre-dialysis CRF patients (20 males and 20 females, mean age 51 +/- 11 years) were studied. Serum creatinine was 209.3 +/- 117.4 mcmol/l. 19 patients had chronic heart failure (CHF) of NYHA class I-III. M-mode echocardiography and Doppler echocardiography were performed. Transmitral and pulmonary venous flows were assessed by Doppler echocardiography and the flow propagation velocity (Vp) was estimated by color M-mode Doppler echocardiography. The ratio of peak E-wave velocity of transmitral flow to Vp (E/Vp) was calculated. All the patients had preserved systolic function (ejection fraction > 45%). RESULTS: Interpretation of transmitral flow was difficult in 16 (40.0%) patients. During Valsalva's manoeuvre the E-wave peak velocities, the A-wave velocities and the ratio E/A were decreasing. However, we did not reveal any correlation between E/A and NYHA class of heart failure (r = 0.18; p = 0.32). Interpretation of pulmonary venous flow was possible only in 24 (60.0%) patients. Vp estimation by color M-mode Doppler echocardiography improved evaluation of diastolic function in 15 of 16 patients with problems of transmitral flow assessment. A negative correlation was revealed between NYHA class and Vp (r = -0.39; p = 0.013) and a positive correlation was between NYHA class and E/Vp (r = 0.45; p = 0.004). CONCLUSION: Vp assessed by color M-mode Doppler echocardiography improves the diagnosis of diastolic dysfunction in patients with chronic renal insufficiency. This method has an advantage over pulmonary venous flow investigation. The Valsalva's manoeuvre is low-effective for differential diagnosis of transmitral flow types.     

Effect of preload reduction by haemodialysis on new indices of diastolic function

Assessment of mitral annular motion diastolic velocities by M-mode or tissue Doppler imaging and the propagation velocity of early diastolic filling (Vp) by colour M-mode have been proposed as preload-independent indices of diastolic function. The aim of the present study was to determine the effects of preload reduction by haemodialysis on these new echocardiographic indices and to assess the relationship between these indices. The study group comprised 17 patients with chronic renal failure in sinus rhythm with normal left ventricular systolic function who underwent echocardiography 30 min prior to and 30 min following haemodialysis. Following dialysis there were significant reductions in weight (P<0.001), left atrial diameter (P=0.001), the peak Doppler velocity of early diastolic transmitral flow (P=0.005) and the ratio of Doppler velocities of early to late diastolic transmitral flow (P=0.02), consistent with a reduction in intravascular volume. There was no change after dialysis in early diastolic mitral annular velocity using M-mode (P=0.19) or tissue Doppler imaging from either the septal or lateral walls (P=0.88 and P=0.15 respectively), but there was a reduction in Vp after dialysis (55 to 49 cm/s; P=0.04). There were only weak correlations between Vp and the early diastolic mitral annular velocities (r<0.6 for all). We conclude that the assessment of diastolic function by the mitral annular early diastolic velocity appears to be preload-independent, that Vp may be affected by preload and that there is only a weak relationship between Vp and the early diastolic mitral annular velocity.     

An evaluation of the use of new Doppler methods for detecting longitudinal function abnormalities in a pacing-induced heart failure model.

BACKGROUND: Doppler tissue echocardiography and color M-mode Doppler flow propagation velocity have proven useful in evaluating cross-sections of patients with left ventricular (LV) dysfunction, but experience with serial changes is limited. Purpose and methods: We tested their use by evaluating the temporal changes of LV function in a pacing-induced congestive heart failure model. Rapid ventricular pacing was initiated and maintained in 20 dogs for 4 weeks. Echocardiography was performed at baseline and weekly during brief pacing cessation. RESULTS: With rapid pacing, LV volume significantly increased and ejection fraction (57%-28%), stroke volume (37-18 mL), and mitral annulus systolic velocity (16.1-6.6 cm/s) by Doppler tissue echocardiography significantly decreased, with ejection fraction and mitral annulus systolic velocity closely correlated (r = 0.706, P <.0001). In contrast to the mitral inflow velocities, mitral annulus early diastolic velocity decreased steadily (12.3-7.3 cm/s) resulting in a dramatic decrease in mitral annulus early/late (1.22-0.57) diastolic velocity with no tendency toward pseudonormalization. The color M-mode Doppler flow propagation velocity also showed significant steady decrease (57-24 cm/s) throughout the pacing period. Multiple regression analysis chose mitral annulus systolic velocity (r = 0.895, P <.0001) and propagation velocity (r = 0.782, P <.0001) for the most important factor predicting LV systolic and diastolic function, respectively. CONCLUSIONS: Doppler tissue echocardiography and color M-mode Doppler flow could evaluate the serial deterioration in LV dysfunction throughout the pacing period. These were more useful in quantifying progressive LV dysfunction than conventional ehocardiographic techniques, and were probably relatively independent of preload. These techniques could be suitable for longitudinal evaluation in addition to the cross-sectional study.     

应变率成像评估左心室不同舒张功能状态患者左心房功能

目的探讨应变率成像（SRI）评估左心室不同舒张功能状态下左心房功能的价值。方法128例受检者根据左心室不同舒张功能状态分成正常组、顺应性降低组、假性正常化组及限制性充盈障碍组。采集心尖四腔观、三腔观和二腔观组织速度图,SRI测量并计算左心室收缩期左心房平均峰值应变率（mSRs）、左心室舒张早期左心房平均值峰应变率（mSRe）、左心房收缩期左心房平均峰值应变率（mSRa）;测量包括二尖瓣口舒张早期前向血流峰值速度（E）与二尖瓣前瓣环纽织多普勒E比值（E／E′）及E与二尖瓣口M型彩色多普勒峰值血流速度Vp比值（E／Vp）等左心室舒张功能相关参数。将SRI所测左心房功能相关参数与反映左心室舒张功能相关参数作对比。结果E／Vp及E／E′随舒张功能障碍加重而增高,1．1±0．3vs1．6±0．2vs2．1±0．3VS2．6±0．4和7．4±2．4 vs 10．4±2．9VS17．6±4．2vs22．8±4．8（均P〈0．05）;4组患者mSRs、mSRe、mSRa差异有统计学意义（P〈0．05）;mSRe随舒张功能障碍加重而降低,（3．73±0．92）^-1 vs（2．84±0．54）^-1 vs（1.94±0．23）s^-1 vs（1．85±0．30）s。（均P〈0．05）,mSRs及mSRa在舒张功能降低组最高,而在限制性充盈障碍组中最低;E／E′、E／Vp与mSRe呈良好负相关（r=0．813,P〈0．01;r=-0．793,P〈0．01）。结论SRI可准确评价左心室不同舒张功能状态患者左心房功能。     

多普勒组织成像技术评价尿毒症患者左心室舒张功能

目的　探讨脉冲多普勒组织成像 (PW DTI)技术在评价尿毒症患者心脏舒张功能中的价值。方法2 0例对照者 ,3 5例尿毒症患者均行常规超声心动图及PW DTI检查。PW DTI分析二尖瓣环 4个位点的DTI平均指标 :舒张早期峰值速率 (VE)、舒张晚期峰值速率 (VA)、VE/VA 比值。结果　根据常规超声心动图检查结果将尿毒症患者分为射血分数 (EF)正常组与EF降低组。与对照组比较 ,尿毒症EF正常组与EF降低组患者二尖瓣环 4个位点平均VE、VE/VA 均显著降低 (P <0 .0 1) ;与尿毒症患者二尖瓣口血流E/A值比较 ,该组患者二尖瓣环 4个位点平均VE/VA<1所占比率显著增高 (P <0 .0 5 )。结论　PW DTI可较准确评价尿毒症患者心脏舒张功能且不受其左心室收缩功能影响。     

彩色M型多普勒超声心动图评价糖尿病患者左心室舒张功能

目的:应用彩色M型多普勒超声心动图测量糖尿病患者左心室舒张早期血流传播速度,评价糖尿病患者的左心室舒张功能;材料与方法:应用彩色M型多普勒超声心动图测量55例糖尿病患者及30例正常人的左心室舒张早期血流传播速度(Vp)。结果:糖尿病患者的左心室舒张早期血流传播速度比正常人明显减低,不论E/A<1或者E/A>1;结论:糖尿病患者存在左心室舒张功能障碍,应用M型彩色多普勒超声心动图测量左心室舒张早期血流传播速度能简便、准确地评价左心室舒张功能。     

超声心动图评价高血压病患者左心功能

目的运用超声心动图技术综合评价高血压病患者左室收缩功能和舒张功能。方法高血压病组56例和对照组36例,M-型和二维(2D)超声心动图检测:左房内径(LAd),舒张期室间隔厚度(IVST)和左室后壁厚度(PWT),左室舒张末期内径(LVDd),二尖瓣EF斜率,室间隔及左室后壁运动幅度,左室射血分数(EF),左室短轴缩短率(FS),每搏量(SV);脉冲多普勒(PW)检测二尖瓣口舒张早期充盈峰速度(VE),舒张晚期充盈峰速度(VA),E/A比值,等容舒张时间(IVRT)。结果高血压病患者左室壁与室间隔收缩期运动幅度普遍增强,与对照组比较P<0.01;左室收缩功能各项参数(EF、FS、SV)高于对照组(P<0.05),高血压病组左室舒张功能各参数异常,表现为VE减低,VA升高,E/A<1,IVRT延长,MV-EF斜率减慢,与对照组比较P<0.001;左房扩大(P<0.001)。结论超声心动图技术可反映高血压病患者左心结构和功能变化,为临床诊治提供客观依据。     

组织多普勒显像评价二尖瓣置换术后左心室功能

目的 探讨应用组织多普勒显像(TDI)评价二尖瓣置换(MVR)术后左室功能的临床价值.方法 45例接受MVR术后3个月以上患者为病例组,根据心律分为心房颤动组和窦性心律组,并选取30例正常人为对照组.应用常规超声心动图测量左房室腔大小、机械瓣口流速、射血分数等指标;应用TDI测量心尖四腔观二尖瓣环间隔处和侧壁处运动收缩期峰值速度(Sm)、舒张期峰值速度(Em)、等容舒张时间(IVRT);计算E/Em.结果 ①与对照组相比,MVR组二尖瓣环Sm、Em均明显减低,IVRT延长(P＜0.001),但窦性心律组与心房颤动组之间差异无统计学意义(P＞0.05);②MVR组E/Em较对照组明显增高,二者差异有统计学意义(P＜0.001),且E/Em与IVRT呈正相关;以E/Em＞15.0为最佳截断值,评价左室舒张功能变化的敏感性为91.11%,特异性为90.32%,ROC曲线下面积为0.9548±0.0402.结论 TDI能够准确评价MVR后左室功能,E/Em作为一种评价心肌舒张和左室充盈压的量化指标可以评价MVR术后患者左室舒张功能.     

Impact of a hemodialysis session on cardiac function in patients with chronic renal failure

AIM: To determine the impact of hemodialysis (HD) session on cardiac function in patients with chronic renal failure. MATERIAL AND METHODS: Thirty patients (17 male, 13 female, mean age 49 +/- 11 years) on bicarbonate HD were studied. M-mode echocardiography was performed and ejection fraction (EF) was estimated. Transmitral flow was assessed by Doppler echocardiography. Peak velocity of early (E) and late (A) filling, E/A ratio, isovolumic relaxation time (IVRT) and early deceleration time (DT) were estimated. All the estimations were made one hour before and immediately after HD by one investigator. Flow propagation velocity of early diastolic flow was assessed by color M-mode Doppler echocardiography. RESULTS: A significant decrease of the ejection fraction (delta EF) was observed only in patients with intradialytic hypotension. Hemodialysis resulted in a decrease of early flow velocity from 99.2 +/- 23.8 to 80.6 + 26.0 cm/s (p = 0.0000) and E/A ratio from 1.23 +/- 0.57 to 0.98 +/- 0.43 (p = 0.006). IVRT and DT showed no significant difference. There was a significant positive correlation between the amount of ultrafiltration and deltaE (r = 0.46; p = 0.01), there was no correlation between the amount of ultrafiltration and delta Vp (r = -0.01; p = 0.9). CONCLUSION: The results show that a hemodialysis session influences cardiac function in patients with chronic renal failure. Early diastolic filling considerably decreased in correlation with ultrafiltration. A significant decrease in an ejection fraction was detected only in patients with intradialytic hypotension. Ultrafiltration had no impact on flow propagation velocity of early diastolic flow of the left ventricle assessed by color M-mode Doppler echocardiography.