Treatment of 37 patients with refractory idiopathic thrombocytopenic purpura by Shengxueling (升血灵)

Objective： To explore the clinical effect and possible mechanism of Shengxueling （升血灵, SXL）, a Chinese medical preparation mainly consisting of ginseng saponins, in treating refractory idiopathic thrombocytopenic purpura （ITP）. Methods： The selected 69 patients with ITP were randomly assigned to two groups, the 37 patients in the treated group were treated orally by SXL with the dose for adult as 60 mg twice a day for two weeks. Then when no marked rise of platelet count after that, the dose would be doubled and administered for another two weeks. Then the dose could be gradually reduced to the initiative level in patients who responded to the treatment, and if they did not, the treatment was regarded as ineffective and be terminated. The 32 patients in the control group were treated with ampeptide elemente instead of SXL, 0.4 g each time three times a day in the first two weeks, and, if that was ineffective, 0.2 g would be added each time and 1.8 g would be administered a day for two more weeks. Four weeks＇ treatment was regarded as one therapeutic course for both groups and the observation lasted for two successive courses in patients showing positive reslbonse. Results： In the 37 patients in the treated group, markedly effective was obtained in 7 （19.0%）, favorably effective in 15 （40.5%）, improved in 5 （13.5%） and ineffective in 10 （27.0%）, the total effective rate being 59.5%. The corresponding number in the 32 patients in the control group was 4 （12.5%）, 6 （18.8%）, 3 （9.4%）, 19 （59.4%） and 31.3% respectively. Comparison showed the difference in therapeutic efficacy between the two groups was significant （P〈0.05）. Conclusion： SXL is a safe and effective preparation for treatment of ITP, showing an immediate effect which is obviously superior to that of ampeptide elemente with less adverse effect.     

Clinical Assessment on Treatment of Hyperlipidemia with Pushen Capsule (蒲参胶囊)

Objective: To explore the therapeutic effect of Pushen capsule (PSC, 蒲参胶囊) in treating primary hyperlipidemia. Methods: Two hundred and forty patients with primary hyperlipidemia were randomly divided into two groups, the 120 patients in the treated group treated with PSC (4 capsules, tid) and the 120 patients in the control group treated with Zhibituo tablet (脂必妥, 3 tablets, tid), and they were administered at the same time with Zhibituo placebo. The therapeutic course for both groups was 4 weeks. The therapeutic effect and the effects on blood lipids and viscosity were observed. Results: The effective rate in thetreated group was 76. 3%, which was significantly higher than that in the control group (48. 7% , P< 0. 01). PSC showed a significant lowering effect on TC, TG and LDL-C and raising effect on HDL-C, and the effect in lowering TG was significantly better than that of Zhibituo (P<0.01). PSC also showed a certain effect in decreasing whole blood viscosity of both high-sheared and low-shear     

Clinical effect and action mechanism of Weicao Capsule (威草胶囊) in treating gout

Objective： To study the therapeutic effect of Weicao Capsule （威草胶囊, WCC） on gout. Methods： Two hundred gout patients were assigned to two groups. The treated group was treated with WCC and the control group was treated with Tongfengding Capsule （痛风定胶囊）. Both groups were given the respective treatments orally 3 times a day, 2 capsules each time with 2 weeks as one course and all patients received 2 successive courses of treatment. Changes of blood β2- microglobulin （13 2-M）, hemoglobin （Hb）, 24 h urinary protein （24 h UP）, pH value of urine and blood uric acid （BUA） as well as kidney function were observed. Results： After treatment, level of β 2-M got lowered significantly, Hb and 24 h UP, blood urea nitrogen, serum creatinine and the clearance rate of creatinine, as well as blood lipids all improved obviously in the treated group （all P〈0.01）, while these parameters remained unchanged in the control group （P〉0.05）. The pH value of urine was improved in both groups showing an insignificant difference between them （P〉0.05）. BUA was decreased in both groups with a decrease to a larger extent in the treated group （P〈0.01）. The total effective rate was 87% in the treated group, which was superior to that in the control group （62%, P〈0.05）. Conclusion： WCC has a favorable therapeutic effect on gout and its mechanism of action for improving renal function and reducing urinary protein could be related with the lowering of blood β 2-M, BUA and lipids.     

Summarization on Current Status of the Research on Clinical Application of Xuezhikang Capsule (血脂康胶囊)

XuezhikangCapsule(XZK,血脂康胶囊)isabloodlipidregulatormadeofspecialrefinedredyeast,anditwasprovedthroughlotsofclinicalpracticeinthe10years,tohavesafe,sta bleandevidenteffectinreg ulatingbloodlipids.Thecur rentstatusresearchesonXZKinclinicalapplicationisnowreportedasfollows.EffectsinRegulatingBloodLipids1.BloodlipidsregulatoryeffectonpatientswithprimaryhyperlipidemiaWithpre posttreatmentself controllingorpla cebocontrollingmethodadopted,XZKhasbeenusedtotreatover3000patientsoftheHannation…     

Clinical observation of the treatment of myelodysplastic syndrome mainly with Qinghuang Powder (青黄散)

Objective  

To observe the clinical effectiveness of Qinghuang Powder (青黄散, QHP) combined with Bupi Yishen Decoction (补脾益肾汤, BPYS) in treating myelodysplastic syndrome (MDS), and its relationship with France, America, and Britain (FAB) type, international prognosis scaling system (IPSS) risk, and chromosome karyotype.     

Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

Objective  

To study the changes in cardiac function of rheumatoid arthritis (RA) patients and: to observe the effect of Xinfeng Capsule (新风胶囊, XFC) on them.     

Clinical observation on treatment of hyperplasia of mammary gland by Lirukang Granule (利乳康颗粒)

Objective:To explore the effi cacy and mechanism of Lirukang Granule(利乳康颗粒,LRKG) in treating hyperplasia of mammary gland(HMG).Methods:One hundred patients with HMG were randomly assigned to two groups,50 in each group.The patients in the treated group were orally administered with LRKG thrice a day,one package each time,and those in the control group were given orally Rukuaixiao Tablet(乳块消,RKX) thrice a day,4 tablets each time.The therapeutic course for both groups was 4 months.The clinical eff icacy,pain alleviating rate,as well as changes of local sign and symptom scores were observed before and after treatment.The changes of serum estradiol(E2),progesterone(P),testosterone(T),follicle stimulating hormone(FSH),luteinizing hormone(LH) and prolactin(PRL) in some randomly selected patients(24 patients in the treated group and 24 in the control group) before and after treatment were measured with radioimmunoassay.Results:The total clinical effi cacy in the treated group was superior to that in the control group,signifi cant difference was shown between the two groups(P<0.01).The cure-effective rate and total effective rate in the treated group were 70.0%and 88.0% respectively,signif icantly higher than those in the control group(38.0% and 64.0%) respectively(P<0.01),and the pain alleviating rate in the treated group was also significantly higher in the former than that in the latter(88.0% vs 64.0%,P<0.05).Moreover,the treated group showed obvious superiority in improving the patients' symptom and sign scores(P<0.01),and abnormalities of gonadal hormone as compared with the respective items in the control group(P<0.01).Conclusion:LRKG has good effi cacy in the treatment of HMG,and its mechanism may be related to the regulation on endocrine and immune function.     

Clinical Study on the Piweiping Capsule (脾胃平胶囊) in Treating Patients with Metaplasia of Gastric Mucosa

Intestinalmetaplasiaofgastricmucosaiscloselyrelatedtotheoccuranceofgastriccan-cerandistheprecancerouslesionofgastriccancer(l'2).Secondarypreventivemeasuresf0rgastriccanceraredesignedtost0pthedevelop-mentofitsprecancerouschange.TheauthorsusedPiweipingCapsule(PWPC)orSanji-uweitai(SJWT,-Agr$)totreatl43pa-tientssufferingfromchronicgastritisofgastricantrumwithintestinalmetaplasia(IM),andtakingpathology,cyclicadem0sinemon0phos-phate(cAMP),deoxyribonucleicacid(DNA)ofgastricmuc0saandlymphocyte…     

Clinical observation on treatment of 32 patients with measles by Qingzhen Decoction (清疹汤)

Objective： To observe the clinical effect of Qingzhen Decoction （清疹汤, QZD） on measles. Methods： Adopting the randomizing digital table, 62 patients with measles were assigned to two groups, 32 in the treated group and 30 in the control group. All patients were treated with routine therapy, but QZD was given to the treated group additionally for 5 days. Changes of clinical symptoms, blood routine and liver function before and after treatment were observed, and the medical cost was calculated. Results： After the 5-day treatment, the normalization rate of irritative cough in the treated and the control group was 88.9% （24/27） and 56.0% （14/25） respectively, that of conjunctival congestion was 90.0% （27/30） and 65.5% （19/29） respectively, showing significant differences between groups （P〈0.05）. The liver function normalization rate in the two groups was 28.6% （2/7） and 25.0% （2/8）, and the average medical cost ￥740.7 and ￥749.3, respectively. The total effective rate in the two groups was 96.9% and 93.3% respectively, showing insignificant difference between groups （P〉0.05）. Conclusion： QZD could actively improve the respiratory symptoms like irritative cough and the inflammatory symptoms of eye like conjunctival congestion in patients with measles.     

Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

Objective:To explore the efficacy and mechanism of Yixuesheng capsule(益血生胶囊,YXS) combined with recombination human erythropoietin(RHE) in treating male neoplastic anemia(NA).Methods: Sixty-five patients were randomized into two groups,the 33 patients in the treated group treated with a combined therapy of YXS and RHE,and the 32 in the control group treated with RHE alone,all for 12 weeks.Related clinical indexes,including hemoglobin(Hgb),red blood cell(RBC),hematocrit(HMC),testosterone(T),estradiol (E_2)...     

难治性特发性血小板减少性紫癜的治疗

目的 探讨治疗难治性特发性血小板减少性紫癜(idiopathic thrombocytopenic purpura,ITP)的有效方法.方法 回顾性分析41例成人难治性ITP患者,根据免疫分析结果将患者分为三组:9例应用环孢霉素A(cyclosporin A,CsA)治疗;21例应用长春新碱(vincristine,VCR)治疗;11例应用大剂量地塞米松(dexamethasone,DXm)治疗,连续4周,观察疗效.结果 CsA治疗组9例,有效6例(66.7%);VCR治疗组21例,有效15例(71.4%);DXm治疗组11例,有效7例(63.6%).且CsA治疗组患者的异常细胞免疫得以改善;而后两组大部分患者血小板抗体水平明显降低.结论 对于经糖皮质激素、静脉用丙种球蛋白等治疗无效的难治性ITP患者根据不同的免疫机制,采取针对性治疗,能够取得较满意的效果.     

部分脾栓塞术治疗难治性原发性血小板减少性紫癜疗效观察

目的观察部分脾栓塞术(partial splenicembolization,PSE)治疗难治性原发性血小板减少性紫癜(re-fractory idiopathic thrombocytopenic purpura,R-ITP)的治疗效果。方法对24例经正规内科药物治疗无效的原发性血小板减少性紫癜患者行部分脾栓塞术后随访3个月～4年观察其临床疗效及血小板计数的变化。结果术后所有患者血小板均有不同程度的上升。显效11例,良效8例,进步2例,总有效率79.1%。结论部分脾栓塞治疗R-ITP有明显疗效。     

长春新碱联合白介素11治疗难治性特发性血小板减少性紫癜疗效观察

目的探讨长春新碱联合重组人白介素11治疗难治性血小板减少性紫癜的疗效方法.方法通过分析我院2006年3月~2011年2月间符合23例难治性血小板减少性紫癜的临床资料,采用长春新碱联合重组人白介素11进行治疗.结果显效8例,良9例,进步2例,无效4例,总有效率达73.9%(17/23).结论长春新碱联合重组人白介素11治疗难治性ITP疗效切实可行,不良反应小.     

重组人白细胞介素-11治疗慢性难治性特发性血小板减少性紫癜的临床观察

目的观察重组人白细胞介素-1(1rhIL-11)对慢性难治性特发性血小板减少性紫癜(ITP)的疗效和安全性。方法慢性难治性ITP患者皮下注射rhIL-1150ug/kg,1次/d,疗程14d。结果32例患者用药前血小板计数平均值为(15.3±7.8)×109/L,给药后7、10、14d分别升至(38.6±17.0)×109/L(,52.6±26.5)×109/L(,66.5±34.4)×109/L,与用药前相比有显著升高(P<0.01)。停药后血小板逐渐回落,2个月后降至(52.0±30.2)×109/L,但仍然显著高于治疗前(P<0.01)。治疗的总有效率75%,12例出现轻微不良反应。结论rhIL-11治疗某些慢性难治性ITP有较好疗效,不良反应轻微。     

理血汤治疗慢性原发性血小板减少性紫癜的临床观察

目的 观察理血汤治疗慢性原发性血小板减少性紫癜（简称CITP）的临床疗效。方法 将CITP患随机分为理血汤治疗组（29例）和对照组（20例）。观察治疗前后外周血小板计数、血小板相关抗体、骨髓巨核细胞的变化。结果 治疗组和对照组的缓解率、显效率、总有效率分别为13.8%,24.1%.86.2%和5%,10%,60%。经统计学处理两组差异有非常显性（P＜0．01）,治疗组疗效明显优于对照组。停药后1个月治疗组外周血血小板计数仍明显高于对照组。结论 理血汤治疗CITP有较好疗效,具有很好的开发应用前景。     

益气养血活血方对难治性血小板减少性紫癜患者血小板参数的影响

目的 观察益气养血活血方对难治性血小板减少性紫癜(RITP)患者血小板参数的影响.方法 40例RITP患者为治疗组,36例健康体检者为对照组.治疗组口服益气养血活血方治疗.将治疗组治疗前血小板计数(PLT)、血小板比积(PCT)、平均血小板体积(MPV)和血小板分布宽度(PDW)与对照组比较,并将治疗组治疗前后上述血小板参数进行对比,观察血小板参数的变化.结果 治疗组治疗前PLT数值低于对照组(火0.01),PCT低于对照组(P＜0.05),MPV,PDW高于对照组(P＜0.05).治疗组治疗后与治疗前比较,PLT数值明显上升(P＜0.01),PCT明显上升(P＜0.05),MPV,PDW明显下降(P＜0.05),差异有统计学意义.结论 益气养血活血方除能提升RITP患者的PLT数值外,还可对PCT,MPV,PDW等血小板参数产生影响.     

妊娠合并特发性血小板减少性紫癜7例临床分析

目的：探讨特发性血小板减少性紫癜（ITP）合并妊娠的围产期处理方法。方法：回顾性分析我院1999年-2001年间7例ITP合并妊娠的临床处理经验。结果：7例ITP合并妊娠患者中3例经阴道分娩，3例行剖宫产术，均无产后出血，产褥感染及手术，麻醉并发症，新生儿无1例有出血倾向及颅内出血，结论：ITP合并妊娠时如无产科指征以阴道分娩为宜，血小板极低的情况下可以在血源充足时行选择性剖宫产术，应加强妊娠合并ITP的孕期监护及治疗。     

幽门螺杆菌根除对儿童急性特发性血小板减少性紫癜的疗效

目的 观察幽门螺杆菌(Hp)根除治疗对常规视治的轻度儿童急性特发性血小板减少性紫癜(ITP)的疗效.方法 血清Hp阳性的急性ITP初治患儿93例被随机分为治疗组(A组51例)和对照组(B组42例).B组行常规激素治疗,A组在此基础上加根除Hp治疗.结果 A组Hp清除率87.5%;两组间近期疗效无显著性差异,但1年内复发率A组低于B组(P=0.033).结论 Hp清除对儿童急性ITP的疗效无影响,但能减少复发率,对于Hp感染的ITP患儿建议行根除Hp治疗.     

儿童特发性血小板减少性紫癜病因学的初步研究

应用 Ｐ Ｃ Ｒ 和 Ｅ Ｌ Ｉ Ｓ Ａ 技术对３２ 例急性特发性血小板减少性紫癜（ Ｉ Ｔ Ｐ） 患儿的外周血进行了人细小病毒 Ｂ１９（ Ｈ Ｐ Ｖ Ｂ１９） 、 Ｅ Ｂ 病毒（ Ｅ Ｂ Ｖ） 、巨细胞病毒（ Ｃ Ｍ Ｖ） 及乙型肝炎病毒（ Ｈ Ｂ Ｖ） 系列检测。结果：病例组 Ｈ Ｐ Ｖ Ｂ１９ Ｄ Ｎ Ａ 阳性８ 例（２５ ．０ ％ ） ,与正常对照组比较有显著性差异（ Ｐ＜ ０ ．０５） 。 Ｅ Ｂ Ｖ Ｄ Ｎ Ａ 阳性２ 例, Ｃ Ｍ Ｖ Ｄ Ｎ Ａ 阳性３ 例, Ｈ Ｂｓ Ａｇ 和 Ｈ Ｂｅ Ａｇ 同时阳性２ 例,４种病毒的总阳性率为４６ ．９ ％ （１５／３２ 例） 。提示：近半数儿童 Ｉ Ｔ Ｐ 病例的发生可能与上述病毒感染有关,而 Ｈ Ｐ Ｖ Ｂ１９ 较其他病毒与 Ｉ Ｔ Ｐ 的关系更为密切。