102例老年临终住院患者生活质量及其影响因素分析

目的了解老年临终住院患者的生活质量(QOL)及其影响因素.方法对102例临终患者的生活质量情况,以社会支持、生活满意度(LSIA)、焦虑抑郁(HAD)、疼痛程度(VRS)、日常生活活动指数(ADL)等评分作为相关因素进行调查及多元逐步回归分析.结果QOL与ADL及社会支持总分呈正相关,与HAD及VRS呈负相关.结论老年临终住院患者QOL受多种因素的影响,应针对性地给予临终关怀措施,提高生活质量.     

102例老年临终住院患者生活质量及其影响因素分析

目的了解老年临终住院患者的生活质量(QOL)及其影响因素。方法对102例临终患者的生活质量情况,以 社会支持、生活满意度(LSIA)、焦虑抑郁(HAD)、疼痛程度(VRS)、日常生活活动指数(ADL)等评分作为相关因素 进行调查及多元逐步回归分析。结果QOL与ADL及社会支持总分呈正相关,与HAD及VRS呈负相关。结论 老年临终住院患者QOL受多种因素的影响,应针对性地给予临终关怀措施,提高生活质量。     

社会支持与老年高血压病患者生活质量的相关性分析

目的探讨社会支持与老年高血压病患者生活质量的相关关系.方法采用健康状况调查问卷(SF-36)和社会支持评定量表(SSRS)对162例老年高血压病患者及100例健康老年体检者的生活质量及社会支持进行评定,并对两者的相关关系进行统计学分析.结果老年高血压病患者的生活质量及社会支持评分均低于正常人群(P<0.05,P<0.01);除患者机体功能状态外,社会支持与生活质量各维度之间呈显著正相关(P<0.05,P<0.01).结论社会支持可从心理层面影响老年高血压病患者的生活质量.     

严重烧伤患者康复期生活质量调查及其影响因素分析

目的 调查严重烧伤患者康复期的生活质量及相关影响因素.方法 采用社会支持评定量表、生活质量综合评定问卷和回顾性调查方法,对96例(病例组)16岁以上严重烧伤患者康复期的生活质量进行评估.分析生活质量与伤者一般情况及烧伤原因、烧伤面积、烧伤深度、住院时间、医疗费用支付情况和重返岗位之间的关系,与96名健康人(对照组)进行比较.结果 病例组患者生活质量总分为(53±12)分,与对照组(63±10)分比较,差异有统计学意义(P＜0.01).性别、年龄、文化程度、烧伤原因、住院时间及医疗费用支付情况各异者的生活质量比较,差异无统计学意义(P＞0.05).有配偶者社会功能维度和物质功能维度评分比无配偶者高;社会支持总分、重返岗位、伤后时间、职业与生活质量呈正相关;深度烧伤面积与生活质量呈负相关.结论 严重烧伤患者康复期的生活质量处于低水平,社会支持力度、重返岗位情况、伤后时间、职业、深度烧伤面积等因素与生活质量相关.     

社会支持对系统性红斑狼疮患者生活质量的影响

目的:探讨社会支持对系统红斑狼疮(SLE)生活质量的影响.方法:选择我院住院的68例SLE患者,随机分为实验组和对照组,每组各34例.实验组SLE患者在采用常规治疗和护理同时,并争取社会支持;而对照组只采用常规治疗和护理.对于两组SLE患者采用“社会支持评定量表(SSRS)”和“生活质量自评量表(SF-36QOL)”进行调查测评.两组性别、年龄、文化程度、心理状态及病情具有可比性(P＞0.05).结果:实验组SLE患者的社会支持总分(43.65±5.37)、生活质量总健康(79.53±10.34)及各个维度较对照组明显提高,差异具有统计学意义(P＜0.01).结论:社会支持可以提高SLE患者的生活质量,尽可能调动社会支持系统,以促进SLE患者的康复.     

癌症患者临终阶段症状特点及与生存期的关系

目的 探讨癌症患者临终阶段的症状特点及与生存期的关系.方法 回顾性分析1 480例晚期癌症患者的临床资料.结果 癌症患者临终阶段的症状以体质量下降发生率最高(74.66%),其次为疲乏(68.38%)、食欲减退(43.78%)、疼痛(27.84%)、呕吐(27.70%)等;且以症状群为表现特点,每例患者平均存在5种症状.对生存时间有显著影响的指标有性别、恶心、呼吸困难、水肿、脱水、吞咽困难、体质量下降、恶病质、KPS评分和生存质量(QOL)(P<0.05,P<0.01).结论 癌症患者临终阶段症状多样、复杂,部分症状可作为预测生存期的指标.需加强对癌症患者临终阶段症状特点的认识,以提高临终关怀的水平,改善患者临终阶段的生活质量.     

家庭支持度对家居癌症患者生活质量及心理状态的影响

目的 探讨家庭支持度对家居癌症患者生活质量及心理状态的影响.方法 采用家庭关怀度指数(APGAR)问卷、中国癌症患者生活质量(QOL)调查问卷、症状自评量表(SCL-90)对156例家居癌症患者进行问卷调查.结果 家居癌症患者的APGAR评分为7.99±1.66.QOL评分为43.31士7.35,SCL-90评分为138.00士17.59;APGAR与QOL呈显著正相关、与SCL-90呈显著负相关(均P<0.01).结论 家庭支持与家居癌症患者的生活质量和心理状态密切相关,应当重视家居癌症患者的家庭功能.     

老年膝骨关节炎合并骨质疏松患者生活质量状况及影响因素分析

目的了解老年膝骨关节炎合并骨质疏松患者的生活质量状况,并探讨其影响因素。方法对456例老年膝骨关节炎合并骨质疏松患者进行问卷调查,收集患者的生活质量相关资料并进行统计学分析。结果不同性别、年龄、职业、居住情况、病程、西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and Mc Master Universities Osteoarthritis Index,WOMAC)评估、膝关节疼痛程度、社会支持总分患者间的生活质量得分差异有统计学意义(P0.05);多因素Logistic回归分析结果显示,WOMAC(OR=0.595,95%CI=0.102~0.896)、膝关节疼痛程度(OR=0.168,95%CI=0.014~0.805)、社会支持总分(OR=4.601,95%CI=2.210~18.102)是影响膝骨关节炎合并骨质疏松老年患者生活质量的重要因素。结论 WOMAC指数和膝关节疼痛程度越高,社会支持程度越低,膝骨关节炎合并骨质疏松老年患者的生活质量越低,应重视该类人群的防治。     

电子健康素养与社会支持在老年慢性病患者抑郁和生活质量间的中介作用

目的 探讨电子健康素养与社会支持在老年慢性病患者抑郁和健康相关生活质量间的链式中介作用,为制定针对性干预措施提升患者的健康相关生活质量做参考。方法 多阶段分层整群抽取1 545例老年慢性病患者为研究对象,采用一般资料调查表、电子健康素养量表、医院焦虑抑郁量表、社会支持评定量表和欧洲五维健康量表进行调查。结果 老年慢性病患者抑郁评分为9(8,11)分,健康相关生活质量为0.784(0.533,0.897)分。老年慢性病患者抑郁与电子健康素养、社会支持和健康相关生活质量呈负相关（均P<0.05）。经中介效应检验,电子健康素养与社会支持在抑郁与健康相关生活质量中起链式中介作用,中介效应占总效应的15.6%。结论 抑郁不仅直接影响老年慢性病患者的健康相关生活质量,还可通过电子健康素养和社会支持的中介作用间接预测健康相关生活质量。     

年龄相关性黄斑变性患者视觉相关生活质量与社会支持的相关研究

目的探讨年龄相关性黄斑变性患者视觉相关生活质量及社会支持的关系,为提高患者的生活质量提供参考。方法选取年龄相关性黄斑变性患者250例,采用黄斑变性生活质量量表(MacDQoL)和领悟社会支持评定量表(PSSS)对患者进行视觉相关生活质量和社会支持状况调查。结果年龄相关性黄斑变性对患者视觉相关生活质量的影响主要体现在日常生活方面,排在前5位的分别是购物、业余爱好/休闲活动、个人私事、外出及花费时间;其社会支持得分(60.66±5.31)分;视觉相关生活质量影响得分与社会支持呈负相关性(P0.05)。结论年龄相关性黄斑变性对患者视觉相关生活质量的影响主要体现在日常生活方面,社会支持水平可影响患者的生活质量,护理人员应重视年龄相关性黄斑变性患者的社会支持,通过提高社会支持程度,进而提高患者的视觉相关生活质量。     

杭州健康女性定量骨超声测定原发性骨质疏松

目的 评价杭州健康女性骨超声速度(SOS)值随增龄减少和骨质疏松患病率，建立杭州地区女性骨超声速度值参考数据库。方法 定量超声法测定1208例杭州地区健康女性桡骨远端(RAD)，第3指骨近节(PLX)，第V跖骨(MTR)和胫骨中段(TIB)的超声速度值。结果 RAD、PLX、MTR和TIBSOS峰值(Peak of SOS)均出现在40-45岁，TJB的SOS峰值出现在35—40岁，此后随年龄增长而下降。绝经后妇女在绝经后早期和晚期各有1个SOS快速减少期，前见于桡骨近端，平均年减少率为2．4％，后见于胫骨中段，平均年减少率为1．8％。各部位骨SOS累积减少率随年龄增长而增加，到85岁4部位累积减少为13％-18％。60岁以后骨质疏松性症(OP)检出率为45％-70％，OP检出率以桡骨远端最高，60-70岁平均为67％，第3指骨近端次之约50％，胫骨中段最低为36％；75岁以后分别为70％，65％和45％。结论 全身各部位骨超声速度值到达峰值的年龄不同，峰值也各有差异。绝经后妇女骨超声速度值随年龄增加减少较快，应予激素和补钙治疗，桡骨远端为本地区SOS检测和OP检出的敏感部位。     

Importance of echocardiography in prognosis of surgical outcomes in cholecystitis in elderly patients

The authors propose to use more often echocardiography (EchoCG) in examination of elderly (over 60 years) of age patients with cholecystitis that permits to increase surgical activity to 92.4%. Left ventricular ejection fraction is the most informative. When this fraction is lower than 45% surgery must be recommended on vital indications only. EchoCG was used in 155 patients with cholecystitis, 131 of them were operated. 2 (1.52%) patients died due to acute cardio-vascular insufficiency and pulmonary artery thromboembolism.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

目的 评价脊髓胶质细胞在小鼠骨癌痛形成中的作用.方法 健康雄性C3H/He小鼠40只,周龄8～10周,体重18～22 g,随机分为4组(n=10):假手术组(S组)、骨癌痛组(B组)、PBS组(P组)和米诺环素组(M组).S组跟骨骨髓腔内注射PBS 10 μl;余3组跟骨骨髓腔内注射含2×105个骨纤维肉瘤细胞的PBS 10 μl制备骨癌痛模型,于造模前即刻开始PBS组鞘内注射PBS 5μl,M组鞘内注射米诺环素(用PBS溶解为0.2 mmol/L)5μl,1次/d,连续11 d.于造模前1 d、造模后即刻、3、5、7、9、11 d时测定机械痛阈;于造模后3、7、9、11 d机械痛阈测定结束后测定冷痛阈.痛阈测定结束后处死小鼠,取脊髓组织,测定神经胶质纤维酸性蛋白(GFAP)和CD11b的表达水平.结果 与S组比较,B组和P组造模后3-11 d时、M组造模后3、5 d时机械痛阈升高,B组、P组和M组造模后7～11 d时冷痛阈升高,脊髓CD11b和GFAP表达上调(P<0.05).与B组比较,M组造模后3-11 d时机械痛阈降低,造模后7-11 d时冷痛阈降低,脊髓CD11b和GFAP表达下调(P<0.05).结论 脊髓胶质细胞(星形胶质细胞和小胶质细胞)的激活参与了小鼠骨癌痛的形成.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.     

脊髓胶质细胞在小鼠骨癌痛形成中的作用

Objective To evaluate the role of gliocyte in the spinal cord in the development of bone cancer pain (BCP) in mice. Methods Forty male C3H/He mice aged 8-10 weeks weighing 18-22 g were randomly divided into 4 groups ( n = 10 each) : group I sham operation (group S) , group II BCP, group Ⅲ PBS and group IV minocyline (group M) . In group BCP, PBS and M, bone cancer pain was produced by injection of NCTC2472 fibrosarcoma cell suspension (2 x 105 cells) 10 μl into medullary cavity of calcaneus bone, while in group S, PBS solution 10 μl was injected instead of cancer cell suspension. In group PBS and M, PBS 5 μl and minocyline 5 μl (dissolved to 0.2 mmol/L in PBS)_were given IT immediately before cancer cell inoculation once a day for 11 consecutive days respectively. Mechanical pain threshold was measured at 1 d before cancer cell inoculation, and at 0, 3, 5, 7, 9 and 11d after cancer cell inoculation. Cold pain threshold was measured at 3, 7, 9 and 11d after cancer cell inoculation. The animals were killed after measurement of pain threshold and L4-6, segment of spinal cord was removed for determination of GFAP and CD11b expression by Western blot. Results Compared with group S, mechanical pain threshold was significantly increased at 3-11 d after cancer cell inoculation in group BCP and PBS, and at 3 and S d after cancer cell inoculation in group M, and cold pain threshold was significantly increased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was up-regulated in group BCP, PBS and M ( P < 0.05) . Compared with group BCP, mechanical pain threshold was significantly decreased at 3-11 d after cancer cell inoculation, cold pain threshold was significantly decreased at 7-11 d after cancer cell inoculation, and expression of CD11b and GFAP was down-regulated in group M ( P <0.05) . ConclusionThe activiton of gliocyte in the spinal cord is involved in the development of bone cancer pian in mice.